Pearl T. and Samuel J. Kimura Chair in Opthalmology, UCSF
Director, Ocular Oncology, UCSF
| CONTACT | |
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(415) 502-3206 (voice) Box 0730, UCSF; San Francisco, CA 94143-0730 |
additional websites: |
| EDUCATION | |
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Middlebury College, Middlebury, VT, BA, 1979, Psychology/English Lit
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| PROFESSIONAL EXPERIENCE | |
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1988-1989 |
Clinical Fellow in Ophthalmic Pathology, Massachusetts Eye and Ear Infirmary, Boston |
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1988-1989 |
Research Fellow in Ophthalmic Pathology (Molecular Biology), Howe Laboratory of Ophthalmology, Harvard Medical School and Cancer Research Center, Massachusetts General Hospital, Boston |
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1989-1992 |
Resident in Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston |
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1992-1993 |
Clinical Fellow / Instructor in Ocular Oncology, University of California, San Francisco |
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1993-1995 |
Co-Director, Ocular Oncology, UCSF |
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1993-1998 |
Assistant Professor, Ophthalmology, UCSF |
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1995-Present |
Director, Ocular Oncology, UCSF |
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1998-2004 |
Associate Professor, Ophthalmology, UCSF |
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2004-Present |
Professor, Ophthalmology, UCSF |
| HONORS & AWARDS | |
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1989-1994 |
NIH / NEI - R01 EY01917-22 Research Grant - Co-Investigator with Daniel M. Albert, M.D. Howe Laboratory of Ophthalmology, Harvard Medical School |
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1994 |
University of California, San Francisco - Faculty Development Award |
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1994-1997 |
American Cancer Society - Career Development Award |
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1997 |
American Academy of Ophthalmology - Honor Award |
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1998-Present |
University of California, San Francisco, Pearl and Samuel Kimura Endowed Chair in Ophthalmology |
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1999-Present |
American Board of Ophthalmology - Associate Examiner |
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2000 |
Emory University, Department of Ophthalmology - Invited Visiting Professor |
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2000 |
H. Talmage Dobbs, Jr. Lecture in Ophthalmology |
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2001-2003 |
Research to Prevent Blindness - Physician Scientist Award |
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2002 |
University of Wisconsin-Madison - Alice McPherson Invited Lecture in Ophthalmology |
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2002-Present |
NIH / NEI - R01 EY13812 Research Grant - Principal Investigator |
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2005 |
Harvard University - Claes Dohlmann Visiting Professor in Ophthalmology |
| SELECTED PUBLICATIONS | |
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O'Brien JM, Marcus DM, Niffenegger AS, Bernards R, Carpenter JL, Windle JJ, Mellon P, Albert DM: Trilateral retinoblastoma in transgenic mice. Trans Am Ophthalmol Soc 87:301-322, 1989. | |
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Windle JJ, Albert DM, O'Brien JM, et al. Retinoblastoma in transgenic mice. Nature 343:665-669, 1990. | |
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O'Brien JM, Marcus DM, Bernards R, Carpenter JL, Windle JJ, Mellon PL, Albert DM: A transgenic mouse model for trilateral retinoblastoma. Arch Ophthalmol 108:1145-1151, 1990. | |
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Marcus DM, Carpenter JL, O'Brien JM, et al.: Primitive neuroectodermal tumor of the midbrain in a murine model of retinoblastoma. Invest Ophthalmol Vis Sci 32:293-301, 1991. | |
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Kivela T, Virtanen I, Marcus DM, O'Brien JM, Carpenter JL, Brauner E, Tarkkanen A, Albert DM: Neuronal and glial properties of a murine transgenic retinoblastoma model. Am J Pathol 138:1135-1148, 1991. | |
