June MayLin Chan, ScD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
June MayLin Chan, ScD

Program Director, Genitourinary Cancer Epidemiology and Population Sciences, Department of Urology, UCSF
Steven and Christine Burd-Safeway Distinguished Professor, UCSF

june.chan@ucsf.edu

Phone: (415) 415-4923 (voice)
Box 9001, UCSF
San Francisco, CA 94143-9001

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Cancer Center Membership

Program Member » Prostate Cancer

Research Summary

My main research interests are in understanding how diet, exercise, hormones, and genetics contribute to prostate cancer incidence, progression, and death. I am particularly interested in identifying modifiable lifestyle risk factors for prostate cancer progression and using this information to help us better understand prostate cancer biology, as well as inform public health guidelines. I have worked in this area for 17+ years and was awarded the Steven & Christine Burd-Safeway Distinguished Professorship at UCSF in 2009 in recognition of my teaching, research, and service activities in the field of prostate cancer.

My work is highly collaborative, and the goals of our clinical and translational research studies are to identify risk-reduction strategies for men with or at high risk for prostate cancer; evaluate novel molecular markers of prostate cancer aggressiveness that may improve screening, diagnosis, or prognosis of clinically relevant disease; and improving cancer survivorship for the millions of men living with prostate cancer worldwide. I initiated the prospective Diet and Lifestyle Study within the Cancer of the Prostate Strategic Urologic Research Endeavor (CaPSURE) in 2004. I also collaborate with colleagues at the Harvard School of Public Health on the Health Professionals Follow-up Study to examine diet and lifestyle risk factors for prostate cancer progression, metastases, and death. I am PI on a randomized clinical trial examining an exercise intervention among men pursuing active surveillance for prostate cancer; co-PI on a large Dept. of Defense Translational Impact Award focused on improving risk stratification and decision support for men considering active surveillance for low risk prostate cancer; co-leader for a True NTH USA project focused on lifestyle; and Steering Committee member for GAP 4 (RCT on exercise in men with advanced prostate cancer).

Education

Harvard College, Cambridge, MA , B.A., 1994, Applied Math in Biology
Harvard School of Public Health, Boston, MA, ScD, 11/98, Epidemiology (Cancer)
Harvard School of Public Health, Boston, MA, 11/98-11/00, Postdoctoral Fellow-Epidemiology


Professional Experience

  • 1992-94, 1995-96
    Research Assistant, Department of Nutrition, Harvard School of Public Health
  • 1994-95
    Fulbright Scholar, Uppsala University, Sweden, Dept. of Medical Epidemiology
  • 1995-97
    National Research Service Award Fellowship, National Cancer Institute (NCI), Training Program in Cancer Epidemiology - pre-doctoral
  • 1997-98
    Teaching Fellow, Harvard School of Public Health
  • 1997- present
    Project Director, Prostate Cancer Survivors Follow-up, Harvard Sch. of Public Health
  • 1998-2000
    Postdoctoral Fellow, Depts of Epidemiology/Nutrition, Harvard Sch. Public Health; National Research Service Award Fellowship, NCI, Training Program in Cancer Epidemiology - post-doctoral
  • 1999
    Visiting Researcher, Dept. of Nutrition, National Public Health Institute, Helsinki, Finland
  • 1999
    Instructor of Medicine, Harvard Medical School
  • 2001-2007
    Assistant Professor, In Residence, Departments of Epidemiology & Biostatistics and Urology, University of California San Francisco (UCSF)
  • 2005-present
    Program Director, Genitourinary Cancer Epid. and Pop. Sci., Dept. of Urology, UCSF
  • 2007-present
    Associate Professor, In Residence, Departments of Epidemiology & Biostatistics and Urology, University of California San Francisco (UCSF)

Honors & Awards

  • 1994-96
    Fulbright Scholar, Uppsala University, Sweden, Dept. of Medical Epidemiology
  • 1996 & 1997
    Pforzheimer Public Service Fellowship, Harvard University
  • 1998
    Society for Epidemiologic Research Abraham Lilienfeld Student Prize
  • 1998
    Association for the Cure of Cancer of the Prostate ("CaPCURE") - Young Investigator Award
  • 2000
    AACR-AFLAC Young Investigator Scholars in Cancer Research Award
  • 2001
    REAC Intramural award, UCSF
  • 2002
    AACR-California Department of Health Services Early Career Development Award in Gender-Related Cancer Research (prostate)
  • 2003
    Prostate Cancer Foundation ("CaPCURE") - Competitive Award (6/03 & 12/03)
  • UCSF Equal Opportunity Faculty Development Award

