Donna G. Albertson, PhD

Professor in Residence, UCSF Helen Diller Family Comprehensive Cancer Center
Evelyn and Mattie Anderson Endowed Chair in Cancer Research, UCSF

albertson@cc.ucsf.edu

Phone: (415) 502-8463 (voice); (415) 502-7228 (lab)
Box 0128, UCSF
San Francisco, CA 94143-0128

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Education

Mount Holyoke College, MA, B.A., 1969, Biology and Chemistry
Harvard University, MA, Ph.D., 1972, Biological Chemistry
Harvard University, MA, Postdoc, 1973-1974, Molecular Cytogenetics
MRC Laboratory of Molecular Biology, UK, Postdoc, 1974-1978, Molecular Biology/Genetics
 

Professional Experience

• 1978-1979
  Visiting Research Associate, Dept. of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO.
• 1981-1986
  Scientific Staff, MRC Laboratory of Molecular Biology, Cambridge, U.K.
• 1986-1991
  Scientific Staff, MRC Molecular Genetics Unit, Cambridge, U.K.
• 1991-1996
  Scientific Staff, MRC Laboratory of Molecular Biology, Cambridge, U.K.
• 1995-1998
  Scientist, Life Sciences Division, E. O. Lawrence Berkeley National Laboratory, Berkeley, CA
• 1998-present
  Professor, Cancer Research Institute, University of California, San Francisco, CA
• 2005-present
  Associate Director, Cancer Research Institute, University of California San Francisco, San Francisco, CA

Honors & Awards

• 1973-1975
  N.I.H. Postdoctoral Fellowship
• 1975-1977
  Muscular Dystrophy Association of America, Inc.
• 1981-1982
  Usher Fellow, MRC Laboratory of Molecular Biology, Cambridge, U.K.
• 2008
  Second Annual AACR Team Science Award

