Joseph L. Wiemels, PhD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Joseph L. Wiemels, PhD

Associate Professor, Department of Epidemiology and Biostatistics, UCSF

joe.wiemels@ucsf.edu

Phone: (415) 514-0577 (voice)
Box 0520, 1450 3rd Street
San Francisco, CA 94158

UCSF Profiles

Cancer Center Membership

Program Member » Neurologic Oncology» Pediatric Malignancies

Research Summary

I am a trained molecular epidemiologist with a strong focus on immunologic and genetic approaches at understanding disease etiology, particularly in childhood immune development and leukemia. I currently hold a primary appointment in the Department of Epidemiology and Biostatistics, with a secondary appointment in Neurological Surgery, and am the co-President of the Brain Tumor Epidemiology Consortium. This combination of expertise makes me well suited to serve as a HDFCCC Member in the Programs of Pediatric Malignancies and Neurological Oncology. I have worked on cancer etiology for more than 18 years for both hematologic cancers and brain cancers. Discovering the etiology and preventive modalities for cancer, particularly brain and hematologic ones in both children and adults, is my life’s work.

Education

Kenyon College, BA, 1988, Biology
University of California Berkeley, PhD, 1997, Environmental Health Science/Toxicology


Professional Experience

  • 1988-90
    Science Teacher, St. Johns College, Levuka, Fiji
  • 1992-97
    Graduate Student Researcher, University of California Berkeley
  • 1997-99
    Postdoctoral Fellow, Leukaemia Research Fund Centre, Institute of Cancer Research, London
  • 1999-2000
    Assistant Research Molecular Epidemiologist, University of California San Francisco
  • 2001-2002
    Assistant Adjunct Professor, University of California San Francisco
  • 2002-2006
    Assistant Professor in Residence, University of California San Francisco
  • 2006-present
    Associate Professor, University of California San Francisco

Honors & Awards

  • 1986
    Maxwell Elliot Power Prize, Kenyon College
  • 1988
    Phi Beta Kappa, Kenyon College
  • 1993
    Public Health Alumni Scholarship, University of California Berkeley
  • 1993
    National Science Foundation Predoctoral Fellowship in Toxicology awarded
  • 1993-97
    Postdoctoral Fellow, Howard Hughes Medical Institute, University of California Berkeley
  • 2002
    Scholar, Leukemia and Lymphoma Society of America

