Nancy J. Boudreau, PhD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
boudreau_nancy

Professor, Department of Surgery, UCSF

nancyjb@itsa.ucsf.edu

Phone: (415) 206-6951 (voice)
Box 1302, UCSF
San Francisco, CA 94143-1302

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Education

Dalhousie University, Halifax, Nova Scotia, Canada, B.Sc. (Hon), 1981, Biology
Dalhousie University, Halifax, Nova Scotia, Canada, M.Sc., 1984, Pharmacology
University of Toronto, Ph.D., 1991, Pathology

Professional Experience

  • 1985-1987
    Research Assistant, Division of Cardiovascular Research, Hospital for Sick Children, Toronto, Ontario, Canada; Maintenance of vascular cell differentiated phenotype in culture
  • 1987-1991
    Graduate Student, Department of Pathology, University of Toronto; Extracellular matrix and vascular cell behavior. Ontario Graduate Scholarship-1989; University of Toronto Open Graduate Fellowship-1989; Emmanuel Farber Award in Pathology-1989; Canadian Society of Clinical Investigation Trainee Award-1990; Medical Research Council of Canada Studentship-1990
  • 1991-1995
    Postdoctoral Fellow, Laboratory of Cell and Molecular Biology, LBL, University of California, Berkeley; Susceptibility of endothelium to transformation in the chick embryo: Apoptosis and the regulation of gene expression by the extracellular matrix. Medical Research Council of Canada Fellowship-1992-1995.
  • 1995-1996
    Postdoctoral Fellow, Department of Vascular Biology and Immunology, The Scripps Research Institute, La Jolla, CA; Extracellular matrix regulation of endothelial homeobox expression and regulation of endothelial integrin expression in angiogenesis. Joseph Drown Foundation Fellowship–1995-1996.
  • 1996-1998
    Assistant Professor, Department of Anatomy, Medical College of Virginia, Richmond, VA; Homeobox genes and angiogenesis and regulation of endothelial gene expression by the extracellular matrix
  • 1998-2003
    Assistant Professor, Department of Surgery, University of California, San Francisco
  • 2003-present
    Director, Surgical Research Lab, San Francisco General Hospital
  • 3003-present
    Associate Professor, Department of Surgery, University of California, San Francisco
  • 2009-present
    Professor, Department of Surgery, University of California San Francisco

Honors & Awards

  • 1989
    Ontario Graduate Scholarship
  • 1989
    University of Toronto Open Graduate Fellowship
  • 1989
    Emmanuel Farber Award in Pathology
  • 1990
    Canadian Society of Clinical Investigation Trainee Award
  • 1990
    Medical Research Council of Canada Studentship
  • 1992-1995
    Medical Research Council of Canada Fellowship
  • 1995-1996
    Joseph Drown Foundation Fellowship

