Professor, Chemistry, Pharmaceutical Chemistry, and Pharmacology, UCSF
Member, UCSF Biomedical Sciences Graduate Program (BMS) and Herbert Boyer Program in Biological Sciences (PIBS)
| CONTACT | |
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ortiz@cgl.ucsf.edu Box 2280, UCSF; San Francisco, CA 94143-2280 |
additional websites: |
| EDUCATION | |
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Mass. Institute of Technology (Cambridge, MA), B.S., 1964, Chemistry
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| PROFESSIONAL EXPERIENCE | |
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1969 - 1971 |
Group Leader, Syntex Research Laboratories |
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1972 - 1980 |
Assistant/Associate Professor, University of California, San Francisco |
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1980 - present |
Professor of Chemistry, Pharmaceutical Chemistry, and Pharmacology, University of California, San Francisco |
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1982 - 1994 |
Vice Chairman, Department of Pharmaceutical Chemistry |
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1978 - 1979 |
Professeur Associé, Institut de Chimie, Université Louis Pasteur, Strasbourg, France |
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1985 - 1986 |
Honorary Fellow, Department of Biochemistry, University College, London |
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1993 - 1994 |
Professeur Rhone Poulenc, Université René Descartes (Paris V), Paris, France |
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2000 - 2001 |
Visiting Academic, Department of Biochemistry & Molec. Biol., University College, London |
| HONORS & AWARDS | |
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(1960-1964) |
McDermott Scholar (MIT) |
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(1965-1968) |
NIH Predoctoral Fellow (Harvard) |
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(1968-1969) |
NATO Postdoctoral Fellow |
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(1988) |
Alfred P. Sloan Foundation Research Science |
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(1989) |
John Moffat Lecturer, University of British Columbia |
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(1989-1999) |
NIH MERIT Award |
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(1989, 1996, 1997) |
UCSF Long Foundation Award for Excellence in Teaching |
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(1991) |
King/Chavez/Parks Visiting Professor, University of Michigan |
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(1991) |
Distinguished University Lecturer, University of Utah |
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(1994) |
Wellcome Visiting Professor, Washington State University |
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(1994) |
B. B. Brodie Award in Drug Metabolism of the American Society of Pharmacology and Experimental Therapeutics |
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(1998) |
Robert A. Welch Foundation Lecturer, University of Texas Campuses |
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(2000) |
Chauncey Leake Lecturer, University of Texas Medical Branch Galveston |
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(2001) |
Karcher Lecturer, University of Oklahoma |
| SELECTED PUBLICATIONS | |
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(selected from a total of 320) | |
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The Active Site of the Thermophilic CYP119 from Sulfolobus solfataricus. Koo, L.S., Tschirret-Guth, R.A., Straub, W., Moënne-Loccoz, P., Loehr, T.M., and Ortiz de Montellano, P.R. (2000) J. Biol. Chem. 275, 14112-14123. | |
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Reaction Intermediates and Single Turnover Rate Constants for the Oxidation of Heme by Human Heme Oxygenase-1. Liu, Y., and Ortiz de Montellano, P.R. (2000) J. Biol. Chem. 275, 5297-5307. | |
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The Active Site of the Thermophilic CYP119 from Sulfolobus solfataricus. Koo, L.S., Tschirret-Guth, R.A., Straub, W., Moënne-Loccoz, P., Loehr, T.M., and Ortiz de Montellano, P.R. (2000) J. Biol. Chem. 275, 14112-14123. | |
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The AhpC and AhpD Antioxidant Defense System of Mycobacterium tuberculosis. Hillas, P.J., Soto del Alba, F., Oyarzabal, J., Wilks, A., and Ortiz de Montellano, P.R. (2000) J. Biol. Chem. 275, 18801-18809. | |
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Rational Design of Selective Submicromolar Inhibitors of Tritrichomonas foetus Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase. Aronov, A.M., Munagala, N.R., Ortiz de Montellano, P.R., Kuntz, I.D., and Wang, C.C. (2000) Biochemistry 39, 4684-4691. | |
