Professor, Departments of Biopharmaceutical Sciences, Pharmaceutical Chemistry, and Microbiology/Immunology, UCSF
Additional Websites
Education
Harvard University, Massachusetts, B.A., 1976, Biochemistry
Oxford University, England, D. Phil., 1979, Genetics
Harvard University, Massachusetts, Postdoc 1980, Biochemistry
Stanford University, California Postdoc, 1980-82, Structural Biology
Professional Experience
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1976-1979
Graduate Student with Dr. W.F. Bodmer, Genetics Laboratory, Oxford, U.K.
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1979-1980
Postdoctoral Fellow with Dr. J.L. Strominger, Harvard University, Cambridge, MA
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1980-1982
Postdoctoral Fellow with Dr. P. Parham, Stanford University, School of Medicine, Stanford, CA
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1982-1986
Program Manager, Cell Biology, Research and Development Department, Becton Dickinson Immunocytometry Systems
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1987-1991
Assistant Professor of Pharmacy and Pharmaceutical Chemistry, School of Pharmacy; Assistant Adjunct Professor of Microbiology, School of Medicine, University of California, San Francisco.
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1991-1994
Associate Professor of Pharmacy and Pharmaceutical Chemistry, School of Pharmacy; Associate Professor of Microbiology and Immunology, School of Medicine, University of California, San Francisco
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1994-Present
Professor of Biopharmaceutical Sciences and Pharmaceutical Chemistry, School of Pharmacy; Professor of Microbiology and Immunology, School of Medicine, University of California, San Francisco
Honors & Awards
- 1975
Dreyfus Fellowship (summer research), Phi Beta Kappa-junior year - 1976
Graduated Summa cum laude in Biochemical Sciences, Harvard - 1976-1979
Marshall Scholarship for study in the United Kingdom - 1980-1982
Damon Runyon-Walter Winchell Fund, Postdoctoral Fellowship - 1984-1999
Member, Editorial Board of Human Immunology - 1987
Pharmaceutical Manufacturers Association Fund Research Starter Grant - 1988-1992
Pew Scholar award - 2005
Boehinger-Ingelheim Lecturer, McGill University - 2005-2007
Honorary Professor, Institute for Molecular Bioscience, University of Queensland - 2006-2011
Member, Searle Scholars Advisory Board - 2006
Margaret Pittman Lecturer, National Institutes of Health - 2006
Visiting fellow, King's College Cambridge
Selected Publications
- Bonazzi M, Kühbacher A, Toledo-Arana A, Mallet A, Vasudevan L, Pizarro-Cerdá J, Brodsky FM, Cossart P. A Common Clathrin-Mediated Machinery Co-ordinates Cell-Cell Adhesion and Bacterial Internalization. Traffic. 2012 Dec; 13(12):1653-66.
View on PubMed - Foraker AB, Camus SM, Evans TM, Majeed SR, Chen CY, Taner SB, Corrêa IR, Doxsey SJ, Brodsky FM. Clathrin promotes centrosome integrity in early mitosis through stabilization of centrosomal ch-TOG. J Cell Biol. 2012 Aug 20; 198(4):591-605.
View on PubMed - Brodsky FM. Diversity of clathrin function: new tricks for an old protein. Annu Rev Cell Dev Biol. 2012 Nov 10; 28:309-36.
View on PubMed - Brodsky FM, Thattai M, Mayor S. Evolutionary cell biology: Lessons from diversity. Nat Cell Biol. 2012 Jul; 14(7):651.
View on PubMed - Bonazzi M, Vasudevan L, Mallet A, Sachse M, Sartori A, Prevost MC, Roberts A, Taner SB, Wilbur JD, Brodsky FM, Cossart P. Clathrin phosphorylation is required for actin recruitment at sites of bacterial adhesion and internalization. J Cell Biol. 2011 Oct 31; 195(3):525-36.
View on PubMed - Stoddart A, Tennant TR, Fernald AA, Anastasi J, Brodsky FM, Le Beau MM. The clathrin-binding domain of CALM-AF10 alters the phenotype of myeloid neoplasms in mice. Oncogene. 2012 Jan 26; 31(4):494-506.
View on PubMed - Shieh JC, Schaar BT, Srinivasan K, Brodsky FM, McConnell SK. Endocytosis regulates cell soma translocation and the distribution of adhesion proteins in migrating neurons. PLoS One. 2011; 6(3):e17802.
