marynak@itsa.ucsf.edu
(415) 750-2104 (voice)
(415) 750-6920 (fax)

VAMC 111R; San Francisco, CA 94143

Swarthmore College, Swarthmore, PA, B.A., 1981, Biology
Yale University School of Medicine, New Haven, CT, M.D., cum laude, 1986, Medicine
Intern and resident, Department of Internal Medicine, UCSF, San Francisco, CA, 1986-1989
Rheumatology Fellow, Div. Rheumatology, Johns Hopkins U., Baltimore, MD, 1990-1991
Rheumatology Fellow, Div. Rheumatology, UCSF, San Francisco, CA, 1991-1994

Jackson, D.E., Lally, E.T., Nakamura, M.C., and Montgomery, P.C. Migration of IgA-Bearing Lymphocytes into Salivary Glands. Cellular Immunology 68:203, 1981.

Nakamura, M., Mimori, T., Hardin, J.A. Anti-Ku Antibodies in American Patients with SLE: Detection with ELISA, Immunoblotting and Immunodiffusion Assays. Arthritis and Rheumatism 28 (supp):S96, 1985.

Forman, M.S., Nakamura, M., Mimori, T., Gelpi, C., and Hardin, J.A. Antibodies to snRNPs and scRNPs: Detection with Unlabeled Cell Extracts. Arthritis and Rheumatism 287:1361, 1985.

Chisari, F.V., Nakamura, M., Milich, D.R., Han, K., Molden, D., and Leroux-Roels, G.G. Production of Two Distinct and Independent Hepatic Immunoregulatory Molecular By the Perfused Rat Liver. Hepatology 5:735, 1985.

Daniels, B.F., Nakamura, M.C., Rosen, S.D., Yokoyama, W.M., and Seaman, W.E. Ly-49A, a receptor of H-2Dd, has a functional carbohydrate recognition domain. Immunity 1:785, 1994.

Ryan, J.C., Niemi, E.C., Nakamura, M., and Seaman, W.E. NKR-P1A is a target-specific receptor that activates natural killer cell cytotoxicity. J. Exp. Med. 181:1911, 1995.

Seaman, W.E., Daniels, B., Ryan, J., Nakamura, M., and Niemi, E. Recognition and signaling by mouse Ly-49 receptors. Chemical Immunology 64:19, 1996.

Nakamura, M.C., Niemi, E.C., Fisher, M.J., Shultz, L.D., Seaman, W.E., and Ryan, J.C. Mouse Ly-49A interrupts early signaling events in NK cell cytotoxicity and functionally associates with the SHP-1 tyrosine phosphatase. J. Exp. Med. 185:673, 1997

Nakamura, M.C. Natural Killer Cells in Immune Regulation. Clinical Immunology Newsletter. 17 (10): 151, 1997

Naper, C., Ryan, J.C., Nakamura, M.C., Lambracht, D., Rolstad, B. and Vaage, J.T. Identification of an inhibitory MHC receptor on alloreactive rat NK cells. J. Immunology 160:219, 1998.

SundbSØck, J., Nakamura, M.C., WaldenstrsØm, M., Niemi, E.C., Seaman, W.E., Ryan, J.C., and KSØrre, K. The a2 Domain of H-2Dd Restricts the Allelic Specificity of the Murine NK Cell Inhibitory Receptor Ly-49A. J. Immunology 160:5971, 1998.

McVicar, D.W., L.S. Taylor, P. Gosselin, J. Willete-Brown, A.I. Mikhael, M.C. Nakamura, P. Linnemeyer, W.E. Seaman, J.R. Ortaldo, S.K. Anderson and L.H. Mason. DAP12 mediated signal transduction in NK cells: a dominant role for the Syk protein tyrosine kinase. J. Biol. Chem. 273(49):32934, 1998

Johansson M.H., E. Hoglund, M.C. Nakamura, J.C. Ryan,.and P. Hoglund. a1/a2 domains of H-2Dd, but not H-2Ld, induce "missing self" reactivity in vivo--no effect of H-2Ld on protection against NK cells expressing the inhibitory receptor Ly49G2. Eur. J. Immunology, 28(12):4198, 1998.

Nakamura, M.C., P. A. Linnemeyer, E. C. Niemi, L. H. Mason, J. R. Ortaldo, J. C. Ryan, and W. E. Seaman. Mouse Ly-49D Recognizes H-2Dd and Activates Natural Killer Cell Cytotoxicity. J. Exp. Med. 189:493,1999.

Ryan, J.C., E. C. Niemi, and M.C. Nakamura. Functional Analysis of NK Cell Receptors in the RNK-16 Leukemic Line. In Natural Killer Cell Protocols: Functions, Receptors and Clinical Applications. M.C. Eds. K.S. Campbell, editor. Humana Press, NJ. 1999.

Eriksson, M., J.C. Ryan, M.C. Nakamura, and C.L. Sentman. Ly49A inhibitory receptors redistribute on natural killer cells during target cell interaction. Immunology 97:341, 1999.

Nakamura, M.C., C. Naper, E.C. Niemi, S.C. Spusta, B. Rolstad, G.W. Butcher, W.E. Seaman, and J.C. Ryan. Natural killing of xenogeneic cells mediated by the mouse Ly-49D receptor. J. Immunol. 163:4694, 1999.

Eriksson, M., G. Leitz, F. llman E, O. Axner, J.C. Ryan, M.C. Nakamura, and C.L. Sentman. Inhibitory Receptors Alter Natural Killer Cell Interactions with Target Cells yet Allow Simultaneous Killing of Susceptible Targets. J. Exp. Med. 190:1005, 1999.

Nakamura, M.C., S. Hayashi, E.C. Niemi, J.C. Ryan, and W.E. Seaman. Activating Ly-49D and Inhibitory Ly-49A NK Cell Receptors Demonstrate Distinct Requirements for Interaction with H2-Dd. J. Exp. Med. 192:447-454, 2000

Karnbach, C., Daws, M.R., Niemi, E.C., and M.C. Nakamura. Immune Rejection of a Large Sarcoma Following Cyclophosphamide and Il-12 Treatment Requires Both NK and NKT Cells and is Associated with the Induction of a Novel NKT Cell Population. J Immunol. 167:25692576, 2001

Nakamura, M.C., and W.E. Seaman. Ligand interactions by activating and inhibitory Ly-49 receptors. Immunological Reviews 181:138-148, 2001

Routes, J.M., Ryan, J., Ryan, S., and M. Nakamura. MHC Class I molecules on adenovirus EIA-expressing tumor cells inhibit NK cell killing but not NK cell-mediated tumor rejection. International Immunology 2001 13: 1301-1307

12/17/02