mcmahon@cc.ucsf.edu
(415) 502-5829 (voice)
(415) 502-3179 (fax)

Box 0128, UCSF; San Francisco, CA 94143-0128

additional websites:

McMahon Lab Website

University of Glasgow, Glasgow, Scotland, B.Sc., 1981, Biochemistry
University of London, London, England, Ph.D., 1985, Biochemistry

Samuels, M., Bishop, JM., Weber, MJ. and McMahon, M. (1993). Conditional transformation of cells and rapid activation of the MAP kinase cascade by an estradiol dependent form of the raf-1 kinase. Mol. Cell Biol. 13: 6241-6252.

Thorburn J., McMahon, M. and Thorburn A. (1994) Raf-1 kinase activity is necessary for gene expression changes but not sufficient for cellular morphology changes associated with cardiac myocyte hypertrophy. J. Biol. Chem. 269: 30580-30586.

Minden, A., Lin, A., McMahon, M., Lange-Carter, C., Derijard, B., Davis RJ. Johnson, GL. and Karin, M. (1994) Differential activation of ERK and JNK MAP kinases by Raf-1 and MEKK. Science. 266: 1719-1723.

Samuels, ML. and McMahon, M. (1994) Inhibition of PDGF- and EGF-mediated mitogenesis and signaling in 3T3 cells expressing ĢRaf-1:ER, an estradiol-regulated form of Raf-1. Mol. Cell Biol. 14: 7855-7866

McCarthy, SA., Samuels, ML. Pritchard, CA. Abraham, JA. and McMahon, M. (1995) Rapid induction of Heparin binding Epidermal Growth Factor/Diphtheria Toxin receptor expression by Raf and Ras oncogenes. Genes Dev. 9: 1953-1964

Pritchard, CA., Samuels ML. Bosch, E. and McMahon, M. (1995) Conditionally oncogenic forms of the A-Raf and B-Raf protein kinases display different biological and biochemical activities in NIH 3T3 cells. Mol. Cell Biol. 15: 6430-6442.

Pritchard, CA. Bolin, L, Slattery, R., Murray, RL. and McMahon, M. (1996) Post-natal lethality and neurological and gastrointestinal defects in mice with targeted disruption of the A-Raf protein kinase gene. Curr. Biol. 6: 614-617.

Lloyd, AC., Obermuller, F., Staddon, S., Barth, CF., McMahon, M. and Land, H. (1997) Co-operating oncogenes converge to regulate Cyclin/cdk complexes. Genes Dev. 11: 663-677.

McCarthy, SA., Aziz, N. and McMahon, M. Identification of immediate-early gene targets of the Raf serine/threonine protein kinase using an estradiol-dependent fusion protein, ĢRaf-1:ER. Differential Display, Methods and Applications in Methods in Molecular Biology, Humana Press 85: 137-151.

McCarthy, SA., Yang, B-S., Chen, D., Cherwinski, H., Hauser, CA., Chen X-R., Klagsbrun, ML. Ostrowski, MC. and McMahon, M. (1997) Rapid phosphorylation of Ets-2 accompanies MAP kinase activation and the induction of gene expression by oncogenic Raf-1. Mol. Cell Biol. 17: 2401-2412.

Bosch, E., Cherwinski, H. and McMahon, M. (1997) Mutations of critical amino acid residues affect the biological and biochemical properties of oncogenic A-Raf and Raf-1. Oncogene. 9: 1021-1033.

Woods, D., Parry, D., Cherwinski, H., Bosch, E., Lees E. and McMahon, M. (1997) Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1. Mol. Cell Biol. 17: 5598-5611.

Zhu J., Woods, D., McMahon, M. and Bishop, JM. (1998) Senescence of human fibroblasts induced by oncogenic Raf. Genes. Dev. 12: 2997-3007.

Cook, S., Aziz, N., and McMahon, M. (1999) The repertoire of Fos and Jun proteins expressed during the G1 phase of the cell cycle is determined by the duration of MAP kinase activation. Mol. Cell. Biol. 19: 330-341.

