Jay A. Nadel, MD

Temple University, Philadelphia, PA, A.B., 1949, Physiology
Jefferson Medical College, Philadelphia, PA, M.D., 1953, Medicine

• 1964-present
  Senior Staff Member, Cardiovascular Research Institute, UCSF
• 1960-1978
  Chief, Pulmonary Function Laboratory, Cardiovasular Research Institute, UCSF
• 1970-present
  Professor, Department of Medicine, UCSF
• 1974-present
  Professor, Department of Radiology, UCSF
• 1977-present
  Professor, Department of Physiology, UCSF
• 1977-present
  Director, NIH Multidisciplinary Research Training Program in Pulmonary Diseases, CVRI
• 1979-1997
  Director, NIH Program Project Grant HL-24136
• 1983-1996
  Director, UCSF Cystic Fibrosis Research Center
• 1968-1999
  Chief, Section of Pulmonary Diseases, Department of Medicine, UCSF

• 1960
  Gianninni Award
• 1984
  Clean Air Award, ALA Calif
• 1984
  California Medal, American Lung Association Calif
• 1987
  Honorary Member Cal Thoracic Society
• 1987
  Distinguished Lecturer in Physiology, American College of Chest Physicians
• 1990
  Pfizer Visiting Professor, Royal Society of Medicine
• 1991
  Honorary Degree of Medicine and Surgery, University of Ferrara
• 1992
  Crocker Clean Air Award, American Lung Association
• 1992
  Sam J. Sills Honorary Lectureship, University of Southern California
• 1992
  Distinguished Achievement Award, Ben Gurion University
• 1992
  Robert F. Johnston, M.D., Honorary Lecturer, Philadelphia
• 1993
  Amberson Honorary Lecturer, American Thoracic Society
• 1994
  Medal of The University of Helsinki
• 1994
  Honorary Member, German Society of Pulmonology
• 1994
  Honorary Member, Finnish Association of Pulmonary Physicians
• 1996
  Honorary Doctorate of Medicine, University of Lund, Sweden
• 1997
  Trudeau Medal, American Thoracic Society
• 1997
  Honorary Degree in Law: Dickinson Law School, Carlisle, PA
• 1998
  Alumni Achievement Award, Jefferson Medical College (JH Coley Lectureship)
• 1998
  Best Doctors of America
• 1999
  Best Doctors of SF Bay Area

