Vice Chair and Professor, Physiology; Professor, Physiology, Biochemistry, Biophysics, UCSF
Member, UCSF Biomedical Sciences Graduate Program (BMS) and Herbert Boyer Program in Biological Sciences (PIBS)
| CONTACT | |
|
dmorgan@cgl.ucsf.edu Box 2200, UCSF; San Francisco, CA 94143-2200 |
additional websites: |
| EDUCATION | |
|
University of Calgary, Canada, B.Sc. (Hon.), 1980, Animal Biology
|
|
| PROFESSIONAL EXPERIENCE | |
|
9/81-8/86 |
Ph.D. student in Endocrinology, Department of Physiology, UCSF, with Richard A. Roth |
|
9/86-7/87 |
Postdoctoral fellow with William J. Rutter, Department of Biochemistry & Biophysics, UCSF |
|
7/87-9/89 |
Postdoctoral fellow with Harold E. Varmus, Department of Microbiology & Immunology, UCSF |
|
10/89-6/95 |
Assistant Professor, Department of Physiology, UCSF. Joint appointment in Department of Biochemistry and Biophysics as of July, 1991 |
|
7/95-7/97 |
Associate Professor, Departments of Physiology and Biochemistry & Biophysics, UCSF |
|
7/97-present |
Professor, Departments of Physiology and Biochemistry & Biophysics, UCSF |
|
7/98-present |
Vice-chair, Dept. of Physiology, UCSF. |
| HONORS & AWARDS | |
|
1987-1989 |
Helen Hay Whitney Foundation Postdoctoral Fellowship |
|
1990-1993 |
Searle Scholar Award |
|
1990-1992 |
March of Dimes Basil O'Connor Starter Scholar Award |
|
1991-1996 |
Rita Allen Foundation Scholar Award |
| SELECTED PUBLICATIONS | |
|
De Bondt, H.L., Rosenblatt, J., Jancarik, J., Jones, H.D., Morgan, D.O., and Kim, S.-H. (1993) Crystal structure of cyclin-dependent kinase 2. Nature 363, 595-602. | |
|
Gu, Y., Turck, C.W., and Morgan, D.O. (1993) Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit. Nature 366, 707-710. | |
|
Fisher, R.P., and Morgan, D.O. (1994) A novel cyclin associates with MO15/CDK7 to form the CDK activating kinase. Cell 78, 713-724. | |
|
Shiekhattar, R., Mermelstein, F., Fisher, R.P., Drapkin, R., Dynlacht, B., Wessling, H.C., Morgan, D.O., and Reinberg, D. (1995) Cdk-activating kinase (CAK) complex is a component of human transcription factor IIH. Nature 374, 283-287. | |
|
Fisher, R.P., Jin, P., Chamberlin, H.M., and Morgan, D.O. (1995) Alternative mechanisms of CAK assembly require an assembly factor or an activating kinase. Cell 83, 47-57. | |
|
Espinoza, F.H., Farrell, A., Erdjument-Bromage, H., Tempst, P., and Morgan, D.O. (1996) A major cyclin-dependent-kinase-activating kinase (CAK) in budding yeast unrelated to vertebrate CAK. Science 273, 1714-1717. | |
|
Kim, K.-K., Chamberlin, H.M., Morgan, D.O., and Kim, S.-H. (1996) Three-dimensional structure of human cyclin H, a positive regulator of the CDK-activating kinase. Nature Structural Biology 3, 849-855. | |
|
Jin, P., Hardy, S., and Morgan, D.O. (1998) Nuclear localization of cyclin B1 controls mitotic entry after DNA damage. J. Cell Biol. 141, 875-885. | |
|
Jaspersen, S.L., Charles, J.F., Tinker-Kulberg, R.L., and Morgan, D.O. (1998) A late mitotic regulatory network controlling cyclin destruction in Saccharomyces cerevisiae. Mol. Biol. Cell 9, 2803-2817. | |
|
Jaspersen, S.L., Charles, J.F., and Morgan, D.O. (1999) Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14. Curr. Biol. 9, 227-236. | |
|
Takizawa, C.G., Weis, K., and Morgan, D.O. (1999) Ran-independent nuclear import of cyclin B1-Cdc2 by importin-ƒÀ. Proc. Natl. Acad. Sci. USA 96, 7938-7943. | |
|
Tinker-Kulberg, R., and Morgan, D.O. (1999) Pds1 and Esp1 control both anaphase and mitotic exit in normal cells and following DNA damage. Genes Dev. 13, 1936-1949. | |
|
Jaspersen, S.L., and Morgan, D.O. (2000) Cdc14 activates Cdc15 to promote mitotic exit in budding yeast. Curr. Biol. 10, 615-618. | |
|
Bishop, A.C., Ubersax, J.A., Petsch, D.T., Matheos, D., Gray, N.S., Blethrow, J., Shimizu, E., Tsien, J.Z., Schultz, P.G., Rose, M.D., Wood, J.L., Morgan, D.O., and Shokat, K.M. (2000) A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature 407, 395-401. | |
|
Garrett, S., Barton, W.A., Knights, R., Jin, P., Morgan, D.O., and Fisher, R.P. (2001) Reciprocal activation by CDK2 and CDK7 is directed by substrate specificity determinants outside the T-loop. Mol. Cell Biol. 21, 88-99. | |
|
Kraybill, B.C., Elkin, L.L., Blethrow, J.D., Morgan, D.O., and Shokat, K.M. (2002) Inhibitor scaffolds as new allele-specific kinase substrates. J. Amer. Chem. Soc. 124, 12118-12128. | |
|
Carroll, C.W., and Morgan, D.O. (2002) The Doc1 subunit is a processivity factor for the anaphase-promoting complex. Nat. Cell Biol. 4, 880-887. | |
|
Ubersax, J.A., Woodbury, E.L., Quang, P.N., Paraz, M., Blethrow, J.D., Shah, K., Shokat, K.M., and Morgan, D.O. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature, 425, 859-864. | |
|
Carroll, C.W., Enquist-Newman, M., and Morgan, D.O. (2005) The APC subunit Doc1 promotes recognition of the substrate destruction box. Curr. Biol. 15, 11-18. | |
|
Loog, M., and Morgan, D.O. (2005) Cyclin specificity in the phosphorylation of cyclin-dependent kinase substrates. Nature 434, 104-108. (Commentary: Nature 434, 34-35; and Nat. Rev. Mol. Cell Biol. 6, 280) | |
|
Carroll, C.W., and Morgan, D.O. (2005) Enzymology of the Anaphase-Promoting Complex. Meth. Enzymol. 398, 219-230. | |
|
Thornton, B.R., Ng, T.M., Matyskiela, M.E., Carroll, C.W., Morgan, D.O., and Toczyski, D.P. (2006) An architectural map of the anaphase-promoting complex. Genes Dev. 20, 449-460. | |
|
Book: | |
|
Morgan, D.O. (2007) The Cell Cycle: Principles of Control. London: New Science Press. | |
|
12/11/06 |
|
