University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Carolyn S. Calfee, MD

Carolyn S. Calfee, MD

Associate Professor, Department of Medicine, UCSF

Cancer Center Program Memberships

Tobacco Control

Research Summary

My research program focuses on clinical and translational approaches to studying the development of the Acute Respiratory Distress Syndrome (ARDS) in critically ill patients. I have two major areas of focus: (1) the prognostic and pathogenetic value of biomarkers of lung epithelial and endothelial injury in ARDS, including novel approaches to molecular phenotyping of ARDS; and (2) the epidemiology and mechanisms of association between active and passive cigarette smoke exposure and the development of ARDS. I also have a particular interest in the early identification of patients with or at high risk for ARDS, with several publications on clinical and biological approaches to early detection of ARDS.

Education

Yale University, BA, 1991-1995, English
University of Pennsylvania, MD, 1995-1999, Medicine
University of California, San Francisco Internship/Residency, 1999-2002, Internal Medicine
University of California, San Francisco Chief Residency, 2002-2003, Internal Medicine
University of California, San Francisco Fellowship, 2003-2007, Pulmonary/Critical Care
University of California, San Francisco Masters in Clinical Research (expected), 2007-2009, Clinical Research


Professional Experience

  • PROFESSIONAL EXPERIENCE
  • 1999-2002
    Internship and Residency, Internal Medicine, University of California, San Francisco
  • 2002-2003
    Chief Medical Resident, Internal Medicine, Moffitt-Long Hospital, UCSF
  • 2002-2003
    Clinical Instructor, Department of Medicine, UCSF
  • 2002-2003
    Attending Physician, Medical Service, Moffitt-Long Hospital, UCSF
  • 2003-2004
    Clinical Fellow, Pulmonary and Critical Care Division, UCSF
  • 2005-2006
    Advanced Training in Clinical Research Program, UCSF Department of Epidemiology and Biostatistics
  • 2005-2007
    Research Fellow, Pulmonary and Critical Care Division, UCSF
  • 2007-2012
    Assistant Professor, Pulmonary and Critical Care Division, UCSF Dept of Medicine
  • 2012-present
    Associate Professor, Pulmonary and Critical Care Division, UCSF Depts of Medicine and Anesthesia
  • 2007-present
    Faculty, Center for Tobacco Control, Research, and Education, UCSF

Honors & Awards

  • 1994
    Phi Beta Kappa, Yale University
  • 1995
    Bachelor of Arts awarded magna cum laude, with Distinction in the Major
  • 1998
    Alpha Omega Alpha, University of Pennsylvania School of Medicine
  • 1999
    Julia M. Glasgow Award, University of Pennsylvania School of Medicine
  • 1999
    Spencer Morris Prize, University of Pennsylvania School of Medicine
  • 2000
    Intern of the Year, University of California, San Francisco, Department of Medicine
  • 2005
    Walter Travel Award, American Lung Association
  • 2012
    Associate Scientific Advisor, Science Translational Medicine
  • 2013
    American Society for Clinical Investigation Young Physician-Scientist Award
  • 2013
    Highlighted abstract, 2013 American Thoracic Society International Conference (sr. author)
  • 2013
    Finalist, UCSF Pathways to Discovery Mentor Award