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Crystal Structure of a Thermophilic Cytochrome P450 from the Archaeon Sulfolobus solfataricus. Yano, J.K., Koo, L.S., Schuller, D.J., Li, H., Ortiz de Montellano, P.R., and Poulos, T.L. (2000) J. Biol. Chem., 275, 31086-31092. | |
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Molecular Basis for the w-Regiospecificity of the CYP4A2 and CYP4A3 Fatty Acid Hydroxylases. Hoch, U., Falck, J.R., and Ortiz de Montellano, P.R. (2000) J. Biol. Chem., 275, 26952-26958. | |
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Replacement of the Distal Glycine-139 Transforms Human Heme Oxygenase-1 into a Peroxidase. Liu, Y., Lighning, L.K., Huang, H.W., Moënne-Loccoz, P., Schuller, D.J., Loehr, T.M., Poulos, T.L., and Ortiz de Montellano, P. R. (2000) J. Biol. Chem. 275, 34501-34507. | |
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An Ala245Thr Mutation Conveys on Cytochrome P450eryF the Ability to Oxidize Alternative Substrates. Xiang, H., Tschirret-Guth, R.A., and Ortiz de Montellano, P.R., J. Biol. Chem., 275, 35999-36006. | |
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Disruption of an Active Site Hydrogen bond converts Human Heme Oxygenase-1 into a Peroxidase. Lightning, L.K., Huang, H., Moënne-Loccoz, P., Loehr, T.M., Schuller, D.J., Poulos, T.L., and Ortiz de Montellano, P.R. (2001) J. Biol. Chem. 276, 10612-10619. | |
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Reversible Pressure Deformation of A Thermophilic Cytochrome P450 Enzyme (CYP119) and Its Active-Site Mutants. Tschirret-Guth, R.A., Koo, L.S., Hui Bon Hoa, G., and Ortiz de Montellano, P.R. (2001) J. Am. Chem. Soc 123, 3412-3417. | |
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Covalently-linked Heme in Cytochrome P4504A Fatty Acid Hydroxylases. Hoch, U., and Ortiz de Montellano, P.R. (2001) J. Biol. Chem. 276, 11339-11346. | |
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Roles of the Proximal Heme Thiolate Ligand of Cytochrome P450cam. Auclair, K., Moënne-Loccoz, P., and Ortiz de Montellano, P.R. (2001) J. Am. Chem. Soc., 123, 4877-4885. | |
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Solution 1H NMR of the Molecular and Electronic Structure of the Heme Cavity and Substrate Binding Pocket of High-Spin Ferric Horseradish Peroxidase. Asokan, A., de Ropp, J.S., Newmyer, S.L., Ortiz de Montellano, P.R., and La Mar, G.N. (2001) J. Am Chem. Soc. 123, 4243-4254. | |
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Solution 1H NMR of the Active Site of Substrate-Bound, Cyanide-Inhibited, Human Heme Oxygenase: Comparison to the Crystal Structure of the Water-ligated Form. La Mar, G.N., Asokan, A., Espiritu, B., Yeh, D.C., Auclair, K., and Ortiz de Montellano, P.R. (2001) J. Biol. Chem. 276, 15676-15687. | |
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Control of Electron Transfer in Nitric Oxide Synthases. Swapping of Autoinhibitory Elements among Nitric Oxide Synthase Isoforms (2001) Nishida, C.R., and Ortiz de Montellano, P.R. J. Biol. Chem.. 267, 20116-20124. | |
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H2O2-Mediated Cross-Linking of Lactoperoxidase with Myoglobin. Evidence for Protein-to Protein Radical Transfer Reactions. Lardinois, O.M., and Ortiz de Montellano, P.R. (2001) J. Biol. Chem., 276, 23186-23191. | |
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The Antituberculosis Drug Ethionamide is Activated by a Flavoprotein Monoxygenase. Vannelli, T., Dykman, A., and Ortiz de Montellano, P.R. (2001) Submitted for publication. | |
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Antihypertensive Effect of Mechanism-Based Inhibition of Renal Arachidonic Acid w-Hydroxylase Activity. Xu, F., Pak, W., Su, P., Straub, W.O., Ortiz de Montellano, P.R., and Kroetz, D.L. (2001) submitted for publication. | |
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Asp225 and Glu375 in Autocatalytic Attachment of the Prosthetic Heme Group of Lactoperoxidase. Colas, C., Kuo, J.M., and Ortiz de Montellano, P. R. (2001) submitted for publication. | |
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Ehanced Electron Transfer and Lauric Acid Hydroxylation by Site-Directed Mutagenesis of CYP199. Koo, L.S., Immoos, C.E., Cohen, M.S., Farmer, P.J., and Ortiz de Montellano, P.R. (2001) submitted for publication. | |
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Selected Book Chapters and Reviews | |
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Inhibition of Cytochrome P450 4A enzymes and Peroxisome Proliferation. Ortiz de Montellano, P. R., Kaikaus, R. M., Chan, W. K., Sui, Z., and Bass, N. M. (1994) In "Peroxisome Proliferators: Unique Inducers of Drug-Metabolizing Enzymes" (Moody, D. E., Ed.) CRC Press, Boca Raton, Florida, pp. 51-62. | |
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Mechanisms of Myoglobin as an Oxidative Catalyst. Ortiz de Montellano, P. R., Rao, S. I., and Wilks, A. (1994) Life Chemistry Reports 10, 29-32. | |