Selected Publications

1. Kumar P, Mukherjee M, Johnson JP, Patel M, Huey B, Albertson DG, Simin K. Cooperativity of Rb, Brca1, and p53 in Malignant Breast Cancer Evolution. PLoS Genet. 2012 Nov; 8(11):e1003027.
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2. Jarrell TA, Wang Y, Bloniarz AE, Brittin CA, Xu M, Thomson JN, Albertson DG, Hall DH, Emmons SW. The connectome of a decision-making neural network. Science. 2012 Jul 27; 337(6093):437-44.
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3. Bhattacharya A, Roy R, Snijders AM, Hamilton G, Paquette J, Tokuyasu T, Bengtsson H, Jordan RC, Olshen AB, Pinkel D, Schmidt BL, Albertson DG. Two distinct routes to oral cancer differing in genome instability and risk for cervical node metastasis. Clin Cancer Res. 2011 Nov 15; 17(22):7024-34.
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4. Quigley DA, To MD, Kim IJ, Lin KK, Albertson DG, Sjolund J, Pérez-Losada J, Balmain A. Network analysis of skin tumor progression identifies a rewired genetic architecture affecting inflammation and tumor susceptibility. Genome Biol. 2011; 12(1):R5.
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5. Ostrovnaya I, Olshen AB, Seshan VE, Orlow I, Albertson DG, Begg CB. A metastasis or a second independent cancer? Evaluating the clonal origin of tumors using array copy number data. Stat Med. 2010 Jul 10; 29(15):1608-21.
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6. Davari P, Hebert JL, Albertson DG, Huey B, Roy R, Mancianti ML, Horvai AE, McDaniel LD, Schultz RA, Epstein EH. Loss of Blm enhances basal cell carcinoma and rhabdomyosarcoma tumorigenesis in Ptch1+/- mice. Carcinogenesis. 2010 Jun; 31(6):968-73.
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7. Halberg RB, Waggoner J, Rasmussen K, White A, Clipson L, Prunuske AJ, Bacher JW, Sullivan R, Washington MK, Pitot HC, Petrini JH, Albertson DG, Dove WF. Long-lived Min mice develop advanced intestinal cancers through a genetically conservative pathway. Cancer Res. 2009 Jul 15; 69(14):5768-75.
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8. Kwek SS, Roy R, Zhou H, Climent J, Martinez-Climent JA, Fridlyand J, Albertson DG. Co-amplified genes at 8p12 and 11q13 in breast tumors cooperate with two major pathways in oncogenesis. Oncogene. 2009 Apr 30; 28(17):1892-903.
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9. Kuijper A, Snijders AM, Berns EM, Kuenen-Boumeester V, van der Wall E, Albertson DG, van Diest PJ. Genomic profiling by array comparative genomic hybridization reveals novel DNA copy number changes in breast phyllodes tumours. Cell Oncol. 2009; 31(1):31-9.
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10. Snijders AM, Huey B, Connelly ST, Roy R, Jordan RC, Schmidt BL, Albertson DG. Stromal control of oncogenic traits expressed in response to the overexpression of GLI2, a pleiotropic oncogene. Oncogene. 2009 Feb 5; 28(5):625-37.
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11. Clark SM, Hamilton GE, Nordmeyer RA, Uber D, Cornell EW, Brown N, Segraves R, Davis R, Albertson DG, Pinkel D. High-efficiency microarray printer using fused-silica capillary tube printing pins. Anal Chem. 2008 Oct 1; 80(19):7639-42.
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12. Albertson DG. Conflicting evidence on the frequency of ESR1 amplification in breast cancer. Nat Genet. 2008 Jul; 40(7):821-2.
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13. Snijders AM, Hermsen MA, Baughman J, Buffart TE, Huey B, Gajduskova P, Roydasgupta R, Tokuyasu T, Meijer GA, Fridlyand J, Albertson DG. Acquired genomic aberrations associated with methotrexate resistance vary with background genomic instability. Genes Chromosomes Cancer. 2008 Jan; 47(1):71-83.
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14. Nowee ME, Snijders AM, Rockx DA, de Wit RM, Kosma VM, Hämäläinen K, Schouten JP, Verheijen RH, van Diest PJ, Albertson DG, Dorsman JC. DNA profiling of primary serous ovarian and fallopian tube carcinomas with array comparative genomic hybridization and multiplex ligation-dependent probe amplification. J Pathol. 2007 Sep; 213(1):46-55.
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15. Tomioka N, Oba S, Ohira M, Misra A, Fridlyand J, Ishii S, Nakamura Y, Isogai E, Hirata T, Yoshida Y, Todo S, Kaneko Y, Albertson DG, Pinkel D, Feuerstein BG, Nakagawara A. Novel risk stratification of patients with neuroblastoma by genomic signature, which is independent of molecular signature. Oncogene. 2008 Jan 17; 27(4):441-9.
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16. Byrd KN, Huey B, Roydasgupta R, Fridlyand J, Snijders AM, Albertson DG. FBXW7 and DNA copy number instability. Breast Cancer Res Treat. 2008 May; 109(1):47-54.
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17. Tokuyasu TA, Cotter PD, Segraves R, Harris J, Elder ME, Gonzales M, Pinkel D, Albertson DG, Rauen KA. Detection of single clone deletions using array CGH: identification of submicroscopic deletions in the 22q11.2 deletion syndrome as a model system. Am J Med Genet A. 2007 May 1; 143A(9):925-32.
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18. Climent J, Dimitrow P, Fridlyand J, Palacios J, Siebert R, Albertson DG, Gray JW, Pinkel D, Lluch A, Martinez-Climent JA. Deletion of chromosome 11q predicts response to anthracycline-based chemotherapy in early breast cancer. Cancer Res. 2007 Jan 15; 67(2):818-26.
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19. Gajduskova P, Snijders AM, Kwek S, Roydasgupta R, Fridlyand J, Tokuyasu T, Pinkel D, Albertson DG. Genome position and gene amplification. Genome Biol. 2007; 8(6):R120.
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20. Yau C, Fedele V, Roydasgupta R, Fridlyand J, Hubbard A, Gray JW, Chew K, Dairkee SH, Moore DH, Schittulli F, Tommasi S, Paradiso A, Albertson DG, Benz CC. Aging impacts transcriptomes but not genomes of hormone-dependent breast cancers. Breast Cancer Res. 2007; 9(5):R59.
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