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Helen Diller Family Compr Cancer Ctr
MICHAEL D. PRADOS, MD

Charles B. Wilson, MD, Endowed Chair in Neurological Surgery, UCSF
Chief, Neuro-Oncology Service, UCSF
Co-Leader, Neurologic Oncology Program, UCSF Helen Diller Family Comprehensive Cancer Center

CONTACT

(415) 353-2966 (appts)
(415) 353-2167 (fax)

Box 0372, UCSF; San Francisco, CA 94143-0372

additional websites:

UCSF Physician Referral Directory
Faculty Profile

EDUCATION

Mississippi State University, Starkville, 1966-1969, Biology
University of New Orleans, BS, 1969-1970, Biology
LSU School of Medicine, MD, 1970-1974, Medicine
LSU Charity Hospital, New Orleans, LA, Internship, 1974-1975, Medicine
LSU Earl K Long Hospital, Baton Rouge, LA, Residency, 1975-1977, Internal Medicine

PROFESSIONAL EXPERIENCE

1977 - 1978

Instructor, Department of Internal Medicine, LSU School of Medicine, New Orleans, LA

1979 - 1982

Assistant Professor, Department of Medicine, LSU School of Medicine, Earl K Long Hospital, Baton Rouge, LA

1980 - 1982

Clinical Director, Medical Oncology, Dept. of Medicine, LSU School of Medicine, Earl K Long Hospital, Baton Rouge, LA

1984 - 1985

Asst. Clinical Director, Dept. of Pulmonary Medicine, Touro Infirmary, New Orleans, LA

1985 - 1987

Clinical Instructor, Neuro-Oncology Service, Brain Tumor Research Center & Dept. of Neurological Surgery, University of California, San Francisco, CA

1987 (2 months)

Medical Director, US AID Child Survival Project, Tokar, The Sudan, Africa

1988 - 1991

Asst. Clinical Prof., Neuro-Oncology Service, Brain Tumor Research Center & Dept. of Neurological Surgery, School of Medicine, University of California, San Francisco, CA

1991 - 1995

Assoc. Clinical Professor, Chief, Neuro-Oncology Service, Brain Tumor Research Center & Dept. of Neurological Surgery, School of Medicine, University of California, San Francisco, CA

1995 - present

Professor, Chief, Neuro-Oncology Service, Brain Tumor Research Center & Dept. of Neurological Surgery, School of Medicine, University of California, San Francisco, CA

SELECTED PUBLICATIONS

Chang SM, Lamborn KR, Nicholas MK, Larson D, Wara W, Sneed P, Malec M, Rabbitt J, Page M, Prados MD: Phase II study of temozolomide and thalidomide with radiation therapy for glioblastoma multiforme. Int J Radiat Oncol Biol Phys 60: 353-357, 2004

Puduvalli VK, Yung WKA, Hess KR, Kuhn JC, Groves MD, Levin VA, Zweibel J, Chang SM, Cloughesy TF, Junck L, Wen P, Lieberman F, Conrad CA, Gilbert MR, Meyers CA, Liu V, Minesh MP, Nicholas MK, and Prados M: Phase II study of Fenretinide in Adults with recurrent malignant glioma: A North American Brain Tumor Consortium Study. J Clin Oncol 22: 4282-4289, 2004

Cha S, Tihan T, Crawford F, Fischbein NJ, Chang S, Bollen A, Nelson SJ, Prados M, Berger MS, Dillon WP: Differentiation of low-grade oligodendrogliomas from low-grade astrocytomas by using quantitative blood-volume measurements derived from dynamic susceptibility contrast enhanced MR imaging. AJNR 26 (2): 266-273, 2005

Butowski N, Prados MD, Lamborn KR, Larson DA, Sneed PK, Wara WM, Malec M, Rabbitt J, Page, M, Chang SM: A Phase-2 study of concurrent temozolomide and cis-retinoic acid with radiation for adult patients with newly diagnosed supratentorial glioblastoma. Int. J Radiat Oncol Biol Phys 61 (5): 1454-1459, 2005

Chang SM, Wen PW, Cloughesy T, Greenberg H, Schiff D, Conrad C, Fink K, Robins IH, De Angelis L, Razier J, Hess K, Aldape K, Lamborn KR, Kuhn J, Dancey J, Prados MD: Phase II study of CCI-779 in patients with recurrent glioblastoma multiforme. Investigational New Drugs 23(44): 357-361, 2005

Blaney SM, Boyett J, Friedman H, Gajjar A, Geyer R, Horowtiz M, Hur D, Kieran M, Kun L, Packer R, Phillips P, Pollack IF, Prados M, Heideman R: Phase I clinical trial of mafosfamide in infants and children aged 3 years or younger with newly diagnosed embryonal tumors: A Pediatric Brain Tumor Consortium Study (PBTC-001). J Clin Oncol 23 (3): 525-531, 2005

Parsa AT, Wachhorst S, Lamborn KR, Prados MD, McDermott MW, Berger MS, Chang SM: Prognostic significance of intracranial dissemination of glioblastoma multiforme in adults. J Neurosurg 102: 622-628, 2005

