Associate Adjunct Professor, Medicine, UCSF
Member and Associate Director for Alliance Management, UCSF Helen Diller Family Comprehensive Cancer Center
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meleset@medsch.ucsf.edu Box 0875, UCSF; San Francisco, CA 94143-0875 |
| EDUCATION | |
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University of California, Berkeley, A.B., 1977, Neurobiology and Literature
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| PROFESSIONAL EXPERIENCE | |
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1978-1982 |
Graduate Student (Dr. Stephen Rothman), Dept. of Cell Biology, University of California, SF |
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1982-1986 |
Postdoctoral Fellow, Dept. of Biochemistry (Dr. Paul D. Boyer), Molecular Biology Institute, University of California, Los Angeles |
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1986-1987 |
American Cancer Sr. Research Fellow (Dr. Michael Grunstein), Molecular Biology Institute, Dept. of Molecular Biology, University of California, Los Angeles |
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January 1988-December 1992 |
Assistant Professor, Dept. of Biological Sciences , Columbia University, New York |
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January 1993-July 1997 |
Associate Professor, Dept. of Biological Sciences, Columbia University, New York |
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July 1997-July 1999 |
Adjunct Associate Professor, Dept. of Biological Sciences, Columbia University, New York |
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July 1997-July 2001 |
Director Surrogate Genetics/Lead Discovery, Iconix Pharmaceuticals Inc. |
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July 2001-present |
Associate Adjunct Professor, Department of Medicine, University of California, San Francisco |
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Professional Activities |
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Chair of Workshop at Yeast Genetics Meetings July 25-30, 2000 Seattle Washington. |
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Reviewer; Journal of Cell Biology, Molecular Cellular Biology and The Journal of Cell Science. |
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| HONORS & AWARDS | |
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UC Regents Fellowship | |
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Cystic Fibrosis Research Fellowship | |
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National Research Service Award (NIH) | |
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American Cancer Society Senior Postdoctoral Fellowship | |
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6/1/91-5/31/99 |
NIH (5 R01 GM44901-07) |
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3/15/88-8/31/91 |
NSF (DCB 87 46701) |
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9/1/89-6/30/92 |
March of Dimes (5-745) |
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6/1/90-2/28/94 |
NSF Presidential Young Investigator Award (MCB 88 58613) |
| SELECTED PUBLICATIONS | |
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Melese, Teri and Rothman, Stephen S. The pancreatic epithelium is permeable to sucrose and inulin across secretory cells. 1983 Proc. Nat'l. Acad. Sci. USA Vol. 80, 4870-4874. | |
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Melese, Teri and Rothman, Stephen S. Distribution of three hexose derivatives across the pancreatic epithelium: Paracellular shunts or cellular passage? 1983 Biochim. et. Biophysica. Acta Vol. 763: 212-219. | |
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Melese,Teri and Rothman, Stephen S. Increased phosphate efflux from the acinar cell during protein secretion. 1983 Amer. J. Physiol. Vol. 244, Cell Section C121-C124 | |
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Kanpal, Rajandra P., Melese, Teri, Stroop, Steven D. and Boyer Paul D. Mitochondrial F1 ATPase will bind and cleave ATP and slowly release products after DCCD or NBD-Cl derivatization of one subunit. 1985 J. Biol. Chem. Vol. 260: 5542-5547. | |
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Melese, Teri and Boyer, P.D. Derivatization of the catalytic subunits of the chloroplast ATPase by 2-azido ATP and dicyclohexylcarbodiimide: Evidence for catalytically induced interchange of the subunits. 1985 J. Biol. Chem. Communication Vol. 260:15398-15401 | |
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Xue, Zhixiong, Zhou, Jun Mei, Melese,Teri, Cross, Richard L. and Boyer, Paul D, Accelerated Publication Chloroplast F1 ATPase has more than three nucleotide binding sites and both catalytic and non-catalytic sites are on or close to the beta-subunit. 1987 Biochemistry Vol. 26: 3749-3753 | |
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Zhou, Jun Mei, Xue, Zhixiong, Melese, Teri and Boyer Paul D. The relationship of tightly bound ADP and ATP to control and catalysis by the chloroplast ATP synthase. 1988 Biochemistry Vol. 27: 5129-5135. | |
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Melese, Teri, Xue, Zhixiong, Stempel, Kerstin and Boyer, Paul D. Catalytic Properties of chloroplast F1 ATPase modified at catalytic or non-catalytic sites by 2-azido adenine nucleotides. 1988 J. Biol. Chem. Vol. 263: 5833-5840. | |
