passeguee@stemcell.ucsf.edu
(415) 476-2426 (voice)
(415) 514-2346 (fax)

Box 0525, UCSF; San Francisco, CA 94143-0525

Paris-XI University, Paris, France, B.S., 1990, Molecular Biology
Paris-XI University, Paris, France, Diploma, 1991, Endocrinology
Paris-XI University, Paris, France, Ph.D., 1995, Endocrinology
IMP, Vienna, Austria, Mouse genetic,
Stanford University, Stanford, CA, Stem cell biology

Gourdji, D., Laverri�re, J-N., Passegueacute;, E., and Richard, J-L. (1992). Hypophyseal cells model systems: the GH rat tumor-derived cell lines as a tool for the study of gene expression. Cell. Biol. Toxicol. 8, 38-49

Passegueacute;, E., Laverri�re, J-N., and Gourdji D. (1994). Thyrotropin-Releasing Hormone stimulates in parallel jun B and c-fos messenger ribonucleic acids in GH3B6 pituitary cells: comparison with PRL secretion. Mol. Cell. Neurosci. 5, 109-118

Passegueacute;, E., Laverri�re, J-N., Boulla, G., and Gourdji, D. (1995). C-fos and jun B nuclear proto-oncogenes increased expression: a possible role in the signaling of TRH-induced stimulation in rat pituitary GH3B6 cells. C. R. Soc. Biol. (Paris) 189, 97-110

Passegueacute;, E., Richard, J-L., Boulla, G., and Gourdji, D. (1995). Multiple intracellular signaling are involved in thyrotropin-releasing hormone (TRH)-induced c-fos and jun B mRNA levels in clonal prolactin cells. Mol. Cell. Endocrinol. 107, 29-40

Jochum, W., Passegueacute;, E., and Wagner, E.F. (1999). Loss of junB expression causes a myeloproliferative syndrome resembling chronic myeloid leukemia. Verh. Dtsch. Ges. Pathol. 83, 216-217

Passegueacute;, E., and Wagner, E.F. (2000). JunB suppresses cell proliferation by transcriptional activation of p16INK4a expression. EMBO J. 19, 2969-2979

Passegueacute;, E., Jochum, W., Schorpp-Kistner, M., Mšhle-Steinlein, U., and Wagner, E.F. (2001). Chronic myeloid leukemia with increased granulocyte progenitors in mice lacking JunB expression in the myeloid lineage. Cell 104, 21-32

Jochum, W., Passegueacute;, E., and Wagner, E.F. (2001). AP-1 in mouse development and tumorigenesis. Oncogene 20, 2401-2412

Passegueacute;, E., Jochum, W., Behrens, A., and Wagner, E.F. (2002). JunB replaces c-Jun in mediating embryonic development and cell proliferation. Nat. Genetics 30, 158-166

So, C.W., Karsunky, H., Passegueacute;, E., Cozzio, A., Weissman, I.L., and Cleary, M.L. (2003). MLL-GAS7 transforms multipotent hematopoietic progenitors and induces mixed lineage leukemias in mice. Cancer Cell 3, 161-171

Szremska, A.P., Kenner, L., Weisz, E., Ott, R.G., Passegueacute;, E., Artwohl, M., Freissmuth, M., Stoxreiter, R., Theussl, H.C., Baumgartner Parzer, S., Moriggl, R., Wagner, E.F. and Sexl, V. (2003). JunB inhibits proliferation and transformation in B lymphoid cells. Blood 102, 4159-6415

Passegueacute;, E., Jamieson, C.H.M., Ailles, L.E., and Weissman, I.L. (2003). Normal and leukemic hematopoiesis: are leukemias a stem cell disorder or a reacquisition of stem cell characteristics? Proc. Nat. Acad. Sci. USA 100 Suppl. 1, 11842-11849

Cozzio, A., Passegueacute;, E., Ayton, P., Karsunky, H., Cleary, M.L., and Weissman, I.L. (2003). Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors. Genes Dev. 17, 3029-3035

Jamieson, C.H.M., Passegueacute;, E., and Weissman, I.L. (2004). Leukemia and leukemic stem cells. In Stem Cells in the Nervous System: Functional and Clinical Implications, R. Gage, ed. (Berlin: Springer-Verlag) pp. 157-182