• Widdicombe JG, Kent DC, Nadel JA. Mechanisms of bronchoconstriction during inhalation of dust. J Appl Physiol 17:613-616, 1962.
• Nadel JA, Salem H, Tamplin B, Tokiwa Y. Mechanism of bronchoconstriction during inhalation of sulfur dioxide. J Appl Physiol 20:164-167, 1965.
• Simonsson BG, Jacobs FM, Nadel JA. Role of autonomic nervous system and the cough reflex in the increased responsiveness of airways in patients with obstructive airway disease. J Clin Invest 46:1812-1818, 1967.
• Goldsmith JR, Nadel JA. Experimental exposure of human subjects to ozone. J Air Pollut Control Assoc 19:329-330, 1969.
• Olver RE, Davis B, Marin MG, Nadel JA. Active transport of Na+ and Cl- across the canine tracheal epithelium in vitro. Am Rev Respir Dis 112:811-815, 1975.
• Empey DW, Laitinen LA, Jacobs L, Gold WM, Nadel JA. Mechanisms of bronchial hyperreactivity in normal subjects following upper respiratory tract infection. Am Rev Respir Dis 113:131-139, 1976.
• Sheppard D, Wong WS, Uehara CF, Nadel JA, Boushey HA. Lower threshold and greater bronchomotor responsiveness of asthmatic subjects to sulfur dioxide. Am Rev Respir Dis 122:873-878, 1980.
• Sheppard D, Saisho A, Nadel JA, Boushey HA. Exercise increases sulfur dioxide-induced bronchoconstriction in asthmatic subjects. Am Rev Respir Dis 123:486-491, 1981.
• Sigal E, Craik CS, Highland E, Grunberger D, Costello LL, Dixon RAF, Nadel JA. Molecular cloning and primary structure of human 15-lipoxygenase. Biochem Biophys Res Commun 157:457-464, 1988.
• Sekizawa K, Caughey GH, Lazarus SC, Gold WM, Nadel JA. Mast cell tryptase causes airway smooth muscle hyperresponsiveness in dogs. J Clin Invest 83:175-179, 1989.
• Sommerhoff CP, Nadel JA, Basbaum CB, Caughey GH. Neutrophil elastase and cathepsin G stimulate secretion from cultured bovine airway gland serous cells. J Clin Invest 85:682-689, 1990.
• Nadel JA, Ueki IF, Schuster A, Conrad DJ, Sigal E. Immunocytochemical localization of arachidonate 15-lipoxygenase in erythrocytes, leukocytes, and airway cells. J Clin Invest 87:1139-1145, 1991.
• Rosenecker J, Zhang W, Hong K, Lausier J, Geppetti P, Yoshihara S, Papahadjopoulos D, Nadel JA. Increased liposome extravasation in selected tissues: effect of substance P. Proc Natl Acad Sci U S A, 93:7236-7241, 1996.
• Takeyama K, Agustí C, Ueki I, Lausier J, Cardell LO, Nadel JA. Neutrophil-dependent goblet cell degranulation: role of membrane-bound elastase and adhesion molecules. Am J Physiol: Lung Cell Mol Physiol, 19:L294-L302, 1998.
• Takeyama K, Dabbagh K, Lee H-M, Agustí C, Lausier JA, Ueki IF, Grattan KM, Nadel JA. Epidermal growth factor system regulates mucus production in airways. Proc Nat Acad Sci, 96:3081-3086, 1999.
• Burgel P-R, Escudier E, Coste A, Dao-Pick T, Ueki IF, Takeyama K, Shim JJ, Murr AH, Nadel JA. Relation of EGF receptor expression to goblet cell hyperplasia in nasal polyps. J. Allergy Clin. Immunol, 106:705-712, 2000.
• Lee H-M, Takeyama K, Dabbagh K, Lausier JA, Ueki IF, Nadel JA. Agarose plug instillation causes goblet cell metaplasia by activating EGF receptors in rat airways. Am J Physiol: Lung Cell Mol Physiol 278:L185-L192, 2000.
• Lee H-M, Malm L, Dabbagh K, Dao-Pick T, Ueki IF, Kim S, Shim JJ, Nadel JA. Epidermal growth factor receptor signaling mediates regranulation of nasal goblet cells. J Allergy Clin Immunol, 107:1046-1050, 2001.
• Takeyama K, Dabbagh K, Shim JJ, Dao-Pick T, Ueki IF, Nadel JA. Oxidative stress causes mucin synthesis via transactivation of epidermal growth factor receptor: role of neutrophils. J Immunol, 164:1546-1552, 2000.
• Shim JJ, Dabbagh K, Ueki IF, Dao-Pick T, Burgel P-R, Takeyama K, Tam D C-W, Nadel JA. Interleukin-13 induces mucin production by stimulating epidermal growth factor receptors and by activating neutrophils. Am J Physiol: Lung Cell Mol Physiol, 280:L134-L140, 2001.
• Takeyama K, Jung B, Shim JJ, Burgel P-R, Dao-Pick T, Ueki IF, Protin U, Kroschel P, Nadel JA. Activation of epidermal growth factor receptors is responsible for mucin synthesis induced by cigarette smoke. Am J Physiol: Lung Cell Mol Physiol, 280:L165-L172, 2001.
• Takeyama K, Fahy JV, Nadel JA. Relationship of epidermal growth factor receptors to airway goblet cell production. Am J Respir Crit Care Med, 163:511-516, 2001.
• Kim S, Shim JJ, Burgel P-R, Ueki IF, Dao-Pick T, Tam D C-W, Nadel JA. IL-13-induced clara cell secretory protein expression in airway epithelium: role of EGFR signaling pathway. Am J Physiol: Lung Cell Mol Biol, 283:L67-L75, 2002.
• Kohri K, Ueki IF, Nadel JA. Neutrophil elastase induces mucin production by ligand-dependent epidermal growth factor receptor activation. Am J Physiol: Lung Cell Mol Physiol, 283:L531-L540, 2002.
• Kohri K, Ueki IF, Shim JJ, Burgel P-R, Oh Y-M, Tam DC, Dao-Pick T, Nadel JA. Pseudomonas aeruginosa induces MUC5AC production via epidermal growth factor receptor. Eur Respir J, 20:1263-1270, 2002.
• Nadel JA. Role of epidermal growth factor cascade in airway hypersecretion and proposal for novel therapy. In: Cilia and Mucus: From Development to Respiratory Disease. Salathe M, Satir P, Adler KB, Boucher RD, eds., Marcel Dekker, Inc., New York, pp. 315-337, 2001.
• Burgel P-R, Nadel JA. Mucus and mucin-secreting cells. In: Asthma and COPD: Basic Mechanisms and Clinical Management. Barnes PJ, Drazen JM, Rennard S, Thompson NC, eds., Academic Press, London, pp. 155-163, 2002.
• Shao M XG, Ueki IF, Nadel JA. Tumor Necrosis Factor-α Converting Enzyme (TACE) mediates MUC5AC expression in cultured human airway epithelial cells. Proc Nat Acad Sci USA 100:11618-23, 2003.
• Shao MXG, Nakanaga T, Nadel JA. Cigarette smoke induces MUC5AC mucin overproduction via tumor necrosis factor-α converting enzyme in human airway epithelial cells. Am J Physiol: Lung Cell Mol Physiol, 287:L420-L427, 2004.
• Kim S, Nadel JA. Role of neutrophils in mucus hypersecretion in COPD and implications for therapy. In: Treatments in Respiratory Medicine 3:147-159, 2004.
• Burgel P, Nadel JA. Roles of epidermal growth factor receptor activation in epithelial cell repair and mucin production in airway epithelium. In: Thorax 59:992-996, 2004.