Suzanne Marie Haderle and Robert Vincent Haderle Endowed Chair, UCSF
Research Programs Leader, Neurologic Oncology Program, UCSF Helen Diller Family Comprehensive Cancer Center,
| CONTACT | |
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rpieper@cc.ucsf.edu Box 0875, UCSF; San Francisco, CA 94143-0875 |
| EDUCATION | |
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University of Wisconsin, Madison, WI, B.S., 1982, Pharmacy
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| PROFESSIONAL EXPERIENCE | |
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1987-1990 |
Research Associate, Section of Hematology/Oncology, Dept. of Medicine, Loyola Univ. Med. Center, Maywood, IL |
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1990-1991 |
Research Assistant Professor, Dept. of Medicine, Loyola University Med. Center |
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1991-1996 |
Assistant Professor of Medicine and Pharmacology, Loyola University Med. Center |
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1996-1998 |
Associate Professor of Medicine and Pharmacology, Loyola University Med. Center |
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1998-2004 |
Associate Professor, Brain Tumor Research Center and the Dept. of Neurological Surgery, University of California, San Francisco, CA |
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2003-Present |
Vice-Chairman, Dept. of Neurological Surgery, UCSF |
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2004-Present |
Professor, Brain Tumor Research Center and the Dept. of Neurological Surgery, University of California, San Francisco, CA |
| HONORS & AWARDS | |
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2000-Present |
Suzanne Marie Haderle and Robert Vincent Haderle Endowed Chair in Molecular Neuro-Oncology |
| SELECTED PUBLICATIONS | |
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Futscher, B.W., Pieper, R.O., Dalton. W.S., Erikson, L.C. Gene-specific DNA interstrand crosslinks produced by nitrogen mustard in the human tumor cell line COLO 320HSR. Cell Growth and Differ. 3:217-223, 1992. | |
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Morgan, S.E., Kelley, M.R., Pieper, R.O. The role of the carboxyl-terminal tail in human O-6-methylguanine-DNA methyltransferase substrate specificity and temperature sensitivity. J. Biol. Chem. 268:19809-19809, 1993. | |
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Pieper, R.O., Morgan, S.E., Kelley, M.R. The role of two conserved amino acids, glutamine 90 and asparagines 137, in O-6-mehtylguanine-DNA methyltransferase stability, activity, and substrate specificity. Carcinogenesis 15:1895-1902, 1994. | |
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Costello, J.F., Futscher, B.W., Kroes, R.A., Pieper, R.O. Methylation-related chromatin structure is associated with exclusion of the O-6-methylguanine DNA methyltransferase (MGMT) gene in human glioma cell lines. Molecular and Cellular Biology 14:6516-6521, 1994. | |
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Costello, J.F., Futscher, B.W., Tano, K., Graunke, D.M., Pieper, R.O. Graded methylation in the promoter and the body of the O-6-methylguanine DNA methyltransferase (MGMT) gene correlates with MGMT expression in human glioma cells. J. Biol. Chem. 269: 17228-17237, 1994. | |
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Pieper, R.O., Noftz, S.L., Erickson, L.C. In vitro transcription termination by N,NÕ-Bis(2-chloroethyl)-N-nitrosourea-induced DNA lesions. Molecular Pharmacology 47: 290-295, 1995. | |
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Pieper, R.O., Patel S.A., Ting, S.A., Futscher, B.W., Costello, J.F. Methylation of CpG island transcription factor building sites is unnecessary for aberrant silencing of the human MGMT gene. J. Biol. Chem. 271: 13916-13924, 1996. | |
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Watts, G.S., Pieper, R.O., Costello, J.F., Peng, Y.M., Dalton, W.S., Futscher, B.W. Methylation of discrete regions of the MGMT CpG island is associated with heterochromatinization of the MGMT transcription start site and silencing of the gene. Mol. Cell. Biol. 17: 5612-5619, 1997. | |
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Patel, S.A., Graunke, D.M., Pieper, R.O. Aberrant Silencing of the CpG island-cotaining human MGMT gene is associated with the loss of nucleosome-like positioning. Mol. Cell. Biol. 17: 5813-5822, 1997. | |
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Pieper, R.O. ÒUnderstanding and manipulating O-6 methylguanine DNA methyltransferase expression.Ó Pharmacology and Therapeutics 74: 285-297, 1997. (Invited Review) | |
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Pieper, R.O. ÒCellular Responses to Methylation DamageÓ In: DNA Damage and Repair: Biochemistry, Genetics, and Cell Biology. Jac Nickoloff and Merl Hoekstra, Eds. Humana Press, pp. 33-51, 1998. | |
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Graunke, D.M., Fornace, A.J., Jr., and Pieper, R.O. Presetting of chromatin structure and transcription factor binding poise the human gadd 45 gene for transcriptional upregulation Nuc. Acids Res. 27 (19): 3881-3890, 1999. | |
