Professor, Laboratory Medicine, Pathology, Medicine, UCSF
| CONTACT | |
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mmcgrath@php.ucsf.edu Box 1317, UCSF; San Francisco, CA 94143-1317 |
additional websites: |
| EDUCATION | |
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University of Minnesota, B.S., 1974, Biology Medicine
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| PROFESSIONAL EXPERIENCE | |
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1972-1974 |
Research Assistant, Dept of Medicine with Dr. Charles Moldow, University of Minnesota: Identification and analysis of fibroblast receptors for avian tumor viruses. |
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1974-1980 |
M.D./Ph.D. Predoctoral Fellow, Dept of Pathology, Stanford University School of Medicine, Stanford Medical Scientist Training Program. Enrolled in Cancer Biology Ph.D. Program with Dr. Irving Weissman. Thesis: Receptor mediated leukemogenesis. |
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1980 |
ICRETT Fellowship in Cancer Research with Dr. George Klein, Karolinska Institute, Stockholm, Sweden: Relationship between leukemogenesis and chromosomal abnormalities. |
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1980-1982 |
NIH Postdoctoral Fellow, Department of Pathology, Stanford University. |
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1980-1982 |
Visiting Fellow, Department of Biology, California Institute of Technology with Dr. Lee Hood: Molecular Biology of Immunoglobulin and T Cell Receptor Genes. |
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1980-1982 |
Hematology Fellow, Dept of Medicine, Stanford University School of Medicine. |
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1982-1984 |
Residency in Internal Medicine, Stanford University. |
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1984-1985 |
Fellow in Hematology, Stanford University, Department of Medicine. |
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1985 |
Assistant Professor of Medicine, AIDS/Oncology Division, University of California, San Francisco/San Francisco General Hospital. |
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1985 |
Ad hoc grant reviewer for NIMH, NCI, NIAID, VA |
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1985-present |
Scientific Advisory Board, The American Foundation for AIDS Research (AmFAR) |
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1991-1992 |
Assistant Professor of Laboratory Medicine, UCSF/SFGH |
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1992 |
Associate Professor of Laboratory Medicine and Medicine, UCSF/SFGH |
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1995 |
Associate Professor of Pathology, UCSF/SFGH |
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1998-present |
Professor in Residence of Laboratory Medicine, Medicine and Pathology, UCSF/SFGH |
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1999-2000 |
Sabbatical with Dr. Stefan Meuer, Institut fur Immunologie, University of Heidelberg, Germany |
| HONORS & AWARDS | |
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1973 |
Third Annual Livermore Award for Outstanding Student in Hematologic Research, University of Minnesota Medical School |
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1974 |
summa cum laude in Biology |
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1990 |
Outstanding Speaker Award, American Association for Clinical Chemistry |
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1999-2000 |
Mercatur Scholar, University of Heidelberg, Germany |
| SELECTED PUBLICATIONS | |
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Shiramizu BS, Herndier BG and McGrath MS. Identification of a common clonal HIV integration site in HIV virus-associated lymphomas. Cancer Research 1994;54: 2069-2072. | |
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Herndier B, Kaplan L and McGrath MS. Pathogenesis of AIDS Lymphomas. AIDS 1994;8: 1025-1049. | |
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Hurt M, Herndier B., Ng V, McGrath MS. Inter VH-Gene-Family Shared Idiotype on AIDS associated by lymphomas. Blood 1994;84: 986-987. | |
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Marsh J, Herndier B, Ng VL, Shiramizu B, Abbey N, Sanchez H, McGrath MS. Cytokine expression in AIDS associated large cell lymphomas. J Interferon & Cytokine Research 1995;15: 261-268. | |
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McGrath MS, Shiramizu B, Herndier B. Identification of a clonal form of HIV in early Kaposi's sarcoma: evidence for a novel model of oncogenesis, "sequential neoplasia". JAIDS 1995;8: 379-385. | |
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Kaplan LD, Shiramizu B, Herndier B, Hahan J, Meeker TC, Ng V, Volberding PA, and McGrath MS. Influence of molecular characteristics on clinical outcome in HIV-associated non-Hodgkin's lymphoma: Identification of a subgroup with favorable clinical outcome. Blood 1995;85: 1727-1735. | |
