Xin Chen, PhD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Xin Chen, PhD

Assistant Professor, Department of Bioengineering and Therapeutic Sciences, UCSF

chenx@pharmacy.ucsf.edu

Phone: (415) 502-6526 (voice)
Box 0446, UCSF
San Francisco, CA 94143-0446

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Cancer Center Membership

Program Member » Cancer Genetics

Research Summary

I am a leading scientist in the field of molecular genetics and signaling pathways in hepatic carcinogenesis. So far, I have published total 80 peer-reviewed manuscripts with over 40 papers relating to liver cancer research. I am the corresponding author to manuscripts published at Journal of Clinical Investigation, PNAS, Gastroenterology, Hepatology, Cancer Research, and Oncogene.

Education

Beijing Medical University, Beijing China, Bachelor of Medicine, 1992, Medicine
Harvard University, Ph.D., 1997, Cell and Developmental Biology


Professional Experience

  • 1991-1992
    Undergraduate Research Assistant, Dept. of Biophysics, Beijing Medical University, Beijing, China
  • 1992-1997
    Graduate Research Assistant, Dept. of Cell Biology, Harvard Medical School, Boston, MA
  • 1997-1998
    Postdoctoral Research Fellow, Dept. of Cell Biology, Harvard Medical School, Boston, MA
  • 1998-2001
    Postdoctoral Research Associate, Howard Hughes Medical Institute, Stanford University, Stanford, CA
  • 2001-2002
    Research Associate, Dept. of Surgery, Stanford University, Stanford, CA
  • 2003-present
    Assistant Professor, Dept. of Biopharmaceutical Science, UCSF, San Francisco, CA

Honors & Awards

  • 1991-1992
    First Prize Award, Beijing Medical University, Beijing, China
  • 1998-2001
    Postdoctoral Fellowship Award, Life Science Research Foundation, Baltimore, MD

Selected Publications

  1. Hydrodynamic transfection for generation of novel mouse models for liver cancer research. Am J Pathol. 2014 Apr; 184(4):912-23.
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  2. Granulin-epithelin precursor overexpression promotes growth and invasion of hepatocellular carcinoma. Clin Cancer Res. 2004 Nov 15; 10(22):7629-36.
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  3. Novel endothelial cell markers in hepatocellular carcinoma. Mod Pathol. 2004 Oct; 17(10):1198-210.
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  4. Expression profiling identifies chemokine (C-C motif) ligand 18 as an independent prognostic indicator in gastric cancer. Gastroenterology. 2004 Aug; 127(2):457-69.
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  5. The novel marker, DOG1, is expressed ubiquitously in gastrointestinal stromal tumors irrespective of KIT or PDGFRA mutation status. Am J Pathol. 2004 Jul; 165(1):107-13.
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  6. The chromatin-remodeling BAF complex mediates cellular antiviral activities by promoter priming. Mol Cell Biol. 2004 May; 24(10):4476-86.
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  7. Gene expression patterns in human embryonic stem cells and human pluripotent germ cell tumors. Proc Natl Acad Sci U S A. 2003 Nov 11; 100(23):13350-5.
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  8. Variation in gene expression patterns in human gastric cancers. Mol Biol Cell. 2003 Aug; 14(8):3208-15.
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  9. Molecular profiling of anemia in acute renal allograft rejection using DNA microarrays. Am J Transplant. 2003 Jan; 3(1):17-22.
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  10. Phospholipase A2 group IIA expression in gastric adenocarcinoma is associated with prolonged survival and less frequent metastasis. Proc Natl Acad Sci U S A. 2002 Dec 10; 99(25):16203-8.
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  11. BMP4 initiates human embryonic stem cell differentiation to trophoblast. Nat Biotechnol. 2002 Dec; 20(12):1261-4.
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  12. Comprehensive analysis of the gene expression profiles in human gastric cancer cell lines. Oncogene. 2002 Sep 19; 21(42):6549-56.
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  13. Maximal induction of a subset of interferon target genes requires the chromatin-remodeling activity of the BAF complex. Mol Cell Biol. 2002 Sep; 22(18):6471-9.
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  14. Identify metastasis-associated genes in hepatocellular carcinoma through clonality delineation for multinodular tumor. Cancer Res. 2002 Aug 15; 62(16):4711-21.
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  15. Gene expression patterns in human liver cancers. Mol Biol Cell. 2002 Jun; 13(6):1929-39.
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  16. Regulation of CSF1 promoter by the SWI/SNF-like BAF complex. Cell. 2001 Aug 10; 106(3):309-18.
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  17. Genomic analysis of renal allograft dysfunction using cDNA microarrays. Transplant Proc. 2001 Feb-Mar; 33(1-2):297-8.
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