Assistant Professor, Hematology and Oncology, UCSF
Additional Websites
Education
Vanderbilt University, B.S., 1998, Molecular Biology
New York University, School of Medicine, Ph.D., 2004, Cell and Mol. Biology
New York University, School of Medicine, M.D., 2005, Medicine
Brigham and Women’s Hospital/Harvard, 2005-2007, Internal Medicine
Memorial Sloan-Kettering Cancer Center, 2007-2011, Medical Oncology
Professional Experience
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1998-2005
MD-PhD, Medical Scientist Training Program, NYU School of Medicine
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2005-2007
Resident House Staff, Internal Medicine, Brigham and Women’s Hospital
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2007-2011
Medical Oncology Fellow, Memorial Sloan-Kettering Cancer Center
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2008-2011
Research Fellow, Laboratory of Charles Sawyers, Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center
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7/2011-present
Assistant Professor, Department of Medicine, Division of Hematology/Oncology, University of California, San Francisco
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7/2011- present
Member, UCSF Helen Diller Comprehensive Cancer Center
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7/2011- present
Faculty Member, California Institute for Quantitative Biosciences (QB3)
Honors & Awards
- 1998
Vanderbilt University Honors Degree in Molecular Biology - 1998
Vanderbilt University Research Excellence Award - 1998-2005
NIH Medical Scientist Training Program Award - 2005
Medical Science Writing Award, NYU School of Medicine - 2007
US Patent 20060083742 Prenyl-electrostatic Switch - 2008-2010
Charles A. Dana Foundation Clinical Scholars Research Fellowship - 2009
Julia Zelmanovich Young Alumnus Award, NYU School of Medicine - 2010
American Society of Clinical Oncology Young Investigator Award - 2010
Uniting Against Lung Cancer Research Investigator - 2011
NIH/NCI Clinical Investigator Career Development Award (K08)
- 2012
National Lung Cancer Partnership Young Investigator Award
- 2012
Sidney Kimmel Foundation Kimmel Scholar Award
- 2012
Damon Runyon Clinical Investigator Award Finalist
- 2012
Doris Duke Clinical Scientist Development Award
- 2012
American Lung Association Lung Cancer Discovery Award
- 2012
Doris Duke Charitable Foundation Clinical Scientist Development Award - 2012
Visiting Scholar Howard Hughes Medical Institute (HHMI) Scholars Program at California, State University-Fullerton - 2012
NIH Director's New Innovator Award (DP2)
Selected Publications
- Hrustanovic G, Lee BJ, Bivona TG. Mechanisms of resistance to EGFR targeted therapies. Cancer Biol Ther. 2013 Apr 1; 14(4):304-14.
View on PubMed - Neel DS, Bivona TG. Secrets of Drug Resistance in NSCLC Exposed by New Molecular Definition of EMT. Clin Cancer Res. 2013 Jan 1; 19(1):3-5.
View on PubMed - Blakely CM, Bivona TG. Resiliency of Lung Cancers to EGFR Inhibitor Treatment Unveiled, Offering Opportunities to Divide and Conquer EGFR Inhibitor Resistance. Cancer Discov. 2012 Oct; 2(10):872-5.
View on PubMed - Lin L, Bivona TG. Mechanisms of Resistance to Epidermal Growth Factor Receptor Inhibitors and Novel Therapeutic Strategies to Overcome Resistance in NSCLC Patients. Chemother Res Pract. 2012; 2012:817297.
View on PubMed - Zhang Z, Lee JC, Lin L, Olivas V, Au V, LaFramboise T, Abdel-Rahman M, Wang X, Levine AD, Rho JK, Choi YJ, Choi CM, Kim SW, Jang SJ, Park YS, Kim WS, Lee DH, Lee JS, Miller VA, Arcila M, Ladanyi M, Moonsamy P, Sawyers C, Boggon TJ, Ma PC, Costa C, Taron M, Rosell R, Halmos B, Bivona TG. Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer. Nat Genet. 2012 Aug; 44(8):852-60.
View on PubMed - Morris LG, Taylor BS, Bivona TG, Gong Y, Eng S, Brennan CW, Kaufman A, Kastenhuber ER, Banuchi VE, Singh B, Heguy A, Viale A, Mellinghoff IK, Huse J, Ganly I, Chan TA. Genomic dissection of the epidermal growth factor receptor (EGFR)/PI3K pathway reveals frequent deletion of the EGFR phosphatase PTPRS in head and neck cancers. Proc Natl Acad Sci U S A. 2011 Nov 22; 108(47):19024-9.