View on PubMed - Taner SB, Pando MJ, Roberts A, Schellekens J, Marsh SG, Malmberg KJ, Parham P, Brodsky FM. Interactions of NK cell receptor KIR3DL1*004 with chaperones and conformation-specific antibody reveal a functional folded state as well as predominant intracellular retention. J Immunol. 2011 Jan 1; 186(1):62-72.
View on PubMed - Wilbur JD, Hwang PK, Ybe JA, Lane M, Sellers BD, Jacobson MP, Fletterick RJ, Brodsky FM. Conformation switching of clathrin light chain regulates clathrin lattice assembly. Dev Cell. 2010 May 18; 18(5):841-8.
View on PubMed - Wilbur JD, Hwang PK, Brodsky FM, Fletterick RJ. Accommodation of structural rearrangements in the huntingtin-interacting protein 1 coiled-coil domain. Acta Crystallogr D Biol Crystallogr. 2010 Mar; 66(Pt 3):314-8.
View on PubMed - Esk C, Chen CY, Johannes L, Brodsky FM. The clathrin heavy chain isoform CHC22 functions in a novel endosomal sorting step. J Cell Biol. 2010 Jan 11; 188(1):131-44.
View on PubMed - Vassilopoulos S, Esk C, Hoshino S, Brodsky FM. [The CHC22 human clathrin heavy chain isoform, intracellular traffic of the glucose transporter GLUT4, and type 2 diabetes]. Med Sci (Paris). 2010 Jan; 26(1):33-6.
View on PubMed - Sharma D, Bastard K, Guethlein LA, Norman PJ, Yawata N, Yawata M, Pando M, Thananchai H, Dong T, Rowland-Jones S, Brodsky FM, Parham P. Dimorphic motifs in D0 and D1+D2 domains of killer cell Ig-like receptor 3DL1 combine to form receptors with high, moderate, and no avidity for the complex of a peptide derived from HIV and HLA-A*2402. J Immunol. 2009 Oct 1; 183(7):4569-82.
View on PubMed - Vassilopoulos S, Esk C, Hoshino S, Funke BH, Chen CY, Plocik AM, Wright WE, Kucherlapati R, Brodsky FM. A role for the CHC22 clathrin heavy-chain isoform in human glucose metabolism. Science. 2009 May 29; 324(5931):1192-6.
View on PubMed - Wilbur JD, Chen CY, Manalo V, Hwang PK, Fletterick RJ, Brodsky FM. Actin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chain. J Biol Chem. 2008 Nov 21; 283(47):32870-9.
View on PubMed - Kirkham M, Nixon SJ, Howes MT, Abi-Rached L, Wakeham DE, Hanzal-Bayer M, Ferguson C, Hill MM, Fernandez-Rojo M, Brown DA, Hancock JF, Brodsky FM, Parton RG. Evolutionary analysis and molecular dissection of caveola biogenesis. J Cell Sci. 2008 Jun 15; 121(Pt 12):2075-86.
View on PubMed - Sowinski S, Jolly C, Berninghausen O, Purbhoo MA, Chauveau A, Köhler K, Oddos S, Eissmann P, Brodsky FM, Hopkins C, Onfelt B, Sattentau Q, Davis DM. Membrane nanotubes physically connect T cells over long distances presenting a novel route for HIV-1 transmission. Nat Cell Biol. 2008 Feb; 10(2):211-9.
View on PubMed - Knuehl C, Chen CY, Manalo V, Hwang PK, Ota N, Brodsky FM. Novel binding sites on clathrin and adaptors regulate distinct aspects of coat assembly. Traffic. 2006 Dec; 7(12):1688-700.
View on PubMed - Chen TT, Li L, Chung DH, Allen CD, Torti SV, Torti FM, Cyster JG, Chen CY, Brodsky FM, Niemi EC, Nakamura MC, Seaman WE, Daws MR. TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis. J Exp Med. 2005 Oct 3; 202(7):955-65.
View on PubMed - Wakeham DE, Abi-Rached L, Towler MC, Wilbur JD, Parham P, Brodsky FM. Clathrin heavy and light chain isoforms originated by independent mechanisms of gene duplication during chordate evolution. Proc Natl Acad Sci U S A. 2005 May 17; 102(20):7209-14.
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