Nancy J. Boudreau, PhD

Nancy J. Boudreau, PhD

Professor, Department of Surgery, UCSF

Phone: (415) 206-6951 (voice)
Box 1302, UCSF
San Francisco, CA 94143-1302

UCSF Profiles

Cancer Center Membership

Associate Member » Breast Oncology» Cancer, Immunity, and Microenvironment


Dalhousie University, Halifax, Nova Scotia, Canada, B.Sc. (Hon), 1981, Biology
Dalhousie University, Halifax, Nova Scotia, Canada, M.Sc., 1984, Pharmacology
University of Toronto, Ph.D., 1991, Pathology

Professional Experience

  • 1985-1987
    Research Assistant, Division of Cardiovascular Research, Hospital for Sick Children, Toronto, Ontario, Canada; Maintenance of vascular cell differentiated phenotype in culture
  • 1987-1991
    Graduate Student, Department of Pathology, University of Toronto; Extracellular matrix and vascular cell behavior. Ontario Graduate Scholarship-1989; University of Toronto Open Graduate Fellowship-1989; Emmanuel Farber Award in Pathology-1989; Canadian Society of Clinical Investigation Trainee Award-1990; Medical Research Council of Canada Studentship-1990
  • 1991-1995
    Postdoctoral Fellow, Laboratory of Cell and Molecular Biology, LBL, University of California, Berkeley; Susceptibility of endothelium to transformation in the chick embryo: Apoptosis and the regulation of gene expression by the extracellular matrix. Medical Research Council of Canada Fellowship-1992-1995.
  • 1995-1996
    Postdoctoral Fellow, Department of Vascular Biology and Immunology, The Scripps Research Institute, La Jolla, CA; Extracellular matrix regulation of endothelial homeobox expression and regulation of endothelial integrin expression in angiogenesis. Joseph Drown Foundation Fellowship–1995-1996.
  • 1996-1998
    Assistant Professor, Department of Anatomy, Medical College of Virginia, Richmond, VA; Homeobox genes and angiogenesis and regulation of endothelial gene expression by the extracellular matrix
  • 1998-2003
    Assistant Professor, Department of Surgery, University of California, San Francisco
  • 2003-present
    Director, Surgical Research Lab, San Francisco General Hospital
  • 3003-present
    Associate Professor, Department of Surgery, University of California, San Francisco
  • 2009-present
    Professor, Department of Surgery, University of California San Francisco

Honors & Awards

  • 1989
    Ontario Graduate Scholarship
  • 1989
    University of Toronto Open Graduate Fellowship
  • 1989
    Emmanuel Farber Award in Pathology
  • 1990
    Canadian Society of Clinical Investigation Trainee Award
  • 1990
    Medical Research Council of Canada Studentship
  • 1992-1995
    Medical Research Council of Canada Fellowship
  • 1995-1996
    Joseph Drown Foundation Fellowship

