University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Mitchel S. Berger, MD

Mitchel S. Berger, MD

Chair, Department of Neurological Surgery, and Director, Brain Tumor Research Center, UCSF
Berthold and Belle N. Guggenhime Professorship, UCSF

Cancer Center Program Memberships

Neurologic Oncology

Research Summary

Dr. Berger's main clinical interests are the treatment of brain tumors in adults and children and of epilepsy related to brain tumors. He has extensive expertise in intraoperative mapping of the brain to identify the sites of motor, sensory, and language function and thereby avoid their involvement or injury during surgery.

Dr. Berger is Director of the Neuro-Oncology Surgery Program. His current research interests involve identifying molecular markers in gliomas as correlates of tumor progression and prognosis. He also works in conjunction with Dr. Krys Bankiewicz to test small molecule inhibitors in brain tumors using convection enhanced delivery. Other collaborations include functional mapping localization of language pathways in the brain in conjunction with Dr. Robert Knight and the Cognitive Neuroscience Graduate Program at UC Berkeley. Dr. Berger is currently the Principal Investigator of UCSF's SPORE Brain Tumor Program. He is also the Principal Investigator of a Pediatric Brain Tumor Foundation Institute award to study the origins and treatment of pediatric brain tumors.

Education

Harvard University, Cambridge, MA, A.B., 1975, Social Psychology
University of Miami, Miami, FL, M.D., 1979, Medicine
University of California, San Francisco, CA (UCSF), Dept. of Neurological Surgery, Brain Tumor Research Center (BTRC) Research Fellow 1983 - 1984 Neurosurgery
UCSF, BTRC, Neuro-Oncology Service, Clinical Fellow, 7/85 - 12/85, Neurosurgery
Hospital for Sick Children, Toronto, Ontario, Canada, Pediatric Neurosurgery Fellow, 1/86 - 6/86, Neurosurgery


Professional Experience

  • 1980 - 1982
    Residency, Dept. of Neurological Surgery, University of California, San Francisco, CA (UCSF)
  • 1986 - 1992
    Asst. Professor, Dept. of Neurological Surgery, University of Washington, Seattle, WA
  • 1990 - 1992
    Assoc. Professor, Dept. of Neurological Surgery, University of Washington, Seattle, WA
  • 1995 - 1992
    American Cancer Society Prof. of Clinical Oncology, University of Washington, Seattle, WA
  • 1996 - 1992
    Professor, Dept. of Neurological Surgery, University of Washington, Seattle, WA
  • 1997 - present
    Professor and Chair, Dept. of Neurological Surgery, UCSF, San Francisco, CA
  • 1997 - present
    Director, Brain Tumor Research Center, Dept. of Neurological Surgery, UCSF

Honors & Awards

  • 1997-Present
    Joint Section on Tumors Advisory Council, American Association of Neurological Surgeons and Congress of Neurological Surgeons
  • 1997-1999
    Vice-President, Congress of Neurological Surgeons; President, Society for Neuro-Oncology
  • 2002-Present
    America’s Top Doctors, peer-nominated referral index from Castle Connolly
  • 2006
    Tumor Section, 2006 Ronald L. Bittner Lecturer; 2006 Farber Award Winner
  • 2007–Present
    Board of Directors of the American Association of Neurological Surgeons
  • 2007–Present
    Member of the American Board of Neurological Surgeons
  • 2010
    Vice-President, American Association of Neurological Surgeons
  • 2011
    President Elect, American Association of Neurological Surgeons
  • 2012
    President, American Association of Neurological Surgeons

