stephen.nishimura@ucsf.edu
(415) 206-5906 (voice)
(415) 206-4123 (fax)

Box 0854, UCSF; San Francisco, CA 94143-0854

Wesleyan University, Middletown, CT, B.A., 1981, Chemistry
University of Vermont College of Medicine, M.D., 1988, Medicine
University of California, San Francisco, Resident, 1988-1991, Anatomic and Clinical Pathology
University of California, San Francisco, Fellow, 1991-1995, Molecular Biology

Nishimura, S., Pasternak, G. W. Opiate and Opioid Peptide Binding in Rat and Goldfish: Further Evidence for Opiate Receptor Heterogeneity. Br Res, 1982, 248:192-195

Wolozin, B. L., Nishimura S. L., Pasternak, G. W. The Binding of k- and s- Opiates in Rat Brain. J Neuroscience, 1982, 2(6):708-13.

Nishimura, S. L., Recht, L. D., Pasternak, G. W. Biochemical Characterization of High Affinity 3H-Opioid Binding; Further Evidence for Mul Sites. Mol Pharm, 1983, 25:29-37.

Ling, G. S. F., Spiegel, K., Nishimura, S. L., Pasternak, G. W. Dissociation of Morphine's Analgesic and Respiratory Depressant Actions. Eur J Pharm, 1983, 86:487-488.

Pasternak, G. W., Gintzler, A., Houghton, R. A., Ling, G. S. F., Goodman, R. R., Spiegel, K., Nishimura, S. L., Johnson, N. J., Recht, L. D. Biochemical and Pharmacological Evidence of Opiate Receptor Multiplicity in the Central Nervous System. Life Sci, 1983, Sup 1, pp. 167-173.

Laher, F., Nishimura, S. L., Bevan, J. A. Prazosin Selectively Antagonizes Norepinephrine Contractions at Low-Affinity, Non-Alpha, Adrenoceptor Sites (Extraceptors) in Arterial Smooth Muscle. J Pharm and Exp Ther, 1986, 239(3).

Perkocha, L. A., Geaghan, S. M., Yen, B., Nishimura, S. L., Chan, S., Garcia-Kennedy, R., Honda, G., Stoloff, A., Klein, H., Goldman, R. L., Van Meter, S., Ferrell, L., LeBoit, P. Clinical and Pathological Features of Bacillary Peliosis Hepatis in Association with Human Immunodeficiency Infection, NEJM, 1990, 323(23):1581-1586.

Frank, U., Nishimura, S. L., Li, N., Yajko, D., Sugai, K., Hadley, K., Ng, V. Comparison of the Meridian Premier® Cryptococcal Antigen Enzyme Immunoassay and the Meridian Cryptococcal Antigen Latex Agglutination System (CALAS®) for the Detection of Cryptococcal Infections in a Population with or at Risk for HIV Infection. J Clin Microbiol, 1993, 31(1):97-101.

Weinacker, A., Chen, A., Agrez, M., Cone, R., Nishimura, S. L., Wayner, E., Pytela, R., Sheppard, D. Role of the Integrin αvβ6 in Cell Attachment to Fibronectin, Heterologous Expression of Intact and Secreted Forms of the Receptor. J Biol Chem, 1994, 269(4):6940-6948.

Nishimura, S.L., Sheppard, D., Pytela, R. Integrin αvβ8: Interaction with Vitronectin and Functional Divergence of the β8 Cytoplasmic Domain. J Biol Chem, 1994, 269(46):28708-28715.

Breuss, JM, Gallo, J, DeLisser, HM, Klimanskaya, IV, Folkesson, HG, Pittet, JF, Nishimura, SL, Aldape, K, Landers, DV, Carpenter, Gillett, N, Sheppard, DS, Matthay, MA, Albelda, SM, Kramer, RH, Pytela, R. Expression of the β6 Integrin Subunit in Development, Neoplasia, and Tissue Repair suggests a role in Epithelial Remodeling. J Cell Sci, 1995, 108, 2241-2251.

Ramos, D.M., Chen, B.L., Boylen,K., Stern,M., Kramer, R.H., Sheppard, D., Nishimura,S.L., Greenspan, D., Zardi,L., Pytela,R. Stromal Fibroblasts Influence Oral Squamous-cell Carcinoma Cell Interactions with tenascin-C. International Journal of Cancer, 1997, 72(2):369-76.