Aziz, N., Cherwinski, H., and McMahon, M. (1999) Complementation of defective CSF-1 receptor signaling and mitogenesis by Raf and Src. Mol. Cell. Biol. 19: 1101-1115

Chen, D., Heath, V., O'Garra, A., Johnston, J., McMahon, M. (1999) Sustained activation of the Raf-MEK-ERK pathway elicits cytokine unresponsiveness in T cells J. Immunol. 163: 5796-5805.

Ries, S., Biederer, C., Woods, D., Shifman, O., Shirisawa, S., Sasazuki, T., McMahon, M., Oren, M. and McCormick, F. (2000) Opposing effects of Ras on p53: Transcriptional activation of mdm2 and induction of p19ARF. Cell 103: 321-330

Schulze, A., Lehmann, K., Jefferies, HB., McMahon, M. and Downward, J. (2000) Analysis of the transcriptional program induced by Raf in epithelial cells: implication of an EGF-like autocrine loop in protection from anoikis. Genes Dev. 15: 981-994

Lehmann, K., Janda, E., Pierreux, CE., Rytomaa, M., Schulze, A., McMahon, M., Hill, CS., Beug, H. and Downward, J. (2000) Raf induces TGFb production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells. Genes Dev. 14: 2610-2622

Hansen, SH., Zegers, MMP., Rodriquez-Viciana, P., Chardin, P., Mostov, KE., and McMahon, M. (2000) Induced expression of Rnd3 links activation of the ERK pathway to oncogenesis of polarized epithelial cells. Mol. Cell. Biol. 20: 9364-9375

McMahon, M and Woods, D. (2001) Regulation of the p53 pathway by Ras, the plot thickens. BBA Reviews on Cancer Online, 1461: M63-M71

McMahon, M., (2001) Steroid receptor fusion proteins for conditional activation of the Raf-MEK-ERK signaling pathway. Meth. Enzymol. 332: 401-417

Woods, D., Cherwinski, H., Venetsanakos, E., Bhat, A., Gysin, S., Humbert, M., Bray, PF., Saylor VL. and McMahon, M. (2001) Induction of β3-integrin gene expression by sustained activation of the Ras-regulated Raf-MEK-ERK signaling pathway. Mol. Cell. Biol. 21: 3192-3205

Sonoda, Y., Ozawa, T., Hirose, T., Aldape, K., McMahon, M., Berger, MS and Pieper, RO. (2001) Formation of intracranial tumors by genetically modified human astrocytes defines four pathways critical in the development of human anaplastic astrocytoma. Cancer Research 61: 4956-4960

Fanton, CP., McMahon, M and Pieper, RO. (2001) Dual growth arrest pathways in astrocytes and astrocytic tumors in response to Raf-1 activation. J. Biol. Chem. 276: 18871-18877

Blalock WL, Pearce M, Chang F, Lee JT, Pohnert SC, Burrows C, Steelman LS, Franklin RA, McMahon M and McCubrey JA. Effects of inducible MEK1 activation on the cytokine dependency of lymphoid cells. Leukemia (2001) 15: 794-807

Weinstein-Oppenheimer, CR, Henriquez-Roldan, CF, Davis, JM, Navolanic, PM, Saleh, OA, Steelman, LS, Franklin, RA, Robinson, PJ, McMahon, M, McCubrey JA. (2001) Role of the Raf signal transduction cascade in the in vitro resistance to the anticancer drug doxorubicin. Clin. Cancer Res. 7: 2898-907.

Lagunoff, M., Roy, A-M., Venetsanakos, E., Abbey, N., Herndier, B., Bechtel, J., McMahon, M and Ganem, D. (2002) De novo infection and serial transmission of Kaposi�fs sarcoma-associated herpes virus (KSHV) in cultured endothelial cells. J. Virol. 76: 2440-8

Venetsanakos E., Mirza A., Fanton, C., Romanov SR, Tlsty TD. and McMahon M. (2002) Induction by glioblastoma cells of tubulogenesis in telomerase-immortalized human microvascular endothelial cells Exp. Cell Res. 273: 21-33

Woodrow, MA., Woods, D., Cherwinski, HM., Stokoe D. and McMahon M. (2003) Ras-induced serine phosphorylation of the focal adhesion protein paxillin is mediated by the Raf�¨MEK�¨ERK pathway Exp. Cell. Res. 287: 325-338

Anders, M., Christian, C., McMahon, M. McCormick, F and Korn, WM (2003) Inhibition of the Raf-MEK-ERK pathway upregulates expression of the Coxsackie and Adenovirus receptor in cancer cells. Cancer Res. 63: 2088-95.