Selected Publications

  1. Kachgal S, Mace KA, Boudreau NJ. The dual roles of homeobox genes in vascularization and wound healing. Cell Adh Migr. 2012 Nov-Dec; 6(6):457-70.
    View on PubMed
  2. Bahrami SB, Veiseh M, Boudreau NJ. Isolation and expansion of endothelial progenitor cells derived from mouse embryonic stem cells. Methods Mol Biol. 2012; 916:81-96.
    View on PubMed
  3. Bahrami SB, Veiseh M, Dunn AA, Boudreau NJ. Temporal changes in Hox gene expression accompany endothelial cell differentiation of embryonic stem cells. Cell Adh Migr. 2011 Mar-Apr; 5(2):133-41.
    View on PubMed
  4. Gilbert PM, Mouw JK, Unger MA, Lakins JN, Gbegnon MK, Clemmer VB, Benezra M, Licht JD, Boudreau NJ, Tsai KK, Welm AL, Feldman MD, Weber BL, Weaver VM. HOXA9 regulates BRCA1 expression to modulate human breast tumor phenotype. J Clin Invest. 2010 May; 120(5):1535-50.
    View on PubMed
  5. Sounni NE, Dehne K, van Kempen L, Egeblad M, Affara NI, Cuevas I, Wiesen J, Junankar S, Korets L, Lee J, Shen J, Morrison CJ, Overall CM, Krane SM, Werb Z, Boudreau N, Coussens LM. Stromal regulation of vessel stability by MMP14 and TGFbeta. Dis Model Mech. 2010 May-Jun; 3(5-6):317-32.
    View on PubMed
  6. Chen A, Cuevas I, Kenny PA, Miyake H, Mace K, Ghajar C, Boudreau A, Bissell MJ, Bissell M, Boudreau N. Endothelial cell migration and vascular endothelial growth factor expression are the result of loss of breast tissue polarity. Cancer Res. 2009 Aug 15; 69(16):6721-9.
    View on PubMed
  7. Mace KA, Restivo TE, Rinn JL, Paquet AC, Chang HY, Young DM, Boudreau NJ. HOXA3 modulates injury-induced mobilization and recruitment of bone marrow-derived cells. Stem Cells. 2009 Jul; 27(7):1654-65.
    View on PubMed
  8. Zhu Y, Cuevas IC, Gabriel RA, Su H, Nishimura S, Gao P, Fields A, Hao Q, Young WL, Yang GY, Boudreau NJ. Restoring transcription factor HoxA5 expression inhibits the growth of experimental hemangiomas in the brain. J Neuropathol Exp Neurol. 2009 Jun; 68(6):626-32.
    View on PubMed
  9. Cuevas I, Boudreau N. Managing tumor angiogenesis: lessons from VEGF-resistant tumors and wounds. Adv Cancer Res. 2009; 103:25-42.
    View on PubMed
  10. Arderiu G, Cuevas I, Chen A, Carrio M, East L, Boudreau NJ. HoxA5 stabilizes adherens junctions via increased Akt1. Cell Adh Migr. 2007 Oct-Dec; 1(4):185-95.
    View on PubMed
  11. Yu DH, Mace KA, Hansen SL, Boudreau N, Young DM. Effects of decreased insulin-like growth factor-1 stimulation on hypoxia inducible factor 1-alpha protein synthesis and function during cutaneous repair in diabetic mice. Wound Repair Regen. 2007 Sep-Oct; 15(5):628-35.
    View on PubMed
  12. Mace KA, Yu DH, Paydar KZ, Boudreau N, Young DM. Sustained expression of Hif-1alpha in the diabetic environment promotes angiogenesis and cutaneous wound repair. Wound Repair Regen. 2007 Sep-Oct; 15(5):636-45.
    View on PubMed
  13. Vlahakis NE, Young BA, Atakilit A, Hawkridge AE, Issaka RB, Boudreau N, Sheppard D. Integrin alpha9beta1 directly binds to vascular endothelial growth factor (VEGF)-A and contributes to VEGF-A-induced angiogenesis. J Biol Chem. 2007 May 18; 282(20):15187-96.
    View on PubMed
  14. Hansen SL, Dosanjh A, Young DM, Boudreau N, Hoffman WY. Hemangiomas and homeobox gene expression. J Craniofac Surg. 2006 Jul; 17(4):767-71.
    View on PubMed
  15. Boudreau N, Weaver V. Forcing the third dimension. Cell. 2006 May 5; 125(3):429-31.
    View on PubMed
  16. Charboneau A, East L, Mulholland N, Rohde M, Boudreau N. Pbx1 is required for Hox D3-mediated angiogenesis. Angiogenesis. 2005; 8(4):289-96.
    View on PubMed
  17. Morimoto-Tomita M, Uchimura K, Bistrup A, Lum DH, Egeblad M, Boudreau N, Werb Z, Rosen SD. Sulf-2, a proangiogenic heparan sulfate endosulfatase, is upregulated in breast cancer. Neoplasia. 2005 Nov; 7(11):1001-10.
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  18. Carrio M, Arderiu G, Myers C, Boudreau NJ. Homeobox D10 induces phenotypic reversion of breast tumor cells in a three-dimensional culture model. Cancer Res. 2005 Aug 15; 65(16):7177-85.
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  19. Cambier S, Gline S, Mu D, Collins R, Araya J, Dolganov G, Einheber S, Boudreau N, Nishimura SL. Integrin alpha(v)beta8-mediated activation of transforming growth factor-beta by perivascular astrocytes: an angiogenic control switch. Am J Pathol. 2005 Jun; 166(6):1883-94.
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  20. Mace KA, Hansen SL, Myers C, Young DM, Boudreau N. HOXA3 induces cell migration in endothelial and epithelial cells promoting angiogenesis and wound repair. J Cell Sci. 2005 Jun 15; 118(Pt 12):2567-77.
    View on PubMed

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