Selected Publications

  1. McKinney A, Lindberg OR, Engler JR, Chen KY, Kumar A, Gong H, Lu KV, Simonds EF, Cloughesy TF, Liau LM, Prados M, Bollen AW, Berger MS, Shieh JTC, James CD, Nicolaides TP, Yong WH, Lai A, Hegi ME, Weiss WA, Phillips JJ. Mechanisms of resistance to EGFR inhibition reveal metabolic vulnerabilities in human GBM. Mol Cancer Ther. 2019 Jul 03.
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  2. Chandra A, Young JS, Dalle Ore C, Dayani F, Lau D, Wadhwa H, Rick JW, Nguyen AT, McDermott MW, Berger MS, Aghi MK. Insurance type impacts the economic burden and survival of patients with newly diagnosed glioblastoma. J Neurosurg. 2019 Jun 21; 1-11.
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  3. Widhalm G, Olson J, Weller J, Bravo J, Han SJ, Phillips J, Hervey-Jumper SL, Chang SM, Roberts DW, Berger MS. The value of visible 5-ALA fluorescence and quantitative protoporphyrin IX analysis for improved surgery of suspected low-grade gliomas. J Neurosurg. 2019 May 10; 1-10.
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  4. Morshed RA, Young JS, Hervey-Jumper SL, Berger MS. The management of low-grade gliomas in adults. J Neurosurg Sci. 2019 Aug; 63(4):450-457.
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  5. Lee JC, Mazor T, Lao R, Wan E, Diallo AB, Hill NS, Thangaraj N, Wendelsdorf K, Samuel D, Kline CN, Banerjee A, Auguste K, Raffel C, Gupta N, Berger M, Raleigh DR, Shai A, Phillips JJ, Bollen AW, Tihan T, Perry A, Costello J, Solomon DA. Recurrent KBTBD4 small in-frame insertions and absence of DROSHA deletion or DICER1 mutation differentiate pineal parenchymal tumor of intermediate differentiation (PPTID) from pineoblastoma. Acta Neuropathol. 2019 May; 137(5):851-854.
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  6. Morshed RA, Young JS, Safaee M, Sankaran S, Berger MS, McDermott MW, Hervey-Jumper SL. Delirium Risk Factors and Associated Outcomes in a Neurosurgical Cohort: A Case-Control Study. World Neurosurg. 2019 Mar 11.
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  7. Sabelström H, Quigley DA, Fenster T, Foster DJ, Fuchshuber CAM, Saxena S, Yuan E, Li N, Paterno F, Phillips JJ, James CD, Norling B, Berger MS, Persson AI. High density is a property of slow-cycling and treatment-resistant human glioblastoma cells. Exp Cell Res. 2019 May 01; 378(1):76-86.
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  8. Li YB, Shen CP, Yuan CZ, Adachi I, Aihara H, Al Said S, Asner DM, Aushev T, Ayad R, Badhrees I, Ban Y, Bansal V, Beleño C, Berger M, Bhardwaj V, Bhuyan B, Bilka T, Biswal J, Bondar A, Bozek A, Bracko M, Cao L, Cervenkov D, Chen A, Cheon BG, Chilikin K, Cho K, Choi SK, Choi Y, Cinabro D, Cunliffe S, Di Carlo S, Doležal Z, Dong TV, Drásal Z, Eidelman S, Fast JE, Fulsom BG, Garg R, Gaur V, Gabyshev N, Garmash A, Giri A, Goldenzweig P, Greenwald D, Grube B, Hayasaka K, Hayashii H, Hsu CL, Iijima T, Inami K, Inguglia G, Ishikawa A, Itoh R, Iwasaki M, Iwasaki Y, Jacobs WW, Jia S, Jin Y, Joffe D, Joo KK, Karyan G, Kawasaki T, Kichimi H, Kim DY, Kim HJ, Kim JB, Kim KT, Kim SH, Kinoshita K, Kodyš P, Korpar S, Kotchetkov D, Križan P, Kroeger R, Krokovny P, Kumita T, Kuzmin A, Kwon YJ, Lee JY, Lee SC, Li LK, Li Gioi L, Libby J, Liventsev D, Lubej M, MacNaughton J, Masuda M, Matsuda T, Merola M, Miyabayashi K, Miyata H, Mizuk