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Howard E, Marcus D, O'Brien J, Albert D, Bernards R: Five DNA tumor viruses undetectable in human retinoblastomas. Invest Ophthalmol Vis Sci 33:1564-1567, 1992. | |
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Albert DM, Marcus DM, Gallo JP, O'Brien JM: The antineoplastic effect of vitamin D in transgenic mice with retinoblastoma. Invest Ophthalmol Vis Sci 33:2354-2364, 1992. | |
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Soparker CN, O'Brien JM, Albert DM: Investigation of the role of the ras protooncogene point mutation in human uveal melanomas. Invest Ophthalmol Vis Sci 34:2203-2209, 1993. | |
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Maandag ECR, van der Valk M, Vlaar M, Feltkamp C, O'Brien J, et al.: Developmental rescue of an embryonic-lethal mutation in the retinoblastoma gene in chimeric mice. EMBO J 13:4260-4268, 1994. | |
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Gordon KB, Thompson CT, Char DH, O'Brien JM, et al.: Comparative genomic hybridization in the detection of DNA copy number abnormalities in uveal melanoma. Cancer Res 54:4764-4768, 1994. | |
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O'Brien JM:Infections, inflammations and immune mediated orbital disease. Curr Op Ophthal 6:59-69, 1995. | |
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O'Brien JM, Char DH, Tucker N, Gordon KB, Norman D: Efficacy of unanesthetized spiral computed tomography scanning in initial evaluation of childhood leukocoria. Ophthalmology 102:1345-1350, 1995. | |
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O'Brien JM, Harbour JW, Smith B, et al.: Utility of initial metastatic tests and serial bone scans in patients with retinoblastoma. Invest Ophthalmol Vis Sci 36(4), 1995. | |
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Smith B, O'Brien JM: Genetics of retinoblastoma. J Pediatr Ophthalmol Strabismus 33(2):120-123, 1996. | |
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Harbour JW, Murray TG, Hamasaki D, Cicciarelli N, Hernandez E, Smith B, Windle J, O'Brien J: Local carboplatin therapy in transgenic murine retinoblastoma. Invest Ophthalmol Vis Sci 37(9):1892-1898, 1996. | |
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Chan HSL,DeBoer G, Thiessen JJ, Budning A, Kingston JE, O'Brien JM, et al.: Combining cyclosporin with chemotherapy controls intraocular Rb without requiring radiation. Clin Cancer Res 2:1499-1508, 1996. | |
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O'Brien JM, Smith BJ: Chemotherapy in the treatment of Rb. Int Ophthalmol Clin 36:11-24, 1996. | |
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Murray TG, O'Brien JM, Steeves RA, et al.: Radiation therapy and ferromagnetic hyperthermia in the treatment of murine transgenic retinoblastoma. Arch Ophthal 114:1376-1381, 1996. | |
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Murray TG, Roth DB, O'Brien JM, et al.: Local carboplatin and radiation therapy in the treatment of murine transgenic retinoblastoma. Arch Ophthalmol 114:1385-1389, 1996. | |
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Murray TG, Cicciarelli N, O'Brien JM, et al.: Subconjunctival carboplatin therapy and cryotherapy in the treatment of transgenic murine retinoblastoma. Arch Ophthalmol 115:1286-1290, 1997. | |
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Murray T, Cicciarelli N, Hernandez E, McCabe C, Ksander B, Schiffman J, Meeler W, O'Brien JM: In vitro efficacy of carboplatin and hyperthermia in a murine Rb cell line. InvestOphthalmol Vis Sci 38:2516-2522,1997. | |
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Kaiser PK, Murray TG, O'Brien JM: Laser photocoagulation of choroidal and retinal tumors. Ophth Surg Lasers 29:59-78, 1998. | |
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O'Brien JM: Alternative treatment in retinoblastoma (Guest Editorial) Ophthalmology 105:571-572,1998. | |
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Hasenyager Smith J, Murray TG, Fulton L, O'Brien JM: Siblings of retinoblastoma patients: Are we underestimating their risk? A brief report. Am J Ophthalmol 129:396-398, 2000. | |
