University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
June MayLin Chan, ScD

June MayLin Chan, ScD

Program Director, Genitourinary Cancer Epidemiology and Population Sciences, Department of Urology, UCSF
Steven and Christine Burd-Safeway Distinguished Professor, UCSF

Cancer Center Program Memberships

Prostate Cancer

Research Summary

My main research interests are in understanding how diet, exercise, and genetics contribute to prostate cancer incidence, progression, and death. Our program aims to identify modifiable lifestyle risk factors for prostatecancer progression, use this information to better understand prostate cancer biology, and inform public health guidelines. I have worked in this area for ~20 years and was awarded the Steven & Christine Burd-Safeway Distinguished Professorship at UCSF (University of California San Francisco) in 2009 in recognition of my teaching, research, and service activities in prostate cancer. Our work is highly collaborative, and our clinical and translational studies work to identify risk-reduction strategies for men with or at high risk for prostate cancer, evaluate novel molecular markers of prostate cancer aggressiveness that may improve screening, diagnosis, or prognosis of clinically relevant disease, and improve cancer survivorship for the millions of men living with prostate cancer world wide.

I initiated the prospective Diet and Lifestyle Study within the Cancer of the Prostate Strategic Urologic Research Endeavor (CaPSURE) in 2004; am PI of a randomized clinical trial examining an exercise intervention among men pursuing active surveillance for prostate cancer; co-PI on a large Dept. of Defense Translational Impact Award focused on improving risk stratification and decision support for men considering active surveillance for low risk prostate cancer; site co-PI for a global clinical trial of exercise among men with metastatic prostate cancer; and am mentoring two junior facultyon three distinct lifestyle intervention trials for cancer survivors. I have mentored ~22 pre-doctoral students, 8 fellows, and 6 faculty. I have worked closely with Dr. Carroll for 15+ yrs on research related to identifying and testing novel biomarkers to discern aggressive from lethal prostate cancer. In this proposal, we bring together expertise in lifestyle risk factors for lethal prostate cancer, experience in elucidating the molecular drivers for aggressive prostate cancer, and experience implementing prostate cancer registries and biobanks. We have assembled unique study and data resources to evaluate if/how lifestyle factors influence tumor and host inflammation, insulin regulation, and metabolism pathways to drive aggressive disease; examine if lifestyle changes may mitigate such drivers to prevent lethal prostate cancer; and begin to address these same hypothesis in African American men with prostate cancer.

Education

Harvard College, Cambridge, MA , B.A., 1994, Applied Math in Biology
Harvard School of Public Health, Boston, MA, ScD, 11/98, Epidemiology (Cancer)
Harvard School of Public Health, Boston, MA, 11/98-11/00, Postdoctoral Fellow-Epidemiology


Professional Experience

  • 1992-94, 1995-96
    Research Assistant, Department of Nutrition, Harvard School of Public Health
  • 1994-95
    Fulbright Scholar, Uppsala University, Sweden, Dept. of Medical Epidemiology
  • 1995-97
    National Research Service Award Fellowship, National Cancer Institute (NCI), Training Program in Cancer Epidemiology - pre-doctoral
  • 1997-98
    Teaching Fellow, Harvard School of Public Health
  • 1997- present
    Project Director, Prostate Cancer Survivors Follow-up, Harvard Sch. of Public Health
  • 1998-2000
    Postdoctoral Fellow, Depts of Epidemiology/Nutrition, Harvard Sch. Public Health; National Research Service Award Fellowship, NCI, Training Program in Cancer Epidemiology - post-doctoral
  • 1999
    Visiting Researcher, Dept. of Nutrition, National Public Health Institute, Helsinki, Finland
  • 1999
    Instructor of Medicine, Harvard Medical School
  • 2001-2007
    Assistant Professor, In Residence, Departments of Epidemiology & Biostatistics and Urology, University of California San Francisco (UCSF)
  • 2005-present
    Program Director, Genitourinary Cancer Epid. and Pop. Sci., Dept. of Urology, UCSF
  • 2007-present
    Associate Professor, In Residence, Departments of Epidemiology & Biostatistics and Urology, University of California San Francisco (UCSF)
  • 2007-present
    Course Director & Epidemiology and Evidence-based Medicine Discipline Leader, Essential Core Curriculum, UCSF School of Medicine
  • 2012-present
    Professor, Departments of Epidemiology & Biostatistics and Urology, UCSF
  • 2013-2014
    Interim Division Chief, Genetic & Cancer Epidemiology, Dept. of Epid. & Biostats., UCSF

