Efim Guzik Distinguished Professor of Cancer Biology, UCSF
Member, Biomedical Sciences Graduate Program (BMS) and Herbert Boyer Program in Biological Sciences (PIBS)
Associate Director for Professional Education; and Co-Leader, Pancreas Cancer Research Group and Liver Cancer Program, UCSF Helen Diller Family Comprehensive Cancer Center
| CONTACT | |
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mcmahon@cc.ucsf.edu Box 0128, UCSF; San Francisco, CA 94143-0128 |
additional websites: |
| EDUCATION | |
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University of Glasgow, Glasgow, Scotland, B.Sc., 1981, Biochemistry |
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| PROFESSIONAL EXPERIENCE | |
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1985-1989 |
Postdoctoral Fellow, G. W. Hooper Foundation, University of California, San Francisco, CA |
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1989-1991 |
Assistant Specialist Virologist, G. W. Hooper Foundation, University of California, San Francisco, CA |
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1991-1997 |
Staff Scientist, Depts. of Molecular Biology and Cell Signaling, DNAX Research Institute, Palo Alto, CA |
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1997-1998 |
Senior Staff Scientist, Dept. of Cell Signaling, DNAX Research Institute, Palo Alto, CA |
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1998-present |
Associate Professor, Cancer Research Institute, University of California, San Francisco, SF, CA |
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2001-present |
Efim Guzik Distinguished Professor of Cancer Biology, Cancer Research Institute, UCSF |
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2003-present |
Co-Director of the UCSF Biomedical Sciences Graduate Program |
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2004-present |
Co-Leader of the UCSF Helen Diller Family Comprehensive Cancer Center Program in Liver Cancer |
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2006-present |
Professor-In-Residence, UCSF Cancer Research Institute |
| HONORS & AWARDS | |
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1977-1981 |
Imperial Chemical Industries (ICI) Undergraduate Educational Scholarship |
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1981 |
J. N. Davidson Memorial Prize in Biochemistry |
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1981-1985 |
ICI Graduate Student Bursary and Postgraduate Educational Scholarship |
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1985-1987 |
Imperial Cancer Research Fund Postdoctoral Fellowship |
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1988-1990 |
American Cancer Society (California Division) Senior Postdoctoral Fellowship |
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2006 |
Diana Ashby Award of the Melanoma Research Foundation |
| SELECTED PUBLICATIONS | |
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Pritchard, CA. Bolin, L, Slattery, R., Murray, RL. and McMahon, M. (1996) Post-natal lethality and neurological and gastrointestinal defects in mice with targeted disruption of the A-Raf protein kinase gene. Curr. Biol. 6: 614-617. |
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Lloyd, AC., Obermuller, F., Staddon, S., Barth, CF., McMahon, M. and Land, H. (1997) Co-operating oncogenes converge to regulate Cyclin/cdk complexes. Genes Dev. 11: 663-677. |
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McCarthy, SA, Yang, B-S., Chen, D., Cherwinski, H., Hauser, CA, Chen X-R., Klagsbrun, ML. Ostrowski, MC. and McMahon M. (1997) Rapid phosphorylation of Ets-2 accompanies MAP kinase activation and the induction of gene expression by oncogenic Raf-1. Mol. Cell Biol. 17: 2401-2412. |
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Bosch, E., Cherwinski, H. and McMahon, M. (1997) Mutations of critical amino acid residues affect the biological and biochemical properties of oncogenic A-Raf and Raf-1. Oncogene. 9: 1021-1033. |
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Woods, D., Parry, D., Cherwinski, H., Bosch, E., Lees E. and McMahon, M. Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1. Mol. Cell Biol. 17: 5598-5611. |
