UCSF Helen Diller Family Comprehensive Cancer Center

Photo of Russell O. Pieper, PhD  Russell O. Pieper, PhD

Suzanne Marie Haderle and Robert Vincent Haderle Endowed Chair, UCSF
Professor, Department of Neurological Surgery, UCSF; and Co-Leader, Neurologic Oncology Program, UCSF Helen Diller Family Comprehensive Cancer Center

Contact

.(JavaScript must be enabled to view this email address)
(415) 502-7132 (voice)
(415) 502-6779 (fax)

Box 0875, UCSF; San Francisco, CA 94143-0875

Education

University of Wisconsin, Madison, WI, B.S., 1982, Pharmacy
George Washington Univ., Washington, D.C., Ph.D., 1987, Pharmacology

Professional Experience

  • 1987-1990
    Research Associate, Section of Hematology/Oncology, Dept. of Medicine, Loyola Univ. Med. Center, Maywood, IL
  • 1990-1991
    Research Assistant Professor, Dept. of Medicine, Loyola University Med. Center
  • 1991-1996
    Assistant Professor of Medicine and Pharmacology, Loyola University Med. Center
  • 1996-1998
    Associate Professor of Medicine and Pharmacology, Loyola University Med. Center
  • 1998-2004
    Associate Professor, Brain Tumor Research Center and the Dept. of Neurological Surgery, University of California, San Francisco, CA
  • 2003-present
    Vice-Chairman, Dept. of Neurological Surgery, UCSF
  • 2004-present
    Professor, Brain Tumor Research Center and the Dept. of Neurological Surgery, University of California, San Francisco, CA

Honors & Awards

  • 2000-present
    Suzanne Marie Haderle and Robert Vincent Haderle Endowed Chair in Molecular Neuro-Oncology

Selected Publications

  • (15 out of 66, in Chronological Order)
  • Costello, J.F., Futscher, B.W., Kroes, R.A., Pieper, R.O. Methylation-related chromatin structure is associated with exclusion of the O-6-methylguanine DNA methyltransferase (MGMT) gene in human glioma cell lines. Molecular and Cellular Biology 14:6516-6521, 1994. PMCID: PMC359181
  • Costello, J.F., Futscher, B.W., Tano, K., Graunke, D.M., Pieper, R.O. Graded methylation in the promoter and the body of the O-6-methylguanine DNA methyltransferase (MGMT) gene correlates with MGMT expression in human glioma cells. J. Biol. Chem. 269: 17228-17237, 1994. PMID: 8006031
  • Patel, S.A., Graunke, D.M., Pieper, R.O. Aberrant Silencing of the CpG island-cotaining human MGMT gene is associated with the loss of nucleosome-like positioning. Mol. Cell. Biol. 17: 5813-5822, 1997. PMCID: PMC232429
  • Sonoda, Y., Ozawa, T., Hirose, Y., Aldape, K.D., McMahon, M., Berger, M.S., and Pieper, R.O. Formation of intracranial tumors by genetically modified human astrocytes defines four pathways critical in the development of human anaplastic astrocytoma. Cancer Res. 61: 4956-60, 2001. PMID: 11431323
  • Hirose, Y., Berger, M.S., and Pieper, R.O. Abrogation of the Chk1-mediated G2 checkpoint pathway potentiates temozolomide-induced toxicity in a p53-independent manner in human glioblastoma cells. Cancer Res. 61: 5843-5849, 2001. PMID: 11479224
  • Sonoda, Y., Ozawa, T., Aldape, K.D., Den, D.F., Berger, M.S., and Pieper, R.O. Akt pathway activation converts anaplastic astrocytoma to glioblastoma multiforme in a human astrocyte model of glioma. Cancer Res. 61:6674-6678, 2001. PMID: 11559533
  • Hirose, Y., Katayama, M., Stokoe, D., Haas-Kogan, D.A., Berger, M.S., and Pieper, R.O. The p38 mitogen-activated protein kinase pathway links the DNA mismatch repair system to the G2 checkpoint and to resistance to chemotherapeutic DNA-methylating agents. Mol. Cell. Biol. 23:8306-8315, 2003. PMCID: PMC262371
  • Panner, A., Berger, M.S., and Pieper, R.O. mTOR controls FLIPs translation and TRAIL sensitivity in glioblastoma multiforme cells. Mol. Cell. Biol. 25, 8809-8823, 2005. PMID: 16199861
  • Lee, J.C., Huang, J.H.Y., Beroukhim, R., Feng, W.L., DeBiasi, R.M., King, J.C., Nghiemphu, P., Yuza, Y., Xu, Q., Greulich, H., Thomas, R.K., Paez, J.G., Peck, T.C., Linhart, D.J., Glatt, K.A., Getz, G., Onofrio, R., Ziaugra, L., Levine, R.L., Gabriel, S., Kawaguchi, T., Liau, L.M., Nelson, S., Mischel, P., Pieper, R.O., Cloughesy, T., Leahy, D.J., Sellers, W.R., Sawyers, C.L., Meyerson, M., and Mellinghoff, I.K. EGFR activation in glioblastoma through novel missense mutations in the extracellular domain. PLoS Medicine 3(12): e485, 2006. PMID: 17177598
  • Katayama, M., Kawaguchi, T., Berger, M.S., and Pieper, R.O. DNA damaging agent-induced autophagy produces a cytoprotective adenosine triphosphate surge in malignant glioma cells. Cell Death and Differentiation 14:548-58, 2007. PMID: 16946731
  • Parsa A.T., Waldron J.S., Panner A., Parney I.F., Stokoe D., Tihan T., Jensen M.C., Mischel P.S., Cachola K., Murray J.C., Sison C.E., and Pieper R.O. A novel link between PTEN loss and cancer immunoresistance. Nat. Med. 13(1):84-88, 2007. PMID: 17159987
  • Nakamura, JL, Garcia, E, and Pieper, RO. S6K1 plays a key role in glial transformation. Cancer Res. 68:6516-23, 2008. PMCID: PMC2538583
  • Crane CA, Panner A, Murray JC, Wilson SP, Xu H, Chen L, Simko JP, Waldman FM, Pieper RO, Parsa AT. PI3Kinase is associated with a mechanism of immunoresistance in breast and prostate cancer. Oncogene. 28(2):306-12, 2009. PMID: 18850006
  • Panner, A., Crane, C.A., Weng, C., Feletti, A., Parsa, A.T., and Pieper, R.O. A novel PTEN-dependent link to ubiquitination controls FLIPs stability and TRAIL sensitivity in glioblastoma multiforme. Cancer Res. 69: 6843-48, 2009. PMID: 19808964
  • Panner, A., Crane, C.A., Weng, C., Feletti, A., Fang, S., Parsa, A.T., Pieper, R.O. Ubiquitin-specific protease 8 links the PTEN-Akt-AIP4 pathway to the control of FLIPS stability and TRAIL sensitivity in glioblastoma multiforme. Cancer Res. 70(12):5046-53, 2010. PMID: 20484045

Updated: July 29, 2011