June MayLin Chan, ScD

June MayLin Chan, ScD

Program Director, Genitourinary Cancer Epidemiology and Population Sciences, Department of Urology, UCSF
Steven and Christine Burd-Safeway Distinguished Professor, UCSF


Phone: (415) 415-4923 (voice)
Box 9001, UCSF
San Francisco, CA 94143-9001

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Cancer Center Membership

Program Member » Prostate Cancer

Research Summary

My main research interests are in understanding how diet, exercise, hormones, and genetics contribute to prostate cancer incidence, progression, and death. I am particularly interested in identifying modifiable lifestyle risk factors for prostate cancer progression and using this information to help us better understand prostate cancer biology, as well as inform public health guidelines. I have worked in this area for 17+ years and was awarded the Steven & Christine Burd-Safeway Distinguished Professorship at UCSF in 2009 in recognition of my teaching, research, and service activities in the field of prostate cancer.

My work is highly collaborative, and the goals of our clinical and translational research studies are to identify risk-reduction strategies for men with or at high risk for prostate cancer; evaluate novel molecular markers of prostate cancer aggressiveness that may improve screening, diagnosis, or prognosis of clinically relevant disease; and improving cancer survivorship for the millions of men living with prostate cancer worldwide. I initiated the prospective Diet and Lifestyle Study within the Cancer of the Prostate Strategic Urologic Research Endeavor (CaPSURE) in 2004. I also collaborate with colleagues at the Harvard School of Public Health on the Health Professionals Follow-up Study to examine diet and lifestyle risk factors for prostate cancer progression, metastases, and death. I am PI on a randomized clinical trial examining an exercise intervention among men pursuing active surveillance for prostate cancer; co-PI on a large Dept. of Defense Translational Impact Award focused on improving risk stratification and decision support for men considering active surveillance for low risk prostate cancer; co-leader for a True NTH USA project focused on lifestyle; and Steering Committee member for GAP 4 (RCT on exercise in men with advanced prostate cancer).


Harvard College, Cambridge, MA , B.A., 1994, Applied Math in Biology
Harvard School of Public Health, Boston, MA, ScD, 11/98, Epidemiology (Cancer)
Harvard School of Public Health, Boston, MA, 11/98-11/00, Postdoctoral Fellow-Epidemiology

Professional Experience

  • 1992-94, 1995-96
    Research Assistant, Department of Nutrition, Harvard School of Public Health
  • 1994-95
    Fulbright Scholar, Uppsala University, Sweden, Dept. of Medical Epidemiology
  • 1995-97
    National Research Service Award Fellowship, National Cancer Institute (NCI), Training Program in Cancer Epidemiology - pre-doctoral
  • 1997-98
    Teaching Fellow, Harvard School of Public Health
  • 1997- present
    Project Director, Prostate Cancer Survivors Follow-up, Harvard Sch. of Public Health
  • 1998-2000
    Postdoctoral Fellow, Depts of Epidemiology/Nutrition, Harvard Sch. Public Health; National Research Service Award Fellowship, NCI, Training Program in Cancer Epidemiology - post-doctoral
  • 1999
    Visiting Researcher, Dept. of Nutrition, National Public Health Institute, Helsinki, Finland
  • 1999
    Instructor of Medicine, Harvard Medical School
  • 2001-2007
    Assistant Professor, In Residence, Departments of Epidemiology & Biostatistics and Urology, University of California San Francisco (UCSF)
  • 2005-present
    Program Director, Genitourinary Cancer Epid. and Pop. Sci., Dept. of Urology, UCSF
  • 2007-present
    Associate Professor, In Residence, Departments of Epidemiology & Biostatistics and Urology, University of California San Francisco (UCSF)

Honors & Awards

  • 1994-96
    Fulbright Scholar, Uppsala University, Sweden, Dept. of Medical Epidemiology
  • 1996 & 1997
    Pforzheimer Public Service Fellowship, Harvard University
  • 1998
    Society for Epidemiologic Research Abraham Lilienfeld Student Prize
  • 1998
    Association for the Cure of Cancer of the Prostate ("CaPCURE") - Young Investigator Award
  • 2000
    AACR-AFLAC Young Investigator Scholars in Cancer Research Award
  • 2001
    REAC Intramural award, UCSF
  • 2002
    AACR-California Department of Health Services Early Career Development Award in Gender-Related Cancer Research (prostate)
  • 2003
    Prostate Cancer Foundation ("CaPCURE") - Competitive Award (6/03 & 12/03)
  • UCSF Equal Opportunity Faculty Development Award