Selected Publications

  • Martins-Green, M., Boudreau, N. and Bissell, M.J. (1994) Inflammation is responsible for the development of wound-induced tumors in chickens infected with Rous sarcoma virus. Cancer Research 54:4334-4341.
  • Boudreau, N., Sympson, C., Werb, Z. and Bissell, M. (1995) Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix. Science 287:891-893.
  • Boudreau, N., Myers, C.A. and Bissell, M.J. (1995) From laminin to lamin: Regulation of tissue-specific gene expression by the ECM. Trends in Cell Biology 5:1-4.
  • Jones, P.L., Boudreau, N., Myers, C.A., Erikson, H. and Bissell, M. (1995) Tenascin-C inhibits extracellular matrix-dependent gene expression in mammary epithelial cells. J. Cell Science 108:519-527.
  • Boudreau, N., Reddy, S., Stoker, A., Fairman, C. and Bissell, M. (1995) The extracellular matrix attenuates v-src oncogenesis in chick chondroblasts. Molec. Cell Diff. 3:261-274.
  • Boudreau, N., Martins-Green, M. and Bissell, M.J. (1994) Oncogenic transformation in chick embryos correlates with cell differentiation. Molec. Biol. Cell 4, 355a.
  • Boudreau, N., Werb, Z., and Bissell, M.J. (1996) Suppression of apoptosis requires basement membrane induced three-dimensional tissue organization and cell cycle withdrawal. Proc. Natl. Acad. Sci. USA 93:3509-3513.
  • Boudreau, N., and Bissell, M.J. (1996) Regulation of Gene Expression by the Extracellular Matrix, In: Structure and Function of Extracellular Matrices of Connective Tissue, Comper, W., ed., Gordon and Breach, Volume 2.
  • Zhou, B., Boudreau, N., Hammabeck, J., Coulber, C. and Rabinovitch, M. (1997) Microtubule associated protein-1 light chain 3 is a fibronectin mRNA binding protein linked to mRNA translation. J. Clin. Invest. 100:3070-3082.
  • Boudreau, N., Andrews, C., Srebrow, A., Ravanpay, A., and Cheresh, D.A. (1997) Hox D3 mediates an angiogenic phenotype in endothelial cells. J. Cell Biol. 139:257-264.
  • Boudreau, N., and Bissell, M.J. (1998) Extracellular matrix signaling: Integration of form and function in normal and malignant cells. Curr. Op. Cell Biol. 10(5):640-646.
  • Boudreau, N., and Jones, P.L. (1999) Extracellular matrix and integrin signaling: The shape of things to come. Biochem. J. 339:481-488.
  • Myers, C.A., Charboneau, A. and Boudreau, N. (2000) Homeobox B3 promotes capillary morphogenesis and angiogenesis. J. Cell Biol. 148:348-351.
  • Boudreau, N. and Bissell, M.J. (2001) Extracellular Matrix: The Networking Solution. IN: The Cancer Handbook, Gullick, W. and Saloman, D., Eds., MacMillan Press. In Press.
  • Uyeno, L., Newman-Keagle, J., Cheung, I., Hunt, T.K., Young, D.M. and Boudreau, N. (2001) Homeobox D3 in normal and impaired wound healing. J. Surg. Res. 100:46-56.
  • Hashimoto, T., Lam, T. X., Boudreau, N., Bollen, A. and Young, W.L. (2001) Abnormal Balance in Angiopoietin-Tie-2 Signaling in Human Brain Arteriovenous Malformations. Circ. Res. 89:111-113.
  • Myers, C. A., Charboneau, A., Cheung, I. and Boudreau, N. (2002) Homeobox D10 inhibits VEGF-induced angiogenesis in vivo. Am. J. Pathol. 161:2099-2019.
  • Hashimoto T., Wen G., Boudreau N., Lawson M.T. Yang G-Y.Barbaro N.M., Dowd C.F., Halbach V.V. and Yung W.L. (2002) Abnormal expresson of MMP and TIMPs in BAVMs. Stroke 34:925-931.
  • Boudreau, N. and C. Myers (2002) Angiogenesis in breast cancer- the role of the microenvironment Breast Cancer Res. 5:140-146.
  • Zhong, J., Zhu, Y., Elicieri, B., Stupack, D., Howell, G., Wilson, E., Penta, K., Sakamoto, G., Quertermous, T., Boudreau, N., Colemen, M. and Varner, J. (2002) Neovascularization of ischemic tissue by gene delivery of Del-1. J. Clin. Invest. 112:30-41.
  • Boudreau, N. (2003) Organized Living: From cell surfaces to basement membranes. Science STKE 196:34.
  • Hansen, S.L., Myers, C.A., Young, D.M. and Boudreau, N. (2003) Gene transfer of Hox D3 accelerates wound repair in diabetic (db/db) mice. Am. J. Pathology 163:1-11.
  • Hansen, S.L., Young, D. and Boudreau, N. (2003) Hox D3 and collagen expression in diabetic fibroblasts. Wound Rep. Regen. 11:474-480.
  • Boudreau, N., and Varner, J.A. (2004) The homeobox transcription factor Hox D3 directly regulates Beta3 and Alpha 5 integrin expression in angiogenic endothelium. J. Biol. Chem. 279(6):4862-8.
