Emmanuelle Passegué, PhD

Paris-XI University, Paris, France, B.S., 1990, Molecular Biology
Paris-XI University, Paris, France, Diploma, 1991, Endocrinology
Paris-XI University, Paris, France, Ph.D., 1995, Endocrinology
IMP, Vienna, Austria, Mouse genetics
Stanford University, Stanford, CA, Stem cell biology

• 1991-1995
  Graduate student, College de France, Paris, France
• 1996-2000
  Postdoctoral fellow, Institute of Molecular Pathology (IMP), Vienna, Austria
• 2001-2003
  Postdoctoral fellow, Department of Pathology, Stanford University, CA
• 2003-2005
  Research Associate, Department of Pathology, Stanford University, CA
• 2005-2010
  Assistant Professor, Department of Medicine, Division of Hematology/Oncology, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA
• 2010-present
  Associate Professor, Department of Medicine, Division of Hematology/Oncology, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA

• 2001
  Long-term EMBO postdoctoral fellowship
• 2002
  Jose Carreras International Leukemia Foundation postdoctoral fellowship (FIJC-01/EDTHOMAS)
• 2007
  ASH Scholar Award
• 2008
  Rita Allen Scholar Award
• 2008
  CIRM New Investigator Award

• Passegué E, Wagner EF. JunB suppresses cell proliferation by transcriptional activation of p16INK4a expression. EMBO J. 19:2969-79 (2000).
• Passegué E, Jochum W, Schorpp-Kistner M, Möhle-Steinlein U, Wagner EF. Chronic myeloid leukemia with increased granulocyte progenitors in mice lacking JunB expression in the myeloid lineage. Cell 104:21-32 (2001).
• Cozzio A, Passegué E, Ayton P, Karsunky H, Cleary ML, Weissman IL. Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors. Genes Dev. 17:3029-35 (2003).
• Passegué E, Wagner EF, Weissman IL. JunB-deficiency leads to a myeloproliferative disorder arising from hematopoietic stem cells. Cell. 119:431-43 (2004).
• Passegué E, Wagers AJ, Guiriato S, Anderson W, Weissman IL. Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates. J Exp Med. 202:1599-611 (2005).
• Forsberg EC, Serwold TC, Kogan S, Weissman IL, Passegué E. New evidence supporting megakaryocyte-erythrocyte potential of Flk2/Flt3+ multipotent hematopoietic progenitors. Cell. 26:415-26 (2006).
• Santaguida M, Schepers K, King B, Sabnis AJ, Forsberg EC, Attema JL, Braun BS, Passegué E. JunB protects against myeloid malignancies by limiting hematopoietic stem cell proliferation and differentiation without affecting self-renewal. Cancer Cell. 15:341-52 (2009).
• Passegué E, Ernst P. INF-alpha wakes up sleeping hematopoietic stem cells. Nat Med. 15:612-3 (2009).
• Forsberg EC, Passegué E, Prohaska SS, Wagers AJ, Koeva M, Stuart JM, Weissman IL. Molecular signatures of quiescent, mobilized and leukemia-initiating hematopoietic stem cells. PloS One. 5:e8785 (2010).
• Mohrin M, Bourke E, Alexander D, Warr M, Barry-Holson K, LeBeau M, Morrison CG, Passegué E. Hematopoietic stem cell quiescence promotes error prone DNA repair and mutagenesis. Cell Stem Cell. 7:174-85 (2010).
• Subramanyam D, Belair CD, Barry-Holson KQ, Lin H, Kogan SC, Passegué E, Blelloch R. PML-RAR? and Dnmt3a1 cooperate in vivo to promote acute promyelocytic leukemia. Cancer Res. 70:8792-801 (2010).
• Blanpain C, Mohrin M, Sotiropoulou P, Passegué E. DNA damage response in tissue-specific and cancer stem cells. Cell Stem Cell. 8:16-29 (2011).
• Warr MR, Pietras E, Passegué E. Mechanisms controlling HSC functions during normal hematopoiesis and hematological malignancies. Wiley Interdisciplinary Reviews: Systems Biology and Medicine. Mar 15 (2011). doi: 10.1002/wsbm.145. [Epub ahead of print]
• Garcia D, Warr MR, Martins CP, Brown Swigart L, Passegué E, Evan GI. Validation of MdmX as a therapeutic target for reactivating p53 in tumors. Genes Dev. 25:1746-57 (2011).
• Pietras EM, Warr MR, Passegué E. Cell cycle regulation in hematopoietic stem cells. J. Cell Biology (in press).
• Reynaud D, Pietras E, Barry-Holson K, Mir A, Binnewies M, Jeanne M, Sala-Torra O, Radich JP, Passegué E. IL-6 controls leukemic multipotent progenitor cell fate and contributes to chronic myelogenous leukemia development. Cancer Cell (in press).