Manish K. Aghi, MD, PhD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Manish K. Aghi, MD, PhD

Associate Professor in Residence, Department of Neurological Surgery, UCSF

Phone: (415) 353-7500 (appts)
Box 0112, UCSF
San Francisco, CA 94143-0112

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Cancer Center Membership

Program Member » Neurologic Oncology

Research Summary

I am a neurosurgeon-scientist, and I have been running a neurosurgical practice caring for brain tumor patients and a basic science lab in the UCSF Brain Tumor Research Center (BTRC) since my initial faculty appointment at UCSF in 2008. Throughout that time, my lab has been well funded by the NIH and numerous private foundations, with the central focus of the lab being mechanisms of angiogenesis, invasion, and therapeutic resistance in brain tumors like glioblastoma, metastases, and pituitary tumors. My clinical practice has developed in parallel with my laboratory, with my glioblastoma and pituitary tumor surgical cases often providing valuable tissue for lab research as part of my clinical and translational research programs. The expertise from my scientific and clinical research has been supplemented by numerous successful collaborations with academic and industry investigators in the past eight years. As a neurosurgeon-scientist, I have mentored numerous medical and graduate students, postdoctoral fellows, and neurosurgery residents on scientific and clinical projects, as well as assisting them developing their careers integrating dual roles combining neurosurgical practices with scientific investigation. My position as a neurosurgeon and scientist specializing in the care of patients with aggressive brain tumors and the role of the tumor microenvironment in driving this aggressive biology and therapeutic resistance uniquely positions me to serve as PI for a variety of grants.

Education

Stanford University (Stanford, CA), BS, 1993, Biological Sciences
Stanford University (Stanford, CA), MS, 1993, Biological Sciences
Harvard Medical School (Boston, MA), MD, 2000, Medicine
Harvard Medical School (Boston, MA), PhD, 2000, Neuroscience


Professional Experience

  • 2000-2001
    Intern, General Surgery, Massachusetts General Hospital, Boston, MA
  • 2001-2007
    Resident, Neurosurgery, Massachusetts General Hospital, Boston, MA
  • 2007
    Assistant Professor, Neurosurgery, Massachusetts General Hospital, Boston, MA
  • 2008-2012
    Assistant Professor in Residence, Neurosurgery, University of California, San Francisco, CA
  • 2012-present
    Associate Professor in Residence, Neurosurgery, University of California, San Francisco, CA

Honors & Awards

  • 2004
    Preuss Award, best basic science brain tumor research, American Association of Neurologic Surgeons (AANS) meeting, "Generation of Brain Tumor Neovasculature from Transplanted Bone Marrow."
  • 2005
    Ronald L. Bittner Award, best brain tumor research, American Association of Neurologic Surgeons (AANS) meeting
  • 2005
    William Scoville Resident Research Award, New England Neurosurgery meeting, "Generation of Glioma Neovasculature from Transplanted Bone Marrow."
  • 2005
    Congress of Neurologic Surgeons (CNS) Resident Research Award, "Enhanced Replication of Oncolytic HSV in Glioma Cells that Evade Temozolomide Chemotherapy Through DNA Repair."
  • 2005
    American Academy of Neurologic Surgeons Resident Research Award, "Stromal Derived Factor-1 Interacts with Environmental Cues to Induce Bone Marrow-Derived Cells to Differentiate into Tumor Endothelium and Pericytes."
  • 2006
    Mahaley Award, best clinical study in neuro-oncology, presented at American Association of Neurologic Surgeons (AANS) meeting
  • 2006
    Integra Foundation Award, best benign brain and peripheral nerve tumor research, presented at Congress of Neurologic Surgeons (CNS) meeting
  • 2007
    Synthes Skull Base Award, Congress of Neurologic Surgeons (CNS) meeting
  • 2009
    American Brian Tumor Association (ABTA) Young Investigator Award, Congress of Neurological Surgeons (CNS) meeting

