A. James Barkovich, MD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
A. James Barkovich, MD

Professor in Residence, Departments of Radiology, Pediatrics, Neurology, and Neurological Surgery, UCSF

jim.barkovich@radiology.ucsf.edu

Phone: (415) 353-1668 (appts)
Box 0628, UCSF

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Cancer Center Membership

Associate Member » Neurologic Oncology

Research Summary

A. James Barkovich, MD, is a Professor in Residence and he is Chief of Pediatric Neuroradiology in the Department of Radiology at the University of California, San Francisco. Dr. Barkovich received his medical degree from George Washington University, Washington, D.C., and completed his residency in Radiology from Letterman AMC, San Francisco in 1984, followed by a fellowship in Neuroradiology from Walter Reed AMC in 1986. Dr. Barkovich was also President of the American Society of Neuroradiology 1998-1999 and Secretary General of the World Federation of Neuroradiological Societies from 2002-2006.

Dr. Barkovich serves as the Chief of Pediatric Neuroradiology in the UCSF Department of Radiology and Biomedical Imaging. He specializes in the diagnosis of neurological disorders in infants and children. His main research interests include neonatal brain injury and the use of magnetic resonance (MR) to better understand both normal brain development and to recognize and classify genetic disorders that underlie abnormal brain development.

Dr. Barkovich’s research established correlations between MR findings and the outcome in affected patients. He has 385 published articles, and has authored or co-authored 9 textbooks and 41 book chapters, and he has written and contributed to a collective of more than 400 research documents.

Expertise:

NeuroRadiologist

Specialty:

Pediatric Neuroradiology

Professional Interests:

Neonatal brain injury and the use of magnetic resonance (MR) to better understand both normal brain development and to recognize and classify genetic disorders that underlie abnormal brain development

Education and Training:

• Medical School: George Washington University, Washington, DC (1976-1980)

• Internship: Letterman AMC, San Francisco - Radiology (1980-1981)

• Residency: Letterman AMC, San Francisco - Radiology (1981-1984)

• Fellowship: Walter Reed AMC, Washington, DC - Neuroradiology (1984-1986)

• California Medical License

• Ohio State Medical License (inactive)

• New York State Medical License (inactive)

• American Board of Radiology (1984)

• Certificate of Added Qualification in Neuroradiology (1996, 2006)

Education

Univ. of CA, Davis, BS, 1974, Chemistry
Univ. of CA, Berkeley, MS, 1977, Chemistry Passed Oral Examination for Ph.D., was advanced to candidacy for Ph.D., but did not complete dissertation
Geo. Washington Univ., Washington, D.C., MD, 1980, Medicine
Letterman AMC, San Francisco, CA, Intern, 1980-1981, Radiology
Letterman, AMC, San Francisco, CA, Resident, 1981-1984, Radiology
Walter Reed AMC, Washington, D.C., Fellowship, 1984-1986, Neuroradiology
 


Professional Experience

  • 1971-1972
    Chemistry Department, Research Assistant, Univ. of CA, Davis
  • 1972
    Chemistry Dept. Research Assistant Univ. of CA, Berkeley Teaching Assistant
  • 1974-1972
    U.S. Army, Medical Student, Intern, Radiology Resident, Neuroradiology Fellow, Neuroradiologist, Served on active duty (highest rank - Major) in U.S. Army
  • 1984-1982
    Instructor in Radiology, F. Edward Hébert School of Medicine, Uniformed Services University of Health Sciences
  • 1987-1982
    Assistant Clinical Professor of Radiology, Uniformed Services University of Health Sciences
  • 1986-1982
    Assistant Clinical Professor of Radiology, University of California, San Francisco
  • 1989-1992
    Associate Professor of Radiology, Pediatrics, Neurology and Neurological Surgery in Residence, University of California, San Francisco
  • Present
    Professor of Radiology, Pediatrics, Neurology and Neurosurgery in Residence, University of California, San Francisco

Honors & Awards

  • 1972
    Edward F. Kraft Scholarship Award, U.C. Davis
  • 1973-1972
    President's Undergraduate Research Fellow
  • 1972
    U.S. Atomic Energy Commission Summer Research Fellow,
  • 1982
    Honorable Mention, Exhibit, RSNA Annual Meeting
  • 1992
    Outstanding Teacher Award, Department of Neurology, UCSF
  • 1992
    Editors Excellence for Outstanding Scientific Research, J Comput Assist Tomogr
  • 1992
    Elected to "Best Doctors in America"
  • 1992
    Elected to "Best Doctors in America, Pacific Region"
  • 1992
    Nycomed Distinguished Visiting Lecturer, Armed Forces Institute of Pathology
  • 1992
    Selected to Who's Who in Medicine and Health Care
  • 1992
    Goldenson Technology Award, United Cerebral Palsy Research Foundation
  • 1992
    Selected to Who's Who in the World, 15th Edition
  • 2002
    Selected to Who's Who in Medicine and Health Care
  • 2002
    Selected to Who's Who in America, 57th Edition
  • 2002 and 2002
    Listed in "America's Top Doctors"
  • 2002 and 2002
    Elected to "Best Doctors in America"

