Paul R. Ortiz de Montellano, PhD

Mass. Institute of Technology (Cambridge, MA), B.S., 1964, Chemistry
Harvard University (Cambridge, MA), M.A., 1966, Chemistry
Harvard University (Cambridge, MA), Ph.D., 1968, Bioorganic Chemistry
Eidg. Tech. Hochschule (Zurich, Switzerland), Postdoc, 1968-1969, Bioorganic Chemistry

• 1969-1971
  Group Leader, Syntex Research Laboratories
• 1972-1980
  Assistant/Associate Professor, University of California, San Francisco
• 1980-present
  Professor of Chemistry, Pharmaceutical Chemistry, and Pharmacology, University of California, San Francisco
• 1982-1994
  Vice Chairman, Department of Pharmaceutical Chemistry
• 1978-1979
  Professeur Associe, Institut de Chimie, Universite Louis Pasteur, Strasbourg, France
• 1985-1986
  Honorary Fellow, Department of Biochemistry, University College, London
• 1993-1994
  Professeur Rhone Poulenc, Universite René Descartes (Paris V), Paris, France
• 2000-2001
  Visiting Academic, Department of Biochemistry & Molec. Biol., University College, London

• 1960-1964
  McDermott Scholar (MIT)
• 1965-1968
  NIH Predoctoral Fellow (Harvard)
• 1968-1969
  NATO Postdoctoral Fellow
• 1988
  Alfred P. Sloan Foundation Research Science
• 1989
  John Moffat Lecturer, University of British Columbia
• 1989-1999
  NIH MERIT Award
• 1989, 1996, 1997
  UCSF Long Foundation Award for Excellence in Teaching
• 1991
  King/Chavez/Parks Visiting Professor, University of Michigan
• 1991
  Distinguished University Lecturer, University of Utah
• 1994
  Wellcome Visiting Professor, Washington State University
• 1994
  B. B. Brodie Award in Drug Metabolism of the American Society of Pharmacology and Experimental Therapeutics
• 1998
  Robert A. Welch Foundation Lecturer, University of Texas Campuses
• 2000
  Chauncey Leake Lecturer, University of Texas Medical Branch Galveston
• 2001
  Karcher Lecturer, University of Oklahoma

