Keith Mostov, MD, PhD

University of Chicago, B.A., 1976, Biology
New College, Oxford, Rhodes Scholar, 1976-77, Physiology
Rockefeller University, Ph.D., 1983, Cell Biology
Cornell University Medical College, M.D., 1984, Medicine

• 1977-1984
  MD-PhD Program, Rockefeller University and Cornell University (Advisor Günter Blobel)
• 1984-1988
  Whitehead Fellow and Principal Investigator, Whitehead Institute
• 1988-1992
  Assistant Professor, University of California, San Francisco
• 1992-1998
  Associate Professor, University of California, San Francisco
• 1997-present
  Vice-Chairman, University of California, San Francisco, Department of Anatomy
• 1998-present
  Professor, University of California, San Francisco, Departments of Anatomy, and Biochemistry and Biophysics, Cardiovascular Research Inst., Liver Center and Cell Biology Program

• 1976
  Rhodes Scholar
• 1985
  Charles Hood Foundation Award
• 1989
  Searle Scholar
• 1990
  Annual NOVO Lecturer, Danish Biological Society
• 1990
  Cancer Research Institute Investigator Award
• 1991
  Charles E. Culpeper Foundation Scholar in Medical Science
• 1991
  Edward Mallinckrodt Foundation Medical Scholar
• 1992
  American Heart Association Established Investigator Award
• 1996
  Chairman, Keystone Meeting on Cell Polarity
• 1997
  A.J. Carlson Memorial Lecturer, University of Chicago
• 1998
  Co-chair, Minisymposium on Membrane Sorting and Polarity, ASCB Meeting, 1998 R.R. Bensley Award for Outstanding Young Cell Biologist, American Association of Anatomists
• 1998
  Edward Mallinckrodt Lecturer, Washington University, St. Louis
• 2000
  Alliance for Cellular Signaling, Molecule Page Author (polymeric immunoglobulin receptor)
• 2001
  Co-chair Minisymposium on Cell Polarity, ASCB Meeting
• 2002-2012
  NIAID MERIT Award
• 2004
  Co-organizer, EMBO meeting on Epithelial Polarity

