Annette Molinaro, MA, PhD

Florida State University, Tallahassee, FL BS, 05/92, Statistics
University of California, Berkeley, CA, MA, 05/00, Biostatistics
University of California, Berkeley, CA, PhD, 01/04, Biostatistics
National Cancer Institute, Rockville, MD, 06/04-06/05, Cancer Prevention / Biostatistics

• 1998 - 2004
  Research Assistant, Comprehensive Cancer Center, UCSF, CA.
• 1999 - 1999
  Instructor, Statistics and Biostatistics Departments, University of California, Berkeley, CA.
• 1999 - 2005
  Biostatistician, Department of Medicine, UCSF.
• 2000
  Instructor, Health Careers Opportunity Program, Stanford University, Palo Alto, CA.
• 2004 - 2005
  Cancer Prevention Fellow, National Cancer Institute, NIH, Rockville, MD.
• 2005 - 2011
  Assistant Professor, Division of Biostatistics, Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT.
• 2006 - 2011
  Co-director, Biostatistics & Bioinformatics CORE, Yale Skin Cancer SPORE
• 2011 - present
  Associate Visiting Professor, Division of Biostatistics, Yale University
• 2011 - present
  Associate Professor, Department of Neurological Surgery and Division of Biostatistics, UCSF

• 2004
  Evelyn Fix Prize, UC Berkeley.
• 2004
  Chin Long Chiang Biostatistics Student of the Year, UC Berkeley.
• 2006
  Elected member of the International Statistical Institute
• 2008
  Excellence in Teaching Award, Yale School of Public Health
• 2009
  Selected as a Yale Center for Clinical Investigation Scholar

• Aust DE, Willenbucher RF, Terdiman JP, Ferrell LD, Chang CG, Moore DH, Molinaro AM, Baretton GB Loehrs U, Waldman FM. Chromosomal Alterations in Ulcerative Colitis-Related and Sporadic Colorectal Cancers by Comparative Genomic Hybridization. Human Pathology 31(1): 109-114, 2000. [PMID:10665921].
• Aust DE, Terdiman JP, Willenbucher RF, Chew K, Ferrell L, Florendo C, Molinaro AM, Baretton GB, Loehrs U, Waldman, FM. Altered Distribution of beta-catenin, and its binding proteins E-cadherin and APC, in Ulcerative Colitis-Related Colorectal Cancers. Modern Pathology 14: 29-39, 2001. [PMID: 11211307].
• Etzell JE, Devries S, Chew K, Florendo C, Molinaro AM, Ljung BM, and Waldman FM. Loss of chromosome 16q in lobular carcinoma in situ. Human Pathology 32: 292-6, 2001. [PMID: 11274638].
• Aust DE, Terdiman JP, Willenbucher RF, Chang CG, Molinaro AM, Baretton GB, Loehrs U, and Waldman FM. The apc/beta-catenin pathway in ulcerative colitis-related colorectal carcinomas: A mutational analysis. Cancer 94(5):1421-7., 2002. [PMID: 11920497].
• Dudoit S, van der Laan MJ, Keles¸ S, Molinaro AM, Sinisi S, and Teng SL. Loss-based estimation with cross-validation: Applications to microarray data analysis and motif finding. SIGKDD Explorations 5(2): 37-49, 2003. http://www.bepress.com/ucbbiostat/paper137/
• Kerlikowske K, Molinaro AM, Cha I, Ljung BM, Ernster V, Stewart K, Chew K, Moore D, and Waldman F. Predictors of Recurrence Among Women with DCIS Treated by Lumpectomy. Journal of National Cancer Institute 95(22): 1692-1702, 2003. [PMID: 14625260].
• Molinaro AM, Dudoit S, and van der Laan MJ. Tree-based multivariate regression and density estimation with right-censored data. Journal of Multivariate Analysis 90(1):154-177, 2004. [DOI: 10.1016/j.jmva.2004.02.003].
• Molinaro AM, Simon R, and Pfeiffer RM. Prediction Error Estimation: A Comparison of Resampling Methods. Bioinformatics 21(15):3301-3307, 2005. [PMID: 15905277].
• Hothorn T, Buhlmann P, Dudoit S, Molinaro AM, and van der Laan MJ. Survival Ensembles. Biostatistics. 7: 355-373, 2006. [PMID: 16344280].
• Moore LE, Fung ET, McGuire M, Rabkin C, Molinaro AM, Wang Z, Zhang F, Wang J, Yip C, Meng X, and Pfeiffer RM. Evaluation of Apolipoprotein A1 and Posttranslationally Modified Forms of Transthyretin as Biomarkers for Ovarian Cancer Detection in an Independent Study Population. Cancer Epidemiology Biomarkers and Prevention 15(9):1641-1646, September 2006. [PMID: 16985025].
