University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Susan M. Chang, MD

Susan M. Chang, MD

Professor in Residence, Department of Neurological Surgery, UCSF
Co-Leader, Neurologic Oncology Program, UCSF Helen Diller Family Comprehensive Cancer Center

Lai Wan Kan Endowed Chair, UCSF

Cancer Center Program Memberships

Neurologic Oncology

Research Summary

My research interest is in the development of novel therapies for patients with brain tumors, as well as the assessment of novel imaging biomarkers in the management of patients. I am the principal investigator and co-investigator on more than 15 active clinical trials that evaluate the wide spectrum of therapeutic interventions that span chemotherapy, targeted agents, immunotherapy and convection enhanced delivery of novel agents. I am the site PI of an NIH-funded adult brain tumor consortium and serve on the coordinating committee for that entity. I have served as a member of the Board of Scientific Directors and currently am a member of the Brain Malignancy Steering Committee and the Developmental Therapeutics Study Section at the NIH. I am the program leader for the Neuro-Oncology Program at the Helen Diller Family Comprehensive Cancer Center. I am the PI of a P01 grant related to integrating advances in physiologic and metabolic imaging with tissue biomarkers in order to optimize the management of patients with glioblastoma (GBM). For the UCSF Brain Tumor SPORE, I am the clinical co-PI of the overall grant, a member of the Executive Committee, the co-Director of the Biostatistical and Clinical Core and a co-Leader of a SPORE Project evaluating the role of physiologic imaging in the determination of malignant progression of low-grade glioma.

Education

University of British Columbia, 1981
University of British Columbia, MD, 1985, Medicine
Pasqua Hospital, University of Saskatchewan, Regina, Internship, 1985-1986
Plains Health Centre, Regina, Saskatchewan, Residency, 1986-1987
Toronto General Hospital, U of Toronto, Ontario, Residency, 1987-1989
Princess Margaret Hospital, U of Toronto, Ontario, Residency, 1989-1991
Royal College of Physicians & Surgeons, Canada, FRCPS, 1990, Internal Medicine
Royal College of Physicians & Surgeons, Canada, FRCPS, 1991, Medical Oncology


Professional Experience

  • 1991-1992
    Lecturer, Department of Medicine, University of Toronto, Ontario
  • 1991-1992
    Director of Palliative Care, Department of Medicine, St Michael's Hospital, Toronto, Ontario
  • 1992-1994
    Clinical Instructor, Neuro-Oncology Program, Brain Tumor Research Center, Department of Neurological Surgery, UCSF
  • 1994-1996
    Assistant Clinical Professor, Neuro-Oncology Program, Brain Tumor Research Center, Department of Neurological Surgery, UCSF
  • 1994-present
    Member, Brain Tumor Research Center, Dept. of Neurological Surgery, School of Medicine, UCSF
  • 1996-1998
    Assistant Professor in Residence, Dept. of Neurological Surgery, School of Medicine, UCSF
  • 1998-2004
    Associate Professor in Residence, Dept. of Neurological Surgery, School of Medicine, UCSF
  • 2003-present
    Vice Chair of Clinical Enterprise, Department of Neurological Surgery, UCSF
  • 2004-present
    Professor in Residence, Dept. of Neurological Surgery, School of Medicine, UCSF
  • 2005-present
    Director, Division of Neuro-Oncology, Department of Neurological Surgery, UCSF
  • 2013-present
    Director, Gordon Murray Neuro-Oncology Caregiver Program
  • 2014-present
    Editor in Chief of Neuro-Oncology Practice
  • 2015-present
    Program Leader, Neuro-Oncology Program, UCSF Helen Diller Family Comprehensive Cancer Center

Honors & Awards

  • 2014
    UCSF Voice of the Patient Pinnacle Award x 7 years, Press Ganey award for excellence in patient care per division, Hall of Fame
  • 2014
    John J. Mealey Jr. Neuro-Oncology Lectureship