  • Hashimoto, T., Wu, Y., Boudreau, N., Li, J., Matsumoto, M., and Young, W. (2004) Regulation of Tie2 expression by angiopoietin-potential feedback system. Endothelium 11(3-4):207-210.
  • Chen Y, Xu B, Arderiu G, Hashimoto T, Young WL, Boudreau N, et al. Retroviral delivery of Homeobox D3 gene induces cerebral angiogenesis in mice (2004). J Cereb Blood Flow Metab. 24:1280-1287.
  • Cambier, S., Gline, S.E., Araya, J, Collins, R., Einheber, S., Dolganov, G., Boudreau, N., Nishimura, S.L., (2005) Integrin alpha(v)beta8-mediated activation of TGF-beta: an angiogenic control switch, Am. J. Path., 166, 1883-1894
  • Mace K.A. Hansen, S.L., Myers, C., Young, D. and Boudreau, N. (2005) Hox A3 induces angiogenesis and wound repair. J. Cell Sci. . 118, 2567-2577.
  • Carrio, M., Myers, C.A. G. Arderiu and Boudreau, N. (2005) Hox D10 inhibits breast tumor cell migration and growth in vivo. Cancer Research, 65, 1-10.
  • Charbonneau A., N . Malek , L. East , M. Rohde and N. Boudreau (2005). The co-factor Pbx-1 is required for HoxD3–dependent angiogenesis in vivo- Angiogenesis-In Press
  • Morimoto-Tomita,M., K. Uchimura, A. Bistrup, D. Lum, M. Egeblad, N. Boudreau Z. Werb, and S. D. Rosen (2005) SULF-2, a proangiogenic heparan sulfate endosulfatase, is upregulated in breast cancer–Neoplasia 7, 1001-1010.
  • Rhoads, K., Arderiu, G., Charboneau A., Hansen,S.L., Hoffman,W., and N. Boudreau (2005) A role for Hox A5 in regulating angiogenesis and vascular patterning –Lymphatic Research and Biology 3(4) 240-252
  • Charbonneau A., N . Malek , L. East , M. Rohde and N. Boudreau (2005). The co-factor Pbx-1 is required for HoxD3–dependent angiogenesis in vivo- Angiogenesis November 19, 1-8 2005- epub online, Boudreau, N. and WM Weaver (2006) Forcing the Third Dimension Cell 125, 11-12.
  • Hansen, S.L. A. Dosanjh, D. M. Young, N. Boudreau, and W. Y. Hoffman, (2006) Hemangiomas and Homeobox Gene Expression- J. Craniofacial Surg 17, 767-71 Vlahakis,N.E. B. A. Young, A. Atakilit, A. E. Hawkridge, R. B Issaka, N. Boudreau, D. Sheppard (2007)
  • Integrin alpha9beta1 directly binds to vascular endothelial growth factor (VEGF)-A and is necessary for VEGF-A and tumor induced angiogenesis.- J. Biol. Chem. 282, 15187-15196.
  • Yu,DH, K A. Mace, S L. Hansen,. N. Boudreau, DM. Young, (2007) Effects of Decreased IGF-1 Stimulation of Hif-1alpha Protein Synthesis and Function on Impaired Diabetic Wound Healing- J. Invest. Dermatol. 15, 628-35
  • Mace,K.A. ., D. H. Yu,., K. Z. Paydar N. Boudreau., D. M. Young, (2007) Sustained Expression of Hif-1alpha in the Diabetic Environment Results in Upregulation of Hif-1 Target Genes and Accelerates Wound Repair J. Invest. Dermatol. 15, 636-645
  • Arderiu, G., I. Cuevas, L. East, M. Carrio and N.. Boudreau (2007) HoxA5 promotes vascular stability via increases in Akt and retention of beta catenin in junctions-Cell Adhesion and Migration 1(4). 185-195
  • Zhu, Y., Cuevas, I. Gabriel RA, Su, H, Fields A., Hao Q., Young WL, Yang G-Y and N.Boudreau (2009) Restoring HoxA5 expression inhibits growth of experimental hemangiomas in brain. J. Neurol and Exper. Neurol. 68 -626-632
  • Mace, KA, Restivo, T, RinnJL, Paquet, A., Change H. Young DM and N.Boudreau (2009) HoxA3 modulates injury induced mobilization and recruitment of bone marrow derived cells. Stem Cells 27, 1654-1665.
  • Chen, A. Cuevas I, Kenny P, Boudreau A, Ghagar, C Bissell MJ and N.Boudreau ( 2009) Restoring Polarity in Breast Tumor cells attenuates VEGF expression and Angiogenesis. Cancer Research, 69, 6721-6729.
  • Cuevas, I and N. Boudreau (2009) Managing Tumor Angiogenesis: Lessons from VEGF resistant tumors and wounds Adv. Cancer Res. 103 25-42.
  • Mace, K. and N. Boudreau (2009) Plasmid Based gene transfer of Homeobox genes and improved wound healing- Advances in Wound Care Vol. 1 pp. 388-394
  • Sounni NE, , Dehne K , van Kempen Leon LCL, Lee, J., Overall CM. , Krane SM, Werb Z , Boudreau, N and LM. Coussens (2010) Metallpproteinase and TGFbeta regulation of vascular stability and leakage –Disease Models and Mech. 3, 317-332
  • Gilbert PM, Mouw J., Unger MA, Lakins J. N Boudreau, Tsai KK, Welm A, Feldman MD, Weber B and VM Weaver (2010) HoxA9 regulates BRCA1 expression to modulate breast tumor phenotype-. J. Clin Invest. 120, 1535-1550.
  • Kuri, M. and N. Boudreau (2010) "Homeobox genes and wound healing-evidence linking development and skin regeneration. Adv. Wound Care Vol2. in press June 2010