Selected Publications

  1. Associations between circulating carotenoids, genomic instability and the risk of high-grade prostate cancer. Prostate. 2016 Mar; 76(4):339-48.
    View on PubMed
  2. Development and Application of a Lifestyle Score for Prevention of Lethal Prostate Cancer. J Natl Cancer Inst. 2016 Mar; 108(3).
    View on PubMed
  3. Carotenoids, retinol, tocopherols, and prostate cancer risk: pooled analysis of 15 studies. Am J Clin Nutr. 2015 Nov; 102(5):1142-57.
    View on PubMed
  4. Physical Activity and Prostate Tumor Vessel Morphology: Data from the Health Professionals Follow-up Study. Cancer Prev Res (Phila). 2015 Oct; 8(10):962-7.
    View on PubMed
  5. Postdiagnostic Statin Use and the Risk of Lethal Prostate Cancer in the Health Professionals Follow-up Study. Cancer Epidemiol Biomarkers Prev. 2015 Oct; 24(10):1638-40.
    View on PubMed
  6. Fat intake after prostate cancer diagnosis and mortality in the Physicians' Health Study. Cancer Causes Control. 2015 Aug; 26(8):1117-26.
    View on PubMed
  7. Patterns of Local Failure following Radiation Therapy for Prostate Cancer. J Urol. 2015 Oct; 194(4):977-82.
    View on PubMed
  8. Physical activity, sedentary behavior, and health-related quality of life in prostate cancer survivors in the health professionals follow-up study. J Cancer Surviv. 2015 Sep; 9(3):500-11.
    View on PubMed
  9. Associations of prostate cancer risk variants with disease aggressiveness: results of the NCI-SPORE Genetics Working Group analysis of 18,343 cases. Hum Genet. 2015 Apr; 134(4):439-50.
    View on PubMed
  10. GermLine Variation in Superoxide Dismutase-2 (SOD2) and Survival Outcomes After Radiation Therapy for Prostate Cancer: Results of a Test and Validation Set Analysis. Clin Genitourin Cancer. 2015 Aug; 13(4):370-377.e1.
    View on PubMed
  11. Hair, hormones, and high-risk prostate cancer. J Clin Oncol. 2015 Feb 10; 33(5):386-7.
    View on PubMed
  12. Selenium supplementation and prostate cancer mortality. J Natl Cancer Inst. 2015 Jan; 107(1).
    View on PubMed
  13. Selenoprotein and antioxidant genes and the risk of high-grade prostate cancer and prostate cancer recurrence. Prostate. 2015 Jan; 75(1):60-9.
    View on PubMed
  14. Extended followup and risk factors for disease reclassification in a large active surveillance cohort for localized prostate cancer. J Urol. 2015 Mar; 193(3):807-11.
    View on PubMed
  15. Long-term Health-related Quality of Life After Primary Treatment for Localized Prostate Cancer: Results from the CaPSURE Registry. Eur Urol. 2015 Oct; 68(4):600-8.
    View on PubMed
  16. A 17-gene assay to predict prostate cancer aggressiveness in the context of Gleason grade heterogeneity, tumor multifocality, and biopsy undersampling. Eur Urol. 2014 Sep; 66(3):550-60.
    View on PubMed
  17. What should we tell prostate cancer patients about (secondary) prevention? Curr Opin Urol. 2014 May; 24(3):318-23.
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  18. Plasma antioxidants, genetic variation in SOD2, CAT, GPX1, GPX4, and prostate cancer survival. Cancer Epidemiol Biomarkers Prev. 2014 Jun; 23(6):1037-46.
    View on PubMed
  19. Limited ability of existing nomograms to predict outcomes in men undergoing active surveillance for prostate cancer. BJU Int. 2014 Dec; 114(6b):E18-24.
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  20. Physical activity and prostate gene expression in men with low-risk prostate cancer. Cancer Causes Control. 2014 Apr; 25(4):515-23.
    View on PubMed

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