• Petersen ML, Molinaro AM, Sinisi SE and van der Laan MJ. Cross-Validated Bagged Learning. Journal of Multivariate Analysis, 98(9), 1693-1704, October 2007. [PMCID: PMC2367370].
• Moeder, CB, Giltnane, JM, Harigopal, M, Molinaro, AM, Robinson, A, Gelmon, K, Huntsman, D, Camp, RL, and Rimm, DL. Quantitative justification of the change from 10% to 30% for human epidermal growth factor receptor 2 scoring in the American Society of Clinical Oncology/college of American Pathologists (ASCOCAP) guidelines: Tumor Heterogeneity in Breast Cancer and its implications for Tissue Microarray-based Assessment of Outcome. J Clin Oncol 25, 5418-5425, 2007. [PMID: 18048824].
• Giltnane JM, Molinaro AM, Moeder C, Robinson A, Turbin, D, Gelmon K, Huntsman DG, and Rimm DL. Comparison of Quantitative Immunofluorescence with Conventional Methods for HER-2/neu testing with respect to Response to Trastuzumab Therapy in Metastatic Breast Cancer. Archives of Pathology and Laboratory Medicine. 132:1635-1647, 2008. [PMID:18834223] http://www.archivesofpathology.org/doi/pdf/10.1043/1543-2165%282008%29132%5B1635%3ACOQIWC%5D2.0.CO%3B2
• Kluger HM, Siddiqui SF, Angeletti C, Kelly WK, Molinaro AM, and Camp RL. Classification of renal cell carcinoma (RCC) based on expression of VEGF and its receptors in both tumor cells and endothelial cells. Laboratory Investigation 88:962-972, 2008. [PMID:18626467] doi:10.1038/labinvest.2008.65 http://www.nature.com/labinvest/journal/v88/n9/pdf/labinvest200865a.pdf
• Gustavson MD, Molinaro AM, Tedeschi G, Camp RL, and Rimm DL. AQUA analysis of thymidylate synthase reveals localization to be a key prognostic biomarker in two large cohorts of colorectal carcinoma. Archives of Pathology and Laboratory Medicine. 132:1746-1752, 2008. [PMID:18976010] http://www.archivesofpathology.org/doi/pdf/10.1043/1543-2165-132.11.1746.
• Ghosh S, Sullivan CO, Zerkowski MP, Molinaro AM, Rimm DL, Camp RL, Chung GG. High levels of vascular endothelial growth factor (VEGF) and its receptors (VEGFR-1, VEGFR-2, neuropilin-1) are associated with worse outcome in breast cancer. Human Pathology. 39:1835-1843, 2008. [PMCID: PMC2632946].
• Pelizzola M, Koga Y, Urban AE, Krauthammer M, Weissman S, Halaban R, and Molinaro AM. MEDME: An experimental and analytical methodology for the estimation of DNA methylation levels based on microarray derived MeDIP-enrichment. Genome Research 18:1652-1659, 2008. [PMCID: PMC2556264].
• Halaban, R., Krauthammer, M. Pelizzola, M., Cheng, E., Kovacs, D. Sznol, M. Ariyan, S. Narayan, D., Bacchiocchi, A., Molinaro, A., Kluger, K. Deng, M., Tran, N. Zhang, W. Picardo, M., Enghild, JJ. Integrative Analysis of Epigenetic Modulation in Melanoma Cell Response to Decitabine: Clinical Implications. PLoS ONE 4(2): e4563, 2009. [PMCID: PMC2642998].
• Erickson AH, Wise A, Fleming S, Molinaro AM, Teboh-Ewungkem M, Baird M, Lateef Z, and de Pillis L. A preliminary mathematical model of skin dendritic cell trafficking and induction of t-cell immunity. Discrete and Continuous Dynamical Systems - Series B (DCDS-B): Special Issue on Mathematical Biology and Medicine. Vol. 12, Number 2, 2009. [doi:10.3934/dcdsb.2009.12.323].
• Koga Y, Pelizzola M, Cheng E, Krauthammer M, Molinaro AM, Halaban R, and Weissman S. Genome-Wide Screen of Promoter Methylation Identifies Novel Markers for Tumor Development in Melanoma. Genome Research. 19:1462-1470, 2009. [PMCID: PMC2720187].
• Gould Rothberg BE, Berger AJ, Molinaro AM, Subtil A, Krauthammer MO, Bradley WR, Ariyan S, Kluger HM, and Rimm DL. A melanoma prognostic model using tissue microarrays and genetic algorithms. Journal of Clinical Oncology 27:5772-5780, 2009. [PMCID: PMC2792999].
• Kerlikowske, K./Molinaro, A. M./Gauthier M.*, Berman, H., Waldman, F., Bennington, J., Sanchex, H., Jimenez, C., Stewart, K., Chew, K., Ljung, B., and Tlsty, T. Biomarker Expression and Risk of Subsequent Tumors After Initial Ductal Carcinoma In Situ Diagnosis. J. Natl. Cancer Inst. 102: 627 637, 2010. (* Shared first authorship). [PMCID: PMC2864293].