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Xue Zhixiong, Melese,Teri, Stempel, Kerstin, Reedy T.J. and Boyer, Paul D. Properties of chloroplast F1 ATPase partially modified by 2 azido adenine nucleotides, including demonstration of 3 catalytic pathways. 1988 J. Biol. Chem. Vol. 263: 16880-16885 | |
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Lee, Wen-Ching and Melese, Teri. Identification and characterization of a nuclear localization sequence-binding protein in yeast. 1989 Proc. Nat'l. Acad. Sci. USA Vol. 86: 8808-8812. | |
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Lee, Wen-Ching, Xue, Zhixiong and Melese, Teri. The NSR1 gene encodes a protein that specifically binds nuclear localization sequences and has two RNA recognition motifs. 1991 Journal of Cell Biology Vol. 113: 1-12. | |
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Lee, Wen-Ching, Zabetakis, Daniel and Melese,Teri. NSR1 is required for pre-rRNA processing and for the proper maintenance of steady state levels of ribosomal subunits. 1992 Molecular and Cellular Biology Vol. 12: 3865-3871. | |
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Yan, Catherine and Melese, Teri. Multiple Regions of NSR1 are sufficient for accumulation of a fusion protein within the nucleolus. 1993 Journal of Cell Biology Vol. 123: 1081-1091 | |
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Xue, Zhixiong, Shan, Xiaoyin, Lapeyre, Bruno and Melese, Teri. The amino terminus of mammalian nucleolin specifically recognizes SV40 T-antigen type nuclear localization sequences. 1993 European Journal of Cell Biology Vol. 62: 13-21. | |
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Shan, Xiaoyin, Xue, Zhixiong and Melese,Teri. Yeast NPI46 encodes a novel prolyl cis-trans isomerase that is located in the nucleolus. 1994 Journal of Cell Biology Vol. 126: 853-862. | |
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Xue, Zhixiong, Shan, Xiaoyin, Sinelnikov, Alex and Melese, Teri. Yeast mutants that produce a novel type of ascus containing asci instead of spores. 1996 Genetics Vol. 144: 979-989. | |
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Shan, Xiaoyin, Xue, Zhixiong, Euskirchen, Ghia and Melese, Teri. Nnf1 is an essential yeast gene required for proper spindle orientation nucleolar and nuclear envelope structure and mRNA export. 1997 Journal of Cell Science Vol. 110: 1615-1624. | |
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Yan, Catherine, Leibowitz, Noah and Melese, Teri. A role for the divergent actin gene, ACT2, in nuclear pore structure and function. 1997 EMBO J. Vol. 16: 3572-3586. | |
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Perkins, E., Sun, D., Nguyen, A., Tulac, S., Francesco, M., Tavana, H., Nguyen, H., Tugendreich, S., Barthmaier, P., Couto, J., Yeh, E., Thode, S., Jarnagin, K., Jain, A., Morgans, D. and Melese, T. Novel inhibitors of PARP1 and PARP2 identified using a cell-based screen in Yeast. 2001 Cancer Res. Vol. 61: 4175-4183. | |
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Stuart Tugendreich, Ed Perkins, Joe Couto, Peter Barthmaier, Dongxu Sun, Shawn Tang, Suzana Tulac, Allen Nguyen, Elaine Yeh, Amy Mays, Tom Lila, David Shivak, Mark Prichard, Laura Andrejka, Raymond Kim and Teri Melese. A streamlined process to phenotypically profile heterologous cDNAs in parallel using yeast cell-based assays. 2001 Genome Research, 11(11):1899-912. | |
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Melese, Teri and Hieter, Phil. From genetics and genomics to drug discovery: yeast rises to the challenge. 2002 Trends in Pharmaceutical Sci. 23(12):544-7. | |
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Reviews | |
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Melese, Teri. The unfolding of a catalytic mechanism for the remarkable ATP synthase. 1985 Plenum Press. In: Recent Advances in Biological Membrane Studies: Substructure and Biogenesis: Oxidation and Energetics. Editor, Parker, L. pp. 511-524. | |
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Rothman, Stephen S. and Melese, Teri. "Leaky" cells of the glandular epithelia. 1988 International Review of Cytology Vol. 112: 225-244 | |
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Melese, Teri. Analysis of nuclear envelope ATP-binding proteins. 1990 Academic Press, Inc. In: Biochemical and Structural Dynamics of the Cell Nucleus. Editors, Wang, E. Wang, J., Chien,S. Cheung, W-Y. and Wu, C.W. pp. 227-247. | |
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Xue, Zhixiong and Melese, Teri. Nucleolar proteins that bind NLSs: a role in nuclear import or ribosome biogenesis? 1994 Trends in Cell Biology Vol. 4 414-417. | |
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Melese, Teri and Xue, Zhixiong. The nucleolus: an organelle formed by the act of building a ribsome. 1995 Current Opinion in Cell Biology Vol. 7: 319-324. |
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2/18/03 |
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photo: Chris T. Anderson |
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