Selected Publications

  1. Triebwasser C, Wang R, DeWan AT, Metayer C, Morimoto L, Wiemels JL, Kadan-Lottick N, Ma X. Birth weight and risk of paediatric Hodgkin lymphoma: Findings from a population-based record linkage study in California. Eur J Cancer. 2016 Nov 1; 69:19-27.
    View on PubMed
  2. Barrington-Trimis JL, Cockburn M, Metayer C, Gauderman WJ, Wiemels J, McKean-Cowdin R. Trends in Childhood Leukemia Incidence Over Two Decades from 1992-2013. Int J Cancer. 2016 Oct 25.
    View on PubMed
  3. de Smith AJ, Ojha J, Francis SS, Sanders E, Endicott AA, Hansen HM, Smirnov I, Termuhlen AM, Walsh KM, Metayer C, Wiemels JL. Clonal and microclonal mutational heterogeneity in high hyperdiploid acute lymphoblastic leukemia. Oncotarget. 2016 Sep 24.
    View on PubMed
  4. Johnson KJ, Hainfellner JA, Lau CC, Scheurer ME, Woehrer A, Wiemels J. Immune factors and viral interactions in brain cancer etiology and outcomes, The 2016 Brain Tumor Epidemiology Consortium Meeting report. Clin Neuropathol. 2016 Sep-Oct; 35(5):280-6.
    View on PubMed
  5. Gonseth S, de Smith AJ, Roy R, Zhou M, Lee ST, Shao X, Ohja J, Wrensch MR, Walsh KM, Metayer C, Wiemels JL. Genetic contribution to variation in DNA methylation at maternal smoking sensitive loci in exposed neonates. Epigenetics. 2016 Jul 12; 0.
    View on PubMed
  6. Sapru A, Liu KD, Wiemels J, Hansen H, Pawlikowska L, Poon A, Jorgenson E, Witte JS, Calfee CS, Ware LB, Matthay MA. Association of common genetic variation in the protein C pathway genes with clinical outcomes in acute respiratory distress syndrome. Crit Care. 2016; 20(1):151.
    View on PubMed
  7. Ojha J, Codd V, Nelson CP, Samani NJ, Smirnov IV, Madsen NR, Hansen HM, de Smith AJ, Bracci PM, Wiencke JK, Wrensch MR, Wiemels JL, Walsh KM. Genetic Variation Associated with Longer Telomere Length Increases Risk of Chronic Lymphocytic Leukemia. Cancer Epidemiol Biomarkers Prev. 2016 Jul; 25(7):1043-9.
    View on PubMed
  8. Walsh KM, Whitehead TP, de Smith AJ, Smirnov IV, Park M, Endicott AA, Francis SS, Codd V. Common genetic variants associated with telomere length confer risk for neuroblastoma and other childhood cancers. Carcinogenesis. 2016 Jun; 37(6):576-82.
    View on PubMed
  9. Hsu LI, Briggs F, Shao X, Metayer C, Wiemels JL, Chokkalingam AP, Barcellos LF. Pathway Analysis of Genome-wide Association Study in Childhood Leukemia among Hispanics. Cancer Epidemiol Biomarkers Prev. 2016 May; 25(5):815-22.
    View on PubMed
  10. Wiemels J, Ma X. Stressful exit from the womb and risk of childhood leukaemia. Lancet Haematol. 2016 Apr; 3(4):e155-6.
    View on PubMed
  11. Jiang N, Wiemels RE, Soya A, Whitley R, Held M, Faik A. Composition, Assembly, and Trafficking of a Wheat Xylan Synthase Complex. Plant Physiol. 2016 Apr; 170(4):1999-2023.
    View on PubMed
  12. Carroll RK, Weiss A, Broach WH, Wiemels RE, Mogen AB, Rice KC, Shaw LN. Genome-wide Annotation, Identification, and Global Transcriptomic Analysis of Regulatory or Small RNA Gene Expression in Staphylococcus aureus. MBio. 2016; 7(1):e01990-15.
    View on PubMed
  13. Johnson KJ, Scheurer ME, Woehrer A, Wiemels J. Evolving evidence on tumor and germline genetic classification of gliomas: implications for etiology and survival studies. Clin Neuropathol. 2016 Jan-Feb; 35(1):31-8.
    View on PubMed
  14. Wiemels J. New insights into childhood leukemia etiology. Eur J Epidemiol. 2015 Dec; 30(12):1225-7.
    View on PubMed
  15. Walsh KM, Codd V, Rice T, Nelson CP, Smirnov IV, McCoy LS, Hansen HM, Elhauge E, Ojha J, Francis SS, Madsen NR, Bracci PM, Pico AR, Molinaro AM, Tihan T, Berger MS, Chang SM, Prados MD, Jenkins RB, Wiemels JL. Longer genotypically-estimated leukocyte telomere length is associated with increased adult glioma risk. Oncotarget. 2015 Dec 15; 6(40):42468-77.
    View on PubMed
  16. Morimoto LM, McCauley K, Ma X, Wiemels JL, Chokkalingam AP, Metayer C. Birth weight, fetal growth, and risk of pediatric rhabdomyosarcoma: an updated record linkage study in California. Ann Epidemiol. 2016 Feb; 26(2):141-5.
    View on PubMed
  17. Gonseth S, Roy R, Houseman EA, de Smith AJ, Zhou M, Lee ST, Nusslé S, Singer AW, Wrensch MR, Metayer C, Wiemels JL. Periconceptional folate consumption is associated with neonatal DNA methylation modifications in neural crest regulatory and cancer development genes. Epigenetics. 2015 Dec 2; 10(12):1166-76.
    View on PubMed
  18. de Smith AJ, Walsh KM, Hansen HM, Endicott AA, Wiencke JK, Metayer C, Wiemels JL. Somatic Mutation Allelic Ratio Test Using ddPCR (SMART-ddPCR): An Accurate Method for Assessment of Preferential Allelic Imbalance in Tumor DNA. PLoS One. 2015; 10(11):e0143343.
    View on PubMed
  19. Walsh KM, de Smith AJ, Hansen HM, Smirnov IV, Gonseth S, Endicott AA, Xiao J, Rice T, Fu CH, McCoy LS, Lachance DH, Eckel-Passow JE, Wiencke JK, Jenkins RB, Wrensch MR, Ma X, Metayer C, Wiemels JL. A Heritable Missense Polymorphism in CDKN2A Confers Strong Risk of Childhood Acute Lymphoblastic Leukemia and Is Preferentially Selected during Clonal Evolution. Cancer Res. 2015 Nov 15; 75(22):4884-94.
    View on PubMed
  20. Lee ST, Wiemels JL. Genome-wide CpG island methylation and intergenic demethylation propensities vary among different tumor sites. Nucleic Acids Res. 2016 Feb 18; 44(3):1105-17.
    View on PubMed

Go to UCSF Profiles, powered by CTSI