University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Mitchel S. Berger, MD

Mitchel S. Berger, MD

Chair, Department of Neurological Surgery, and Director, Brain Tumor Research Center, UCSF
Berthold and Belle N. Guggenhime Professorship, UCSF

Cancer Center Program Memberships

Neurologic Oncology

Research Summary

Dr. Berger's main clinical interests are the treatment of brain tumors in adults and children and of epilepsy related to brain tumors. He has extensive expertise in intraoperative mapping of the brain to identify the sites of motor, sensory, and language function and thereby avoid their involvement or injury during surgery.

Dr. Berger is Director of the Neuro-Oncology Surgery Program. His current research interests involve identifying molecular markers in gliomas as correlates of tumor progression and prognosis. He also works in conjunction with Dr. Krys Bankiewicz to test small molecule inhibitors in brain tumors using convection enhanced delivery. Other collaborations include functional mapping localization of language pathways in the brain in conjunction with Dr. Robert Knight and the Cognitive Neuroscience Graduate Program at UC Berkeley. Dr. Berger is currently the Principal Investigator of UCSF's SPORE Brain Tumor Program. He is also the Principal Investigator of a Pediatric Brain Tumor Foundation Institute award to study the origins and treatment of pediatric brain tumors.

Education

Harvard University, Cambridge, MA, A.B., 1975, Social Psychology
University of Miami, Miami, FL, M.D., 1979, Medicine
University of California, San Francisco, CA (UCSF), Dept. of Neurological Surgery, Brain Tumor Research Center (BTRC) Research Fellow 1983 - 1984 Neurosurgery
UCSF, BTRC, Neuro-Oncology Service, Clinical Fellow, 7/85 - 12/85, Neurosurgery
Hospital for Sick Children, Toronto, Ontario, Canada, Pediatric Neurosurgery Fellow, 1/86 - 6/86, Neurosurgery


Professional Experience

  • 1980 - 1982
    Residency, Dept. of Neurological Surgery, University of California, San Francisco, CA (UCSF)
  • 1986 - 1992
    Asst. Professor, Dept. of Neurological Surgery, University of Washington, Seattle, WA
  • 1990 - 1992
    Assoc. Professor, Dept. of Neurological Surgery, University of Washington, Seattle, WA
  • 1995 - 1992
    American Cancer Society Prof. of Clinical Oncology, University of Washington, Seattle, WA
  • 1996 - 1992
    Professor, Dept. of Neurological Surgery, University of Washington, Seattle, WA
  • 1997 - present
    Professor and Chair, Dept. of Neurological Surgery, UCSF, San Francisco, CA
  • 1997 - present
    Director, Brain Tumor Research Center, Dept. of Neurological Surgery, UCSF

Honors & Awards

  • 1997-Present
    Joint Section on Tumors Advisory Council, American Association of Neurological Surgeons and Congress of Neurological Surgeons
  • 1997-1999
    Vice-President, Congress of Neurological Surgeons; President, Society for Neuro-Oncology
  • 2002-Present
    America’s Top Doctors, peer-nominated referral index from Castle Connolly
  • 2006
    Tumor Section, 2006 Ronald L. Bittner Lecturer; 2006 Farber Award Winner
  • 2007–Present
    Board of Directors of the American Association of Neurological Surgeons
  • 2007–Present
    Member of the American Board of Neurological Surgeons
  • 2010
    Vice-President, American Association of Neurological Surgeons
  • 2011
    President Elect, American Association of Neurological Surgeons
  • 2012
    President, American Association of Neurological Surgeons