Parney IF, Kunwar S, McDermott M, Berger M, Prados M, Cha S, Croteau D, Puri RK, Chang SM: Neuroradiographic changes following convection-enhanced delivery of the recombinant cytotoxin interleukin 13-PE38QQR for recurrent malignant glioma. J Neurosurg 102 (2): 267-275, 2005

Macdonald DR, Kiebert G, Prados M, Yung A, Olson J: Benefit of temozolomide compared to procarbazine in treatment of glioblastoma multiforme at first relapse: effect on neurological functioning, performance status, and health related quality of life. Clinical Invest 23 (2): 138-144, 2005

Gomez DR, Missett BT, Wara WM, Lamborn KR, Prados MD, Chang S, Berger MS, Haas-Kogan DA: High failure rate in spinal ependymomas with long-term follow-up. Neuro-Oncology 7 (3): 254-259, 2005

Cloushesy TF, Kuhn J, Robins IH, Abrey L, Wen P, Fink K, Lieberman FS, Mehta M, Chang S, Yung A, DeAngelis L, Schiff D, Junck L, Groves M, Paquette S, Wright J, Lamborn K, Sebti S, Prados M: A Phase I trial of tipifarnib with recurrent malignant glioma taking enzyme-inducing antieleptic drugs: A North American Brain Tumor Consortium Study. J Clin Oncol 23 (27): 6647-6656, 2005

Haas-Kogan DA, Prados MD, Tihan R, Eberhard DA, Jelluma N, Arvold ND, Baumber R, Lamborn KR, Kapadia A, Malec M, Berger MS, Stokoe D: Epidermal growth factor receptor, protein kinase B/Akt, and glioma response to erlotinib. J of Natl Cancer Institute 97 (12): 880-887, 2005

Mellinghoff IK, Wang Y, Haas-Kogan DA, Zhu S, Dia EQ, Lu KV, Yoshimoto K, Huang JH, Chute DJ, Riggs BL, Horvath S, Liau L, Cavenee WK, Rao PN, Beroukhim R, Lee JC, Sellers WR, Stokoe D, Prados M, Cloughesy TF, Sawyers CL, Mischel PS: Molecular determinants of EGFR kinase inhibitor response in glioblastoma. NEJM 353: 2012-2024, 2005

Lassman AB, Rossi MR, Razier JR, Abrey LE, Grefe CN, Lamborn KL, Pao W, Shih AH, Wilson R, Nowak NJ, Cowell JK, DeAngelis LM, Wen P, Gilbert MR, Chang S, Yung WKA, Prados M, Holland EC: Molecular study of malignant gliomas treated with the EGFR inhibitors: tissue analysis from North American Brain Tumor Consortium (NABTC) trials 01-03 and 00-01. Clin Cancer Res 11 (21): 7841-7850, 2005

Haas-Kogan DA, Prados MD, Lamborn KR, Tihan T, Berger MS and Stokoe D: Biomarkers to predict response to Epidermal Growth Factor Receptor inhibitors. Cell Cycle 4 (10): 1369-1372, 2005

Brem SS, Bierman PJ, Black P, Blumenthal DT, Brem H, Chamberlain MC, Chiocca EA, Deangelis LM, Fenstermaker RA, Fine HA, Friedman A, Glass J, Grossman SA, Heimberger AB, Junck L, Levin VA, Loeffler JJ, Maor MM, Narayana A, Newton HB, Olivi A, Portnow J, Prados M, Rraizer JJ, Rosenfeld SS, Shrieve DC, Sills AK, Spence AM, Vrionis FD: Central nervous system cancers. J Natl Compr Canc Netw. 3 (5): 644-690, 2005

Wrensch M, Rice T, Miike R, McMillan A, Lamborn KR, Aldape K, Prados MD: Diagnostic, treatment and demographic factors influencing survival in a Population-Based Adult Glioma patients in the San Francisco Bay area. Neuro-Oncology (in-press)

Laprie A, Pirzkall A, Cha S, Haas-Kogan DA, Banerjee A, Barkovich AJ, Prados M, Le T, Crawford F, Lu Y, Nelson SJ, McKnight T. Longitudinal multivoxel MR Spectroscopy study of pediatric disuse brainstem gliomas treated by radiotherapy. Int J Radiat Oncol Biol Phys (in-press)

Prados MD, Lamborn KR, Chang S, Burton E, Butowski N, Malec M, Kapadia A, Rabbitt J, Page M, Fedoroff: Phase I study of erlotinib HCL alone and in combination with temozolomide in patients with stable or recurrent malignant glioma. Neuro-Oncology (in-press)

Mishra KK, Puri DR, Missett BT, Lamborn KR, Prados MD, Berger MS, Banerjee A, Gupta N, Wara WM, Haas-Kogan DA: The role of upfront radiation therapy for incompletely resected pediatric WHO grade II low-grade glioma. Neuro-Oncology (in-press)

Prados MD, Lamborn K, Yung WKA, Jaeckle K, Robins IH, Mehta M, Fine H, Wen PY, Cloughesy T, Chang SM, Nicholas MK, Schiff D, Greenberg H, Junck L, Fink K, Kuhn J: A phase-2 study of irinotecan (CPT-11) in patients with recurrent malignant glioma: A North American Brain Tumor Consortium Study. Neuro-Oncology 8: 189-193, 2006

12/7/06

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