Honors & Awards

  • 1994-96
    Fulbright Scholar, Uppsala University, Sweden, Dept. of Medical Epidemiology
  • 1996 & 1997
    Pforzheimer Public Service Fellowship, Harvard University
  • 1998
    Society for Epidemiologic Research Abraham Lilienfeld Student Prize
  • 1998
    Association for the Cure of Cancer of the Prostate ("CaPCURE") - Young Investigator Award
  • 2000
    AACR-AFLAC Young Investigator Scholars in Cancer Research Award
  • 2001
    REAC Intramural award, UCSF
  • 2002
    AACR-California Department of Health Services Early Career Development Award in Gender-Related Cancer Research (prostate)
  • 2003
    Prostate Cancer Foundation ("CaPCURE") - Competitive Award (6/03 & 12/03)
  • UCSF Equal Opportunity Faculty Development Award
  • 2009
    Awarded Steven & Christine Burd-Safeway Distinguished Professorship, Urology, UCSF

Selected Publications

  1. Winters-Stone KM, Kenfield SA, Van Blarigan EL, Moe EL, Ramsdill JW, Daniel K, Macaire G, Paich K, Kessler ER, Kucuk O, Gillespie TW, Lyons KS, Beer TM, Broering JM, Carroll PR, Chan JM. Effect of Increasing Levels of Web-Based Behavioral Support on Changes in Physical Activity, Diet, and Symptoms in Men With Prostate Cancer: Protocol for a Randomized Controlled Trial. JMIR Res Protoc. 2018 Nov 15; 7(11):e11257.
    View on PubMed
  2. Travis RC, Perez-Cornago A, Appleby PN, Albanes D, Joshu CE, Lutsey PL, Mondul AM, Platz EA, Weinstein SJ, Layne TM, Helzlsouer KJ, Visvanathan K, Palli D, Peeters PH, Bueno-de-Mesquita B, Trichopoulou A, Gunter MJ, Tsilidis KK, Sanchez MJ, Olsen A, Brenner H, Schöttker B, Perna L, Holleczek B, Knekt P, Rissanen H, Yeap BB, Flicker L, Almeida OP, Wong YYE, Chan JM, Giovannucci EL, Stampfer MJ, Ursin G, Gislefoss RE, Bjørge T, Meyer HE, Blomhoff R, Tsugane S, Sawada N, English DR, Eyles DW, Heath AK, Williamson EJ, Manjer J, Malm J, Almquist M, Le Marchand L, Haiman CA, Wilkens LR, Schenk JM, Tangen CM, Black A, Cook MB, Huang WY, Ziegler RG, Martin RM, Hamdy FC, Donovan JL, Neal DE, Touvier M, Hercberg S, Galan P, Deschasaux M, Key TJ, Allen NE. A collaborative analysis of individual participant data from 19 prospective studies assesses circulating vitamin D and prostate cancer risk. Cancer Res. 2018 Nov 13.
    View on PubMed
  3. Zhao SG, Lehrer J, Chang SL, Das R, Erho N, Liu Y, Sjöström M, Den RB, Freedland SJ, Klein EA, Karnes RJ, Schaeffer EM, Xu M, Speers C, Nguyen PL, Ross AE, Chan JM, Cooperberg MR, Carroll PR, Davicioni E, Fong L, Spratt DE, Feng FY. The Immune Landscape of Prostate Cancer and Nomination of PD-L2 as a Potential Therapeutic Target. J Natl Cancer Inst. 2018 Oct 13.
    View on PubMed
  4. Kornberg Z, Cowan JE, Westphalen AC, Cooperberg MR, Chan JM, Zhao S, Shinohara K, Carroll PR. Genomic Prostate Score, PI-RADSv2, and Progression in Men with Prostate Cancer on Active Surveillance. J Urol. 2018 Sep 01.
