V. Courtney Broaddus, MD


Professor, Department of Medicine; Associate Director, Lung Biology Center, UCSF


Phone: (415) 206-3513 (voice)
Box 0854, UCSF
San Francisco, CA 94143-0854

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Cancer Center Membership

Program Member » Cancer, Immunity, and Microenvironment


Duke University, Durham, North Carolina, B.S., Summa Cum Laude, 1975, Zoology
University of Pennsylvania, Philadelphia, PA, M.D., 1979, Medicine
University of Pennsylvania, Philadelphia, PA, Intern and Resident, 1979-82, Internal Medicine
University of California San Francisco, CA, Fellow, 1983-84, Pulmonary Disease

Professional Experience

  • 1986-88
    Instructor in Medicine, University of California, San Francisco, CA
  • 1988-1995
    Assistant Professor in Medicine, University of California, San Francisco, CA
  • 1991-present
    Member, Lung Biology Center, University of California, San Francisco, CA
  • 1995-2001
    Associate Professor in Medicine, University of California, San Francisco, CA
  • 1998-present
    Chief, Division of Pulmonary and Critical Care, University of California, San Francisco, CA
  • 2001-present
    Professor in Medicine, University of California, San Francisco, CA
  • 2001-2002
    Visiting Scientist, Comprehensive Cancer Center, Dr. Gerard Evan's Laboratory
  • 2004-present
    Associate Director, Lung Biology Center, Univ. of Calif., San Francisco

Honors & Awards

  • 1978
    Alpha Omega Alpha, University of Pennsylvania
  • 1979
    Janet M. Glasgow Memorial Award and Citation for Outstanding Female Medical Student
  • 1987-1992
    Clinical Investigator Award, NHLBI
  • 1988
    American Physiological Society (elected)
  • 1991
    Associate, Scientific Staff, Cardiovascular Research Institute, UCSF (elected)
  • 1991
    Distinction in Teaching Award, University of California, San Francisco, CA
  • 1992
    Pretenure Award, University of California, San Francisco, CA
  • 1998-2001
    UC Tobacco Related Disease Program Award for "Programmed Cell Death in Cigarette- Induced Lung Disease"
  • 1999-2002
    President, International Mesothelioma Interest Group