Shelton JG., Steelman LS., Lee JT., Knapp SL., Blalock WL., Moye PW., Franklin RA., Pohnert SC., Mirza AM., McMahon M and McCubrey JA. (2003) Effects of the RAF/MEK/ERK and PI3K/AKT signal transduction pathways on the abrogation of cytokine-dependence and prevention of apoptosis in hematopoietic cells. Oncogene 22: 2478-92.

Thayer SP, Pasca di Magliano M, Heiser PW, Roberts DJ, Nielsen CM, Lauwers GY, Qi YP, Gysin S, Fernandez-del Castillo C, Yajnik V, Antoniu B, McMahon, M, Warshaw AL & Hebrok M. Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature (2003) 425: 851-856

Bergo MO, Gavino BJ, Hong C, Beigneux AP, McMahon M, Casey PJ, Young SG. (2004) Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf. J Clin Invest. 113: 539-50.

Balmanno K, Millar T, McMahon M, Cook SJ. (2003) DRaf-1:ER* bypasses the cyclic AMP block of extracellular signal-regulated kinase 1 and 2 activation but not CDK2 activation or cell cycle reentry. Mol Cell Biol. 23: 9303-17.

Shelton JG, Moye PW, Steelman LS, Blalock WL, Lee JT, Franklin RA, McMahon M, McCubrey JA. (2003) Differential effects of kinase cascade inhibitors on neoplastic and cytokine-mediated cell proliferation. Leukemia 17: 1765-82.

McCubrey JA, Shelton JG, Steelman, LS, Franklin RA, Sreevalsan T McMahon M. (2004) Effects of a conditionally active v-erbB and an EGFR inhibitor on transformation of NIH 3T3 cells and abrogation of cytokine dependency of hematopoietic cells. Oncogene 23: 7810-20.

Mirza AM, Gysin, S., Malek N, Nakayama K, Roberts JM and McMahon M. (2004) Cooperative regulation of the cell division cycle by the protein kinases Raf and Akt Mol. Cell Biol., 24: 10868-81

Gysin S, Lee H-S, Dean N and McMahon M. (2005) Pancreatic cancer cell proliferation is regulated by the Raf�¨MEK�¨ERK pathway through suppression of p27Kip1 expression. Cancer Research (2005), 65: 4870-4880

Sreeramene RB, Chaudhry A, McMahon M, Sherr C and Inoue K. (2005) Crucial role of the DMP1 transcription factor in RAS-RAF-ARF signaling. Mol. Cell. Biol. 25:220-32

Gysin, S., Kastury K., Rickert P. and McMahon, M. (2005) Analysis of human pancreatic cancer cell lines by microarray comparative genomic hybridization and mRNA expression analysis. Genes Chromosomes and Cancer 44: 37-51

Banerjee A, Gugasyan R, McMahon M, Gerondakis S (2006) Diverse Toll-like receptors utilize Tpl2 to activate extracellular signal-regulated kinase (ERK) in hemopoietic cells. Proc Natl Acad Sci U S A. 103: 3274-3279

Liu J, Suresh Kumar KG, Yu D, Molton SA, McMahon M, Herlyn M, Thomas Tikhonenko A, Fuchs SY (2007) Oncogenic BRAF regulates beta-Trcp expression and NF-kappaB activity in human melanoma cells Oncogene. 2007 26: 1954-1958

Dankort D, Filenova E, Collado M, Serrano M, Jones, K and McMahon M. (2007) A new mouse model to explore the initiation, progression and therapy of BRaf^V600E-induced lung tumors Genes & Development 21: 379-384

Levin M., Ewald AJ., McMahon M., Werb Z. and Mostov K. (2007) A model of intussusceptive angiogenesis. Novartis Found Symp. 283: 37-42

Cartlidge R., Thomas R., Cagnol S., Jong K., Molton SA., Finch A. and McMahon M. (2008) Anti-apoptotic effect of BRAF→MEK→ERK signaling in melanocytes and melanoma cells is mediated by suppression of BIM expression. Pigment Cell & Melanoma Research

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