    View on PubMed
  5. Ahearn TU, Peisch S, Pettersson A, Ebot EM, Zhou K, Graff RE, Sinnott JA, Fazli L, Judson GL, Bismar TA, Rider JR, Gerke T, Chan JM, Fiorentino M, Flavin R, Sesso HD, Finn S, Giovannucci EL, Gleave M, Loda M, Li Z, Pollak M, Mucci LA. Expression of IGF/insulin receptor in prostate cancer tissue and progression to lethal disease. Carcinogenesis. 2018 Aug 24.
    View on PubMed
  6. Watts EL, Appleby PN, Perez-Cornago A, Bueno-de-Mesquita HB, Chan JM, Chen C, Cohn BA, Cook MB, Flicker L, Freedman ND, Giles GG, Giovannucci E, Gislefoss RE, Hankey GJ, Kaaks R, Knekt P, Kolonel LN, Kubo T, Le Marchand L, Luben RN, Luostarinen T, Männistö S, Metter EJ, Mikami K, Milne RL, Ozasa K, Platz EA, Quirós JR, Rissanen H, Sawada N, Stampfer M, Stanczyk FZ, Stattin P, Tamakoshi A, Tangen CM, Thompson IM, Tsilidis KK, Tsugane S, Ursin G, Vatten L, Weiss NS, Yeap BB, Allen NE, Key TJ, Travis RC. Low Free Testosterone and Prostate Cancer Risk: A Collaborative Analysis of 20 Prospective Studies. Eur Urol. 2018 Aug 01.
    View on PubMed
  7. Cooperberg MR, Erho N, Chan JM, Feng FY, Fishbane N, Zhao SG, Simko JP, Cowan JE, Lehrer J, Alshalalfa M, Kolisnik T, Chelliserry J, Margrave J, Aranes M, Plessis MD, Buerki C, Tenggara I, Davicioni E, Carroll PR. The Diverse Genomic Landscape of Clinically Low-risk Prostate Cancer. Eur Urol. 2018 May 28.
    View on PubMed
  8. Chan JM, Kenfield SA, Platz EA. Association of Statin Use With Overall and Cancer Survival. JAMA Oncol. 2018 May 24.
    View on PubMed
  9. Mascarenhas MN, Chan JM, Vittinghoff E, Van Blarigan EL, Hecht F. Increasing Physical Activity in Mothers Using Video Exercise Groups and Exercise Mobile Apps: Randomized Controlled Trial. J Med Internet Res. 2018 May 18; 20(5):e179.
    View on PubMed
  10. Newton RU, Kenfield SA, Hart NH, Chan JM, Courneya KS, Catto J, Finn SP, Greenwood R, Hughes DC, Mucci L, Plymate SR, Praet SFE, Guinan EM, Van Blarigan EL, Casey O, Buzza M, Gledhill S, Zhang L, Galvão DA, Ryan CJ, Saad F. Intense Exercise for Survival among Men with Metastatic Castrate-Resistant Prostate Cancer (INTERVAL-GAP4): a multicentre, randomised, controlled phase III study protocol. BMJ Open. 2018 May 14; 8(5):e022899.
    View on PubMed
  11. Watts EL, Appleby PN, Albanes D, Black A, Chan JM, Chen C, Cirillo PM, Cohn BA, Cook MB, Donovan JL, Ferrucci L, Garland CF, Giles GG, Goodman PJ, Habel LA, Haiman CA, Holly JMP, Hoover RN, Kaaks R, Knekt P, Kolonel LN, Kubo T, Le Marchand L, Luostarinen T, MacInnis RJ, Mäenpää HO, Männistö S, Metter EJ, Milne RL, Nomura AMY, Oliver SE, Parsons JK, Peeters PH, Platz EA, Riboli E, Ricceri F, Rinaldi S, Rissanen H, Sawada N, Schaefer CA, Schenk JM, Stanczyk FZ, Stampfer M, Stattin P, Stenman UH, Tjønneland A, Trichopoulou A, Thompson IM, Tsugane S, Vatten L, Whittemore AS, Ziegler RG, Allen NE, Key TJ, Travis RC. Circulating sex hormones in relation to anthropometric, sociodemographic and behavioural factors in an international dataset of 12,300 men. PLoS One. 2017; 12(12):e0187741.
