Orlo H. Clark, MD, FACS

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Orlo H. Clark, MD, FACS

Professor, Department of Surgery, UCSF

Phone: (415) 353-7687 (appts)
Box 1926, UCSF
San Francisco, CA 94143-1926

View on UCSF Profiles

Cancer Center Membership

Associate Member ยป Cancer Genetics

Education

Cornell University, B.Sc., 1963, Zoology
Cornell University, Medical College, M.D., 1967, Medicine
UCSF, Internship, 1967-1968, Surgery
UCSF, Residency, 1968-1970, Surgery
Hammersmith Hospital, London, Royal PG Medical School, Registrar 1970-1971, Endocrine Surgery
UCSF, Sr. Resident, 1971-1972, Surgery
UCSF, Chief Resident, 1972-1973, Surgery
Harvard School of Public Health, 1995, Program for Clinical Chiefs


Professional Experience

  • 1973-1974
    University of California San Francisco, Acting Assistant Professor of Surgery
  • 1973-1976
    VA Medical Center, San Francisco, Research Associate
  • 1973-1977
    VA Medical Center, San Francisco, Chief, Surgical Outpatient Clinic
  • 1974-1980
    University of California San Francisco, Assistant Professor of Surgery in Residence
  • 1976-1990
    VA Medical Center, San Francisco, Staff Physician
  • 1980-1985
    University of California San Francisco, Associate Professor of Surgery in Residence
  • 1985-1990
    University of California San Francisco, Professor of Surgery in Residence
  • 1990-Present
    UCSF Department of Surgery, Professor of Surgery
  • 1990-2003
    UCSF Department of Surgery, Vice Chairman
  • 1990-2003
    UCSF/Mount Zion Medical Center, Chief of Surgery
  • 2004-present
    UCSF/Mount Zion Medical Center, Professor of Surgery

Honors & Awards

  • 1999-2002
    Chair, American College of Surgeons Oncology Group, Endocrinology
  • 2000
    Richard G. Martin Jr. Distinguished Professorship, MD Anderson Center
  • 2000
    Martin Sonenberg Light of Life Distinguished Professorship, Memorial Sloan Kettering
  • 2000
    Best Thyroid Research in America
  • 2000-2003
    National Comprehensive Cancer Network - Neuroendocrine Tumors, Chair
  • 2000
    Thyroid Cancer Guidelines Committee, AAES and AACE
  • 2003
    Yank D. Coble Distinguished Service Award
  • 2006
    Oliver Cope Distinguished Service Award, American Association of Endocrine Surgeons
  • 2006
    President Elect, Pacific Coast Surgical Association