• The Active Site of the Thermophilic CYP119 from Sulfolobus solfataricus. Koo, L.S., Tschirret-Guth, R.A., Straub, W., Moënne-Loccoz, P., Loehr, T.M., and Ortiz de Montellano, P.R. (2000) J. Biol. Chem. 275, 14112-14123.
• Reaction Intermediates and Single Turnover Rate Constants for the Oxidation of Heme by Human Heme Oxygenase-1. Liu, Y., and Ortiz de Montellano, P.R. (2000) J. Biol. Chem. 275, 5297-5307.
• The Active Site of the Thermophilic CYP119 from Sulfolobus solfataricus. Koo, L.S., Tschirret-Guth, R.A., Straub, W., Moënne-Loccoz, P., Loehr, T.M., and Ortiz de Montellano, P.R. (2000) J. Biol. Chem. 275, 14112-14123.
• The AhpC and AhpD Antioxidant Defense System of Mycobacterium tuberculosis. Hillas, P.J., Soto del Alba, F., Oyarzabal, J., Wilks, A., and Ortiz de Montellano, P.R. (2000) J. Biol. Chem. 275, 18801-18809.
• Rational Design of Selective Submicromolar Inhibitors of Tritrichomonas foetus Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase. Aronov, A.M., Munagala, N.R., Ortiz de Montellano, P.R., Kuntz, I.D., and Wang, C.C. (2000) Biochemistry 39, 4684-4691.
• Crystal Structure of a Thermophilic Cytochrome P450 from the Archaeon Sulfolobus solfataricus. Yano, J.K., Koo, L.S., Schuller, D.J., Li, H., Ortiz de Montellano, P.R., and Poulos, T.L. (2000) J. Biol. Chem., 275, 31086-31092.
• Molecular Basis for the w-Regiospecificity of the CYP4A2 and CYP4A3 Fatty Acid Hydroxylases. Hoch, U., Falck, J.R., and Ortiz de Montellano, P.R. (2000) J. Biol. Chem., 275, 26952-26958.
• Replacement of the Distal Glycine-139 Transforms Human Heme Oxygenase-1 into a Peroxidase. Liu, Y., Lighning, L.K., Huang, H.W., Moënne-Loccoz, P., Schuller, D.J., Loehr, T.M., Poulos, T.L., and Ortiz de Montellano, P. R. (2000) J. Biol. Chem. 275, 34501-34507.
• An Ala245Thr Mutation Conveys on Cytochrome P450eryF the Ability to Oxidize Alternative Substrates. Xiang, H., Tschirret-Guth, R.A., and Ortiz de Montellano, P.R., J. Biol. Chem., 275, 35999-36006.
• Disruption of an Active Site Hydrogen bond converts Human Heme Oxygenase-1 into a Peroxidase. Lightning, L.K., Huang, H., Moënne-Loccoz, P., Loehr, T.M., Schuller, D.J., Poulos, T.L., and Ortiz de Montellano, P.R. (2001) J. Biol. Chem. 276, 10612-10619.
• Reversible Pressure Deformation of A Thermophilic Cytochrome P450 Enzyme (CYP119) and Its Active-Site Mutants. Tschirret-Guth, R.A., Koo, L.S., Hui Bon Hoa, G., and Ortiz de Montellano, P.R. (2001) J. Am. Chem. Soc 123, 3412-3417.
• Covalently-linked Heme in Cytochrome P4504A Fatty Acid Hydroxylases. Hoch, U., and Ortiz de Montellano, P.R. (2001) J. Biol. Chem. 276, 11339-11346.
• Roles of the Proximal Heme Thiolate Ligand of Cytochrome P450cam. Auclair, K., Moënne-Loccoz, P., and Ortiz de Montellano, P.R. (2001) J. Am. Chem. Soc., 123, 4877-4885.
• Solution 1H NMR of the Molecular and Electronic Structure of the Heme Cavity and Substrate Binding Pocket of High-Spin Ferric Horseradish Peroxidase. Asokan, A., de Ropp, J.S., Newmyer, S.L., Ortiz de Montellano, P.R., and La Mar, G.N. (2001) J. Am Chem. Soc. 123, 4243-4254.
• Solution 1H NMR of the Active Site of Substrate-Bound, Cyanide-Inhibited, Human Heme Oxygenase: Comparison to the Crystal Structure of the Water-ligated Form. La Mar, G.N., Asokan, A., Espiritu, B., Yeh, D.C., Auclair, K., and Ortiz de Montellano, P.R. (2001) J. Biol. Chem. 276, 15676-15687.
• Control of Electron Transfer in Nitric Oxide Synthases. Swapping of Autoinhibitory Elements among Nitric Oxide Synthase Isoforms (2001) Nishida, C.R., and Ortiz de Montellano, P.R. J. Biol. Chem.. 267, 20116-20124.
• H2O2-Mediated Cross-Linking of Lactoperoxidase with Myoglobin. Evidence for Protein-to Protein Radical Transfer Reactions. Lardinois, O.M., and Ortiz de Montellano, P.R. (2001) J. Biol. Chem., 276, 23186-23191.
• The Antituberculosis Drug Ethionamide is Activated by a Flavoprotein Monoxygenase. Vannelli, T., Dykman, A., and Ortiz de Montellano, P.R. (2001) Submitted for publication.
• Antihypertensive Effect of Mechanism-Based Inhibition of Renal Arachidonic Acid w-Hydroxylase Activity. Xu, F., Pak, W., Su, P., Straub, W.O., Ortiz de Montellano, P.R., and Kroetz, D.L. (2001) submitted for publication.
• Asp225 and Glu375 in Autocatalytic Attachment of the Prosthetic Heme Group of Lactoperoxidase. Colas, C., Kuo, J.M., and Ortiz de Montellano, P. R. (2001) submitted for publication.
• Ehanced Electron Transfer and Lauric Acid Hydroxylation by Site-Directed Mutagenesis of CYP199. Koo, L.S., Immoos, C.E., Cohen, M.S., Farmer, P.J., and Ortiz de Montellano, P.R. (2001) submitted for publication.