Selected Publications

  1. Kim DH, Dacey RG, Zipfel GJ, Berger MS, McDermott M, Barbaro NM, Shapiro SA, Solomon RA, Harbaugh R, Day AL. In Reply: Neurosurgical Education in a Changing Healthcare and Regulatory Environment: A Consensus Statement From 6 Programs. Neurosurgery. 2017 Oct 01; 81(4):E47.
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  2. Chan AK, Han SJ, Choy W, Beleford D, Aghi MK, Berger MS, Shieh JT, Bollen AW, Perry A, Phillips JJ, Butowski N, Solomon DA. Familial melanoma-astrocytoma syndrome: synchronous diffuse astrocytoma and pleomorphic xanthoastrocytoma in a patient with germline CDKN2A/B deletion and a significant family history. Clin Neuropathol. 2017 Sep/Oct; 36(5):213-221.
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  3. Das S, Kim AH, Chang S, Berger MS. Management of Elderly Patients with Glioblastoma after CE.6. Front Oncol. 2017; 7:196.
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  4. Magill ST, Wang DD, Rutledge WC, Lau D, Berger MS, Sankaran S, Lau CY, Imershein SG. Changing Operating Room Culture: Implementation of a Post-Operative Debrief and Improved Safety Culture. World Neurosurg. 2017 Aug 23.
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  5. Alexander BM, Ba S, Berger MS, Berry DA, Cavenee WK, Chang SM, Cloughesy TF, Jiang T, Khasraw M, Li W, Mittman R, Poste GH, Wen PY, Yung WKA, Barker AD. Adaptive Global Innovative Learning Environment for Glioblastoma: GBM AGILE. Clin Cancer Res. 2017 Aug 16.
    View on PubMed
  6. Wang Q, Hu B, Hu X, Kim H, Squatrito M, Scarpace L, deCarvalho AC, Lyu S, Li P, Li Y, Barthel F, Cho HJ, Lin YH, Satani N, Martinez-Ledesma E, Zheng S, Chang E, Sauvé CG, Olar A, Lan ZD, Finocchiaro G, Phillips JJ, Berger MS, Gabrusiewicz KR, Wang G, Eskilsson E, Hu J, Mikkelsen T, DePinho RA, Muller F, Heimberger AB, Sulman EP, Nam DH, Verhaak RGW. Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment. Cancer Cell. 2017 Jul 10; 32(1):42-56.e6.
    View on PubMed
  7. Morshed RA, Han SJ, Lau D, Berger MS. Wavelength-specific lighted suction instrument for 5-aminolevulinic acid fluorescence-guided resection of deep-seated malignant glioma: technical note. J Neurosurg. 2017 Jun 30; 1-6.
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  8. Hirose S, Iijima T, Adachi I, Adamczyk K, Aihara H, Al Said S, Asner DM, Atmacan H, Aulchenko V, Aushev T, Ayad R, Babu V, Badhrees I, Bakich AM, Bansal V, Barberio E, Behera P, Berger M, Bhuyan B, Biswal J, Bondar A, Bonvicini G, Bozek A, Bracko M, Browder TE, Cervenkov D, Chang P, Chen A, Cheon BG, Chilikin K, Chistov R, Cho K, Choi Y, Cinabro D, Danilov M, Dash N, Di Carlo S, Dingfelder J, Doležal Z, Drásal Z, Dutta D, Eidelman S, Epifanov D, Farhat H, Fast JE, Ferber T, Fulsom BG, Gaur V, Gabyshev N, Garmash A, Goldenzweig P, Golob B, Greenwald D, Grygier J, Haba J, Hara K, Hasenbusch J, Hayasaka K, Hayashii H, Higuchi T, Hou WS, Hsu CL, Inami K, Inguglia G, Ishikawa A, Itoh R, Iwasaki Y, Jacobs WW, Jaegle I, Jin Y, Joffe D, Joo KK, Julius T, Kato Y, Kawasaki T, Kichimi H, Kiesling C, Kim DY, Kim JB, Kim KT, Kim MJ, Kim SH, Kinoshita K, Kodyš P, Korpar S, Kotchetkov D, Križan P, Krokovny P, Kuhr T, Kulasiri R, Kumar R, Kwon YJ, Lange JS, Li CH, Li L, Li Y, Li Gioi L, Libby J, Liventsev D, Lubej M, Luo T, MacNaughton J, Masuda M, Matsuda T, Matvienko D, Miyabayashi K, Miyake H, Miyata H, Mizuk R, Mohanty GB, Moon HK, Mori T, Mussa R, Nakao M, Nanut T, Nath KJ, Natkaniec Z, Nayak M, Niiyama M, Nisar NK, Nishida S, Ogawa S, Okuno S, Ono H, Onuki Y, Ostrowicz W, Pakhlov P, Pakhlova G, Pal B, Park CW, Park H, Paul S, Pesántez L, Pestotnik R, Piilonen LE, Prasanth K, Ritter M, Rostomyan A, Rozanska M, Sakai Y, Sandilya S, Santelj L, Sanuki T, Sato Y, Savinov V, Schlüter T, Schneider O, Schnell G, Schwanda C, Seino Y, Senyo K, Seon O, Sevior ME, Shebalin V, Shen CP, Shibata TA, Shiu JG, Simon F, Sokolov A, Solovieva E, Staric M, Strube JF, Sumisawa K, Sumiyoshi T, Takizawa M, Tamponi U, Tenchini F, Trabelsi K, Uchida M, Uglov T, Unno Y, Uno S, Urquijo P, Ushiroda Y, Usov Y, Van Hulse C, Varner G, Varvell KE, Vossen A, Wang CH, Wang MZ, Wang P, Watanabe M, Watanabe Y, Widmann E, Won E, Yamashita Y, Ye H, Yelton J, Yuan CZ, Zhang ZP, Zhilich V, Zhulanov V, Zupanc A. Measurement of the t Lepton Polarization and R(D^{*}) in the Decay B[over ¯]?D^{*}t^{-}?[over ¯]_{t}. Phys Rev Lett. 2017 May 26; 118(21):211801.
