Teri Melese, PhD

University of California, Berkeley, A.B., 1977, Neurobiology and Literature
University of California, San Francisco, Ph.D., 1982, Cell Biology/Physiology (UC Regents Fellow)

• 1978-1982
  Graduate Student (Dr. Stephen Rothman), Dept. of Cell Biology, University of California, SF
• 1982-1986
  Postdoctoral Fellow, Dept. of Biochemistry (Dr. Paul D. Boyer), Molecular Biology Institute, University of California, Los Angeles
• 1986-1987
  American Cancer Sr. Research Fellow (Dr. Michael Grunstein), Molecular Biology Institute, Dept. of Molecular Biology, University of California, Los Angeles
• January 1988-December 1992
  Assistant Professor, Dept. of Biological Sciences , Columbia University, New York
• January 1993-July 1997
  Associate Professor, Dept. of Biological Sciences, Columbia University, New York
• July 1997-July 1999
  Adjunct Associate Professor, Dept. of Biological Sciences, Columbia University, New York
• July 1997-July 2001
  Director Surrogate Genetics/Lead Discovery, Iconix Pharmaceuticals Inc.
• July 2001-present
  Associate Adjunct Professor, Department of Medicine, University of California, San Francisco

• UC Regents Fellowship
• Cystic Fibrosis Research Fellowship
• National Research Service Award (NIH)
• American Cancer Society Senior Postdoctoral Fellowship
• 6/1/91-5/31/99
  NIH (5 R01 GM44901-07)
• 3/15/88-8/31/91
  NSF (DCB 87 46701)
• 9/1/89-6/30/92
  March of Dimes (5-745)
• 6/1/90-2/28/94
  NSF Presidential Young Investigator Award (MCB 88 58613)

• Lorizio W, Rugo H, Beattie MS, Tchu S, Melese T, Melisko M, Wu AH, Lawrence HJ, Nikoloff M, Ziv E. Pharmacogenetic testing affects choice of therapy among women considering tamoxifen treatment. Genome Med. 2011; 3(10):64.
• Rauen KA, Banerjee A, Bishop WR, Lauchle JO, McCormick F, McMahon M, Melese T, Munster PN, Nadaf S, Packer RJ, Sebolt-Leopold J, Viskochil DH. Costello and cardio-facio-cutaneous syndromes: Moving toward clinical trials in RASopathies. Am J Med Genet C Semin Med Genet. 2011 May 15; 157(2):136-46.
• Rauen KA, Schoyer L, McCormick F, Lin AE, Allanson JE, Stevenson DA, Gripp KW, Neri G, Carey JC, Legius E, Tartaglia M, Schubbert S, Roberts AE, Gelb BD, Shannon K, Gutmann DH, McMahon M, Guerra C, Fagin JA, Yu B, Aoki Y, Neel BG, Balmain A, Drake RR, Nolan GP, Zenker M, Bollag G, Sebolt-Leopold J, Gibbs JB, Silva AJ, Patton EE, Viskochil DH, Kieran MW, Korf BR, Hagerman RJ, Packer RJ, Melese T. Proceedings from the 2009 genetic syndromes of the Ras/MAPK pathway: From bedside to bench and back. Am J Med Genet A. 2010 Jan; 152A(1):4-24.
• Melese T, Lin SM, Chang JL, Cohen NH. Open innovation networks between academia and industry: an imperative for breakthrough therapies. Nat Med. 2009 May; 15(5):502-7.
• Vottero E, Balgi A, Woods K, Tugendreich S, Melese T, Andersen RJ, Mauk AG, Roberge M. Inhibitors of human indoleamine 2,3-dioxygenase identified with a target-based screen in yeast. Biotechnol J. 2006 Mar; 1(3):282-8.
• Melese T, Hieter P. From genetics and genomics to drug discovery: yeast rises to the challenge. Trends Pharmacol Sci. 2002 Dec; 23(12):544-7.
• Tugendreich S, Perkins E, Couto J, Barthmaier P, Sun D, Tang S, Tulac S, Nguyen A, Yeh E, Mays A, Wallace E, Lila T, Shivak D, Prichard M, Andrejka L, Kim R, Melese T. A streamlined process to phenotypically profile heterologous cDNAs in parallel using yeast cell-based assays. Genome Res. 2001 Nov; 11(11):1899-912.
• Perkins E, Sun D, Nguyen A, Tulac S, Francesco M, Tavana H, Nguyen H, Tugendreich S, Barthmaier P, Couto J, Yeh E, Thode S, Jarnagin K, Jain A, Morgans D, Melese T. Novel inhibitors of poly(ADP-ribose) polymerase/PARP1 and PARP2 identified using a cell-based screen in yeast. Cancer Res. 2001 May 15; 61(10):4175-83.
• Gulli MP, Girard JP, Zabetakis D, Lapeyre B, Melese T, Caizergues-Ferrer M. gar2 is a nucleolar protein from Schizosaccharomyces pombe required for 18S rRNA and 40S ribosomal subunit accumulation. Nucleic Acids Res. 1995 Jun 11; 23(11):1912-8.
• Xue ZX, Melese T, Stempel KE, Reedy TJ, Boyer PD. Properties of chloroplast F1-ATPase partially modified by 2-azido adenine nucleotides, including demonstration of three catalytic pathways. J Biol Chem. 1988 Nov 15; 263(32):16880-5.
• Zhou JM, Xue ZX, Du ZY, Melese T, Boyer PD. Relationship of tightly bound ADP and ATP to control and catalysis by chloroplast ATP synthase. Biochemistry. 1988 Jul 12; 27(14):5129-35.
• Melese T, Xue ZX, Stempel KE, Boyer PD. Catalytic properties of chloroplast F1-ATPase modified at catalytic or noncatalytic sites by 2-azido adenine nucleotides. J Biol Chem. 1988 Apr 25; 263(12):5833-40.
• Rothman SS, Melese T. "Leaky" cells of glandular epithelia. Int Rev Cytol. 1988; 112:225-44.
• Xue ZX, Zhou JM, Melese T, Cross RL, Boyer PD. Chloroplast F1 ATPase has more than three nucleotide binding sites, and 2-azido-ADP or 2-azido-ATP at both catalytic and noncatalytic sites labels the beta subunit. Biochemistry. 1987 Jun 30; 26(13):3749-53.
• Melese T, Boyer PD. Derivatization of the catalytic subunits of the chloroplast ATPase by 2-azido-ATP and dicyclohexylcarbodiimide. Evidence for catalytically induced interchange of the subunits. J Biol Chem. 1985 Dec 15; 260(29):15398-401.
• Kandpal RP, Melese T, Stroop SD, Boyer PD. Mitochondrial F1-ATPase will bind and cleave ATP but only slowly release ADP after N,N'-dicyclohexylcarbodiimide or 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole derivatization. J Biol Chem. 1985 May 10; 260(9):5542-7.
• Melese T, Rothman SS. Increased phosphate efflux from acinar cell during protein secretion. Am J Physiol. 1983 Jul; 245(1):C121-4.