Selected Publications

  1. Jahangiri A, Chen W, Yagnik G, De Lay M, Wagner J, Sidorov M, Flanigan PM, Aghi MK. 333 Obtaining the Genetic Fingerprint of Resistance to Glioblastoma Through a Novel Multigenerational Xenograft Model. Neurosurgery. 2016 Aug; 63 Suppl 1:197.
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  2. Sidorov M, Jahangiri A, Han SW, De Lay M, Wagner J, Castro B, Flanigan PM, Imber BS, Weiss WA, Aghi MK. 340 c-Met/ß1 Integrin: A Receptor Complex Driving Invasive Glioblastoma Resistance to Antiangiogenic Therapy. Neurosurgery. 2016 Aug; 63 Suppl 1:199-200.
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  3. Barajas RF, Butowski NA, Phillips JJ, Aghi MK, Berger MS, Chang SM, Cha S. The Development of Reduced Diffusion Following Bevacizumab Therapy Identifies Regions of Recurrent Disease in Patients with High-grade Glioma. Acad Radiol. 2016 Sep; 23(9):1073-82.
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  4. Rolston JD, Han SJ, Aghi MK. Nationwide shift from microscopic to endoscopic transsphenoidal pituitary surgery. Pituitary. 2016 Jun; 19(3):248-50.
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  5. Han SJ, Bankiewicz K, Butowski NA, Larson PS, Aghi MK. Interventional MRI-guided catheter placement and real time drug delivery to the central nervous system. Expert Rev Neurother. 2016 Jun; 16(6):635-9.
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  6. Shah JK, Potts MB, Sneed PK, Aghi MK, McDermott MW. Surgical Cavity Constriction and Local Progression Between Resection and Adjuvant Radiosurgery for Brain Metastases. Cureus. 2016; 8(4):e575.
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  7. Han SJ, Rolston JD, Zygourakis CC, Sun MZ, McDermott MW, Lau CY, Aghi MK. Preventing Delays in First-Case Starts on the Neurosurgery Service: A Resident-Led Initiative at an Academic Institution. J Surg Educ. 2016 Mar-Apr; 73(2):291-5.
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  8. Bhawe KM, Aghi MK. Microarray Analysis in Glioblastomas. Methods Mol Biol. 2016; 1375:195-206.
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  9. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chowdhury K, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, Cianfanelli V, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-222.
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  10. Aghi MK, Nahed BV, Sloan AE, Ryken TC, Kalkanis SN, Olson JJ. The role of surgery in the management of patients with diffuse low grade glioma : A systematic review and evidence-based clinical practice guideline. J Neurooncol. 2015 Dec; 125(3):503-30.
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  11. Imber BS, Lee HS, Kunwar S, Blevins LS, Aghi MK. Hypophysitis: a single-center case series. Pituitary. 2015 Oct; 18(5):630-41.
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  12. Jahangiri A, Wagner JR, Han SW, Tran MT, Miller LM, Chen R, Tom MW, Ostling LR, Kunwar S, Blevins L, Aghi MK. Improved versus worsened endocrine function after transsphenoidal surgery for nonfunctional pituitary adenomas: rate, time course, and radiological analysis. J Neurosurg. 2016 Mar; 124(3):589-95.
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  13. Flanigan PM, Aghi MK. Adaptation to antiangiogenic therapy in neurological tumors. Cell Mol Life Sci. 2015 Aug; 72(16):3069-82.
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  14. Rutkowski MJ, Breshears JD, Kunwar S, Aghi MK, Blevins LS. Approach to the postoperative patient with Cushing's disease. Pituitary. 2015 Apr; 18(2):232-7.
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  15. Vogelbaum MA, Aghi MK. Convection-enhanced delivery for the treatment of glioblastoma. Neuro Oncol. 2015 Mar; 17 Suppl 2:ii3-ii8.
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  16. Jahangiri A, Wagner JR, Chin AT, Han SW, Tran MT, Miller LM, Tom MW, Chen R, Kunwar S, Blevins L, Aghi MK. Incidence of headache as a presenting complaint in over 1000 patients with sellar lesions and factors predicting postoperative improvement. Clin Neurol Neurosurg. 2015 May; 132:16-20.
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  17. Osorio JA, Clark AJ, Safaee M, Tate MC, Aghi MK, Parsa A, McDermott MW. Intraoperative Conversion from Endoscopic to Open Transcortical-Transventricular Removal of Colloid Cysts as a Salvage Procedure. Cureus. 2015 Feb; 7(2):e247.
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  18. Lau D, Rutledge C, Aghi MK. Cushing's disease: current medical therapies and molecular insights guiding future therapies. Neurosurg Focus. 2015 Feb; 38(2):E11.
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  19. Jahangiri A, Chin AT, Wagner JR, Kunwar S, Ames C, Chou D, Barani I, Parsa AT, McDermott MW, Benet A, El-Sayed IH, Aghi MK. Factors predicting recurrence after resection of clival chordoma using variable surgical approaches and radiation modalities. Neurosurgery. 2015 Feb; 76(2):179-85; discussion 185-6.
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  20. Rutkowski MJ, Flanigan PM, Aghi MK. Update on the management of recurrent Cushing's disease. Neurosurg Focus. 2015 Feb; 38(2):E16.
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