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  9. López G, Oberheim Bush NA, Berger MS, Perry A, Solomon DA. Diffuse non-midline glioma with H3F3A K27M mutation: a prognostic and treatment dilemma. Acta Neuropathol Commun. 2017 05 15; 5(1):38.
    View on PubMed
  10. Kim DH, Dacey RG, Zipfel GJ, Berger MS, McDermott M, Barbaro NM, Shapiro SA, Solomon RA, Harbaugh R, Day AL. Neurosurgical Education in a Changing Healthcare and Regulatory Environment: A Consensus Statement from 6 Programs. Neurosurgery. 2017 Apr 01; 80(4S):S75-S82.
    View on PubMed
  11. Kim DH, Duco B, Wolterman D, Stokes C, Brace R, Solomon RA, Barbaro N, Westmark R, MacDougall D, Bean J, O'Leary J, Moayeri N, Dacey RG, Berger MS, Harbaugh R. A Review and Survey of Neurosurgeon-Hospital Relationships: Evolution and Options. Neurosurgery. 2017 Apr 01; 80(4S):S10-S18.
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  12. Jalbert LE, Elkhaled A, Phillips JJ, Neill E, Williams A, Crane JC, Olson MP, Molinaro AM, Berger MS, Kurhanewicz J, Ronen SM, Chang SM, Nelson SJ. Metabolic Profiling of IDH Mutation and Malignant Progression in Infiltrating Glioma. Sci Rep. 2017 Mar 22; 7:44792.
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  13. Pekmezci M, Rice T, Molinaro AM, Walsh KM, Decker PA, Hansen H, Sicotte H, Kollmeyer TM, McCoy LS, Sarkar G, Perry A, Giannini C, Tihan T, Berger MS, Wiemels JL, Bracci PM, Eckel-Passow JE, Lachance DH, Clarke J, Taylor JW, Luks T, Wiencke JK, Jenkins RB, Wrensch MR. Adult infiltrating gliomas with WHO 2016 integrated diagnosis: additional prognostic roles of ATRX and TERT. Acta Neuropathol. 2017 Jun; 133(6):1001-1016.
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  14. Lin CA, Rhodes CT, Lin C, Phillips JJ, Berger MS. Comparative analyses identify molecular signature of MRI-classified SVZ-associated glioblastoma. Cell Cycle. 2017 Apr 18; 16(8):765-775.
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  15. Meng L, McDonagh DL, Berger MS, Gelb AW. Anesthesia for awake craniotomy: a how-to guide for the occasional practitioner. Can J Anaesth. 2017 May; 64(5):517-529.
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  16. Wahl M, Phillips JJ, Molinaro AM, Lin Y, Perry A, Haas-Kogan DA, Costello JF, Dayal M, Butowski N, Clarke JL, Prados M, Nelson S, Berger MS, Chang SM. Chemotherapy for adult low-grade gliomas: clinical outcomes by molecular subtype in a phase II study of adjuvant temozolomide. Neuro Oncol. 2017 02 01; 19(2):242-251.
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  17. Southwell DG, Riva M, Jordan K, Caverzasi E, Li J, Perry DW, Henry RG, Berger MS. Language outcomes after resection of dominant inferior parietal lobule gliomas. J Neurosurg. 2017 Jan 06; 1-9.
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  18. Imber BS, Kanungo I, Braunstein S, Barani IJ, Fogh SE, Nakamura JL, Berger MS, Chang EF, Molinaro AM, Cabrera JR, McDermott MW, Sneed PK, Aghi MK. Indications and Efficacy of Gamma Knife Stereotactic Radiosurgery for Recurrent Glioblastoma: 2 Decades of Institutional Experience. Neurosurgery. 2017 Jan 01; 80(1):129-139.
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  19. Winkler EA, Birk H, Safaee M, Yue JK, Burke JF, Viner JA, Pekmezci M, Perry A, Aghi MK, Berger MS, McDermott MW. Erratum to: Surgical resection of fourth ventricular ependymomas: case series and technical nuances. J Neurooncol. 2017 Jan; 131(2):423.
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  20. Hu B, Wang Q, Wang YA, Hua S, Sauvé CG, Ong D, Lan ZD, Chang Q, Ho YW, Monasterio MM, Lu X, Zhong Y, Zhang J, Deng P, Tan Z, Wang G, Liao WT, Corley LJ, Yan H, Zhang J, You Y, Liu N, Cai L, Finocchiaro G, Phillips JJ, Berger MS, Spring DJ, Hu J, Sulman EP, Fuller GN, Chin L, Verhaak RG, DePinho RA. Epigenetic Activation of WNT5A Drives Glioblastoma Stem Cell Differentiation and Invasive Growth. Cell. 2016 11 17; 167(5):1281-1295.e18.
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