View on PubMed - Bivona TG, Hieronymus H, Parker J, Chang K, Taron M, Rosell R, Moonsamy P, Dahlman K, Miller VA, Costa C, Hannon G, Sawyers CL. FAS and NF-?B signalling modulate dependence of lung cancers on mutant EGFR. Nature. 2011 Mar 24; 471(7339):523-6.
View on PubMed - Rosell R, Molina MA, Costa C, Simonetti S, Gimenez-Capitan A, Bertran-Alamillo J, Mayo C, Moran T, Mendez P, Cardenal F, Isla D, Provencio M, Cobo M, Insa A, Garcia-Campelo R, Reguart N, Majem M, Viteri S, Carcereny E, Porta R, Massuti B, Queralt C, de Aguirre I, Sanchez JM, Sanchez-Ronco M, Mate JL, Ariza A, Benlloch S, Sanchez JJ, Bivona TG, Sawyers CL, Taron M. Pretreatment EGFR T790M mutation and BRCA1 mRNA expression in erlotinib-treated advanced non-small-cell lung cancer patients with EGFR mutations. Clin Cancer Res. 2011 Mar 1; 17(5):1160-8.
View on PubMed - Quatela SE, Sung PJ, Ahearn IM, Bivona TG, Philips MR. Analysis of K-Ras phosphorylation, translocation, and induction of apoptosis. Methods Enzymol. 2008; 439:87-102.
View on PubMed - Bivona TG, Quatela SE, Bodemann BO, Ahearn IM, Soskis MJ, Mor A, Miura J, Wiener HH, Wright L, Saba SG, Yim D, Fein A, Pérez de Castro I, Li C, Thompson CB, Cox AD, Philips MR. PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis. Mol Cell. 2006 Feb 17; 21(4):481-93.
View on PubMed - Bivona TG, Quatela S, Philips MR. Analysis of Ras activation in living cells with GFP-RBD. Methods Enzymol. 2006; 407:128-43.
View on PubMed - Bivona TG, Philips MR. Analysis of Ras and Rap activation in living cells using fluorescent Ras binding domains. Methods. 2005 Oct; 37(2):138-45.
View on PubMed - Jordan JD, He JC, Eungdamrong NJ, Gomes I, Ali W, Nguyen T, Bivona TG, Philips MR, Devi LA, Iyengar R. Cannabinoid receptor-induced neurite outgrowth is mediated by Rap1 activation through G(alpha)o/i-triggered proteasomal degradation of Rap1GAPII. J Biol Chem. 2005 Mar 25; 280(12):11413-21.
View on PubMed - Dustin ML, Bivona TG, Philips MR. Membranes as messengers in T cell adhesion signaling. Nat Immunol. 2004 Apr; 5(4):363-72.
View on PubMed - Walker SA, Kupzig S, Bouyoucef D, Davies LC, Tsuboi T, Bivona TG, Cozier GE, Lockyer PJ, Buckler A, Rutter GA, Allen MJ, Philips MR, Cullen PJ. Identification of a Ras GTPase-activating protein regulated by receptor-mediated Ca2+ oscillations. EMBO J. 2004 Apr 21; 23(8):1749-60.
View on PubMed - Perez de Castro I, Bivona TG, Philips MR, Pellicer A. Ras activation in Jurkat T cells following low-grade stimulation of the T-cell receptor is specific to N-Ras and occurs only on the Golgi apparatus. Mol Cell Biol. 2004 Apr; 24(8):3485-96.
View on PubMed - Zhang SQ, Yang W, Kontaridis MI, Bivona TG, Wen G, Araki T, Luo J, Thompson JA, Schraven BL, Philips MR, Neel BG. Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment. Mol Cell. 2004 Feb 13; 13(3):341-55.
View on PubMed - Bivona TG, Wiener HH, Ahearn IM, Silletti J, Chiu VK, Philips MR. Rap1 up-regulation and activation on plasma membrane regulates T cell adhesion. J Cell Biol. 2004 Feb 2; 164(3):461-70.
View on PubMed - Mohney RP, Das M, Bivona TG, Hanes R, Adams AG, Philips MR, O'Bryan JP. Intersectin activates Ras but stimulates transcription through an independent pathway involving JNK. J Biol Chem. 2003 Nov 21; 278(47):47038-45.
View on PubMed - Bivona TG, Pérez De Castro I, Ahearn IM, Grana TM, Chiu VK, Lockyer PJ, Cullen PJ, Pellicer A, Cox AD, Philips MR. Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1. Nature. 2003 Aug 7; 424(6949):694-8.
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