University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Jocelyn S. Chapman, MD

Jocelyn S. Chapman, MD

Assistant Professor, Division of Gynecologic Oncology, Department of
Obstetrics, Gynecology & Reproductive Sciences, UCSF

Cancer Center Program Memberships

Cancer Immunology | Cancer Genetics

Research Summary

Next-generation sequencing technologies developed in the last ten years have dramatically widened our view into the many kinds of events that are driving tumor biology. Gene fusions, copy number alterations, mutations, epigenetic changes, stromal microenvironment, immunogenicity and transcript level alterations can all be ascertained via the knife of DNA and RNA sequencing. Statistical methods, factor analysis, insights from evolutionary biology and immunology as well as an understanding of mutation processes at work in tumors can help us distill out the important driver events from the background of non-functional passenger mutations, and give us useful insights into the multiple systemic processes driving tumor progression.

I am specifically interested in using these integrated approaches to help understand and improve treatments for gynecologic cancers. However, the “organ of origin” approach has narrowed our view and exploring carcinogenesis pan-cancer will allow for novel insights into uncommon or difficult to treat gynecologic cancers. To this end, I collaborate with clinicians and scientists across oncology with a goal to further a model of cancer medicine in which genetic data is incorporated.

Education

Carnegie Mellon University, Pittsburgh, PA, B.F.A., 1996-1999, Classical piano
Columbia University, New York, NY, Post-bac, 2002-2003, Pre-medical sciences
Boston University School of Medicine, Boston, MA, M.D., 2004-2008, Medicine
University of California San Francisco, Resident, 2008-2012, Obstetrics, Gynecology & Reproductive Sciences
Stanford University and UCSF, Fellow, 2012-2015, Gynecologic Oncology


Professional Experience

  • 2008 – 2012
    Residency; Obstetrics, Gynecology & Reproductive Sciences, University of California San Francisco, San Francisco, CA.
  • 2012
    Chief Resident; Obstetrics, Gynecology & Reproductive Sciences, University of California San Francisco, San Francisco, CA.
  • 2012 – 2015
    Gynecologic Oncology Fellowship; Stanford University & University of California San Francisco, Stanford & San Francisco, CA.
  • 2013 – 2014
    Computational Research Fellow; The Taylor Lab, Helen Diller Family Comprehensive Cancer Center, San Francisco, CA.
  • 2015 – 2016
    Adjunct Instructor; Division of Gynecologic Oncology, Department of Obstetrics, Gynecology & Reproductive Sciences, University of California San Francisco, San Francisco, CA.
  • 2016 - present
    Assistant Professor; Division of Gynecologic Oncology, Department of Obstetrics, Gynecology & Reproductive Sciences, University of California San Francisco, San Francisco, CA.

Honors & Awards

  • 2009
    Outstanding Resident Award in Medical Student Teaching
  • 2010
    Alpha Omega Alpha
  • 2011
    Resident Scholar - Association of Professors of Gynecology and Obstetrics
  • 2013 & 2014
    Outstanding Fellow Award in Medical Student Teaching
  • 2015
    Leo Lagasse Award for best fellow presentation on clinical research at the 2015 Western Association of Gynecologic Oncologists Annual Meeting

