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Denise A. Chan, PhD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
chan_denise

Assistant Professor in Residence, Department of Radiation Oncology, UCSF

chand@radonc.ucsf.edu

Phone: (415) 476-8091
Box 1331, UCSF
San Francisco, CA 94143-1331

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Additional Websites


Education

Stanford University, Stanford, CA, PhD, 2004, Cancer Biology
University of California, Los Angeles, Los Angeles, CA, BS, 1999, Microbio. & Mol. Genetics


Professional Experience

  • 1996-1999
    Undergraduate Student Researcher, Laboratory of Dr. Sherie L. Morrison, Dept. of Microbiology, Immunology, & Molecular Genetics, UCLA, Los Angeles, CA
  • 1998-1999
    Undergraduate Student Researcher, Laboratory of Dr. Owen N. Witte, Dept. of Microbiology, Immunology, & Molecular Genetics, UCLA, Los Angeles, CA
  • 1999-2004
    Graduate Researcher, Laboratory of Dr. Amato J. Giaccia, Dept. of Radiation Oncology, Stanford University School of Medicine, Stanford, CA
  • 2004-2009
    Postdoctoral Fellow, Laboratory of Dr. Amato J. Giaccia, Dept. of Radiation Oncology, Stanford University School of Medicine, Stanford, CA
  • 2009-present
    Assistant Professor in Residence, Dept. of Radiation Oncology, UCSF, San Francisco, CA

Honors & Awards

  • 1999-2002
    NIH Predoctoral Trainee
  • 2003
    Distinguished Poster, Oxygen and the Cell, Berlin, Germany
  • 2003
    Best Poster Presentation, Program in Cancer Biology Annual Retreat, Asilomar, CA
  • 2004
    Keystone Symposia Scholarship, Biology of Hypoxia: The Role of Oxygen Sensing in Development, Normal Function, and Disease, Keystone Symposia
  • 2004
    Malcolm A. Bagshaw Award, Dept. of Radiation Oncology, Stanford University School of Medicine
  • 2005
    Junior Investigator Award, The Tumor Microenvironment - 9th International Workshop: Hypoxia, Angiogenesis, & Vasculature
  • 2006-2009
    Ruth L. Kirschstein National Research Service Award - Individual postdoctoral fellowship awarded by the National Institutes of Health, National Cancer Institute Branch
  • 2007
    ESH Scholoarship, ESH-Stroma Consortium International Conference on Vascular Targeted Therapies in Oncology, Nice, France
  • 2008
    Helena Anna Henzl-Gabor Young Women in Science Fund Travel Grant
  • 2008
    Lance Armstrong Foundation LIVESTRONG Summit Scholarship Recipient