• Molinaro AM, Lostritto K, van der Laan MJ. partDSA: Deletion/Substitution/Additional Algorithm for Partitioning the Covariate Space in Prediction. Bioinformatics 26:1357-1363, 2010. [PMCID: PMC2865863].
• Kluger HM, Dudek AZ, McCann C, Ritacco J, Southard N, Jilaveanu L, Molinaro AM, and Sznol M. A phase II trial of dasatinib in advanced melanoma. Cancer 15;117(10):2202-8, 2011. [PMID: 21117218] DOI: 10.1002/cncr.25766 http://onlinelibrary.wiley.com/doi/10.1002/cncr.25766/pdf
• Godshalk SE, Paranjape T, Nallur S, Speed W, Molinaro AM, Bacchiocchi A, Hoyt K, Tworkoski K, Stern DF, Sznol M, Ariyan S, Halaban R, Kidd K, Weidhaas J, and Slack FJ. A Variant in a MicroRNA Complementary Site in the KIT Oncogene Increases Melanoma Risk. Oncogene 30, 1542–1550, 2011. [PMID: 21119596] doi: 10.1038/onc.2010.536 http://www.nature.com/onc/journal/vaop/ncurrent/pdf/onc2010536a.pdf
• Kluger HM, Hoyt K, Bacchiocchi A, Mayer T, Kirsch J, Kluger Y, Sznol M, Ariyan S, Molinaro AM and Halaban R. Plasma markers for identifying patients with metastatic melanoma. Clinical Cancer Research 17(8): 2417—25, 2011. [PMID: 21487066] doi: 10.1158/1078-0432.CCR-10-2402. PDF
• Martin KD, Naert L, Goldstein LB, Kasl S, Molinaro AM, and Lichtman JH. Comparison of the Use of Diagnostic Imaging and Receipt of Carotid Endarterectomy in Elderly Black and White Stroke Patients. In print, Journal of Stroke and Cerebrovascular Diseases, 2011. [PMID: 21411337]
• Bai Y, Tolles J, Cheng H, Siddiqui S, Gopinath A, Pectasides E, Camp RL, Rimm DL, and Molinaro AM. Quantitative Assessment Shows Loss of Antigenic Epitopes as a Function of Time to Formalin Fixation. Laboratory Investigation, 2011. August; 91: 1253-1261 doi:10.1038/labinvest.2011.75
• Tolles J, Bai Y, Baquero M, Harris LN, Rimm DL, and Molinaro AM. Optimal Tumor Sampling for Immunostaining of Biomarkers in Breast Carcinoma. Breast Cancer Research, 2011. May 18;13(3):R51. Epub ahead of print. [PMID: 21592345]. doi:10.1186/bcr2882
• Jahangiri A, Molinaro AM, Blevins L, Tarapore PE, Auguste KI, Gupta N, Kunwar S, and Aghi MK. Rathke’s Cleft Cysts in Pediatric Patients: Presentation, Surgical Management, and Postoperative Outcomes. Neurosurgical Focus, 2011. July 1: 31:1, E3. Epub ahead of print. DOI: 10.3171/2011.5.FOCUS1178
• Baquero MT, Lostritto K, Gustavson M, Bassi KA, Appia F, Camp RL, Molinaro AM, Harris L, and Rimm DL. Evaluation of Prognostic and Predictive Value of Microtubule Associated Protein Tau in Two Independent Cohorts. Breast Cancer Research, 2011. 13:R85 doi:10.1186/bcr2937
• Molinaro AM, Carriero NJ, Bjornson R, Hartge P, Rothman N, and Chatterjee, N. Power of data mining methods to detect genetic associations and interactions. Human Heredity, 2011. 72:85-97 (DOI: 10.1159/000330579)
• Potts MB, Smith JS, Molinaro AM, Berger MS. Natural History and Surgical Management of Incidentally-Discovered Low-Grade Gliomas. In print, Journal of Neurosurgery, 2011.
• Ferrucci LM, Cartmel B, Molinaro AM, Gordon PB, Leffell DJ, Bale AE, and Mayne ST. Host phenotype characteristics and MC1R in relation to early-onset basal cell carcinoma. In print, Journal of Investigative Dermatology, 2011.
• . Ferrucci LM, Cartmel B, Molinaro AM, Leffell DJ, Bale AE, and Mayne ST. Indoor tanning and risk of early-onset basal cell carcinoma. In print, Journal of the American Academy of Dermatology, 2011.
• Baquero MT, Hanna JA, Neumeister V, Cheng H, Molinaro AM, Harris L, and Rimm DL. Stathmin Expression and its Relationship to Microtubule Associated Protein Tau and Outcome in Breast Cancer. In print, Cancer.