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Cytochrome P450: Topology and Specificity. Ortiz de Montellano, P. R., Shirane, N., Sui, Z., Fruetel, J. A., Peterson, J. A., and De Voss, J. J. (1994) In Proceedings, 8th International Conference on Cytochrome P450 (Lechner, M. C., Ed.) John Libbey Eurotext Ltd., pp. 409-416. | |
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Structural Determinants of the Catalytic Activities of Peroxidases. Ortiz de Montellano, P. R., Ozaki, S., Newmyer, S. L., Miller, V. P., and Hartmann, C. (1995) Biochem. Soc. Trans. 23, 223-227. | |
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Biotransformations of Drugs and Chemicals. Ortiz de Montellano, P. R. (1995) In Molecul ar Biology and Biotechnology. A Comprehensive Desk Reference (Meyers, R. A., Ed.) VCH, New York, pp. 117-120. | |
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Arylhydrazines as Probes of Hemoprotein Structure and Function. Ortiz de Montellano, P. R. (1995) Biochimie 77, 581-593. | |
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Oxygen Activation and Transfer. Ortiz de Montellano, P. R. (1995) In Cytochrome P450: Structure, Function, and Mechanism, 2nd Ed. (Ortiz de Montellano, P. R., Ed.) Plenum Press, New York, pp. 245-303. | |
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Inhibition of Cytochrome P450 Enzymes. Ortiz de Montellano, P. R. and Correia, M. A. (1995) In Cytochrome P450: Structure, Function, and Mechanism, 2nd Ed. (Ortiz de Montellano, P. R., Ed.) Plenum Press, New York, pp. 305-364. | |
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The 1994 Bernard B. Brodie Award Lecture. Structure, Mechanism, and Inhibition of Cytochrome P450. Ortiz de Montellano, P. R. (1996) Drug Metab. Dispos. 23, 1181-1187. | |
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Substrate Docking Algorithms and the Prediction of Substrate Specificity. De Voss, J. J. and Ortiz de Montellano, P. R. (1996) Methods in Enzymology 272, 336-347. | |
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Biotransformations of Drugs and Chemicals. Ortiz de Montellano, P. R. (1996) In Encycloped ia of Molecular Biology and Molecular Medicine (Meyers, R. A., Ed.) VCH, New York, pp. 192-202. | |
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Cytochrome P450. Ortiz de Montellano, P. R. (1996) In Molecular Toxicology (Josephy, P. D., Ed.) Oxford University Press, New York, pp. 209-252. | |
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Heme Oxygenase Structure and Mechanism. Evidence for an Iron-Bound Electrophilic, Ferric Peroxide Species, Ortiz de Montellano, P. R. (1998) Accts. Chem. Res. 31, 543-549. HTML, PDF | |
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Structure-Function of Cytochromes P450 and Flavin-containing Monooxygenases: Implications for Drug Metabolism. Halpert, J. R., Domanski, T. L., Adali, O., Biagini, C. P., Cosme, J., Dierks, E. A., Johnson, E. F., Jones, J. P., Ortiz de Montellano, P. R., Philpot, R. M., Sibbesen, O., Wyatt, W. K., and Zhang, Z. (1998) Drug Metab. Dispos. 26, 1223-1231. HTML, PDF | |
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Nitric Oxide Synthase Structure and Electron Transfer. Ortiz de Montellano, P. R., Nishida, C., RodrÍguez-Crespo, I., and Gerber, N. (1998) Drug Metab. Dispos. 26, 1185-1189. HTML, PDF | |
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The Cytochrome P450 Oxidative System. Ortiz de Montellano, P. R. (1999) In Handbook of Drug Metabolism (Woolf, T. F., Ed.) Marcel Dekker, New York, pp. 109-130. | |
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Pressure-Induced Rearrangement of Aryl-Iron Complexes in Cytochrome P450 cam : Application to Topological Mapping of the Compressed Active Site. Hui Bon Hoa, G., Tschirret-Guth, R. A., and Ortiz de Montellano, P. R. (1999) In "High Pressure Bioscience and Biotechnology", Conference Proceedings, in press. | |
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Heme Oxygenase Structure and Mechanism. Ortiz de Montellano, P. R. and Wilks, A. (2000) In "Iron Porphyrins", Advances in Inorganic Chemistry (Sykes, G., and Mauk, A. G., Eds.), in press. | |
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Recent Advances in Heme Oxygenase. Ortiz de Montellano, P.R. (2000) Curr. Opinion Chem. Biol. in press. | |
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Books | |
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Cytochrome P-450: Structure, Mechanism and Biochemistry. (Ortiz de Montellano, P.R., Ed.) Plenum Press, New York, (1986). | |
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Cytochrome P-450: Structure, Mechanism and Biochemistry, 2nd Ed. (Ortiz de Montellano, P. R., Ed.) Plenum Press, New York, (1995). |
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1/15/02 |
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