Joseph L. Wiemels, PhD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Joseph L. Wiemels, PhD

Associate Professor, Department of Epidemiology and Biostatistics, UCSF

joe.wiemels@ucsf.edu

Phone: (415) 514-0577 (voice)
Box 0520, 1450 3rd Street
San Francisco, CA 94158

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Cancer Center Membership

Program Member » Neurologic Oncology» Pediatric Malignancies

Research Summary

I am a trained molecular epidemiologist with a strong focus on immunologic and genetic approaches at understanding disease etiology, particularly in childhood immune development and leukemia. I currently hold a primary appointment in the Department of Epidemiology and Biostatistics, with a secondary appointment in Neurological Surgery, and am the co-President of the Brain Tumor Epidemiology Consortium. This combination of expertise makes me well suited to serve as a HDFCCC Member in the Programs of Pediatric Malignancies and Neurological Oncology. I have worked on cancer etiology for more than 18 years for both hematologic cancers and brain cancers. Discovering the etiology and preventive modalities for cancer, particularly brain and hematologic ones in both children and adults, is my life’s work.

Education

Kenyon College, BA, 1988, Biology
University of California Berkeley, PhD, 1997, Environmental Health Science/Toxicology


Professional Experience

  • 1988-90
    Science Teacher, St. Johns College, Levuka, Fiji
  • 1992-97
    Graduate Student Researcher, University of California Berkeley
  • 1997-99
    Postdoctoral Fellow, Leukaemia Research Fund Centre, Institute of Cancer Research, London
  • 1999-2000
    Assistant Research Molecular Epidemiologist, University of California San Francisco
  • 2001-2002
    Assistant Adjunct Professor, University of California San Francisco
  • 2002-2006
    Assistant Professor in Residence, University of California San Francisco
  • 2006-present
    Associate Professor, University of California San Francisco

Honors & Awards

  • 1986
    Maxwell Elliot Power Prize, Kenyon College
  • 1988
    Phi Beta Kappa, Kenyon College
  • 1993
    Public Health Alumni Scholarship, University of California Berkeley
  • 1993
    National Science Foundation Predoctoral Fellowship in Toxicology awarded
  • 1993-97
    Postdoctoral Fellow, Howard Hughes Medical Institute, University of California Berkeley
  • 2002
    Scholar, Leukemia and Lymphoma Society of America