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Cook, S., Beltman, J. Cadwallader, K., McMahon, M. and McCormick, F. Regulation of MKP-1 expression by ERK-dependent and Ca2+-dependent signal pathways in Rat-1 cells. J. Biol. Chem. 272:13309-13319. |
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McCubrey JA, Steelman LS, Hoyle PE, Blalock WL, Weinstein-Oppenheimer C, Franklin RA, Cherwinski H, Bosch E, McMahon M (1998) Differential abilities of activated Raf oncoproteins to abrogatecytokine dependency, prevent apoptosis and induce autocrine growth factor synthesis in human hematopoietic cells. Leukemia 12: 1903-29 |
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Onishi, M., Nosaka T., Misawa K., Mui, A. L-F., Gorman, D., McMahon M., Miyajima, A. and Kitamura, T. (1998) Identification and characterization of a constitutive active STAT5 mutant that promotes cell proliferation. Mol. Cell Biol. 18: 3871-3879. |
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Kamogawa, Y., Lee, H-J., Johnston, J., McMahon, M., OfGarra, A. and Arai, N. (1998) A conditionally active form of STAT6 can mimic certain of the effects of IL-4. J. Immunol. 161: 1074-1077. |
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Zhu J., Woods, D., McMahon, M. and Bishop, JM. (1998) Senescence of human fibroblasts induced by oncogenic Raf. Genes. Dev. 12: 2997-3007. |
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Cook, S., Aziz, N., and McMahon, M. (1999) The repertoire of Fos and Jun proteins expressed during the G1 phase of the cell cycle is determined by the duration of MAP kinase activation. Mol. Cell. Biol. 19: 330 |
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Aziz, N., Cherwinski, H., and McMahon, M. Complementation of defective CSF-1 receptor signaling and mitogenesis by Raf and Src. (1999) Mol. Cell. Biol. 19: 1101-1115 |
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Chen, D., Heath, V., O'Garra, A., Johnston, J., McMahon, M., (1999) Sustained activation of the Raf-MEK-ERK pathway elicits cytokine unresponsiveness in T cells J. Immunol. 163: 5796-5805. |
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Hansen, SH., Mirjam, MP. Zegers, MMP, Rodriquez-Viciana, P., Chardin, P., Mostov, KE, and McMahon, M. (2000) Induced expression of Rnd3 links activation of the ERK pathway to oncogenesis of polarized epithelial cells Mol. Cell. Biol. 20: 9364-9375 |
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Fowles, LF, Martin, ML, Nelsen, L., Stacey, KJ., Douglas D., Clark, YM., Nagamine, Y., McMahon, M., Hume, DA. and Ostrowski, MC. (1998) Persistent Activation of Mitogen-Activated Protein Kinases p42 and p44 and ets-2 Phosphorylation in Response to Colony-Stimulating Factor 1/c-fms Signaling. Mol. Cell. Biol. 18: 5148-5156. |
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Mirza, AM., Kohn, AD., Roth, RA. and McMahon, M. (2000) Oncogenic transformation of cells by conditionally active form of the protein kinase Akt/PKB. Cell Growth and Differentiation 11: 279-292 |
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Ries, S., Biederer, C., Woods, D., Shifman, O., Shirisawa, S., Sasazuki, T., McMahon, M., Oren, M. and McCormick, F. (2000) Opposing effects of Ras on p53: Transcriptional activation of mdm2 and induction of p19ARF. Cell 103: 321-30 |
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Schulze, A., Lehmann, K., Jefferies, HB, McMahon, M. and Downward, J. (2000) Analysis of the transcriptional program induced by Raf in epithelial cells: implication of an EGF-like autocrine loop in protection from anoikis. Genes Dev. 15: 981-994 |
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Lehmann, K., Janda, E., Pierreux, CE., Rytomaa, M., Schulze, A., McMahon, M., Hill, CS., Beug, H. and Downward, J. (2000) Raf induces TGFb production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells. Genes Dev. 14: 2610-2622 |
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Woods, D., Cherwinski, H., Venetsanakos, E., Bhat, A., Gysin, S., Humbert, M., Bray, PF., Saylor VL. And McMahon, M. (2001) Induction of b3-integrin gene expression by sustained activation of the Ras-regulated Raf-MEK-ERK signaling pathway Mol. Cell. Biol. 21: 3192-3205 |