Selected Publications

  1. Barkovich AJ. Hypomyelinating disorders: An MRI approach. Neurobiol Dis. 2015 Oct 15.
    View on PubMed
  2. Al-Maawali A, Barry BJ, Rajab A, El-Quessny M, Seman A, Coury SN, Barkovich AJ, Yang E, Walsh CA, Mochida GH, Stoler JM. Novel loss-of-function variants in DIAPH1 associated with syndromic microcephaly, blindness, and early onset seizures. Am J Med Genet A. 2015 Oct 13.
    View on PubMed
  3. Fullerton HJ, Hills NK, Elkind MS, Dowling MM, Wintermark M, Glaser CA, Tan M, Rivkin MJ, Titomanlio L, Barkovich AJ, deVeber GA. Infection, vaccination, and childhood arterial ischemic stroke: Results of the VIPS study. Neurology. 2015 Oct 27; 85(17):1459-66.
    View on PubMed
  4. Takanashi J, Mizuguchi M, Terai M, Barkovich AJ. Disrupted glutamate-glutamine cycle in acute encephalopathy with biphasic seizures and late reduced diffusion. Neuroradiology. 2015 Nov; 57(11):1163-8.
    View on PubMed
  5. Tunovic S, Barañano KW, Barkovich JA, Strober JB, Jamal L, Slavotinek AM. Novel KIF7 missense substitutions in two patients presenting with multiple malformations and features of acrocallosal syndrome. Am J Med Genet A. 2015 Nov; 167(11):2767-76.
    View on PubMed
  6. Wheway G, Schmidts M, Mans DA, Szymanska K, Nguyen TM, Racher H, Phelps IG, Toedt G, Kennedy J, Wunderlich KA, Sorusch N, Abdelhamed ZA, Natarajan S, Herridge W, van Reeuwijk J, Horn N, Boldt K, Parry DA, Letteboer SJ, Roosing S, Adams M, Bell SM, Bond J, Higgins J, Morrison EE, Tomlinson DC, Slaats GG, van Dam TJ, Huang L, Kessler K, Giessl A, Logan CV, Boyle EA, Shendure J, Anazi S, Aldahmesh M, Al Hazzaa S, Hegele RA, Ober C, Frosk P, Mhanni AA, Chodirker BN, Chudley AE, Lamont R, Bernier FP, Beaulieu CL, Gordon P, Pon RT, Donahue C, Barkovich AJ, Wolf L, Toomes C, Thiel CT, Boycott KM, McKibbin M, Inglehearn CF. An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes. Nat Cell Biol. 2015 Aug; 17(8):1074-87.
    View on PubMed
  7. Gano D, Andersen SK, Glass HC, Rogers EE, Glidden DV, Barkovich AJ, Ferriero DM. Impaired cognitive performance in premature newborns with two or more surgeries prior to term-equivalent age. Pediatr Res. 2015 Sep; 78(3):323-9.
    View on PubMed
  8. Esmaeeli Nieh S, Madou MR, Sirajuddin M, Fregeau B, McKnight D, Lexa K, Strober J, Spaeth C, Hallinan BE, Smaoui N, Pappas JG, Burrow TA, McDonald MT, Latibashvili M, Leshinsky-Silver E, Lev D, Blumkin L, Vale RD, Barkovich AJ, Sherr EH. De novo mutations in KIF1A cause progressive encephalopathy and brain atrophy. Ann Clin Transl Neurol. 2015 Jun; 2(6):623-35.
    View on PubMed
  9. Barkovich AJ, Dobyns WB, Guerrini R. Malformations of cortical development and epilepsy. Cold Spring Harb Perspect Med. 2015 May; 5(5):a022392.
    View on PubMed
  10. Nakayama T, Al-Maawali A, El-Quessny M, Rajab A, Khalil S, Stoler JM, Tan WH, Nasir R, Schmitz-Abe K, Hill RS, Partlow JN, Al-Saffar M, Servattalab S, LaCoursiere CM, Tambunan DE, Coulter ME, Elhosary PC, Gorski G, Barkovich AJ, Markianos K, Poduri A, Mochida GH. Mutations in PYCR2, Encoding Pyrroline-5-Carboxylate Reductase 2, Cause Microcephaly and Hypomyelination. Am J Hum Genet. 2015 May 7; 96(5):709-19.
    View on PubMed