R, Mohanty GB, Mussa R, Nakano E, Nakao M, Nath KJ, Nayak M, Niiyama M, Nishida S, Ono H, Onuki Y, Pakhlov P, Pakhlova G, Pal B, Pardi S, Park SH, Paul S, Pedlar TK, Pestotnik R, Piilonen LE, Popov V, Prencipe E, Russo G, Sakai Y, Salehi M, Sandilya S, Santelj L, Sanuki T, Savinov V, Schneider O, Schnell G, Schueler J, Schwanda C, Schwartz AJ, Seino Y, Senyo K, Sevior ME, Shibata TA, Shiu JG, Shwartz B, Solovieva E, Staric M, Sumihama M, Sumiyoshi T, Sutcliffe W, Takizawa M, Tanida K, Tao Y, Tenchini F, Trabelsi K, Uchida M, Uglov T, Unno Y, Uno S, Urquijo P, Van Tonder R, Varner G, Wang B, Wang CH, Wang MZ, Wang P, Wang XL, Won E, Yang SB, Ye H, Yelton J, Yin JH, Yusa Y, Zhang ZP, Zhilich V, Zhukova V. First Measurements of Absolute Branching Fractions of the ?_{c}^{0} Baryon at Belle. Phys Rev Lett. 2019 Mar 01; 122(8):082001.
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  9. Morshed RA, Young JS, Han SJ, Hervey-Jumper SL, Berger MS. The transcortical equatorial approach for gliomas of the mesial temporal lobe: techniques and functional outcomes. J Neurosurg. 2019 Mar 01; 130(3):822-830.
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  10. Sumihama M, Adachi I, Ahn JK, Aihara H, Al Said S, Asner DM, Atmacan H, Aushev T, Ayad R, Babu V, Badhrees I, Bahinipati S, Bakich AM, Bansal V, Beleño C, Berger M, Bhardwaj V, Bhuyan B, Bilka T, Biswal J, Bonvicini G, Bozek A, Bracko M, Browder TE, Cervenkov D, Chekelian V, Chen A, Cheon BG, Chilikin K, Cho K, Choi SK, Choi Y, Choudhury S, Cinabro D, Cunliffe S, Czank T, Dash N, Di Carlo S, Doležal Z, Dong TV, Drásal Z, Eidelman S, Epifanov D, Fast JE, Fulsom BG, Garg R, Gaur V, Gabyshev N, Garmash A, Gelb M, Giri A, Goldenzweig P, Guido E, Haba J, Hayasaka K, Hayashii H, Hirose S, Hou WS, Inami K, Inguglia G, Ishikawa A, Itoh R, Iwasaki M, Iwasaki Y, Jacobs WW, Jeon HB, Jia S, Jin Y, Joo KK, Julius T, Kaliyar AB, Kang KH, Karyan G, Kato Y, Kiesling C, Kim DY, Kim JB, Kim KT, Kim SH, Kinoshita K, Kodyš P, Korpar S, Kotchetkov D, Križan P, Kroeger R, Krokovny P, Kumar R, Kuzmin A, Kwon YJ, Lange JS, Lee IS, Lee SC, Li LK, Li YB, Li Gioi L, Libby J, Liventsev D, Lubej M, Luo T, Masuda M, Matsuda T, Matvienko D, Merola M, Miyabayashi K, Miyata H, Mizuk R, Mohanty GB, Moon HK, Mori T, Mussa R, Nakano E, Nakano T, Nakao M, Nanut T, Nath KJ, Natkaniec Z, Niiyama M, Nisar NK, Nishida S, Ono H, Pakhlov P, Pakhlova G, Pal B, Pardi S, Park H, Paul S, Pedlar TK, Pestotnik R, Piilonen LE, Popov V, Ritter M, Russo G, Sahoo D, Sandilya S, Santelj L, Sanuki T, Savinov V, Schneider O, Schnell G, Schwanda C, Seino Y, Senyo K, Sevior ME, Shebalin V, Shen CP, Shibata TA, Shiu JG, Shwartz B, Simon F, Sokolov A, Solovieva E, Staric M, Strube JF, Sumiyoshi T, Takizawa M, Tamponi U, Tanida K, Taniguchi N, Tenchini F, Uchida M, Uglov T, Uno S, Urquijo P, Vahsen SE, Van Hulse C, Varner G, Vorobyev V, Vossen A, Wang B, Wang CH, Wang MZ, Wang P, Wang XL, Watanabe M, Watanuki S, Widmann E, Won E, Ye H, Yelton J, Yuan CZ, Yusa Y, Zakharov S, Zhang ZP, Zhilich V, Zhukova V, Zhulanov V. Observation of ?(1620)^{0} and Evidence for ?(1690)^{0} in ?_{c}^{+}??^{-}p^{+}p^{+} Decays. Phys Rev Lett. 2019 Feb 22; 122(7):072501.
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  11. Ries SK, Piai V, Perry D, Griffin S, Jordan K, Henry R, Knight RT, Berger MS. Roles of ventral versus dorsal pathways in language production: An awake language mapping study. Brain Lang. 2019 04; 191:17-27.