Passegueacute;, E., Wagner, E.F., and Weissman, I.L. (2004). JunB-deficiency leads to a myeloproliferative disorder arising from hematopoietic stem cells. Cell 119, 431-443

Jamieson, C.H.M., Weissman, I.L., and Passegueacute;, E. (2004). Chronic versus acute myelogenous leukemia: A question of self-renewal. Cancer Cell 6, 531-533

Passegueacute;, E. (2005). Hematopoietic stem cells, leukemic stem cells and chronic myelogenous leukemia. Cell Cycle 4, 266-268

Passegueacute;, E. and Weissman I.L. (2005). Leukemic stem cells: where do they come from? Stem Cell Review 3, 181-188

Passegueacute;, E., Wagers, A.J., Guiriato, S., Anderson, W., and Weissman, I.L. (2005). Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates. J. Exp. Med. 202, 1599-1611

Passegueacute;, E., and Wagers, A.J. (2006). Regulating quiescence: new insights into hematopoietic stem cell biology. Dev. Cell 10, 415-417

Nyholm, S.V., Passegueacute;, E., Ludington, W.B., Voskoboynik, A., Mitchel, K., Weissman, I.L., and De Tomaso, A.W. (2006). Isolation and characterization of fester, a candidate allorecognition receptor from a primitive chordate. Immunity 25, 163-173

Passegueacute;, E. (2006). A game of subversion. Nature 442, 754-755

Forsberg, E.C., Serwold, T.C., Kogan, S., Weissman, I.L., and Passegueacute;, E. (2006). New evidence supporting megakaryocyte-erythrocyte potential of Flk2/Flt3+ multipotent hematopoietic progenitors. Cell 26, 415-426

Steidl,U., Rosenbauer, F., Verhaak, R., Gu, X., Otu, H.U., Bruns, I., Steidl, C., Costa, D.B., Klippel, S., Wagner, K., Aivado, M., Kobbe, G., Passegueacute;, E., Libermann, T.A., Delwel, R., and Tenen, D.G. (2006). Essential role of Jun family transcription factors in PU.1-induced leukemic stem cells. Nat. Genetics 38, 1269-1277

Giuriato, S., Ryeom, S., Fan, A.C., Bachireddy, P., Lynch, R.C., Rioth, M.J., Riggelen, J.V., Kopelman, A., Passegueacute;, E., Tang, F., Folkman, J., and Felsher, D.W. (2006). Sustained regression of tumors upon MYC inactivation requires p53 or TSP-1 to reverse the angiogenic switch. Proc. Nat. Acad. Sci. USA 103, 16266-16271

Van Meter, M.E., Diaz-Flores, E., Archard, J.A., Passegueacute;, E., Irish, J.M., Kotecha, N., Nolan, G.P., Shannon, K., and Braun, B.S. (2007). K-RasG12D expression induces hyperproliferation and aberrant signaling in primary hematopoietic stem/progenitor cells. Blood 109, 3945-3952

Tothova, Z., Kollipara, R., Huntly, B.J., Lee, B.H., Castrillon, D.H., Cullen, D.E, McDowell, E.P., Lazo-Kallanian, S., Williams, I.R., Sears, C., Armstrong, S.A., Passegueacute;, E., DePinho, R.A., and Gilliland, D.G. (2007). FoxOs Are Critical Mediators of Hematopoietic Stem Cell Resistance to Physiologic Oxidative Stress. Cell 128, 325-339.

Hu, Y-L., Passegueacute;, E., Fong, S., Largman, C., and Lawrence, H.J. (2007). Evidence that the Pim1 kinase gene is a direct target of HOXA9 and a mediator of HOXA9Õs effects on hematopoiesis. Blood 109, 4732-4738.

Rajasekhar, V.K., Dalerba, P., Passegueacute;, E., Lagasse, E., and Najbauer, J. (2007). Stem Cells, Cancer, and Context Dependence. Stem Cells 26, 292-298.

Du, R., Lu, K.V., Petritsch, C., Liu, P., Ganss, R., Passegueacute;, E., Song, H., VandenBerg, S., Werb, Z., and Bergers, G. (2008). HIF1a induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell 13, 206-220.

Min, I.M., Pietramaggiori, G., Kim, F.S., Passegueacute;, E., Stevenson, K.E., and Wagers, A.J. (2008). The transcription factor EGR1 controls both the proliferation and localization of hematopoietic stem cells. Cell Stem Cell 2, 380-391.

5/8/08