Scott A. Oakes, MD

Elmira College, Elmira, NY, B.A., 1993, Biochemistry
University of Connecticut, Farmington, CT, M.D., 1998, Medicine

• 1995-1996
  Research Scholar, HHMI, Lymphocyte Cell Biology Section, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD. Advisor: John J. O'Shea, M.D.
• 1998-2000
  Resident, Anatomic Pathology, Brigham and Women's Hospital, Boston, MA
• 1998-2002
  Clinical Fellow in Pathology, Harvard Medical School, Boston, MA
• 2000-2005
  Research Associate, Department of Cancer Immunology & AIDS, Dana-Farber Cancer Institute, Boston, MA. Advisor: Stanley J. Korsmeyer, M.D.
• 2002-2005
  Instructor in Pathology, Harvard Medical School, Boston, MA.
• 2005-present
  Assistant Professor, Department of Pathology, University of California San Francisco

• 1989
  Salutatorian Scholarship
• 1990
  Borden Highest Freshman GPA Prize
• 1991
  Phi Beta Kappa Prize
• 1992
  Phi Beta Kappa Prize
• 1992
  Gorman Prize for Most Scholarly Work in Chemistry
• 1993
  Outstanding Senior Chemistry Award
• 1993
  Elmira College Valedictorian
• 1998
  American Endocrine Society Award
• 1998
  American Endocrine Society Award
• 2000-2003
  NIH Pathology Training Grant Recipient
• 2003-2008
  NIH Mentored Clinical Scientist Development Award (K08)
• 2006-2007
  American Cancer Society Junior Investigator Award
• 2007-2011
  HHMI Early Career Physician Scientist Award

• Candotti F, Oakes SA, Johnston JA, Notarangelo LD, O’Shea JJ, Blaese RM. In vitro correction of JAK3-deficient severe combined immunodeficiency by retroviral-mediated gene transduction. J. Exp. Med. 1996;183:2687-2692. PMID: 8676091
• Oakes SA, Candotti F, Johnston JA, Chen YQ, Ryan JJ, Taylor N, Lui X, Hennighauser L, Notarangelo LD, Paul WE, Blaese RM, O’Shea JJ. Signaling via IL-2 and IL-4 in JAK3-deficient severe combined immunodeficiency lymphocytes: JAK3-dependent and –independent pathways. Immunity 1996;5:605-615. PMID: 8986719
• Scorrano L, Ashiya M, Buttle K, Weiler S, Oakes SA, Mannella CA, Korsmeyer SJ. Distinct pathways remodel mitochondrial cristae or release cytochrome c during apoptosis. Dev. Cell 2002;2:55-67. PMID: 11782314
• Scorrano L*, Oakes SA*, Opferman JT, Cheng EH, Sorcinelli MD, Pozza T, Korsmeyer SJ. BAX and BAK regulation of endoplasmic reticulum Ca2+:a control point for apoptosis. Science 2003;300:135-139. *These authors contributed equally. PMID: 12624178
• Oakes SA, Opferman JT, Pozzan T, Korsmeyer SJ, Scorrano L. Regulation of endoplasmic reticulum Ca2+ dynamics by proapoptotic BCL-2 family members. Biochem. Pharmacol. 2003:66:1335-1340. PMID: 14555206
• Bassik MC, Scorrano L, Oakes SA, Pozzan T, Korsmeyer SJ. Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis. EMBO J. 2004;23:1207-1216. PMID: 15010700
• Oakes SA, Korsmeyer SJ. Untangling the web: mitochondrial fission and apoptosis. Dev. Cell. 2004;7:460-462. PMID: 15469833
• Oakes SA, Scorrano L, Opferman JT, Bassik MC, Nishino M, Pozzan T, Korsmeyer SJ. Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum. Proc. Natl. Acad. Sci. USA. 2005;102:105-110. PMID: 15613488
• Oakes SA, Lin SS, Bassik MC. The control of endoplasmic reticulum-initiated apoptosis by the BCL-2 family of proteins. Curr. Mol. Med. 2006;6:99-109. PMID: 16472117
• Oakes SA. Mitochondria control calcium entry at the immunological synapse. Proc. Natl. Acad. Sci. USA. 2007;104:15171-15172. PMID: 17881558
• Han D, Upton JP, Hagen A, Callahan J, Oakes SA, Papa FR. A kinase inhibitor activates the IRE1alpha RNase to confer cytoprotection against ER stress. Biochem. Biophys. Res. Commun. 2008;365:777-783. PMID: 18035051
• Upton JP, Austgen K, Nishino M, Coakley KM, Hagen A, Han D, Papa FR, Oakes SA. Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress. Mol Cell Biiol. 2008;28(12):3943-3951. PMCID: PMC2423129
• Dan D, Lerner AG, Vande Walle L, Upton JP, Xu W, Hagen A, Backes BJ, Oakes SA, Papa FR. IRE1alpa kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates. Cell. 2009;138(3):562-575. PMCID: PMC2762408 [Available on 2010/8/7]
• Reyes NA, Fisher JK, Austgen K, Vandenberg S, Huang EJ, Oakes SA. Blocking the mitochondrial apoptotic pathway preserves motor neuron viability and function in a mouse model of amyotrophic lateral sclerosis. J Clin Invest. 2010;120(10):3673-3679.
• Fan Q-W, Cheng CK, Hackett C, Feldman M, Houseman BT, Hass-Kogan D, Nicolaides T, James CD, Oakes SA, Debnath J, Shokat KM, Weiss WA. Akt and autophagy cooperate to promote survival of drug-resistant glioma. Sci Signal. 2010;3(147);ra81.