Selected Publications

  1. Lanspa MJ, Gong MN, Schoenfeld DA, Lee KT, Grissom CK, Hou PC, Serpa-Neto A, Brown SM, Iwashyna TJ, Yealy DM, Hough CL, Brower RG, Calfee CS, Hyzy RC, Matthay MA, Miller RR, Steingrub JS, Thompson BT, Miller CD, Clemmer TP, Hendey GW, Huang DT, Mathews KS, Qadir N, Tidswell M. Prospective Assessment of the Feasibility of a Trial of Low Tidal Volume Ventilation for Patients with Acute Respiratory Failure. Ann Am Thorac Soc. 2018 Nov 08.
    View on PubMed
  2. Reilly JP, Wang F, Jones TK, Palakshappa JA, Anderson BJ, Shashaty MGS, Dunn TG, Johansson ED, Riley TR, Lim B, Abbott J, Ittner CAG, Cantu E, Lin X, Mikacenic C, Wurfel MM, Christiani DC, Calfee CS, Matthay MA, Christie JD, Feng R, Meyer NJ. Plasma angiopoietin-2 as a potential causal marker in sepsis-associated ARDS development: evidence from Mendelian randomization and mediation analysis. Intensive Care Med. 2018 Oct 21.
    View on PubMed
  3. Bhatraju PK, Zelnick LR, Herting J, Katz R, Mikacenic C, Kosamo S, Morrell ED, Robinson-Cohen C, Calfee CS, Christie JD, Liu KD, Matthay MA, Hahn WO, Dmyterko V, Slivinski NSJ, Russell JA, Walley KR, Christiani DC, Liles WC, Himmelfarb J, Wurfel MM. Identification of Acute Kidney Injury Sub-phenotypes with Differing Molecular Signatures and Response to Vasopressin Therapy. Am J Respir Crit Care Med. 2018 Oct 18.
    View on PubMed
  4. Sinha P, Delucchi KL, Thompson BT, McAuley DF, Matthay MA, Calfee CS. Latent class analysis of ARDS subphenotypes: a secondary analysis of the statins for acutely injured lungs from sepsis (SAILS) study. Intensive Care Med. 2018 Oct 05.
    View on PubMed
  5. Fielding-Singh V, Matthay MA, Calfee CS. Beyond Low Tidal Volume Ventilation: Treatment Adjuncts for Severe Respiratory Failure in Acute Respiratory Distress Syndrome. Crit Care Med. 2018 Sep 20.
    View on PubMed
  6. Sinha P, Calfee CS, Beitler JR, Soni N, Ho K, Matthay MA, Kallet RH. Physiological Analysis and Clinical Performance of the Ventilatory Ratio in Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2018 Sep 13.
    View on PubMed
  7. Moazed F, Chun L, Matthay MA, Calfee CS, Gotts J. Assessment of industry data on pulmonary and immunosuppressive effects of IQOS. Tob Control. 2018 Aug 29.
    View on PubMed
  8. Chun L, Moazed F, Matthay M, Calfee C, Gotts J. Possible hepatotoxicity of IQOS. Tob Control. 2018 Aug 21.
    View on PubMed
  9. Zinter MS, Delucchi KL, Kong MY, Orwoll BE, Spicer AS, Lim MJ, Alkhouli MF, Ratiu AE, McKenzie AV, McQuillen PS, Dvorak CC, Calfee CS, Matthay MA, Sapru A. Early Plasma Matrix Metalloproteinase Profiles: A Novel Pathway in Pediatric Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2018 Aug 16.
    View on PubMed
  10. Calfee CS, Delucchi KL, Sinha P, Matthay MA, Hackett J, Shankar-Hari M, McDowell C, Laffey JG, O'Kane CM, McAuley DF. Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial. Lancet Respir Med. 2018 Aug 02.
    View on PubMed
  11. Reilly JP, Zhao Z, Shashaty MGS, Koyama T, Christie JD, Lanken PN, Wang C, Balmes JR, Matthay MA, Calfee CS, Ware LB. Low to Moderate Air Pollutant Exposure and Acute Respiratory Distress Syndrome after Severe Trauma. Am J Respir Crit Care Med. 2018 Aug 01.
    View on PubMed
  12. Jabaudon M, Blondonnet R, Pereira B, Cartin-Ceba R, Lichtenstern C, Mauri T, Determann RM, Drabek T, Hubmayr RD, Gajic O, Uhle F, Coppadoro A, Pesenti A, Schultz MJ, Ranieri MV, Brodska H, Mrozek S, Sapin V, Matthay MA, Constantin JM, Calfee CS. Plasma sRAGE is independently associated with increased mortality in ARDS: a meta-analysis of individual patient data. Intensive Care Med. 2018 Jul 26.
    View on PubMed
  13. Leligdowicz A, Chun LF, Jauregui A, Vessel K, Liu KD, Calfee CS, Matthay MA. Human pulmonary endothelial cell permeability after exposure to LPS-stimulated leukocyte supernatants derived from patients with early sepsis. Am J Physiol Lung Cell Mol Physiol. 2018 Jul 19.
    View on PubMed
  14. Kornblith LZ, Robles AJ, Conroy AS, Hendrickson CM, Calfee CS, Fields AT, Callcut RA, Cohen MJ. Perhaps It's Not the Platelet: Ristocetin Uncovers the Potential Role of von Willebrand Factor in Impaired Platelet Aggregation Following Traumatic Brain Injury. J Trauma Acute Care Surg. 2018 Jul 05.
    View on PubMed
  15. Robles AJ, Kornblith LZ, Hendrickson CM, Howard BM, Conroy AS, Moazed F, Calfee CS, Cohen MJ, Callcut RA. Health care utilization and the cost of posttraumatic acute respiratory distress syndrome care. J Trauma Acute Care Surg. 2018 Jul; 85(1):148-154.
    View on PubMed
  16. Serpa Neto A, Bos LD, Campos PPZA, Hemmes SNT, Bluth T, Calfee CS, Ferner M, Güldner A, Hollmann MW, India I, Kiss T, Laufenberg-Feldmann R, Sprung J, Sulemanji D, Unzueta C, Vidal Melo MF, Weingarten TN, Tuip-de Boer AM, Pelosi P, Gama de Abreu M, Schultz MJ. Association between pre-operative biological phenotypes and postoperative pulmonary complications: An unbiased cluster analysis. Eur J Anaesthesiol. 2018 Jun 27.
    View on PubMed
  17. Hendrickson CM, Gibb SL, Miyazawa BY, Keating SM, Ross E, Conroy AS, Calfee CS, Pati S, Cohen MJ. Elevated plasma levels of TIMP-3 are associated with a higher risk of acute respiratory distress syndrome and death following severe isolated traumatic brain injury. Trauma Surg Acute Care Open. 2018; 3(1):e000171.
    View on PubMed
  18. Warren MA, Zhao Z, Koyama T, Bastarache JA, Shaver CM, Semler MW, Rice TW, Matthay MA, Calfee CS, Ware LB. Severity scoring of lung oedema on the chest radiograph is associated with clinical outcomes in ARDS. Thorax. 2018 Jun 14.
    View on PubMed
  19. Gotts JE, Chun LF, Abbott J, Fang X, Takasaki N, Nishimura SL, Springer ML, Schick SF, Calfee CS, Matthay MA. Cigarette smoke exposure worsens acute lung injury in antibiotic-treated bacterial pneumonia in mice. Am J Physiol Lung Cell Mol Physiol. 2018 Mar 15.
    View on PubMed
  20. Delucchi K, Famous KR, Ware LB, Parsons PE, Thompson BT, Calfee CS. Stability of ARDS subphenotypes over time in two randomised controlled trials. Thorax. 2018 Feb 24.
    View on PubMed

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