Mary C. Nakamura, MD

Swarthmore College, Swarthmore, PA, B.A., 1981, Biology
Yale University School of Medicine, New Haven, CT, M.D., cum laude, 1986, Medicine
Intern and resident, Department of Internal Medicine, UCSF, San Francisco, CA, 1986-1989
Rheumatology Fellow, Div. Rheumatology, Johns Hopkins U., Baltimore, MD, 1990-1991
Rheumatology Fellow, Div. Rheumatology, UCSF, San Francisco, CA, 1991-1994

• 1989-1990
  Clinical Instructor, Acquired Immunodeficiencies Clinic, UCSF, San Francisco, CA
• 1995-2000
  Adjunct Assistant Prof. Medicine, UCSF, San Francisco, CA
• 1995-1998
  Director Arthritis Clinic, San Francisco Veterans Affairs Hospital, San Francisco, CA
• 2000-present
  Assistant Prof. of Medicine, in residence, Dept. of Medicine, Division of Rheumatology, San Francisco Veterans Administration Medical Center

• 1977-1981
  Pacific Regional Scholarship, Swarthmore College
• 1981
  Phi Beta Kappa, Sigma Xi
• 1984 and 1985
  Lupus Foundation of America Summer Fellowship
• 1986
  Louis G. Welt Prize for outstanding medical school thesis
• 1986
  Janet M. Glasgow Memorial Achievement Citation, American Medical Women's Association for scholastic achievement
• 1989
  Jeffrey Weingarten Award for Housestaff
• 2000
  Presidential Early Career Award

• Jackson, D.E., Lally, E.T., Nakamura, M.C., and Montgomery, P.C. Migration of IgA-Bearing Lymphocytes into Salivary Glands. Cellular Immunology 68:203, 1981.
• Nakamura, M., Mimori, T., Hardin, J.A. Anti-Ku Antibodies in American Patients with SLE: Detection with ELISA, Immunoblotting and Immunodiffusion Assays. Arthritis and Rheumatism 28 (supp):S96, 1985.
• Forman, M.S., Nakamura, M., Mimori, T., Gelpi, C., and Hardin, J.A. Antibodies to snRNPs and scRNPs: Detection with Unlabeled Cell Extracts. Arthritis and Rheumatism 287:1361, 1985.
• Chisari, F.V., Nakamura, M., Milich, D.R., Han, K., Molden, D., and Leroux-Roels, G.G. Production of Two Distinct and Independent Hepatic Immunoregulatory Molecular By the Perfused Rat Liver. Hepatology 5:735, 1985.
• Daniels, B.F., Nakamura, M.C., Rosen, S.D., Yokoyama, W.M., and Seaman, W.E. Ly-49A, a receptor of H-2Dd, has a functional carbohydrate recognition domain. Immunity 1:785, 1994.
• Ryan, J.C., Niemi, E.C., Nakamura, M., and Seaman, W.E. NKR-P1A is a target-specific receptor that activates natural killer cell cytotoxicity. J. Exp. Med. 181:1911, 1995.
• Seaman, W.E., Daniels, B., Ryan, J., Nakamura, M., and Niemi, E. Recognition and signaling by mouse Ly-49 receptors. Chemical Immunology 64:19, 1996.
• Nakamura, M.C., Niemi, E.C., Fisher, M.J., Shultz, L.D., Seaman, W.E., and Ryan, J.C. Mouse Ly-49A interrupts early signaling events in NK cell cytotoxicity and functionally associates with the SHP-1 tyrosine phosphatase. J. Exp. Med. 185:673, 1997
• Nakamura, M.C. Natural Killer Cells in Immune Regulation. Clinical Immunology Newsletter. 17 (10): 151, 1997
• Naper, C., Ryan, J.C., Nakamura, M.C., Lambracht, D., Rolstad, B. and Vaage, J.T. Identification of an inhibitory MHC receptor on alloreactive rat NK cells. J. Immunology 160:219, 1998.
• SundbSäck, J., Nakamura, M.C., Waldenstrsöm, M., Niemi, E.C., Seaman, W.E., Ryan, J.C., and KSärre, K. The a2 Domain of H-2Dd Restricts the Allelic Specificity of the Murine NK Cell Inhibitory Receptor Ly-49A. J. Immunology 160:5971, 1998.
• McVicar, D.W., L.S. Taylor, P. Gosselin, J. Willete-Brown, A.I. Mikhael, M.C. Nakamura, P. Linnemeyer, W.E. Seaman, J.R. Ortaldo, S.K. Anderson and L.H. Mason. DAP12 mediated signal transduction in NK cells: a dominant role for the Syk protein tyrosine kinase. J. Biol. Chem. 273(49):32934, 1998
• Johansson M.H., E. Hoglund, M.C. Nakamura, J.C. Ryan,.and P. Hoglund. a1/a2 domains of H-2Dd, but not H-2Ld, induce "missing self" reactivity in vivo--no effect of H-2Ld on protection against NK cells expressing the inhibitory receptor Ly49G2. Eur. J. Immunology, 28(12):4198, 1998.
• Nakamura, M.C., P. A. Linnemeyer, E. C. Niemi, L. H. Mason, J. R. Ortaldo, J. C. Ryan, and W. E. Seaman. Mouse Ly-49D Recognizes H-2Dd and Activates Natural Killer Cell Cytotoxicity. J. Exp. Med. 189:493,1999.
• Ryan, J.C., E. C. Niemi, and M.C. Nakamura. Functional Analysis of NK Cell Receptors in the RNK-16 Leukemic Line. In Natural Killer Cell Protocols: Functions, Receptors and Clinical Applications. M.C. Eds. K.S. Campbell, editor. Humana Press, NJ. 1999.
• Eriksson, M., J.C. Ryan, M.C. Nakamura, and C.L. Sentman. Ly49A inhibitory receptors redistribute on natural killer cells during target cell interaction. Immunology 97:341, 1999.
• Nakamura, M.C., C. Naper, E.C. Niemi, S.C. Spusta, B. Rolstad, G.W. Butcher, W.E. Seaman, and J.C. Ryan. Natural killing of xenogeneic cells mediated by the mouse Ly-49D receptor. J. Immunol. 163:4694, 1999.
• Eriksson, M., G. Leitz, F. llman E, O. Axner, J.C. Ryan, M.C. Nakamura, and C.L. Sentman. Inhibitory Receptors Alter Natural Killer Cell Interactions with Target Cells yet Allow Simultaneous Killing of Susceptible Targets. J. Exp. Med. 190:1005, 1999.
• Nakamura, M.C., S. Hayashi, E.C. Niemi, J.C. Ryan, and W.E. Seaman. Activating Ly-49D and Inhibitory Ly-49A NK Cell Receptors Demonstrate Distinct Requirements for Interaction with H2-Dd. J. Exp. Med. 192:447-454, 2000
• Karnbach, C., Daws, M.R., Niemi, E.C., and M.C. Nakamura. Immune Rejection of a Large Sarcoma Following Cyclophosphamide and Il-12 Treatment Requires Both NK and NKT Cells and is Associated with the Induction of a Novel NKT Cell Population. J Immunol. 167:25692576, 2001
• Nakamura, M.C., and W.E. Seaman. Ligand interactions by activating and inhibitory Ly-49 receptors. Immunological Reviews 181:138-148, 2001
• Routes, J.M., Ryan, J., Ryan, S., and M. Nakamura. MHC Class I molecules on adenovirus EIA-expressing tumor cells inhibit NK cell killing but not NK cell-mediated tumor rejection. International Immunology 2001 13: 1301-1307