    View on PubMed
  12. Bauer SR, Van Blarigan EL, Stampfer MJ, Chan JM, Kenfield SA. Mediterranean diet after prostate cancer diagnosis and urinary and sexual functioning: The health professionals follow-up study. Prostate. 2018 Feb; 78(3):202-212.
    View on PubMed
  13. Tat D, Kenfield SA, Cowan JE, Broering JM, Carroll PR, Van Blarigan EL, Chan JM. Milk and other dairy foods in relation to prostate cancer recurrence: Data from the cancer of the prostate strategic urologic research endeavor (CaPSURE™). Prostate. 2018 Jan; 78(1):32-39.
    View on PubMed
  14. Cooperberg MR, Chan JM. Epidemiology of prostate cancer. World J Urol. 2017 Jun; 35(6):849.
    View on PubMed
  15. Van Blarigan EL, Kenfield SA, Tantum L, Cadmus-Bertram LA, Carroll PR, Chan JM. The Fitbit One Physical Activity Tracker in Men With Prostate Cancer: Validation Study. JMIR Cancer. 2017 Apr 18; 3(1):e5.
    View on PubMed
  16. Emami NC, Leong L, Wan E, Van Blarigan EL, Cooperberg MR, Tenggara I, Carroll PR, Chan JM, Witte JS, Simko JP. Tissue Sources for Accurate Measurement of Germline DNA Genotypes in Prostate Cancer Patients Treated With Radical Prostatectomy. Prostate. 2017 Mar; 77(4):425-434.
    View on PubMed
  17. Peisch SF, Van Blarigan EL, Chan JM, Stampfer MJ, Kenfield SA. Prostate cancer progression and mortality: a review of diet and lifestyle factors. World J Urol. 2017 Jun; 35(6):867-874.
    View on PubMed
  18. Fu PL, Bradley KL, Viswanathan S, Chan JM, Stampfer M. Trends in Biometric Health Indices Within an Employer-Sponsored Wellness Program With Outcome-Based Incentives. Am J Health Promot. 2016 Jul; 30(6):453-7.
    View on PubMed
  19. Chan JM, Darke AK, Penney KL, Tangen CM, Goodman PJ, Lee GM, Sun T, Peisch S, Tinianow AM, Rae JM, Klein EA, Thompson IM, Kantoff PW, Mucci LA. Selenium- or Vitamin E-Related Gene Variants, Interaction with Supplementation, and Risk of High-Grade Prostate Cancer in SELECT. Cancer Epidemiol Biomarkers Prev. 2016 07; 25(7):1050-1058.
    View on PubMed
  20. Knudsen BS, Kim HL, Erho N, Shin H, Alshalalfa M, Lam LLC, Tenggara I, Chadwich K, Van Der Kwast T, Fleshner N, Davicioni E, Carroll PR, Cooperberg MR, Chan JM, Simko JP. Application of a Clinical Whole-Transcriptome Assay for Staging and Prognosis of Prostate Cancer Diagnosed in Needle Core Biopsy Specimens. J Mol Diagn. 2016 05; 18(3):395-406.
    View on PubMed

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