Selected Publications

  1. Ohliger MA, Hope TA, Chapman JS, Chen LM, Behr SC, Poder L. PET/MR Imaging in Gynecologic Oncology. Magn Reson Imaging Clin N Am. 2017 Aug; 25(3):667-684.
    View on PubMed
  2. Chen LM, Chen LL, Chapman JS. In Reply. Obstet Gynecol. 2017 Jan; 129(1):208.
    View on PubMed
  3. Roddy E, Chapman J. Genomic insights in gynecologic cancer. Curr Probl Cancer. 2017 Jan - Feb; 41(1):8-36.
    View on PubMed
  4. Chapman JS, Roddy E, Ueda S, Brooks R, Chen LL, Chen LM. Enhanced Recovery Pathways for Improving Outcomes After Minimally Invasive Gynecologic Oncology Surgery. Obstet Gynecol. 2016 Jul; 128(1):138-44.
    View on PubMed
  5. Klauschen F, Bläker H, Stenzinger A, Chapman JS, Collisson EA, Taylor BS. Re: "Clinical Sequencing Contributes to a BRCA-Associated Cancer Rediagnosis That Guides an Effective Therapeutic Course". J Natl Compr Canc Netw. 2016 Mar; 14(3):lxvi-lxviii.
    View on PubMed
  6. Chapman JS, Collisson EA, Taylor BS. The Authors Respond. J Natl Compr Canc Netw. 2016 Mar; 14(3):lxviii.
    View on PubMed
  7. Chang MT, Asthana S, Gao SP, Lee BH, Chapman JS, Kandoth C, Gao J, Socci ND, Solit DB, Olshen AB, Schultz N, Taylor BS. Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. Nat Biotechnol. 2016 Feb; 34(2):155-63.
    View on PubMed
  8. Chapman JS, Asthana S, Cade L, Chang MT, Wang Z, Zaloudek CJ, Ueda S, Collisson EA, Taylor BS. Clinical Sequencing Contributes to a BRCA-Associated Cancer Rediagnosis That Guides an Effective Therapeutic Course. J Natl Compr Canc Netw. 2015 Jul; 13(7):835-45.
    View on PubMed
  9. Chapman JS, Roddy E, Westhoff G, Simons E, Brooks R, Ueda S, Chen L. Post-operative enteral immunonutrition for gynecologic oncology patients undergoing laparotomy decreases wound complications. Gynecol Oncol. 2015 Jun; 137(3):523-8.
    View on PubMed
  10. Chapman JS, Jacoby V, Chen LM. Managing symptoms and maximizing quality of life after preventive interventions for cancer risk reduction. Curr Opin Obstet Gynecol. 2015 Feb; 27(1):40-4.
    View on PubMed
  11. Yadav BS, George P, Sharma SC, Gorsi U, McClennan E, Martino MA, Chapman J, Chen LM, Prakash G, Malhotra P, Tantravahi SK, Glenn MJ, Werner TL, Baksh K, Sokol L, Morris GJ. Primary non-Hodgkin lymphoma of the ovary. Semin Oncol. 2014 Jun; 41(3):e19-30.
    View on PubMed
  12. Henderson JT, Harper CC, Gutin S, Saraiya M, Chapman J, Sawaya GF. Routine bimanual pelvic examinations: practices and beliefs of US obstetrician-gynecologists. Am J Obstet Gynecol. 2013 Feb; 208(2):109.e1-7.
    View on PubMed
  13. Chapman JS, Powell CB, McLennan J, Crawford B, Mak J, Stewart N, Chen LM. Surveillance of survivors: follow-up after risk-reducing salpingo-oophorectomy in BRCA 1/2 mutation carriers. Gynecol Oncol. 2011 Aug; 122(2):339-43.
    View on PubMed
  14. Saleeby E, Chapman J, Morse J, Bryant A. H1N1 influenza in pregnancy: cause for concern. Obstet Gynecol. 2009 Oct; 114(4):885-91.
    View on PubMed
  15. Friedman S, Chen C, Chapman JS, Jeruss S, Terrin N, Tighiouart H, Parsons SK, Wilson JM. Neurodevelopmental outcomes of congenital diaphragmatic hernia survivors followed in a multidisciplinary clinic at ages 1 and 3. J Pediatr Surg. 2008 Jun; 43(6):1035-43.
    View on PubMed
  16. Chen C, Jeruss S, Chapman JS, Terrin N, Tighiouart H, Glassman E, Wilson JM, Parsons SK. Long-term functional impact of congenital diaphragmatic hernia repair on children. J Pediatr Surg. 2007 Apr; 42(4):657-65.
    View on PubMed

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