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  12. Guan Y, Vossen A, Adachi I, Adamczyk K, Ahn JK, Aihara H, Al Said S, Asner DM, Atmacan H, Aulchenko V, Aushev T, Ayad R, Babu V, Badhrees I, Bakich AM, Bansal V, Behera P, Beleño C, Berger M, Bhardwaj V, Bhuyan B, Bilka T, Biswal J, Bobrov A, Bonvicini G, Bozek A, Bracko M, Browder TE, Cao L, Cervenkov D, Chang P, Chekelian V, Chen A, Cheon BG, Chilikin K, Cho K, Choi SK, Choi Y, Cinabro D, Cunliffe S, Dash N, Di Carlo S, Dingfelder J, Doležal Z, Dong TV, Drásal Z, Eidelman S, Epifanov D, Fast JE, Ferber T, Fulsom BG, Garg R, Gaur V, Gabyshev N, Garmash A, Gelb M, Giri A, Goldenzweig P, Golob B, Guido E, Haba J, Hayasaka K, Hayashii H, Hirose S, Hou WS, Iijima T, Inami K, Inguglia G, Ishikawa A, Itoh R, Iwasaki M, Iwasaki Y, Jacobs WW, Jaegle I, Jeon HB, Jia S, Jin Y, Joffe D, Joo KK, Julius T, Kang KH, Kawasaki T, Kiesling C, Kim DY, Kim HJ, Kim JB, Kim KT, Kim SH, Kinoshita K, Kodyš P, Korpar S, Kotchetkov D, Križan P, Kroeger R, Krokovny P, Kuhr T, Kulasiri R, Kuzmin A, Kwon YJ, Lange JS, Lee IS, Lee SC, Li LK, Li YB, Li Gioi L, Libby J, Liventsev D, Lubej M, Luo T, Masuda M, Matsuda T, Matvienko D, Merola M, Miyata H, Mizuk R, Mohanty GB, Moon HK, Mori T, Mussa R, Nakao M, Nanut T, Nath KJ, Natkaniec Z, Nayak M, Niiyama M, Nisar NK, Nishida S, Ogawa S, Okuno S, Ono H, Pakhlov P, Pakhlova G, Pal B, Pardi S, Park H, Paul S, Pedlar TK, Pestotnik R, Piilonen LE, Popov V, Prencipe E, Rabusov A, Rostomyan A, Russo G, Sahoo D, Sakai Y, Salehi M, Sandilya S, Santelj L, Sanuki T, Savinov V, Schneider O, Schnell G, Schwanda C, Seidl R, Seino Y, Senyo K, Seon O, Sevior ME, Shebalin V, Shen CP, Shibata TA, Shiu JG, Simon F, Sokolov A, Solovieva E, Staric M, Strube JF, Sumihama M, Sumiyoshi T, Sutcliffe W, Suzuki K, Takizawa M, Tamponi U, Tanida K, Tenchini F, Uchida M, Uglov T, Unno Y, Uno S, Urquijo P, Usov Y, Vahsen SE, Van Hulse C, Van Tonder R, Varner G, Vinokurova A, Vorobyev V, Waheed E, Wang B, Wang CH, Wang MZ, Wang P, Wang XL, Watanuki S, Widmann E, Won E, Ye H, Yelton J, Yin JH, Yuan CZ, Yusa Y, Zhang ZP, Zhilich V, Zhukova V, Zhulanov V, Zupanc A. Observation of Transverse ?/?[over ¯] Hyperon Polarization in e^{+}e^{-} Annihilation at Belle. Phys Rev Lett. 2019 Feb 01; 122(4):042001.
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  13. Berger MS. Erratum. Obituary. Charles B. Wilson, MD, 1929-2018. J Neurosurg. 2019 Jan 11; 130(3):1022.
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  14. Karsy M, Park MS, Bekelis K, Braca JA, Nahed BV, Colen CB, Barbaro NM, Berger MS, Mukherjee D. Commentary: Deficiencies in Socioeconomic Training During Neurosurgical Training. Neurosurgery. 2019 Jan 01; 84(1):E79-E85.
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  15. Müller DMJ, Robe PAJT, Eijgelaar RS, Witte MG, Visser M, de Munck JC, Broekman MLD, Seute T, Hendrikse J, Noske DP, Vandertop WP, Barkhof F, Kouwenhoven MCM, Mandonnet E, Berger MS, De Witt Hamer PC. Comparing Glioblastoma Surgery Decisions Between Teams Using Brain Maps of Tumor Locations, Biopsies, and Resections. JCO Clin Cancer Inform. 2019 01; 3:1-12.