Milner, R., Wilby, M., Nishimura, S., Boylen, K., Edwards, G. Fawcett, J., Streuli, C., Pytela, P., ffrench-Constant, C. Division of Labor of Schwann Cell Integrins During Migration on Peripheral Nerve Extracellular Matrix Ligands. Developmental Biology, 1997, 185(2):215-28.

Milner, R., Frost, E., Nishimura, S., Delcommenne, M., Streuli, C., Pytela, R., ffrench-Constant, C. Expression of v3 and v8 Integrin during Oligodendrocyte Precursor Differentiation in the Presence and Absence of Axons. Glia, 1997, 21:350-360.

Nishimura, S.L., Boylen, K.B., Einheber, S., Milner,T., Ramos, D.M., Pytela, R. Synaptic and Glial Localization of the Integrin αvβ8 in Mouse and Rat Brain. Br Res 1998, 791:271.

Jacques, Thomas S., Relvas, Joao B., Nishimura, Stephen, Pytela, Robert Edwards, Gwynneth M., Streuli, Charles H., and ffrench-Constant, Charles. Neural Precursor Cell Chain Migration and Division Are Regulated Through Different 1 Integrins. Development, 1998, 125(16):3167-77.

Milner, R., Huang, X., Wu, J., Nishimura, S., Pytela, R., Sheppard, D., ffrench-Constant, C. Distinct roles for astrocyte αvβ5 and αvβ8 integrins in adhesion and migration. J Cell Sci 1999 Dec;112 ( Pt 23):4271-9

Cambier, Stephanie, Mu, De-zhi, O' Connell, D., Boylen, K., Travis, W., Liu, W.,. Broaddus, V C, Nishimura, S. L. A role foe the divergent integrin αvβ8 in negative regulation of epithelial cell growth Cancer Res, 2000 Dec 15;60(24):7084-93

Mu, Dezhi, Cambier, S, Baron, JL, Munger, J, Sheppard, D, Broaddus, VC, Nishimura, SL, The integrin αvβ8 mediates epithelial homeostasis through the MT1-MMP-dependent activation of TGF-β. J Cell Biol, 2002, Apr 29;157(3):493-507.

Baron, J.l., Gardiner, L., Nishimura, S.L., Shinkai, K., Locksley, R., Ganem, D., Activation of a nonclassical NKT cell subset in a transgenic mouse model of hepatitis B virus infection, Immunity, 2002, Apr;16:583-594.

Fjellbirkeland, L., Cambier, S., Dolganov, G., Hill, A., Brunetta, P., Jablons, D., Ten Dijke, P., Nishimura, S.L., Integrin-mediated activation of TGF- inhibits human airway epithelial proliferation in situ, A J Path, 2003, 163(2) 533-542

Jarad, G., Wang, B., Khan, S., DeVore, J., Miao, H., Wu, K., Nishimura, S.L., Wible, B.A., Konieczkowski, M., Sedor, J.R., Schelling, J.R., Fas Activation Induces Renal Tubular Epithelial Cell β8 Integrin Expression and Function in the Absence of Apoptosis, J Biol Chem. 2002 Dec 6;277(49):47826-47833

Morris*, D., Jasmer, R., Huang, , Gotway, M., Nishimura, S.L., King, Jr., T., Sarcoidosis following HIV infection: evidence for CD4+ lymphocyte dependence, Chest. 2003;124:929-93

Jackson T, Clark S, Berryman S, Burman A, Cambier S, Mu D, Nishimura S, King AM. Integrin αvβ8 functions as a receptor for foot-and-mouth disease virus: role of the beta-chain cytodomain in integrin-mediated infection. J Virol. 2004 May;78(9):4533-4

Innes, A, Nishimura, S., Huang, L., Resolution of lymphocytic interstitial pneumonia in a patient with AIDs after highly active retroviral therapy. Sex Trans Infect, 2004 80-417-418.

Gline, S.E., Cambier, S., Govaerts, C., Nishimura, S.L., A 50  separation of the integrin αvβ3 extracellular domain C-termini reveals an intermediate activation state, J Biol Chem, in press (e-published, 10/8/04).

Books/Chapters

Nishimura, S.L., Broaddus, V.C., Asbestos-Related Pleural Diseases, (Chapter), Clin Chest Med, 1998, 19(2):311-329.

Nishimura, S.L., Finkbeiner, W., Pulmonary Pathology, (Chapter), in Textbook of Respiratory Medicine, Murray and Nadel, Eds., 4th Ed., In Press.

1/15/05