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Pieper, R.O., Lester, K.A., and Fanton, C.P. Confluence Ð induced alterations in CpG island methylation in cultured normal human fibroblasts. Nuc. Acids Res. 27 (15): 3229-3235, 1999. | |
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Chang, G.H.-F., Barbaro, N.M., and Pieper, R.O. Phosphatidylserine-dependent phagocytosis of apoptotic glioma cells by normal human microglia, astrocytes, and glioma cells. Neuro-Oncology 2:174-183, 2000. | |
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Hirose, Y., Berger, M.S., and Pieper, R.O. p53 Effects both the duration of G2/M arrest and the fate of temozolomide-treated human glioblastoma cells. Cancer Res. 61:1957-1963, 2001. | |
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Sonoda, Y., Ozawa, T., Hirose, Y., Aldape, K.D., McMahon, M., Berger, M.S., and Pieper, R.O. Formation of intracranial tumors by genetically modified human astrocytes defines four pathways critical in the development of human anaplastic astrocytoma. Cancer Res. 61: 4956-60, 2001. | |
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Fanton, C.P., McMahon, M., and Pieper, R.O. Dual growth arrest pathways in astrocytes and astrocytic tumors in response to raf-1 activation. J. Biol. Chem. 276: 19746-19753, 2001. | |
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Hirose, Y., Berger, M.S., and Pieper, R.O. Abrogation of the Chk1-mediated G2 checkpoint pathway potentiates temozolomide-induced toxicity in a p53-independent manner in human glioblastoma cells. Cancer Res. 61: 5843-5849, 2001. | |
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Sonoda, Y., Ozawa, T., Aldape, K.D., Den, D.F., Berger, M.S., and Pieper, R.O. Akt pathway activation converts anaplastic astrocytoma to glioblastoma multiforme in a human astrocyte model of glioma. Cancer Res. 61:6674-6678, 2001. | |
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Pieper, R.O. Defined human cellular systems in the study of glioma development. Front. Biosci. 8: S19-27, 2002. | |
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Hirose, Y., Kreklau, E.L., Erickson, L.C., Berger, M.S., and Pieper, R.O. Delayed repletion of O6-methylguanine-DNA methyltransferase resulting in failure to protect the human glioblastoma cell line SF767 from temozolomide-induced cytotoxicity. J. Neurosurg. 98: 591-598, 2003. | |
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Hirose, Y., Katayama, M., Stokoe, D., Haas-Kogan, D.A., Berger, M.S., and Pieper, R.O. The p38 mitogen-activated protein kinase pathway links the DNA mismatch repair system to the G2 checkpoint and to resistance to chemotherapeutic DNA-methylating agents. Mol. Cell. Biol. 23:8306-8315, 2003. | |
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Sonoda, Y., Kanamori, M., Deen, D.F., Cheng, S.-Y., Berger, M.S., and Pieper, R.O. Over-expression of VEGF isoforms drives oxygenation and growth, but not progression to glioblastoma multiforme in a human model of gliomagenesis. Cancer Res. 63: 1962-1968, 2003 | |
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Hirose Y., Katayama, M., Berger, M.S., and Pieper R.O. The Chk and p38 pathways function cooperatively in activating G2 arrest following exposure to temozolomide. J. Neurosurg 100: 1060-1065, 2004. | |
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Kanamori, M., Vanden Berg, S.R., Bergers, G., Berger, M.S., and Pieper, R.O. Integrin β3 Overexpression Suppresses Tumor Growth in a Human Model of Gliomagenesis: Implications for the Role of β3 Overexpression in Glioblastoma Multiforme. Cancer Res. 64: 2751-2758, 2004. | |
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Saito R, Bringas JR, Panner A, Tamas M, Pieper RO, Berger MS, Bankiewicz. Convection-enhanced delivery of tumor necrosis factor-related apoptosis-inducing ligand with systemic administration of temozolomide prolongs survival in an intracranial glioblastoma xenograft model. Cancer Res.64:6858-6862, 2004. | |
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Rong Y, Post DE, Pieper RO, Durden DL, Van Meir EG, Brat DJ. PTEN and hypoxia regulate tissue factor expression and plasma coagulation by glioblastoma. Cancer Res. 65(4):1406-1413, 2005. | |
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Nakamura JL, Karlsson A, Arvold ND, Gottschalk AR, Pieper RO, Stokoe D, Haas-Kogan DA. PKB/Akt mediates radiosensitization by the signaling inhibitor LY294002 in human malignant gliomas. J Neurooncol. 71(3):215-222, 2005. | |
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Hirose, Y., Katayama, M., Mirzoeva, O.K., Berger, M.S., and Pieper, R.O. Akt activation suppresses Chk2-mediated, methylating agent-induced G2 arrest and protects from temozolomide -induced mitotic catastrophe and cellular senescence. Cancer Res. 65(11): 4587-4596, 2005. | |
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Panner, A., Berger, M.S., and Pieper, R.O. (2005) mTOR controls FLIPs translation and TRAIL sensitivity in glioblastoma multiforme cells. Mol. Cell. Biol. 25, 8809-8823. | |
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Panner, A, Parsa, AT, Pieper, RO. Translational regulation of TRAIL sensitivity. Cell Cycle 5:147-50, 2006. |
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12/7/06 |
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