Selected Publications

  • (Selected from 353 full length publications)
  • Alsanea O, Wada N, Ain K, Wong M, Taylor K, Ituarte P, Treseler P, Weier H-U, Freimer N, Siperstein AE, Duh Q-Y, Takami H, Clark OH: Is Familial Non-Medullary Thyroid Carcinoma More Aggressive than Sporadic Thyroid Cancer: A Multi-Center Study. Surgery 128:1043-51, 2000.
  • Soh EY, Eigelberger MS, Kim KJ, Wong MG, Young DM, Clark OH, Duh Q-Y: Neutralizing VEGF Activity Inhibits Thyroid Cancer Growth In Vivo. Surgery 128:1059-66, 2000.
  • Kebebew E, Clark OH: Medullary Thyroid Cancer. Current Treatment Options in Oncology, 1:359-67, 2000.
  • Perrier ND, Ituarte P, Kikuchi S, Siperstein AE, Duh QY, Clark OH, Gielow R, Hamill T: Intraoperative Parathyroid Aspiration and Parathyroid Hormone Assay as an Alternative to Frozen Section for Tissue Identification. World J Surg 24:1319-1322, 2000.
  • Kebebew E, Treseler PA, Duh QY, Clark OH: The helix-loop-helix transcription factor ID-1, is overexpressed in medullary thyroid cancer. Surgery 128:952-7, 2000.
  • Duren M, Duh QY, Siperstein AE, Clark OH: Recurrent or persistent thyroid cancer of follicular cell origin. Curr Treat Options Oncol 1(4):339-43, 2000.
  • Alsanea O, Clark OH: Familial Thyroid Cancer. Curr Opin Oncol 13:44-51, 2001.
  • Weier HG, Zitzelsberger HF, Hsieh HB, Sun MV, Wong M, Lersch RA, Yaswen P, Smida J, Kuschnick C, Clark OH: Monitoring signal transduction in cancer: tyrosinase kinase gene expression profiling. J Histochem Cytochem 49:673-4, 2001.
  • Hsieh B, Lersch RA, Callahan DE, Hayward S Wong M, Clark OH, Weier H-U: Monitoring signal transduction in cancer: cDNA microarray for semiquantitative analyses. J Histochemo Cytocgen 49: 1057-1058, 2001.
  • Haigh PI, Ituarte P, Wu HS, Posner MD, Quivey JM, Duh QY, Clark OH: Completely resected anaplastic thyroid carcinoma combined with adjuvant chemoradiation is associated with prolonged survival. Cancer 91:2335-2342, 2001.
  • Eigelberger MS, Wong MG, Duh QY, Clark OH, Phenylacetate enhances the antiproliferative effect of retinoic acid in follicular thyroid cancer. Surgery 130:931-5, 2001.
  • Yutan E, Clark, OH. Hurthle cell carcinoma. Curr Treat Options Oncol 2:331-5, 2001.
  • Perrier N, Villablanca A, Kikushi S, Larsson C, Teh BT, Clark OH: Genetic screening for MEN1 Mutations in Families Presenting with Familial Primary Hyperparathyroidism. World Jounal of Surgery 26:907-913 2002.
  • Kanauchi H, Wada N, Clark OH, Duh QY. Apoptosis regulating genes, bcl-2 and bax, and human telomerase reverse transcriptase messenger RNA expression in adrenal tumors: possible diagnostic and prognostic importance. Surgery 132:1021-6, 2002.
  • Zarnegar R, Brunaud L, Kanauchi H, Wong M, Fung M, Ginginger D, Duh QY, Clark OH. Increasing the effectiveness of radioactive iodine therapy in the treatment of thyroid cancer using Trichostatin A, a histone deacetylase inhibitor. Surgery 132:984-90, 2002.
  • Wada N, Duh QY, Miura D, Brunaud L, Wong MG, Clark OH. Chromosomal aberrations by comparative genomic hybridization in hurthle cell thyroid carcinomas are associated with tumor recurrence. J Clin Endocrinol Metab 87:4595-601, 2002.
  • Kikuchi S, Perrier N, Ituarte P, Treseler PA, Siperstein AE, Duh QY, Greenspan FS, Clark OH: Accuracy of fine needle aspiration cytology in patients with radiation induced thyroid neoplasms. British J Surg 90:6, pp. 755-758, 2003.
  • Miura D, Wada N, Chin K, Magrane G, Wong M, Duh Q-Y, Clark OH: Anaplastic thyroid cancer: cytogenetic patterns by comparative genomic hybridization. Thyroid 13:283-290, 2003
