Russell O. Pieper, PhD

University of Wisconsin, Madison, WI, B.S., 1982, Pharmacy
George Washington Univ., Washington, D.C., Ph.D., 1987, Pharmacology

• 1987-1990
  Research Associate, Section of Hematology/Oncology, Dept. of Medicine, Loyola Univ. Med. Center, Maywood, IL
• 1990-1991
  Research Assistant Professor, Dept. of Medicine, Loyola University Med. Center
• 1991-1996
  Assistant Professor of Medicine and Pharmacology, Loyola University Med. Center
• 1996-1998
  Associate Professor of Medicine and Pharmacology, Loyola University Med. Center
• 1998-2004
  Associate Professor, Brain Tumor Research Center and the Dept. of Neurological Surgery, University of California, San Francisco, CA
• 2003-present
  Vice-Chairman, Dept. of Neurological Surgery, UCSF
• 2004-present
  Professor, Brain Tumor Research Center and the Dept. of Neurological Surgery, University of California, San Francisco, CA

• 2000-present
  Suzanne Marie Haderle and Robert Vincent Haderle Endowed Chair in Molecular Neuro-Oncology

• (15 out of 66, in Chronological Order)
• Costello, J.F., Futscher, B.W., Kroes, R.A., Pieper, R.O. Methylation-related chromatin structure is associated with exclusion of the O-6-methylguanine DNA methyltransferase (MGMT) gene in human glioma cell lines. Molecular and Cellular Biology 14:6516-6521, 1994. PMCID: PMC359181
• Costello, J.F., Futscher, B.W., Tano, K., Graunke, D.M., Pieper, R.O. Graded methylation in the promoter and the body of the O-6-methylguanine DNA methyltransferase (MGMT) gene correlates with MGMT expression in human glioma cells. J. Biol. Chem. 269: 17228-17237, 1994. PMID: 8006031
• Patel, S.A., Graunke, D.M., Pieper, R.O. Aberrant Silencing of the CpG island-cotaining human MGMT gene is associated with the loss of nucleosome-like positioning. Mol. Cell. Biol. 17: 5813-5822, 1997. PMCID: PMC232429
• Sonoda, Y., Ozawa, T., Hirose, Y., Aldape, K.D., McMahon, M., Berger, M.S., and Pieper, R.O. Formation of intracranial tumors by genetically modified human astrocytes defines four pathways critical in the development of human anaplastic astrocytoma. Cancer Res. 61: 4956-60, 2001. PMID: 11431323
• Hirose, Y., Berger, M.S., and Pieper, R.O. Abrogation of the Chk1-mediated G2 checkpoint pathway potentiates temozolomide-induced toxicity in a p53-independent manner in human glioblastoma cells. Cancer Res. 61: 5843-5849, 2001. PMID: 11479224
• Sonoda, Y., Ozawa, T., Aldape, K.D., Den, D.F., Berger, M.S., and Pieper, R.O. Akt pathway activation converts anaplastic astrocytoma to glioblastoma multiforme in a human astrocyte model of glioma. Cancer Res. 61:6674-6678, 2001. PMID: 11559533
• Hirose, Y., Katayama, M., Stokoe, D., Haas-Kogan, D.A., Berger, M.S., and Pieper, R.O. The p38 mitogen-activated protein kinase pathway links the DNA mismatch repair system to the G2 checkpoint and to resistance to chemotherapeutic DNA-methylating agents. Mol. Cell. Biol. 23:8306-8315, 2003. PMCID: PMC262371
• Panner, A., Berger, M.S., and Pieper, R.O. mTOR controls FLIPs translation and TRAIL sensitivity in glioblastoma multiforme cells. Mol. Cell. Biol. 25, 8809-8823, 2005. PMID: 16199861
• Lee, J.C., Huang, J.H.Y., Beroukhim, R., Feng, W.L., DeBiasi, R.M., King, J.C., Nghiemphu, P., Yuza, Y., Xu, Q., Greulich, H., Thomas, R.K., Paez, J.G., Peck, T.C., Linhart, D.J., Glatt, K.A., Getz, G., Onofrio, R., Ziaugra, L., Levine, R.L., Gabriel, S., Kawaguchi, T., Liau, L.M., Nelson, S., Mischel, P., Pieper, R.O., Cloughesy, T., Leahy, D.J., Sellers, W.R., Sawyers, C.L., Meyerson, M., and Mellinghoff, I.K. EGFR activation in glioblastoma through novel missense mutations in the extracellular domain. PLoS Medicine 3(12): e485, 2006. PMID: 17177598
• Katayama, M., Kawaguchi, T., Berger, M.S., and Pieper, R.O. DNA damaging agent-induced autophagy produces a cytoprotective adenosine triphosphate surge in malignant glioma cells. Cell Death and Differentiation 14:548-58, 2007. PMID: 16946731
• Parsa A.T., Waldron J.S., Panner A., Parney I.F., Stokoe D., Tihan T., Jensen M.C., Mischel P.S., Cachola K., Murray J.C., Sison C.E., and Pieper R.O. A novel link between PTEN loss and cancer immunoresistance. Nat. Med. 13(1):84-88, 2007. PMID: 17159987
• Nakamura, JL, Garcia, E, and Pieper, RO. S6K1 plays a key role in glial transformation. Cancer Res. 68:6516-23, 2008. PMCID: PMC2538583
• Crane CA, Panner A, Murray JC, Wilson SP, Xu H, Chen L, Simko JP, Waldman FM, Pieper RO, Parsa AT. PI3Kinase is associated with a mechanism of immunoresistance in breast and prostate cancer. Oncogene. 28(2):306-12, 2009. PMID: 18850006
• Panner, A., Crane, C.A., Weng, C., Feletti, A., Parsa, A.T., and Pieper, R.O. A novel PTEN-dependent link to ubiquitination controls FLIPs stability and TRAIL sensitivity in glioblastoma multiforme. Cancer Res. 69: 6843-48, 2009. PMID: 19808964
• Panner, A., Crane, C.A., Weng, C., Feletti, A., Fang, S., Parsa, A.T., Pieper, R.O. Ubiquitin-specific protease 8 links the PTEN-Akt-AIP4 pathway to the control of FLIPS stability and TRAIL sensitivity in glioblastoma multiforme. Cancer Res. 70(12):5046-53, 2010. PMID: 20484045