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Uusitalo MS,Van Quill KR,Scott IU,Murray TG, O'Brien JM: Evaluation of chemoprophylaxis in patients with unilateral retinoblastoma with high risk features on histopathologic exam. Arch Ophthalmol 119:41-48, 2001. | |
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Daftari I, Barash D, Lin S, O'Brien J: Use of high-frequency ultrasound imaging to improve delineation of anterior uveal melanoma for proton irradiation. Phys Med Biol 46: 579-590, 2001. | |
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Duncan JL, Scott IU, Murray TG, Gombos DS, Van Quill KR, O'Brien JM: Routine neuroimaging in retinoblastoma for the detection of intracranial tumors. Arch Ophthalmol 119:450-452, 2001. | |
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Uusitalo M, Ibarra M, Fulton L, Kaplan M, Hoffman W, Lee C, Carter S, O'Brien J: Reconstruction with rectus abdominis myocutaneous free-flap after orbital exenteration in children. Arch Ophthalmol 119:1705-1709, 2001. | |
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Gordon KB, Rugo HS, Duncan JL, Irvine AR, , Howes EL Jr., O'Brien JM, Carter SR: Ocular manifestations of leukemia: Leukemic infiltration vs. infectious process. Ophthalmology 108:2293-2300, 2001. | |
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Tsai T, O'Brien JM: Masquerade syndromes: Malignancies mimicking inflammation in the eye. Int Ophthalmol Clin 42:115-131, 2002. | |
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Hayden BC, Murray TG, Cicciarelli N, Scott IU, Alexandridou A, Hernandez E, Wu X, Markoe AM, Feuer W, Fulton L, O'Brien JM: Hyperfractionated external beam radiation therapy in the treatment of murine transgenic retinoblastoma. Arch Ophthalmol 120:353-359, 2002. | |
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McCaffery S, Simon EM, Fischbein NJ, Rowley HA, Shimikawa A, Lin S, O'Brien JM: Three-dimensional high-resolution magnetic resonance imaging of ocular and orbital malignancies. Arch Ophthalmol 120:747-754, 2002. | |
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McCaffery S, Wieland M, O'Brien JM, Cooper KL, Wendel R: Atypical retinoblastoma presentations: A challenge for the treating ophthalmologist. Arch Ophthalmol 120:1222-1225, 2002. | |
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Simon EM, McCaffery S, Rowley HA, Fischbein NJ, Shimikawa A, O'Brien JM: High-resolution 3D T2-weighted fast spin echo imaging of ophthalmologic tumors. Neuroradiology 45:489-492, 2003. | |
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Tsai T, Fulton L, Smith BJ, Mueller RL, Gonzalez GA, Uusitalo MS, O'Brien JM: Rapid identification of germline mutations in retinoblastoma by protein truncation testing. Arch Ophthalmol 122:239-248, 2004. | |
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Sobrin L, Hayden BC, Murray TG, Cicciarelli N, Scott IU, Hernandez E, Wu X, Markoe AM, Feuer W, Fulton L, O'Brien JM: External beam radiation ÒsalvageÓ therapy in transgenic murine retinoblastoma. Arch Ophthalmol 122:251-257, 2004. | |
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Gombos DS, Van Quill K, Uusitalo M, O'Brien JM: Disparities in diagnostic screening for metastatic uveal melanoma. Ophthalmology 111:2254-2258, 2004. | |
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Eckstein LA, Van Quill KR, Bui SK, Uusitalo MS, O'Brien JM: Cyclosporin A inhibits calcineurin/nuclear factor of activated T-cells signaling and induces apoptosis in retinoblastoma cells. Invest Ophthalmol Vis Sci 46:782-90, 2005. | |
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Van Quill KR, Dioguardi PK, Tong CT, Gilbert JA, Aaberg TA, Grossniklaus H, Edelhauser HF, O'Brien JM: Subconjunctival carboplatin in fibrin sealant in the treatment of transgenic murine retinoblastoma. Ophthalmology 112:1151-1158, 2005. | |
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Conway RM, Chew T, Golchet P, Desai K, Lin S, O'Brien JM: Ultrasound biomicroscopy: Role in diagnosis and management in 130 consecutive patients evaluated for anterior segment tumors. Br J Ophthalmol 89:950-955, 2005. | |
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Tong CT, Howard SA, Shah HR, Van Quill KR, Lin ET, Grossniklaus HE, O'Brien JM: Effects of celecoxib in human retinoblastoma cell lines and in a transgenic model of retinoblastoma. Br J Ophthalmol 89:1217-1220, 2005. |
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12/11/06 |
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