Selected Publications

  1. Gonseth S, de Smith AJ, Roy R, Zhou M, Lee ST, Shao X, Ohja J, Wrensch MR, Walsh KM, Metayer C, Wiemels JL. Genetic contribution to variation in DNA methylation at maternal smoking sensitive loci in exposed neonates. Epigenetics. 2016 Jul 12; 0.
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  2. Sapru A, Liu KD, Wiemels J, Hansen H, Pawlikowska L, Poon A, Jorgenson E, Witte JS, Calfee CS, Ware LB, Matthay MA. Association of common genetic variation in the protein C pathway genes with clinical outcomes in acute respiratory distress syndrome. Crit Care. 2016; 20(1):151.
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  3. Ojha J, Codd V, Nelson CP, Samani NJ, Smirnov IV, Madsen NR, Hansen HM, de Smith AJ, Bracci PM, Wiencke JK, Wrensch MR, Wiemels JL, Walsh KM. Genetic Variation Associated with Longer Telomere Length Increases Risk of Chronic Lymphocytic Leukemia. Cancer Epidemiol Biomarkers Prev. 2016 Jul; 25(7):1043-9.
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  4. Walsh KM, Whitehead TP, de Smith AJ, Smirnov IV, Park M, Endicott AA, Francis SS, Codd V. Common genetic variants associated with telomere length confer risk for neuroblastoma and other childhood cancers. Carcinogenesis. 2016 Jun; 37(6):576-82.
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  5. Hsu LI, Briggs F, Shao X, Metayer C, Wiemels JL, Chokkalingam AP, Barcellos LF. Pathway Analysis of Genome-wide Association Study in Childhood Leukemia among Hispanics. Cancer Epidemiol Biomarkers Prev. 2016 May; 25(5):815-22.
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  6. Wiemels J, Ma X. Stressful exit from the womb and risk of childhood leukaemia. Lancet Haematol. 2016 Apr; 3(4):e155-6.
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  7. Jiang N, Wiemels RE, Soya A, Whitley R, Held M, Faik A. Composition, Assembly, and Trafficking of a Wheat Xylan Synthase Complex. Plant Physiol. 2016 Apr; 170(4):1999-2023.
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  8. Carroll RK, Weiss A, Broach WH, Wiemels RE, Mogen AB, Rice KC, Shaw LN. Genome-wide Annotation, Identification, and Global Transcriptomic Analysis of Regulatory or Small RNA Gene Expression in Staphylococcus aureus. MBio. 2016; 7(1):e01990-15.
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  9. Johnson KJ, Scheurer ME, Woehrer A, Wiemels J. Evolving evidence on tumor and germline genetic classification of gliomas: implications for etiology and survival studies. Clin Neuropathol. 2016 Jan-Feb; 35(1):31-8.
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  10. Wiemels J. New insights into childhood leukemia etiology. Eur J Epidemiol. 2015 Dec; 30(12):1225-7.
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  11. Walsh KM, Codd V, Rice T, Nelson CP, Smirnov IV, McCoy LS, Hansen HM, Elhauge E, Ojha J, Francis SS, Madsen NR, Bracci PM, Pico AR, Molinaro AM, Tihan T, Berger MS, Chang SM, Prados MD, Jenkins RB, Wiemels JL. Longer genotypically-estimated leukocyte telomere length is associated with increased adult glioma risk. Oncotarget. 2015 Dec 15; 6(40):42468-77.
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  12. Morimoto LM, McCauley K, Ma X, Wiemels JL, Chokkalingam AP, Metayer C. Birth weight, fetal growth, and risk of pediatric rhabdomyosarcoma: an updated record linkage study in California. Ann Epidemiol. 2016 Feb; 26(2):141-5.
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  13. Gonseth S, Roy R, Houseman EA, de Smith AJ, Zhou M, Lee ST, Nusslé S, Singer AW, Wrensch MR, Metayer C, Wiemels JL. Periconceptional folate consumption is associated with neonatal DNA methylation modifications in neural crest regulatory and cancer development genes. Epigenetics. 2015 Dec 2; 10(12):1166-76.
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  14. de Smith AJ, Walsh KM, Hansen HM, Endicott AA, Wiencke JK, Metayer C, Wiemels JL. Somatic Mutation Allelic Ratio Test Using ddPCR (SMART-ddPCR): An Accurate Method for Assessment of Preferential Allelic Imbalance in Tumor DNA. PLoS One. 2015; 10(11):e0143343.
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  15. Walsh KM, de Smith AJ, Hansen HM, Smirnov IV, Gonseth S, Endicott AA, Xiao J, Rice T, Fu CH, McCoy LS, Lachance DH, Eckel-Passow JE, Wiencke JK, Jenkins RB, Wrensch MR, Ma X, Metayer C, Wiemels JL. A Heritable Missense Polymorphism in CDKN2A Confers Strong Risk of Childhood Acute Lymphoblastic Leukemia and Is Preferentially Selected during Clonal Evolution. Cancer Res. 2015 Nov 15; 75(22):4884-94.
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  16. Lee ST, Wiemels JL. Genome-wide CpG island methylation and intergenic demethylation propensities vary among different tumor sites. Nucleic Acids Res. 2016 Feb 18; 44(3):1105-17.
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  17. Wiemels JL, de Smith AJ, Xiao J, Lee ST, Muench MO, Fomin ME, Zhou M, Hansen HM, Termuhlen A, Metayer C, Walsh KM. A functional polymorphism in the CEBPE gene promoter influences acute lymphoblastic leukemia risk through interaction with the hematopoietic transcription factor Ikaros. Leukemia. 2016 May; 30(5):1194-7.
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  18. Rice T, Lachance DH, Molinaro AM, Eckel-Passow JE, Walsh KM, Barnholtz-Sloan J, Ostrom QT, Francis SS, Wiemels J, Jenkins RB, Wiencke JK, Wrensch MR. Understanding inherited genetic risk of adult glioma - a review. Neurooncol Pract. 2016 Mar; 3(1):10-16.
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  19. Eckel-Passow JE, Lachance DH, Molinaro AM, Walsh KM, Decker PA, Sicotte H, Pekmezci M, Rice T, Kosel ML, Smirnov IV, Sarkar G, Caron AA, Kollmeyer TM, Praska CE, Chada AR, Halder C, Hansen HM, McCoy LS, Bracci PM, Marshall R, Zheng S, Reis GF, Pico AR, O'Neill BP, Buckner JC, Giannini C, Huse JT, Perry A, Tihan T, Berger MS, Chang SM, Prados MD, Wiemels J, Wiencke JK, Wrensch MR, Jenkins RB. Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors. N Engl J Med. 2015 Jun 25; 372(26):2499-508.
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  20. Kulis M, Merkel A, Heath S, Queirós AC, Schuyler RP, Castellano G, Beekman R, Raineri E, Esteve A, Clot G, Verdaguer-Dot N, Duran-Ferrer M, Russiñol N, Vilarrasa-Blasi R, Ecker S, Pancaldi V, Rico D, Agueda L, Blanc J, Richardson D, Clarke L, Datta A, Pascual M, Agirre X, Prosper F, Alignani D, Paiva B, Caron G, Fest T, Muench MO, Fomin ME, Lee ST, Wiemels JL, Valencia A, Gut M, Flicek P, Stunnenberg HG, Siebert R, Küppers R, Gut IG, Campo E, Martín-Subero JI. Whole-genome fingerprint of the DNA methylome during human B cell differentiation. Nat Genet. 2015 Jul; 47(7):746-56.
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