Selected Publications

  1. Key TJ, Appleby PN, Travis RC, Albanes D, Alberg AJ, Barricarte A, Black A, Boeing H, Bueno-de-Mesquita HB, Chan JM, Chen C, Cook MB, Donovan JL, Galan P, Gilbert R, Giles GG, Giovannucci E, Goodman GE, Goodman PJ, Gunter MJ, Hamdy FC, Heliövaara M, Helzlsouer KJ, Henderson BE, Hercberg S, Hoffman-Bolton J, Hoover RN, Johansson M, Khaw KT, King IB, Knekt P, Kolonel LN, Le Marchand L, Männistö S, Martin RM, Meyer HE, Mondul AM, Moy KA, Neal DE, Neuhouser ML, Palli D, Platz EA, Pouchieu C, Rissanen H, Schenk JM, Severi G, Stampfer MJ, Tjønneland A, Touvier M, Trichopoulou A, Weinstein SJ, Ziegler RG, Zhou CK, Allen NE. Carotenoids, retinol, tocopherols, and prostate cancer risk: pooled analysis of 15 studies. Am J Clin Nutr. 2015 Nov; 102(5):1142-57.
    View on PubMed
  2. Van Blarigan EL, Gerstenberger JP, Kenfield SA, Giovannucci EL, Stampfer MJ, Jones LW, Clinton SK, Chan JM, Mucci LA. Physical Activity and Prostate Tumor Vessel Morphology: Data from the Health Professionals Follow-up Study. Cancer Prev Res (Phila). 2015 Oct; 8(10):962-7.
    View on PubMed
  3. Chan JM, Kenfield SA, Paciorek A, Platz EA, Giovannucci EL, Stampfer MJ. Postdiagnostic Statin Use and the Risk of Lethal Prostate Cancer in the Health Professionals Follow-up Study. Cancer Epidemiol Biomarkers Prev. 2015 Oct; 24(10):1638-40.
    View on PubMed
  4. Van Blarigan EL, Kenfield SA, Yang M, Sesso HD, Ma J, Stampfer MJ, Chan JM, Chavarro JE. Fat intake after prostate cancer diagnosis and mortality in the Physicians' Health Study. Cancer Causes Control. 2015 Aug; 26(8):1117-26.
    View on PubMed
  5. Jalloh M, Leapman MS, Cowan JE, Shinohara K, Greene KL, Roach M, Chang AJ, Chan JM, Simko JP, Carroll PR. Patterns of Local Failure following Radiation Therapy for Prostate Cancer. J Urol. 2015 Oct; 194(4):977-82.
    View on PubMed
  6. Phillips SM, Stampfer MJ, Chan JM, Giovannucci EL, Kenfield SA. Physical activity, sedentary behavior, and health-related quality of life in prostate cancer survivors in the health professionals follow-up study. J Cancer Surviv. 2015 Sep; 9(3):500-11.
    View on PubMed
  7. Helfand BT, Roehl KA, Cooper PR, McGuire BB, Fitzgerald LM, Cancel-Tassin G, Cornu JN, Bauer S, Van Blarigan EL, Chen X, Duggan D, Ostrander EA, Gwo-Shu M, Zhang ZF, Chang SC, Jeong S, Fontham ET, Smith G, Mohler JL, Berndt SI, McDonnell SK, Kittles R, Rybicki BA, Freedman M, Kantoff PW, Pomerantz M, Breyer JP, Smith JR, Rebbeck TR, Mercola D, Isaacs WB, Wiklund F, Cussenot O, Thibodeau SN, Schaid DJ, Cannon-Albright L, Cooney KA, Chanock SJ, Stanford JL, Chan JM, Witte J, Xu J, Bensen JT, Taylor JA, Catalona WJ. Associations of prostate cancer risk variants with disease aggressiveness: results of the NCI-SPORE Genetics Working Group analysis of 18,343 cases. Hum Genet. 2015 Apr; 134(4):439-50.
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  8. Margalit DN, Jordahl KM, Werner L, Wang X, Gwo-Shu Lee M, Penney KL, Batista JL, Martin NE, Chan JM, Kantoff PW, Stampfer MJ, Nguyen PL, Mucci LA. GermLine Variation in Superoxide Dismutase-2 (SOD2) and Survival Outcomes After Radiation Therapy for Prostate Cancer: Results of a Test and Validation Set Analysis. Clin Genitourin Cancer. 2015 Aug; 13(4):370-377.e1.