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Sonoda, Y., Ozawa, T., Hirose, T., Aldape, K., McMahon, M., Berger, MS and Pieper, RO. (2001) Formation of intracranial tumors by genetically modified human astrocytes defines four pathways critical in the development of human anaplastic astrocytoma. Cancer Research 61: 4956-4960 |
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Fanton, CP., McMahon, M and Pieper, RO. (2001) Dual growth arrest pathways in astrocytes and astrocytic tumors in response to Raf-1 activation. J. Biol. Chem. 276: 18871-18877 |
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Blalock WL, Pearce M, Chang F, Lee JT, Pohnert SC, Burrows C, Steelman LS, Franklin RA, McMahon M and McCubrey JA. Effects of inducible MEK1 activation on the cytokine dependency of lymphoid cells. Leukemia (2001) 15: 794-807 |
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Venetsanakos E., Mirza A., Fanton, C., Romanov SR, Tlsty TD. and McMahon M. (2002) Induction by glioblastoma cells of tubulogenesis in telomerase-immortalized human microvascular endothelial cells Exp. Cell Res. 273: 21-33 |
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Woodrow, MA., Woods, D., Cherwinski, HM., Stokoe D. and McMahon M. (2003) Ras-induced serine phosphorylation of the focal adhesion protein paxillin is mediated by the Raf-MEK-ERK pathway Exp. Cell. Res. 287: 325-338 |
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Anders, M., Christian, C., McMahon, M. McCormick, F and Korn, WM (2003) Inhibition of the Raf-MEK-ERK pathway upregulates expression of the Coxsackie and Adenovirus receptor in cancer cells Cancer Res. Cancer Res. 63:2088-95. |
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Shelton JG., Steelman LS., Lee JT., Knapp SL., Blalock WL., Moye PW., Franklin RA., Pohnert SC., Mirza AM., McMahon M and McCubrey JA. (2003) Effects of the RAF/MEK/ERK and PI3K/AKT signal transduction pathways on the abrogation of cytokine-dependence and prevention of apoptosis in hematopoietic cells Oncogene 22: 2478-92. |
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Thayer SP, Pasca di Magliano M, Heiser PW, Roberts DJ, Nielsen CM, Lauwers GY, Qi YP, Gysin S, Fernandez-del Castillo C, Yajnik V, Antoniu B, McMahon, M, Warshaw AL & Hebrok M. Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis Nature (2003) 425: 851-856 |
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Balmanno K, Millar T, McMahon M, Cook SJ. (2003) Raf-1:ER* Bypasses the Cyclic AMP Block of Extracellular Signal-Regulated Kinase 1/2 Activation but Not CDK2 Activation or Cell Cycle Reentry. Mol Cell Biol. 23: 9303-17. |
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Bergo MO, Gavino BJ, Hong C, Beigneux AP, McMahon M, Casey PJ, Young SG. (2004) Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf. J Clin Invest. 113: 539-50. |
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Mirza AM, Gysin S, Malek N, Nakayama K, Roberts JM, McMahon M. (2004) Cooperative regulation of the cell division cycle by the protein kinases RAF and AKT. Mol Cell Biol. 2004 24:10868-81. |
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Gysin S, Lee H-S, Dean N and McMahon M. (2005) Pancreatic cancer cell proliferation is regulated by the Raf¨MEK¨ERK pathway through suppression of p27Kip1 expression Cancer Research (2005), 65: 4870-4880 |
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Sreeramene RB, Chaudhry A, McMahon M, Sherr C and Inoue K. (2005) Crucial role of the DMP1 transcription factor in RAS-RAF-ARF signaling. Mol. Cell. Biol. 25:220-32 |
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Gysin, S., Kastury K., Rickert P. and McMahon, M. (2005) Analysis of human pancreatic cancer cell lines by microarray comparative genomic hybridization and mRNA expression analysis. Genes Chromosomes and Cancer 44: 37-51 |
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Shelton JG, Steelman LS, Abrams SL, Bertrand FE, Franklin RA, McMahon M, McCubrey JA. (2005) The epidermal growth factor receptor gene family as a target for therapeutic intervention in numerous cancers: what's genetics got to do with it? Expert Opin. Ther. Targets. 9: 1009-30. |
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1/22/07 |
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