  • Brunaud L, Zarnegar R, Wada N, Magrane G, Wong M, Duh Q-H, Clark OH: Chromosomal Aberrations by Comparative Genomic Hybridization in Thyroid Tumors in Patients with Familial Nonmedullary Thyroid Cancer. Thyroid 13:621-629, 2003
  • Park J-W, Yeh M, Wong M, Lobo M, Hyun W, Duh Q-Y, Clark OH: The Heat Shock Protein 90-Binding Geldanamycin Inhibits Cancer Cell Proliferation, Down-Regulates Oncoproteins, and Inhibits Epidermal Growth Factor-Induced Invasion in Thyroid Cancer Cell Lines. J Clin Endocrinol Metab 88:3346-3353, 2003.
  • Kanauchi H, Wada N, Ginzinger D, Yu M, Wong M, Clark OH, Duh Q-Y: Diagnostic and prognostic value of Fas and Telomeric-Repeat Binding Factor-1 Genes in Adrenal Tumors. J Clin Endocrinol Metab 88:3690-3693, 2003
  • Hung CJ, Ginzinger D, Zarnegar R, Kanauchi J, Wong M, Kebebew E, Clark OH and Duh Q-Y: Expression of Vascular Endothelial Growth Factor-C in Benign and Malignant Thyroid Tumors. J Clin Endocrin Metab 88:3694-3699, 2003
  • Wada N, Duh QY, Miura D, Brunaud L, Wong MG, Clark OH. Chromosomal aberrations by comparative genomic hybridization in hurthle cell thyroid carcinomas are associated with tumor recurrence. J Clin Endocrinol Metab 87:4595-601, 2002.
  • Kikuchi S, Perrier N, Ituarte P, Treseler PA, Siperstein AE, Duh QY, Greenspan FS, Clark OH: Accuracy of fine needle aspiration cytology in patients with radiation induced thyroid neoplasms. British J Surg 90:6, pp. 755-758, 2003.
  • Miura D, Wada N, Chin K, Magrane G, Wong M, Duh Q-Y, Clark OH: Anaplastic thyroid cancer: cytogenetic patterns by comparative genomic hybridization. Thyroid 13:283-290, 2003
  • Brunaud L, Zarnegar R, Wada N, Magrane G, Wong M, Duh Q-H, Clark OH: Chromosomal Aberrations by Comparative Genomic Hybridization in Thyroid Tumors in Patients with Familial Nonmedullary Thyroid Cancer. Thyroid 13:621-629, 2003
  • Park J-W, Yeh M, Wong M, Lobo M, Hyun W, Duh Q-Y, Clark OH: The Heat Shock Protein 90-Binding Geldanamycin Inhibits Cancer Cell Proliferation, Down-Regulates Oncoproteins, and Inhibits Epidermal Growth Factor-Induced Invasion in Thyroid Cancer Cell Lines. J Clin Endocrinol Metab 88:3346-3353, 2003.
  • Kanauchi H, Wada N, Ginzinger D, Yu M, Wong M, Clark OH, Duh Q-Y: Diagnostic and prognostic value of Fas and Telomeric-Repeat Binding Factor-1 Genes in Adrenal Tumors. J Clin Endocrinol Metab 88:3690-3693, 2003
  • Hung CJ, Ginzinger D, Zarnegar R, Kanauchi J, Wong M, Kebebew E, Clark OH and Duh Q-Y: Expression of Vascular Endothelial Growth Factor-C in Benign and Malignant Thyroid Tumors. J Clin Endocrin Metab 88:3694-3699, 2003
  • Allia E, Cassoni P, Marrocco T, Volante M, Bussolati B, Wong M, Clark OH, Papotti M: Oxyphilic and non-oxyphilic thyroid carcinoma cell lines differ in expressing apoptosis-related genes. J Endocrinol Invest 26: 660- 667, 2003.
  • Kebebew E, Treseler PA, Duh QY, Clark OH: The helix-loop protein, Id-1, is overexpressed and regulates growth in papillary thyroid cancer. Surgery 134: 235-41, 2003.
  • Haciyanli M, Lal G, Morita E, Duh Q-Y, Kebebew E, Clark OH: Accuracy of preoperative localization studies and intraoperative parathyroid hormone assay in patients with primary hyperparathyroidism and double adenoma. JACS 197: 739-746, 2003.
  • Shattuck TM, Kim TS, Costa J, Yandell DW, Imanishi Y, Palanisamy N, Gaz TD, Shoback D, Clark OH, Monchik JM, Wierman ME, Hollenberg A, Katsuyoshi T, Chaganti RSK, Arnold A. Mutational Analyses of RB and BRCA2 as Candidate Tumour Suppressor Genes in Parathyroid Carcinoma. Clinic Endocrinol 59: 180-9, 2003.