Selected Publications

  1. Barbone D, Follo C, Echeverry N, Gerbaudo VH, Klabatsa A, Bueno R, Felley-Bosco E, Broaddus VC. Autophagy Correlates with the Therapeutic Responsiveness of Malignant Pleural Mesothelioma in 3D Models. PLoS One. 2015; 10(8):e0134825.
    View on PubMed
  2. Broaddus VC, Grippi MA. Medical Subspecialty Textbooks in the 21st Century. Essential or Headed for Extinction? Ann Am Thorac Soc. 2015 Aug; 12(8):1113-5.
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  3. Echeverry N, Ziltener G, Barbone D, Weder W, Stahel RA, Broaddus VC, Felley-Bosco E. Inhibition of autophagy sensitizes malignant pleural mesothelioma cells to dual PI3K/mTOR inhibitors. Cell Death Dis. 2015; 6:e1757.
    View on PubMed
  4. Busacca S, Chacko AD, Klabatsa A, Arthur K, Sheaff M, Barbone D, Mutti L, Gunasekharan VK, Gorski JJ, El-Tanani M, Broaddus VC, Gaudino G, Fennell DA. BAK and NOXA are critical determinants of mitochondrial apoptosis induced by bortezomib in mesothelioma. PLoS One. 2013; 8(6):e65489.
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  5. Barbone D, Cheung P, Battula S, Busacca S, Gray SG, Longley DB, Bueno R, Sugarbaker DJ, Fennell DA, Broaddus VC. Vorinostat eliminates multicellular resistance of mesothelioma 3D spheroids via restoration of Noxa expression. PLoS One. 2012; 7(12):e52753.
    View on PubMed
  6. Lee HK, Park GB, Kim YS, Song H, Broaddus VC, Hur DY. Ligation of CM1 enhances apoptosis of lung cancer cells through different mechanisms in conformity with EGFR mutation. Int J Oncol. 2013 Feb; 42(2):469-77.
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  7. Hurwitz JL, Stasik I, Kerr EM, Holohan C, Redmond KM, McLaughlin KM, Busacca S, Barbone D, Broaddus VC, Gray SG, O'Byrne KJ, Johnston PG, Fennell DA, Longley DB. Vorinostat/SAHA-induced apoptosis in malignant mesothelioma is FLIP/caspase 8-dependent and HR23B-independent. Eur J Cancer. 2012 May; 48(7):1096-107.
    View on PubMed
  8. Phung YT, Barbone D, Broaddus VC, Ho M. Rapid generation of in vitro multicellular spheroids for the study of monoclonal antibody therapy. J Cancer. 2011; 2:507-14.
    View on PubMed
  9. Barbone D, Ryan JA, Kolhatkar N, Chacko AD, Jablons DM, Sugarbaker DJ, Bueno R, Letai AG, Coussens LM, Fennell DA, Broaddus VC. The Bcl-2 repertoire of mesothelioma spheroids underlies acquired apoptotic multicellular resistance. Cell Death Dis. 2011; 2:e174.
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  10. Iyer AK, Lan X, Zhu X, Su Y, Feng J, Zhang X, Gao D, Seo Y, Vanbrocklin HF, Broaddus VC, Liu B, He J. Novel human single chain antibody fragments that are rapidly internalizing effectively target epithelioid and sarcomatoid mesotheliomas. Cancer Res. 2011 Apr 1; 71(7):2428-32.
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  11. Xiang X, Phung Y, Feng M, Nagashima K, Zhang J, Broaddus VC, Hassan R, Fitzgerald D, Ho M. The development and characterization of a human mesothelioma in vitro 3D model to investigate immunotoxin therapy. PLoS One. 2011; 6(1):e14640.
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  12. Broaddus VC, Everitt JI, Black B, Kane AB. Non-neoplastic and neoplastic pleural endpoints following fiber exposure. J Toxicol Environ Health B Crit Rev. 2011; 14(1-4):153-78.
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  13. Bidlingmaier S, He J, Wang Y, An F, Feng J, Barbone D, Gao D, Franc B, Broaddus VC, Liu B. Identification of MCAM/CD146 as the target antigen of a human monoclonal antibody that recognizes both epithelioid and sarcomatoid types of mesothelioma. Cancer Res. 2009 Feb 15; 69(4):1570-7.
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  14. Yang TM, Barbone D, Fennell DA, Broaddus VC. Bcl-2 family proteins contribute to apoptotic resistance in lung cancer multicellular spheroids. Am J Respir Cell Mol Biol. 2009 Jul; 41(1):14-23.
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  15. Wilson SM, Barbone D, Yang TM, Jablons DM, Bueno R, Sugarbaker DJ, Nishimura SL, Gordon GJ, Broaddus VC. mTOR mediates survival signals in malignant mesothelioma grown as tumor fragment spheroids. Am J Respir Cell Mol Biol. 2008 Nov; 39(5):576-83.
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  16. Barbone D, Yang TM, Morgan JR, Gaudino G, Broaddus VC. Mammalian target of rapamycin contributes to the acquired apoptotic resistance of human mesothelioma multicellular spheroids. J Biol Chem. 2008 May 9; 283(19):13021-30.
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  17. An F, Drummond DC, Wilson S, Kirpotin DB, Nishimura SL, Broaddus VC, Liu B. Targeted drug delivery to mesothelioma cells using functionally selected internalizing human single-chain antibodies. Mol Cancer Ther. 2008 Mar; 7(3):569-78.
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  18. Hassan R, Broaddus VC, Wilson S, Liewehr DJ, Zhang J. Anti-mesothelin immunotoxin SS1P in combination with gemcitabine results in increased activity against mesothelin-expressing tumor xenografts. Clin Cancer Res. 2007 Dec 1; 13(23):7166-71.
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  19. Araya J, Cambier S, Markovics JA, Wolters P, Jablons D, Hill A, Finkbeiner W, Jones K, Broaddus VC, Sheppard D, Barzcak A, Xiao Y, Erle DJ, Nishimura SL. Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients. J Clin Invest. 2007 Nov; 117(11):3551-62.
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  20. Acencio MM, Vargas FS, Marchi E, Carnevale GG, Teixeira LR, Antonangelo L, Broaddus VC. Pleural mesothelial cells mediate inflammatory and profibrotic responses in talc-induced pleurodesis. Lung. 2007 Dec; 185(6):343-8.
    View on PubMed

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