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McGrath MS. Pathogenesis of AIDS-associated lymphoma. Leukemia 1996;10: 1077-1078. | |
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Komanduri KV, Luce JA, McGrath MS, Herndier BG, Ng VL. The natural history and molecular heterogenety of HIV-associated primary malignant lymphomatous effusions. JAIDS 1996;13: 215-226. | |
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Renne R, Zhong W, Herndier B, McGrath MS, Abbey NW, Kedes D, Ganem D. Lytic growth of Kaposi's sarcoma - associated herpesvirus (human herpesvirus 8) in B cell lymphoma cells in culture. Nature Med. 1996;2: 342-346. | |
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McGrath MS. T-cells and macrophages in HIV disease. Clin Rev in Allergy & Immun 1996;14: 359-366. | |
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Pulliam L, Gascon R, Stubblebine M, McGuire D, McGrath MS. Unique monocyte subset in patients with AIDS dementia. Lancet 1997;349:692- 695. | |
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Ng V, Hurt M, Herndier B, Fry KE, McGrath MS. VH gene used by HIV-1 associated lymphoproliferations. AIDS Res & Hum Retro 1997;13: 135-149. | |
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Mack KD, Wei R, McGrath MS. A novel method for DEAE-dextran mediated DNA transfection of primary cultured human macrophages. J Immun Methods 1998;211: 79-86 | |
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McGrath MS, Benike C, Kuehne FW, Engleman E. Effect of WF10 (TCDO) on antigen presentation. Transplantation Proceedings 1998;30: 4200-4204. | |
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Ng V, McGrath MS. The immunology of AIDS-associated lymphomas. Immunological Reviews 1998;162: 293-298. | |
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McGrath MS, Kodelja V. Balanced macrophage activation hypothesis: A biological model for development of drugs targeted at macrophage functional states. Pathobiology 1999;67: 277-281. | |
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Holly EA, Lele C. Bracci PM, McGrath MS. Case-control study of non-Hodgkin's lymphoma among heterosexual adults in the San Francisco Bay area. American Journal of Epidemiology 1999;150: 375-389. | |
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McGrath MS, Shiramizu B, Herndier BG. Clonal HIV in the pathogenesis of AIDS-related lymphoma: Sequential pathogenesis. In: Infectious Causes of Cancer: Targets for intervention. James Goedert, ed. (Totowa, NJ: Humana Press), pp. 231-242; 2000 | |
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Zenger E, Abbey NW, Weinstein MD, Gofman I, Millward C, Gascon R, Elbaggari A, Herndier BG, McGrath MS. Injection of human primary effusion lymphoma cells or associated macrophages into SCID mice causes murine lymphomas. Cancer Research 2002;62: 5536-5542. | |
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Gascon RL, Narvaez AB, Zhang R, Kahn JO, Hecht FM, Herndier BG, McGrath MS. Increased HLA-DR expression on peripheral blood monocytes in subsets of subjects with primary HIV infection is associated with elevated CD4 cell apoptosis and CD4 cell depletion. JAIDS 2002;30: 146-153. | |
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Mack KD, Jin X, Kapp L, Wei R, Abbey NW, Elbaggari A, Liu Y, Herndier BG, McGrath MS. HIV insertions within and proximal to host cell genes are a common finding in AIDS-related diseased tissues containing high levels of HIV p24 antigen expression. JAIDS 2003;33: 308-320. | |
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Deeks SG, Kitchen CM, Liu L, Guo H, Gascon R, Narvaez AB, Hunt P, Martin JN, Kahn JO, Levy J, McGrath MS, Hecht FM. Immune activation set-point during early HIV infection predicts subsequent CD4 + T cell changes independent of viral load. Blood 104:942-947; 2004. | |
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Giese T, McGrath MS, Stumm S, Schempp H, Elstner E, Meuer S. Differential effects on innate versus adaptive immune responses by WF10. Cellular Immunology, 229:149-158; 2004. | |
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Zhang RZ, Gascon R, Miller RG, Gelinas D, Mass J, Hadlock K, Jin X, Reis J, Narvaez A, McGrath MS. Evidence for systemic immune system alterations in sporadic Amyotrophic Lateral Sclerosis (sALS). Journal of Neuroimmunology, 159:215-224; 2005. | |
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Salemi M, Lamer S, Yu S, Oliveira T, Fitch W, McGrath MS. Phylodynamic Analysis of Human Immunodeficiency Virus Type 1 in Distinct Brain Compartments Provides a Model for the Neuropathogenesis of AIDS. Journal of Virology 79 (17):11343-11352. 2005. | |
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Zhang, R, Gascon R, Miller RG, Gelinas DF, Mass J, Lancero M, Narvaez A, McGrath MS. MCP-1 chemokine receptor CCR2 is decreased on circulating monocytes in sporadic amyotrophic lateral sclerosis (sALS). J of Neuroimmunology, 179:87-93; 2006. |
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12/6/06 |
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