Manish K. Aghi, MD, PhD

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Manish K. Aghi, MD, PhD

Associate Professor in Residence, Department of Neurological Surgery, UCSF

Phone: (415) 353-7500 (appts)
Box 0112, UCSF
San Francisco, CA 94143-0112

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Cancer Center Membership

Program Member » Neurologic Oncology

Research Summary

I am a neurosurgeon-scientist, and I have been running a neurosurgical practice caring for brain tumor patients and a basic science lab in the UCSF Brain Tumor Research Center (BTRC) since my initial faculty appointment at UCSF in 2008. Throughout that time, my lab has been well funded by the NIH and numerous private foundations, with the central focus of the lab being mechanisms of angiogenesis, invasion, and therapeutic resistance in brain tumors like glioblastoma, metastases, and pituitary tumors. My clinical practice has developed in parallel with my laboratory, with my glioblastoma and pituitary tumor surgical cases often providing valuable tissue for lab research as part of my clinical and translational research programs. The expertise from my scientific and clinical research has been supplemented by numerous successful collaborations with academic and industry investigators in the past eight years. As a neurosurgeon-scientist, I have mentored numerous medical and graduate students, postdoctoral fellows, and neurosurgery residents on scientific and clinical projects, as well as assisting them developing their careers integrating dual roles combining neurosurgical practices with scientific investigation. My position as a neurosurgeon and scientist specializing in the care of patients with aggressive brain tumors and the role of the tumor microenvironment in driving this aggressive biology and therapeutic resistance uniquely positions me to serve as PI for a variety of grants.

Education

Stanford University (Stanford, CA), BS, 1993, Biological Sciences
Stanford University (Stanford, CA), MS, 1993, Biological Sciences
Harvard Medical School (Boston, MA), MD, 2000, Medicine
Harvard Medical School (Boston, MA), PhD, 2000, Neuroscience


Professional Experience

  • 2000-2001
    Intern, General Surgery, Massachusetts General Hospital, Boston, MA
  • 2001-2007
    Resident, Neurosurgery, Massachusetts General Hospital, Boston, MA
  • 2007
    Assistant Professor, Neurosurgery, Massachusetts General Hospital, Boston, MA
  • 2008-2012
    Assistant Professor in Residence, Neurosurgery, University of California, San Francisco, CA
  • 2012-present
    Associate Professor in Residence, Neurosurgery, University of California, San Francisco, CA

Honors & Awards

  • 2004
    Preuss Award, best basic science brain tumor research, American Association of Neurologic Surgeons (AANS) meeting, "Generation of Brain Tumor Neovasculature from Transplanted Bone Marrow."
  • 2005
    Ronald L. Bittner Award, best brain tumor research, American Association of Neurologic Surgeons (AANS) meeting
  • 2005
    William Scoville Resident Research Award, New England Neurosurgery meeting, "Generation of Glioma Neovasculature from Transplanted Bone Marrow."
  • 2005
    Congress of Neurologic Surgeons (CNS) Resident Research Award, "Enhanced Replication of Oncolytic HSV in Glioma Cells that Evade Temozolomide Chemotherapy Through DNA Repair."
  • 2005
    American Academy of Neurologic Surgeons Resident Research Award, "Stromal Derived Factor-1 Interacts with Environmental Cues to Induce Bone Marrow-Derived Cells to Differentiate into Tumor Endothelium and Pericytes."
  • 2006
    Mahaley Award, best clinical study in neuro-oncology, presented at American Association of Neurologic Surgeons (AANS) meeting
  • 2006
    Integra Foundation Award, best benign brain and peripheral nerve tumor research, presented at Congress of Neurologic Surgeons (CNS) meeting
  • 2007
    Synthes Skull Base Award, Congress of Neurologic Surgeons (CNS) meeting
  • 2009
    American Brian Tumor Association (ABTA) Young Investigator Award, Congress of Neurological Surgeons (CNS) meeting