    View on PubMed
  9. Ryan CJ, Chan JM. Hair, hormones, and high-risk prostate cancer. J Clin Oncol. 2015 Feb 10; 33(5):386-7.
    View on PubMed
  10. Kenfield SA, Van Blarigan EL, DuPre N, Stampfer MJ, L Giovannucci E, Chan JM. Selenium supplementation and prostate cancer mortality. J Natl Cancer Inst. 2015 Jan; 107(1).
    View on PubMed
  11. Gerstenberger JP, Bauer SR, Van Blarigan EL, Sosa E, Song X, Witte JS, Carroll PR, Chan JM. Selenoprotein and antioxidant genes and the risk of high-grade prostate cancer and prostate cancer recurrence. Prostate. 2015 Jan; 75(1):60-9.
    View on PubMed
  12. Welty CJ, Cowan JE, Nguyen H, Shinohara K, Perez N, Greene KL, Chan JM, Meng MV, Simko JP, Cooperberg MR, Carroll PR. Extended followup and risk factors for disease reclassification in a large active surveillance cohort for localized prostate cancer. J Urol. 2015 Mar; 193(3):807-11.
    View on PubMed
  13. Punnen S, Cowan JE, Chan JM, Carroll PR, Cooperberg MR. Long-term Health-related Quality of Life After Primary Treatment for Localized Prostate Cancer: Results from the CaPSURE Registry. Eur Urol. 2015 Oct; 68(4):600-8.
    View on PubMed
  14. Klein EA, Cooperberg MR, Magi-Galluzzi C, Simko JP, Falzarano SM, Maddala T, Chan JM, Li J, Cowan JE, Tsiatis AC, Cherbavaz DB, Pelham RJ, Tenggara-Hunter I, Baehner FL, Knezevic D, Febbo PG, Shak S, Kattan MW, Lee M, Carroll PR. A 17-gene assay to predict prostate cancer aggressiveness in the context of Gleason grade heterogeneity, tumor multifocality, and biopsy undersampling. Eur Urol. 2014 Sep; 66(3):550-60.
    View on PubMed
  15. Chan JM, Van Blarigan EL, Kenfield SA. What should we tell prostate cancer patients about (secondary) prevention? Curr Opin Urol. 2014 May; 24(3):318-23.
    View on PubMed
  16. Van Blarigan EL, Ma J, Kenfield SA, Stampfer MJ, Sesso HD, Giovannucci EL, Witte JS, Erdman JW, Chan JM, Penney KL. Plasma antioxidants, genetic variation in SOD2, CAT, GPX1, GPX4, and prostate cancer survival. Cancer Epidemiol Biomarkers Prev. 2014 Jun; 23(6):1037-46.
    View on PubMed
  17. Wang SY, Cowan JE, Cary KC, Chan JM, Carroll PR, Cooperberg MR. Limited ability of existing nomograms to predict outcomes in men undergoing active surveillance for prostate cancer. BJU Int. 2014 Dec; 114(6b):E18-24.
    View on PubMed
  18. Magbanua MJ, Richman EL, Sosa EV, Jones LW, Simko J, Shinohara K, Haqq CM, Carroll PR, Chan JM. Physical activity and prostate gene expression in men with low-risk prostate cancer. Cancer Causes Control. 2014 Apr; 25(4):515-23.
    View on PubMed
  19. Jones LW, Hornsby WE, Freedland SJ, Lane A, West MJ, Moul JW, Ferrandino MN, Allen JD, Kenjale AA, Thomas SM, Herndon JE, Koontz BF, Chan JM, Khouri MG, Douglas PS, Eves ND. Effects of nonlinear aerobic training on erectile dysfunction and cardiovascular function following radical prostatectomy for clinically localized prostate cancer. Eur Urol. 2014 May; 65(5):852-5.
    View on PubMed
  20. Tomaszewski JJ, Richman EL, Sadetsky N, O'Keefe DS, Carroll PR, Davies BJ, Chan JM. Impact of folate intake on prostate cancer recurrence following definitive therapy: data from CaPSURE™. J Urol. 2014 Apr; 191(4):971-6.
    View on PubMed

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