• Mostov, K.E., DeFoor, P., Fleischer, S. and Blobel, G. Co-translational membrane integration of calcium pump protein without signal sequence cleavage. Nature 292:87-88, 1981.
• Mostov, K.E., Friedlander, M.F. and Blobel, G. The receptor for transepithelial transport of IgA and IgM contains multiple immunoglobulin-like domains. Nature 308:37-43, 1984.
• Mostov, K.E. and Simister, N. Transcytosis. Cell 43:389-390, 1985.
• Mostov, K.E. and Deitcher, D.L. Polymeric immunoglobulin receptor expressed in MDCK cells transcytoses IgA. Cell 47:613-621, 1986.
• Mostov, K.E., de Bruyn Kops, A. and Deitcher, D.L. Deletion of the cytoplasmic domain of the polymeric immunoglobulin receptor prevents basolateral localization and endocytosis. Cell 47:359-364, 1986.
• Simister, N.E. and Mostov, K. An Fc receptor structurally related to MHC class I antigens. Nature 337:184-187, 1989.
• Casanova, J.E., Breitfeld, P.P., Ross, S.A. and Mostov, K.E. Phosphorylation is required for efficient transcytosis of the polymeric immunoglobulin receptor. Science, 248: 742-745, 1990.
• Casanova, J.E., Apodaca, G., and Mostov, K.E. An autonomous signal for basolateral sorting in the cytoplasmic domain of the polymeric immunoglobulin receptor. Cell, 66: 65-75, 1991.
• Ma, J. K.-C., Hiatt, A., Hein, M., Vine, N.D., Wang, F., Stabila, P., van Dolleweerd, C., Mostov, K., Lehner, T. Generation and assembly of secretory antibodies in plants. Science 268:716-719, 1995.
• Luton, F., Vergés, M., Vaerman, J.-P., Sudol, M., and Mostov, K.E. The src family protein tyrosine kinase p62yes controls polymeric IgA transcytosis in vivo. Mol. Cell. 4:627-632, 1999.
• Mostov, K.E., ter Beest, M., and Chapin, S.J. Catch the train to the basolateral surface. Cell. 99:121-122, 1999.
• Zhang, J.-R., Mostov, K.E., Lamm, M.E., Nanno, M., Ohwaki, M., Shimada, S.-I., Ohwaki, M., and Tuomanen, E. The polymeric immunoglobulin receptor translocates pneumococci across human nasopharyngeal epithelial cells, Cell:102:827-837, 2000.
• O'Brien, L.E., Jou, T.-S., Pollack, A.L., Zhang, Q., Hansen, S.H., Yurchenco, P., and Mostov, K.E. Rac1 orients epithelial apical polarity through effects on basolateral laminin assembly. Nat. Cell Biol., 3:831-838, 2001.
• von Zastrow, M. and Mostov, K. A new thread in an intricate web. Science. 294:1845-1847, 2001.
• van IJzendoorn, S.C.D., Tuvim, M.J., Weimbs, T., Dickey, B.F., and Mostov, K.E. Direct interaction between Rab3b and the polymeric immunoglobulin receptor controls ligand-stimulated transcytosis in epithelial cells. Develop. Cell, 2:219-228, 2002.
• O'Brien, L.E., Zegers, M.M.P., and Mostov, K.E. Opinion: Building epithelial architecture: insights from three-dimensional culture models. Nat. Rev. Mol. Cell Biol. 3:531-537, 2002.
• Yu, W., O'Brien, L.E., Wang, F., Bourne, H., Mostov, K.E., and Zegers, M.M.P. HGF switches orientation of polarity and movement during morphogenesis of epithelial structures. Mol. Biol. Cell, 14:748-763, 2003.
• Mostov, K.E. and Zegers, M.M.P. Just mix and patch. Nature, 422:267-268, 2003
• Lipschutz,J.H., Lingappa,V.R. and Mostov, K.E. The exocyst affects protein synthesis by acting on the translocation machinery of the endoplasmic reticulum. J. Biol. Chem, 278:20954-20960, 2003.
• Zegers, M.M.P., O'Brien, L.E., Yu, W., Datta, A., and Mostov, K.E. Epithelial polarity and tubulogenesis in vitro. Trends Cell Biol., 13:169-176, 2003
• Mostov, K.E., Su, T., ter Beest, M. Polarized epithelial membrane traffic. Nat Cell Biol. 5:287-293, 2003.
• Zegers, M.M.P, Forget, M.A., Chernoff, J., Mostov, K.E., ter Beest, M., Hansen, S.H. PAK1 and PIX regulate contact inhibition during epithelial wound healing. EMBO J., 22:4155-4165, 2003.
• Kazmierczak, B. I., Mostov, K.E., and Engel, J. N. Epithelial cell polarity alters Rho-GTPase responses to Pseudomonas aeruginosa. Molecular Biology of the Cell, 15:411-419, 2004.
• O'Brien, L.E., Tang., K., Kats E.S., Schutz-Geschwender, A., Lipschutz, J.A., Mostov, K.E., ERK and MMPs Sequentially regulate distinct stages of epithelial tubule development. Developmental Cell, 07:21-32, 2004.
• Vergés, M., Luton, F., Gruber, C., L., Burlingame, A., Haft, C., Mostov K.E. The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor. Nature Cell Biology, 06:763-769, 2004.
• Yu, W., Datta, A., Leroy, P., O'Brien, Mak, G., L.E., Jou, T.S., Matlin, K.S., Mostov, K.E., Zegers, M.M.P. 1-integrin orients epithelial polarity via Rac1 and laminin. Molecular Biology of the Cell. 16:433-445, 2004.
• Tanimizu, N., Saito, H., Mostov, K., and Miyajima, A. Long-term culture of hepatic progenitors derived from mouse Dlk+ hepatoblasts. J. Cell Sci., 117:6425-6434, 2004.
• Kierbel, A., Gassama-Diagne, A., Mostov, K, and Engel, J. N. The Phosphoinositol-3-kinase-Akt pathway is critical for Pseudomonas aeruginosa strain PAK internalization. Mol. Biol. Cell., 16:2577-2585, 2005.
• ter Beest, M., Chapin, S. J., Avrahami, D., and Mostov, K. E. The role of syntaxins in the specificity of vesicle targeting in polarized epithelial cells. Mol Biol Cell, 16:5784-5792, 2005.
• O'Brien, L.E., Yu, W., Tang, K., Jou, T.-S., Zegers, M.M.P., and Mostov, K.E. Morphological and biochemical analysis of Rac1 in three-dimensional epithelial cell cultures. Methods in Enzymology, 406:676-691, 2006.
• Mostov, K. mTOR is out of control in polycystic kidney disease. PNAS, 103:5247-8, 2006
• Fan, Q., Knight, Z. A., Goldenberg, D. D., Yu, W., Mostov, K., Stokoe, D., Shokat, K. M., Weiss, W. A. A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma. Cancer Cell, 9:341-349, 2006.
• Gassama, A, Yu, W., Martin, F., Kierbel, A, , Engel, J., Mostov, K. . Phosphatidylinositol 3,4,5-trisphosphate regulates the formation of the basolateral plasma membrane in epithelial cells. Nat. Cell Biol 8:963-970, 2006
• Mostov, K. and Martin-Belmonte, F. The hole picture. Nature 442: 363-4, 2006.
• Grant, M., Mostov, K., Tlsty, T., Hunt, C. A., Simulating Properties of In Vitro Epithelial Cell Morphogenesis. PLoS Computational Biology 2: e129, 1-17, 2006.
• Reiter, J. and Mostov, K., Vesicle transport, cilium formation and membrane specialization: The origins of a sensory organelle. Proc. Natl. Acad. Sci. USA, 103:18383-4, 2006.