Selected Publications

  1. Müller S, Liu SJ, Di Lullo E, Malatesta M, Pollen AA, Nowakowski TJ, Kohanbash G, Aghi M, Kriegstein AR, Lim DA, Diaz A. Single-cell sequencing maps gene expression to mutational phylogenies in PDGF- and EGF-driven gliomas. Mol Syst Biol. 2016 Nov 25; 12(11):889.
    View on PubMed
  2. Winkler EA, Birk H, Safaee M, Yue JK, Burke JF, Viner JA, Pekmezci M, Perry A, Aghi MK, Berger MS, McDermott MW. Surgical resection of fourth ventricular ependymomas: case series and technical nuances. J Neurooncol. 2016 Nov; 130(2):341-349.
    View on PubMed
  3. Aghi MK, Chen CC, Fleseriu M, Newman SA, Lucas JW, Kuo JS, Barkhoudarian G, Farrell CJ, Sheehan J, Ziu M, Dunn IF. Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines on the Management of Patients With Nonfunctioning Pituitary Adenomas: Executive Summary. Neurosurgery. 2016 Oct; 79(4):521-3.
    View on PubMed
  4. Chen CC, Carter BS, Wang R, Patel KS, Hess C, Bodach ME, Tumialan LM, Oyesiku NM, Patil CG, Litvack Z, Zada G, Aghi MK. Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline on Preoperative Imaging Assessment of Patients With Suspected Nonfunctioning Pituitary Adenomas. Neurosurgery. 2016 Oct; 79(4):E524-6.
    View on PubMed
  5. Fleseriu M, Bodach ME, Tumialan LM, Bonert V, Oyesiku NM, Patil CG, Litvack Z, Aghi MK, Zada G. Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline for Pretreatment Endocrine Evaluation of Patients With Nonfunctioning Pituitary Adenomas. Neurosurgery. 2016 Oct; 79(4):E527-9.
    View on PubMed
  6. Newman SA, Turbin RE, Bodach ME, Tumialan LM, Oyesiku NM, Litvack Z, Zada G, Patil CG, Aghi MK. Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline on Pretreatment Ophthalmology Evaluation in Patients With Suspected Nonfunctioning Pituitary Adenomas. Neurosurgery. 2016 Oct; 79(4):E530-2.
    View on PubMed
  7. Lucas JW, Bodach ME, Tumialan LM, Oyesiku NM, Patil CG, Litvack Z, Aghi MK, Zada G. Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline on Primary Management of Patients With Nonfunctioning Pituitary Adenomas. Neurosurgery. 2016 Oct; 79(4):E533-5.
    View on PubMed
  8. Sheehan J, Lee CC, Bodach ME, Tumialan LM, Oyesiku NM, Patil CG, Litvack Z, Zada G, Aghi MK. Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline for the Management of Patients With Residual or Recurrent Nonfunctioning Pituitary Adenomas. Neurosurgery. 2016 Oct; 79(4):E539-40.
    View on PubMed
  9. Ziu M, Dunn IF, Hess C, Fleseriu M, Bodach ME, Tumialan LM, Oyesiku NM, Patel KS, Wang R, Carter BS, Chen JY, Chen CC, Patil CG, Litvack Z, Zada G, Aghi MK. Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline on Posttreatment Follow-up Evaluation of Patients With Nonfunctioning Pituitary Adenomas. Neurosurgery. 2016 Oct; 79(4):E541-3.
    View on PubMed
  10. Kuo JS, Barkhoudarian G, Farrell CJ, Bodach ME, Tumialan LM, Oyesiku NM, Litvack Z, Zada G, Patil CG, Aghi MK. Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline on Surgical Techniques and Technologies for the Management of Patients With Nonfunctioning Pituitary Adenomas. Neurosurgery. 2016 Oct; 79(4):E536-8.
    View on PubMed
  11. Han SJ, Reis G, Kohanbash G, Shrivastav S, Magill ST, Molinaro AM, McDermott MW, Theodosopoulos PV, Aghi MK, Berger MS, Butowski NA, Barani I, Phillips JJ, Perry A, Okada H. Expression and prognostic impact of immune modulatory molecule PD-L1 in meningioma. J Neurooncol. 2016 Dec; 130(3):543-552.
    View on PubMed
  12. Jahangiri A, Chen W, Yagnik G, De Lay M, Wagner J, Sidorov M, Flanigan PM, Aghi MK. 333 Obtaining the Genetic Fingerprint of Resistance to Glioblastoma Through a Novel Multigenerational Xenograft Model. Neurosurgery. 2016 Aug; 63 Suppl 1:197.
    View on PubMed
  13. Sidorov M, Jahangiri A, Han SW, De Lay M, Wagner J, Castro B, Flanigan PM, Imber BS, Weiss WA, Aghi MK. 340 c-Met/ß1 Integrin: A Receptor Complex Driving Invasive Glioblastoma Resistance to Antiangiogenic Therapy. Neurosurgery. 2016 Aug; 63 Suppl 1:199-200.
    View on PubMed
  14. Barajas RF, Butowski NA, Phillips JJ, Aghi MK, Berger MS, Chang SM, Cha S. The Development of Reduced Diffusion Following Bevacizumab Therapy Identifies Regions of Recurrent Disease in Patients with High-grade Glioma. Acad Radiol. 2016 Sep; 23(9):1073-82.
    View on PubMed
  15. Imber BS, Kanungo I, Braunstein S, Barani IJ, Fogh SE, Nakamura JL, Berger MS, Chang EF, Molinaro AM, Cabrera JR, McDermott MW, Sneed PK, Aghi MK. Indications and Efficacy of Gamma Knife Stereotactic Radiosurgery for Recurrent Glioblastoma: 2 Decades of Institutional Experience. Neurosurgery. 2016 Jul 13.
    View on PubMed
  16. Han SJ, Bankiewicz K, Butowski NA, Larson PS, Aghi MK. Interventional MRI-guided catheter placement and real time drug delivery to the central nervous system. Expert Rev Neurother. 2016 Jun; 16(6):635-9.
    View on PubMed
  17. Shah JK, Potts MB, Sneed PK, Aghi MK, McDermott MW. Surgical Cavity Constriction and Local Progression Between Resection and Adjuvant Radiosurgery for Brain Metastases. Cureus. 2016; 8(4):e575.
    View on PubMed
  18. Han SJ, Rolston JD, Zygourakis CC, Sun MZ, McDermott MW, Lau CY, Aghi MK. Preventing Delays in First-Case Starts on the Neurosurgery Service: A Resident-Led Initiative at an Academic Institution. J Surg Educ. 2016 Mar-Apr; 73(2):291-5.
    View on PubMed
  19. Bhawe KM, Aghi MK. Microarray Analysis in Glioblastomas. Methods Mol Biol. 2016; 1375:195-206.
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  20. Aghi MK, Nahed BV, Sloan AE, Ryken TC, Kalkanis SN, Olson JJ. The role of surgery in the management of patients with diffuse low grade glioma : A systematic review and evidence-based clinical practice guideline. J Neurooncol. 2015 Dec; 125(3):503-30.
    View on PubMed

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