Selected Publications

  1. Timmerman LA, Holton T, Yuneva M, Louie RJ, Padró M, Daemen A, Hu M, Chan DA, Ethier SP, van 't Veer LJ, Polyak K, McCormick F, Gray JW. Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target. Cancer Cell. 2013 Oct 14; 24(4):450-65.
    View on PubMed
  2. Anbalagan S, Pires IM, Blick C, Hill MA, Ferguson DJ, Chan DA, Hammond EM. Radiosensitization of renal cell carcinoma in vitro through the induction of autophagy. Radiother Oncol. 2012 Jun; 103(3):388-93.
    View on PubMed
  3. Chan DA, Sutphin PD, Nguyen P, Turcotte S, Lai EW, Banh A, Reynolds GE, Chi JT, Wu J, Solow-Cordero DE, Bonnet M, Flanagan JU, Bouley DM, Graves EE, Denny WA, Hay MP, Giaccia AJ. Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality. Sci Transl Med. 2011 Aug 3; 3(94):94ra70.
    View on PubMed
  4. Chan DA, Giaccia AJ. Harnessing synthetic lethal interactions in anticancer drug discovery. Nat Rev Drug Discov. 2011 May; 10(5):351-64.
    View on PubMed
  5. Bonnet M, Flanagan JU, Chan DA, Lai EW, Nguyen P, Giaccia AJ, Hay MP. SAR studies of 4-pyridyl heterocyclic anilines that selectively induce autophagic cell death in von Hippel-Lindau-deficient renal cell carcinoma cells. Bioorg Med Chem. 2011 Jun 1; 19(11):3347-56.
    View on PubMed
  6. Patten DA, Lafleur VN, Robitaille GA, Chan DA, Giaccia AJ, Richard DE. Hypoxia-inducible factor-1 activation in nonhypoxic conditions: the essential role of mitochondrial-derived reactive oxygen species. Mol Biol Cell. 2010 Sep 15; 21(18):3247-57.
    View on PubMed
  7. Wiley M, Sweeney KR, Chan DA, Brown KM, McMurtrey C, Howard EW, Giaccia AJ, Blader IJ. Toxoplasma gondii activates hypoxia-inducible factor (HIF) by stabilizing the HIF-1alpha subunit via type I activin-like receptor kinase receptor signaling. J Biol Chem. 2010 Aug 27; 285(35):26852-60.
    View on PubMed
  8. Chan DA, Giaccia AJ. PHD2 in tumour angiogenesis. Br J Cancer. 2010 Jun 29; 103(1):1-5.
    View on PubMed
  9. Hay MP, Turcotte S, Flanagan JU, Bonnet M, Chan DA, Sutphin PD, Nguyen P, Giaccia AJ, Denny WA. 4-Pyridylanilinothiazoles that selectively target von Hippel-Lindau deficient renal cell carcinoma cells by inducing autophagic cell death. J Med Chem. 2010 Jan 28; 53(2):787-97.
    View on PubMed
  10. Chan DA, Kawahara TL, Sutphin PD, Chang HY, Chi JT, Giaccia AJ. Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment. Cancer Cell. 2009 Jun 2; 15(6):527-38.
    View on PubMed
  11. Ghosh AK, Shanafelt TD, Cimmino A, Taccioli C, Volinia S, Liu CG, Calin GA, Croce CM, Chan DA, Giaccia AJ, Secreto C, Wellik LE, Lee YK, Mukhopadhyay D, Kay NE. Aberrant regulation of pVHL levels by microRNA promotes the HIF/VEGF axis in CLL B cells. Blood. 2009 May 28; 113(22):5568-74.
    View on PubMed
  12. Chang EI, Bonillas RG, El-ftesi S, Chang EI, Ceradini DJ, Vial IN, Chan DA, Michaels J, Gurtner GC. Tissue engineering using autologous microcirculatory beds as vascularized bioscaffolds. FASEB J. 2009 Mar; 23(3):906-15.
    View on PubMed
  13. Chan DA, Giaccia AJ. Targeting cancer cells by synthetic lethality: autophagy and VHL in cancer therapeutics. Cell Cycle. 2008 Oct; 7(19):2987-90.
    View on PubMed
  14. Huang M, Chan DA, Jia F, Xie X, Li Z, Hoyt G, Robbins RC, Chen X, Giaccia AJ, Wu JC. Short hairpin RNA interference therapy for ischemic heart disease. Circulation. 2008 Sep 30; 118(14 Suppl):S226-33.
    View on PubMed
  15. Turcotte S, Chan DA, Sutphin PD, Hay MP, Denny WA, Giaccia AJ. A molecule targeting VHL-deficient renal cell carcinoma that induces autophagy. Cancer Cell. 2008 Jul 8; 14(1):90-102.
    View on PubMed
  16. Choi CY, Chan DA, Paulmurugan R, Sutphin PD, Le QT, Koong AC, Zundel W, Gambhir SS, Giaccia AJ. Molecular imaging of hypoxia-inducible factor 1 alpha and von Hippel-Lindau interaction in mice. Mol Imaging. 2008 May-Jun; 7(3):139-46.
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  17. Lauzier MC, Robitaille GA, Chan DA, Giaccia AJ, Richard DE. (2R)-[(4-Biphenylylsulfonyl)amino]-N-hydroxy-3-phenylpropionamide (BiPS), a matrix metalloprotease inhibitor, is a novel and potent activator of hypoxia-inducible factors. Mol Pharmacol. 2008 Jul; 74(1):282-8.
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  18. Chang EI, Loh SA, Ceradini DJ, Chang EI, Lin SE, Bastidas N, Aarabi S, Chan DA, Freedman ML, Giaccia AJ, Gurtner GC. Age decreases endothelial progenitor cell recruitment through decreases in hypoxia-inducible factor 1alpha stabilization during ischemia. Circulation. 2007 Dec 11; 116(24):2818-29.
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  19. Pagé EL, Chan DA, Giaccia AJ, Levine M, Richard DE. Hypoxia-inducible factor-1alpha stabilization in nonhypoxic conditions: role of oxidation and intracellular ascorbate depletion. Mol Biol Cell. 2008 Jan; 19(1):86-94.
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  20. Glassford AJ, Yue P, Sheikh AY, Chun HJ, Zarafshar S, Chan DA, Reaven GM, Quertermous T, Tsao PS. HIF-1 regulates hypoxia- and insulin-induced expression of apelin in adipocytes. Am J Physiol Endocrinol Metab. 2007 Dec; 293(6):E1590-6.
    View on PubMed

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