Manish K. Aghi, MD, PhD

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Manish K. Aghi, MD, PhD

Associate Professor in Residence, Department of Neurological Surgery, UCSF

Phone: (415) 353-7500 (appts)
Box 0112, UCSF
San Francisco, CA 94143-0112

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Cancer Center Membership

Program Member » Neurologic Oncology

Research Summary

I am a neurosurgeon-scientist, and I have been running a neurosurgical practice caring for brain tumor patients and a basic science lab in the UCSF Brain Tumor Research Center (BTRC) since my initial faculty appointment at UCSF in 2008. Throughout that time, my lab has been well funded by the NIH and numerous private foundations, with the central focus of the lab being mechanisms of angiogenesis, invasion, and therapeutic resistance in brain tumors like glioblastoma, metastases, and pituitary tumors. My clinical practice has developed in parallel with my laboratory, with my glioblastoma and pituitary tumor surgical cases often providing valuable tissue for lab research as part of my clinical and translational research programs. The expertise from my scientific and clinical research has been supplemented by numerous successful collaborations with academic and industry investigators in the past eight years. As a neurosurgeon-scientist, I have mentored numerous medical and graduate students, postdoctoral fellows, and neurosurgery residents on scientific and clinical projects, as well as assisting them developing their careers integrating dual roles combining neurosurgical practices with scientific investigation. My position as a neurosurgeon and scientist specializing in the care of patients with aggressive brain tumors and the role of the tumor microenvironment in driving this aggressive biology and therapeutic resistance uniquely positions me to serve as PI for a variety of grants.

Education

Stanford University (Stanford, CA), BS, 1993, Biological Sciences
Stanford University (Stanford, CA), MS, 1993, Biological Sciences
Harvard Medical School (Boston, MA), MD, 2000, Medicine
Harvard Medical School (Boston, MA), PhD, 2000, Neuroscience


Professional Experience

  • 2000-2001
    Intern, General Surgery, Massachusetts General Hospital, Boston, MA
  • 2001-2007
    Resident, Neurosurgery, Massachusetts General Hospital, Boston, MA
  • 2007
    Assistant Professor, Neurosurgery, Massachusetts General Hospital, Boston, MA
  • 2008-2012
    Assistant Professor in Residence, Neurosurgery, University of California, San Francisco, CA
  • 2012-present
    Associate Professor in Residence, Neurosurgery, University of California, San Francisco, CA

Honors & Awards

  • 2004
    Preuss Award, best basic science brain tumor research, American Association of Neurologic Surgeons (AANS) meeting, "Generation of Brain Tumor Neovasculature from Transplanted Bone Marrow."
  • 2005
    Ronald L. Bittner Award, best brain tumor research, American Association of Neurologic Surgeons (AANS) meeting
  • 2005
    William Scoville Resident Research Award, New England Neurosurgery meeting, "Generation of Glioma Neovasculature from Transplanted Bone Marrow."
  • 2005
    Congress of Neurologic Surgeons (CNS) Resident Research Award, "Enhanced Replication of Oncolytic HSV in Glioma Cells that Evade Temozolomide Chemotherapy Through DNA Repair."
  • 2005
    American Academy of Neurologic Surgeons Resident Research Award, "Stromal Derived Factor-1 Interacts with Environmental Cues to Induce Bone Marrow-Derived Cells to Differentiate into Tumor Endothelium and Pericytes."
  • 2006
    Mahaley Award, best clinical study in neuro-oncology, presented at American Association of Neurologic Surgeons (AANS) meeting
  • 2006
    Integra Foundation Award, best benign brain and peripheral nerve tumor research, presented at Congress of Neurologic Surgeons (CNS) meeting
  • 2007
    Synthes Skull Base Award, Congress of Neurologic Surgeons (CNS) meeting
  • 2009
    American Brian Tumor Association (ABTA) Young Investigator Award, Congress of Neurological Surgeons (CNS) meeting

Selected Publications

  1. The role of surgery in the management of patients with diffuse low grade glioma : A systematic review and evidence-based clinical practice guideline. J Neurooncol. 2015 Dec; 125(3):503-30.
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  2. Hypophysitis: a single-center case series. Pituitary. 2015 Oct; 18(5):630-41.
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  3. Adaptation to antiangiogenic therapy in neurological tumors. Cell Mol Life Sci. 2015 Aug; 72(16):3069-82.
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  4. Approach to the postoperative patient with Cushing's disease. Pituitary. 2015 Apr; 18(2):232-7.
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  5. Convection-enhanced delivery for the treatment of glioblastoma. Neuro Oncol. 2015 Mar; 17 Suppl 2:ii3-ii8.
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  6. Incidence of headache as a presenting complaint in over 1000 patients with sellar lesions and factors predicting postoperative improvement. Clin Neurol Neurosurg. 2015 May; 132:16-20.
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  7. Intraoperative Conversion from Endoscopic to Open Transcortical-Transventricular Removal of Colloid Cysts as a Salvage Procedure. Cureus. 2015 Feb; 7(2):e247.
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  8. Cushing's disease: current medical therapies and molecular insights guiding future therapies. Neurosurg Focus. 2015 Feb; 38(2):E11.
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  9. Factors predicting recurrence after resection of clival chordoma using variable surgical approaches and radiation modalities. Neurosurgery. 2015 Feb; 76(2):179-86.
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  10. Update on the management of recurrent Cushing's disease. Neurosurg Focus. 2015 Feb; 38(2):E16.
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  11. Pituicytomas and spindle cell oncocytomas: modern case series from the University of California, San Francisco. Pituitary. 2015 Feb; 18(1):150-8.
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  12. Sinonasal morbidity following endoscopic endonasal skull base surgery. Clin Neurol Neurosurg. 2015 Mar; 130:162-7.
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  13. A predictive algorithm for evaluating elevated serum prolactin in patients with a sellar mass. J Clin Neurosci. 2015 Jan; 22(1):155-60.
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  14. Molecularly targeted therapies for recurrent glioblastoma: current and future targets. Neurosurg Focus. 2014 Dec; 37(6):E15.
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  15. Bevacizumab for glioblastoma: current indications, surgical implications, and future directions. Neurosurg Focus. 2014 Dec; 37(6):E9.
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  16. Risk factors for postoperative cerebrospinal fluid leak and meningitis after expanded endoscopic endonasal surgery. J Clin Neurosci. 2015 Jan; 22(1):48-54.
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  17. Epidermal growth factor-like module containing mucin-like hormone receptor 2 expression in gliomas. J Neurooncol. 2015 Jan; 121(1):53-61.
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  18. Optimizing glioblastoma resection: intraoperative mapping and beyond. CNS Oncol. 2014 Sep; 3(5):359-66.
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  19. Rate and time course of improvement in endocrine function after more than 1000 pituitary operations. Neurosurgery. 2014 Aug; 61 Suppl 1:163-6.
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  20. Gangliogliomas of the optic pathway. J Clin Neurosci. 2014 Dec; 21(12):2244-9.
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