  11. D'Gama AM, Geng Y, Couto JA, Martin B, Boyle EA, LaCoursiere CM, Hossain A, Hatem NE, Barry BJ, Kwiatkowski DJ, Vinters HV, Barkovich AJ, Shendure J, Mathern GW, Walsh CA, Poduri A. Mammalian target of rapamycin pathway mutations cause hemimegalencephaly and focal cortical dysplasia. Ann Neurol. 2015 Apr; 77(4):720-5.
    View on PubMed
  12. Vulto-van Silfhout AT, Nakagawa T, Bahi-Buisson N, Haas SA, Hu H, Bienek M, Vissers LE, Gilissen C, Tzschach A, Busche A, Müsebeck J, Rump P, Mathijssen IB, Avela K, Somer M, Doagu F, Philips AK, Rauch A, Baumer A, Voesenek K, Poirier K, Vigneron J, Amram D, Odent S, Nawara M, Obersztyn E, Lenart J, Charzewska A, Lebrun N, Fischer U, Nillesen WM, Yntema HG, Järvelä I, Ropers HH, de Vries BB, Brunner HG, van Bokhoven H, Raymond FL, Willemsen MA, Chelly J, Xiong Y, Barkovich AJ, Kalscheuer VM, Kleefstra T, de Brouwer AP. Variants in CUL4B are Associated with Cerebral Malformations. Hum Mutat. 2015 Jan; 36(1):106-17.
    View on PubMed
  13. Tate MC, Lindquist RA, Nguyen T, Sanai N, Barkovich AJ, Huang EJ, Rowitch DH, Alvarez-Buylla A. Postnatal growth of the human pons: A morphometric and immunohistochemical analysis. J Comp Neurol. 2015 Feb 15; 523(3):449-62.
    View on PubMed
  14. Wintermark M, Hills NK, deVeber GA, Barkovich AJ, Elkind MS, Sear K, Zhu G, Leiva-Salinas C, Hou Q, Dowling MM, Bernard TJ, Friedman NR, Ichord RN, Fullerton HJ. Arteriopathy diagnosis in childhood arterial ischemic stroke: results of the vascular effects of infection in pediatric stroke study. Stroke. 2014 Dec; 45(12):3597-605.
    View on PubMed
  15. Jissendi-Tchofo P, Severino M, Nguema-Edzang B, Toure C, Soto Ares G, Barkovich AJ. Update on neuroimaging phenotypes of mid-hindbrain malformations. Neuroradiology. 2015 Feb; 57(2):113-38.
    View on PubMed
  16. Kanal E, Froelich J, Barkovich AJ, Borgstede J, Bradley W, Gimbel JR, Gosbee J, Greenberg T, Jackson E, Larson P, Lester J, Sebek E, Shellock FG, Weinreb J, Wilkoff BL, Hernandez D. Standardized MR Terminology and Reporting of Implants and Devices as Recommended by the American College of Radiology Subcommittee on MR Safety. Radiology. 2015 Mar; 274(3):866-70.
    View on PubMed
  17. Gano D, Andersen SK, Partridge JC, Bonifacio SL, Xu D, Glidden DV, Ferriero DM, Barkovich AJ, Glass HC. Diminished White Matter Injury over Time in a Cohort of Premature Newborns. J Pediatr. 2015 Jan; 166(1):39-43.
    View on PubMed
  18. Wang DD, Benkli B, Auguste KI, Garcia PA, Sullivan J, Barkovich AJ, Chang EF, Tihan T. Unilateral holohemispheric central nervous system lesions associated with medically refractory epilepsy in the pediatric population: a retrospective series of hemimegalencephaly and Rasmussen's encephalitis. J Neurosurg Pediatr. 2014 Dec; 14(6):573-84.
    View on PubMed
  19. De Ciantis A, Barkovich AJ, Cosottini M, Barba C, Montanaro D, Costagli M, Tosetti M, Biagi L, Dobyns WB, Guerrini R. Ultra-high-field MR imaging in polymicrogyria and epilepsy. AJNR Am J Neuroradiol. 2015 Feb; 36(2):309-16.
    View on PubMed
  20. Rogers EE, Bonifacio SL, Glass HC, Juul SE, Chang T, Mayock DE, Durand DJ, Song D, Barkovich AJ, Ballard RA, Wu YW. Erythropoietin and hypothermia for hypoxic-ischemic encephalopathy. Pediatr Neurol. 2014 Nov; 51(5):657-62.
    View on PubMed

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