Selected Publications

  1. Mazor T, Chesnelong C, Pankov A, Jalbert LE, Hong C, Hayes J, Smirnov IV, Marshall R, Souza CF, Shen Y, Viswanath P, Noushmehr H, Ronen SM, Jones SJM, Marra MA, Cairncross JG, Perry A, Nelson SJ, Chang SM, Bollen AW, Molinaro AM, Bengtsson H, Olshen AB, Weiss S, Phillips JJ, Luchman HA, Costello JF. Clonal expansion and epigenetic reprogramming following deletion or amplification of mutant IDH1. Proc Natl Acad Sci U S A. 2017 Sep 15.
    View on PubMed
  2. Nagueh SF, Chang SM, Nabi F, Shah DJ, Estep JD. Cardiac Imaging in Patients With Heart Failure and Preserved Ejection Fraction. Circ Cardiovasc Imaging. 2017 Sep; 10(9).
    View on PubMed
  3. Alexander BM, Ba S, Berger MS, Berry DA, Cavenee WK, Chang SM, Cloughesy TF, Jiang T, Khasraw M, Li W, Mittman R, Poste GH, Wen PY, Yung WKA, Barker AD. Adaptive Global Innovative Learning Environment for Glioblastoma: GBM AGILE. Clin Cancer Res. 2017 Aug 16.
    View on PubMed
  4. Wahl M, Anwar M, Hess CP, Chang SM, Lupo JM. Relationship between radiation dose and microbleed formation in patients with malignant glioma. Radiat Oncol. 2017 Aug 10; 12(1):126.
    View on PubMed
  5. Anwar M, Molinaro AM, Morin O, Chang SM, Haas-Kogan DA, Nelson SJ, Lupo JM. Identifying Voxels at Risk for Progression in Glioblastoma Based on Dosimetry, Physiologic and Metabolic MRI. Radiat Res. 2017 Sep; 188(3):303-313.
    View on PubMed
  6. van den Bent MJ, Smits M, Kros JM, Chang SM. Diffuse Infiltrating Oligodendroglioma and Astrocytoma. J Clin Oncol. 2017 Jul 20; 35(21):2394-2401.
    View on PubMed
  7. Wen PY, Chang SM, Van den Bent MJ, Vogelbaum MA, Macdonald DR, Lee EQ. Response Assessment in Neuro-Oncology Clinical Trials. J Clin Oncol. 2017 Jul 20; 35(21):2439-2449.
    View on PubMed
  8. Chang SM, Chakavarti A, Bell EH. Reply to letter on results of NRG Oncology RTOG 9813. Neuro Oncol. 2017 05 01; 19(5):739.
    View on PubMed
  9. Jalbert LE, Elkhaled A, Phillips JJ, Neill E, Williams A, Crane JC, Olson MP, Molinaro AM, Berger MS, Kurhanewicz J, Ronen SM, Chang SM, Nelson SJ. Metabolic Profiling of IDH Mutation and Malignant Progression in Infiltrating Glioma. Sci Rep. 2017 Mar 22; 7:44792.
    View on PubMed
  10. Clarke JL, Molinaro AM, Cabrera JR, DeSilva AA, Rabbitt JE, Prey J, Drummond DC, Kim J, Noble C, Fitzgerald JB, Chang SM, Butowski NA, Taylor JW, Park JW, Prados MD. A phase 1 trial of intravenous liposomal irinotecan in patients with recurrent high-grade glioma. Cancer Chemother Pharmacol. 2017 Mar; 79(3):603-610.
    View on PubMed
  11. Wahl M, Phillips JJ, Molinaro AM, Lin Y, Perry A, Haas-Kogan DA, Costello JF, Dayal M, Butowski N, Clarke JL, Prados M, Nelson S, Berger MS, Chang SM. Chemotherapy for adult low-grade gliomas: clinical outcomes by molecular subtype in a phase II study of adjuvant temozolomide. Neuro Oncol. 2017 02 01; 19(2):242-251.
    View on PubMed
  12. Neill E, Luks T, Dayal M, Phillips JJ, Perry A, Jalbert LE, Cha S, Molinaro A, Chang SM, Nelson SJ. Quantitative multi-modal MR imaging as a non-invasive prognostic tool for patients with recurrent low-grade glioma. J Neurooncol. 2017 Mar; 132(1):171-179.
    View on PubMed
  13. Sulman EP, Ismaila N, Chang SM. Radiation Therapy for Glioblastoma: American Society of Clinical Oncology Clinical Practice Guideline Endorsement of the American Society for Radiation Oncology Guideline. J Oncol Pract. 2016 Nov 29; JOP2016018937.
    View on PubMed
  14. Sulman EP, Ismaila N, Armstrong TS, Tsien C, Batchelor TT, Cloughesy T, Galanis E, Gilbert M, Gondi V, Lovely M, Mehta M, Mumber MP, Sloan A, Chang SM. Radiation Therapy for Glioblastoma: American Society of Clinical Oncology Clinical Practice Guideline Endorsement of the American Society for Radiation Oncology Guideline. J Clin Oncol. 2017 Jan 20; 35(3):361-369.
    View on PubMed
  15. Abudiab MM, McKay J, Deavers M, Zoghbi WA, Chang SM. Pannus of Mitral Valve Prosthesis Causing Left Ventricular Outflow Tract Obstruction. Methodist Debakey Cardiovasc J. 2016 Sep; 12(3):183.
    View on PubMed
  16. Han SJ, Chang SM, Berger MS. Laser Ablation vs Open Resection for Deep-Seated Tumors: The Case for Open Resection. Neurosurgery. 2016 Aug; 63 Suppl 1:10-4.
    View on PubMed
  17. Barajas RF, Butowski NA, Phillips JJ, Aghi MK, Berger MS, Chang SM, Cha S. The Development of Reduced Diffusion Following Bevacizumab Therapy Identifies Regions of Recurrent Disease in Patients with High-grade Glioma. Acad Radiol. 2016 Sep; 23(9):1073-82.
    View on PubMed
  18. Bush NA, Chang SM, Berger MS. Current and future strategies for treatment of glioma. Neurosurg Rev. 2017 Jan; 40(1):1-14.
    View on PubMed
  19. Jalbert LE, Neill E, Phillips JJ, Lupo JM, Olson MP, Molinaro AM, Berger MS, Chang SM, Nelson SJ. Magnetic resonance analysis of malignant transformation in recurrent glioma. Neuro Oncol. 2016 Aug; 18(8):1169-79.
    View on PubMed
  20. Chaikriangkrai K, Maragiannis D, Belousova T, Little S, Nabi F, Mahmarian J, Chang SM. Clinical Utility of Multidetector Computed Tomography in Redo Valve Procedures. J Card Surg. 2016 Mar; 31(3):139-46.
    View on PubMed

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