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  16. Hervey-Jumper SL, Berger MS. Insular glioma surgery: an evolution of thought and practice. J Neurosurg. 2019 Jan 01; 130(1):9-16.
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  17. Yang T, Xu G, Newton PT, Chagin AS, Mkrtchian S, Carlström M, Zhang XM, Harris RA, Cooter M, Berger M, Maddipati KR, Akassoglou K, Terrando N. Maresin 1 attenuates neuroinflammation in a mouse model of perioperative neurocognitive disorders. Br J Anaesth. 2019 Mar; 122(3):350-360.
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  18. Traut T, Sardesh N, Bulubas L, Findlay A, Honma SM, Mizuiri D, Berger MS, Hinkley LB, Nagarajan SS, Tarapore PE. MEG imaging of recurrent gliomas reveals functional plasticity of hemispheric language specialization. Hum Brain Mapp. 2019 Mar; 40(4):1082-1092.
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  19. Fulsom BG, Pedlar TK, Adachi I, Aihara H, Al Said S, Asner DM, Atmacan H, Aulchenko V, Aushev T, Ayad R, Babu V, Badhrees I, Bakich AM, Bansal V, Behera P, Beleño C, Berger M, Bhardwaj V, Bhuyan B, Bilka T, Biswal J, Bondar A, Bonvicini G, Bozek A, Bracko M, Browder TE, Cao L, Cervenkov D, Chekelian V, Chen A, Cheon BG, Chilikin K, Cho K, Choi SK, Choi Y, Choudhury S, Cinabro D, Cunliffe S, Dash N, Di Carlo S, Dingfelder J, Doležal Z, Dong TV, Drásal Z, Eidelman S, Epifanov D, Fast JE, Ferber T, Garg R, Gaur V, Gabyshev N, Garmash A, Gelb M, Giri A, Goldenzweig P, Guido E, Haba J, Hayasaka K, Hayashii H, Hirose S, Hou WS, Iijima T, Inami K, Inguglia G, Ishikawa A, Itoh R, Iwasaki M, Iwasaki Y, Jacobs WW, Jeon HB, Jia S, Jin Y, Joffe D, Joo KK, Julius T, Kawasaki T, Kichimi H, Kiesling C, Kim DY, Kim HJ, Kim JB, Kim KT, Kim SH, Kinoshita K, Kodyš P, Korpar S, Kotchetkov D, Križan P, Kroeger R, Krokovny P, Kuhr T, Kulasiri R, Kuzmin A, Kwon YJ, Lange JS, Lee IS, Lee SC, Li LK, Li YB, Li Gioi L, Libby J, Liventsev D, Lubej M, Luo T, Masuda M, Matsuda T, Matvienko D, Merola M, Miyabayashi K, Miyata H, Mizuk R, Mohanty GB, Moon HK, Mori T, Mussa R, Nakao M, Nanut T, Nath KJ, Natkaniec Z, Nayak M, Niiyama M, Nisar NK, Nishida S, Ogawa S, Okuno S, Ono H, Pakhlov P, Pakhlova G, Pal B, Pardi S, Park H, Paul S, Pestotnik R, Piilonen LE, Popov V, Prencipe E, Rabusov A, Ritter M, Rostomyan A, Russo G, Sakai Y, Salehi M, Sandilya S, Santelj L, Sanuki T, Savinov V, Schneider O, Schnell G, Schwanda C, Seino Y, Senyo K, Sevior ME, Shebalin V, Shen CP, Shibata TA, Shiu JG, Shwartz B, Simon F, Singh JB, Sokolov A, Solovieva E, Staric M, Strube JF, Sumihama M, Sumisawa K, Sumiyoshi T, Sutcliffe W, Takizawa M, Tamponi U, Tanida K, Tenchini F, Uchida M, Uglov T, Unno Y, Uno S, Urquijo P, Vahsen SE, Van Hulse C, Van Tonder R, Varner G, Vinokurova A, Vorobyev V, Vossen A, Wang B, Wang CH, Wang P, Wang XL, Watanabe M, Watanuki S, Widmann E, Won E, Ye H, Yin JH, Yuan CZ, Zhang ZP, Zhilich V, Zhukova V, Zhulanov V, Zupanc A. Observation of ?(2S)???_{b}(1S) Decay. Phys Rev Lett. 2018 Dec 07; 121(23):232001.
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  20. Finbloom JA, Aanei IL, Bernard JM, Klass SH, Elledge SK, Han K, Ozawa T, Nicolaides TP, Berger MS, Francis MB. Evaluation of Three Morphologically Distinct Virus-Like Particles as Nanocarriers for Convection-Enhanced Drug Delivery to Glioblastoma. Nanomaterials (Basel). 2018 Dec 05; 8(12).
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