  • Shattuck TM, Valimaki S, Obara T, Gaz RD, Clark OH, Shoback D, Wierman ME, Tojo K, Robbins CM, Carpten JD, Farnebo LO, Larsson AA: Somatic and germline mutations of the HRPT2 gene in sporadic parathyroid carcinoma. N Engl J Med 349: 1722-9, 2003.
  • Park JW, Wong MG, Lobo M, Hyun WC, Duh QY, Clark OH: Modulation of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Induced Apoptosis by Chemotherapy in Thyroid Cancer Cell Lines. Thyroid 13: 1103-1110, 2003.
  • D'Avanzo A, Tresseler P, Ituarte P, Wong M, Streja L, Greenspan F, Siperstein, A, Duh Q-Y, Clark O: Follicular Thyroid Cancer: Histology and Prognosis. Cancer 100:1123-1129, 2004.
  • Yeh MW, Demircan O, Ituarte P, Clark OH: False Negative Fine Needle Aspiration Cytology Results Delay Treatment and Adversely Affect Outcome in Patients with Thyroid Carcinoma. Thyroid 14: 207-15, 2004.
  • Park JW, Clark OH: Redifferentiation therapy for thyroid cancer. Surg Clin North Am 84: 921-43, 2004.
  • Shen WT, Kebebew E, Duh QY, Clark OH: Predictors of airway complications after thyroidectomy for substernal goiter. Arch Surg 139: 656-660, 2004.
  • D'Avanzo A, Ituarte P, Treseler P, Kebebew E, Wu J, Wong M, Duh Q-Y, Siperstein AE, Clark OH: Prognostic Scoring Systems in Patients with Follicular Thyroid Cancer: A comparison of different staging systems in predicting the patient outcome. Thyroid 14: 453-458, 2004.
  • Kushchayeva Y, Duh QY, Kebebew E, Clark OH: Prognostic Indications for Huthle Cell Cancer. W J Surg, 28: 1266-70, 2004.
  • Frates MC, Benson CB, Charboneau JW, Cibas ES, Clark OH, Coleman BG, Cronan JJ, Doubilet PM, Evans DB, Goellner JR, Hay ID, Hertzberg BS, Intenzo CM, Jeffrey RB, Langer JE, Larsen PR, Mandel SJ, Middleton WD, Reading CC, Sherman SI, Tessler FN, Society of Radiologist in Ultrasound: Management of thyroid nodules detected at US: Society of Radiologists in Ultrasound consensus conference statement. Radiology. 2005 Dec;237(3):794-800.
  • Shen WT, Wong TS, Chung WY, Wong MG, Kebebew E, Duh QY, Clark OH: Valproic acid inhibits growth, induces apoptosis, and modulates apoptosis-regulatory and differentiation gene expression in human thyroid cancer cells. Surgery. 2005 Dec;138(6):979-84; discussion 984-5.
  • Kebebew E, Peng M, Reiff E, Duh QY, Clark OH, McMillan A: Diagnostic and prognostic value of cell-cycle regulatory genes in malignant thyroid neoplasms. World J Surg. 2006 May; 30(5):767-74
  • Triponez F, Wong M, Sturgeon C, Caron N, Ginzinger DG, Segal MR, Kebebew E, Duh QY, Clark OH: Does familial non-medullary thyroid cancer adversely affect survival? World J Surg. 2006 May; 30(5):787-93.
  • Caron NR, Clark OH: Papillary thyroid cancer. Curr Treat Options Oncol. 2006 Jul; 7(4); 309-19
  • Kebebew E, Peng M, Treseler PA, Clark OH, Duh QY, Ginzinger D, Miner R: Id1 gene expression is up-regulated in hyperplastic and neoplastic thyroid tissue and regulates growth and differentiation in thyriod cancer cells. JCEM 89: 6105-6111, 2004.
  • Caron N and Clark OH: Well differentiated thyroid cancer. Scandanavian J of Surgery 93: 261-271, 2004.
  • Kebebew E, Greenspan FS, Clark OH, Woeber KA, McMillan A: Anaplastic Thyroid Carcinoma. Cancer, 103: 1330-5, 2005.
  • Park JW, Hyun WC, Wong MW, Lobo M, Cotter P, Duh QY, Clark OH: Troglitazone, The Peroxisome Proliferator-Activated Receptor (PPAR) Gamma Agonist Inhibits Growth and Down Regulates Dedifferentiation Mark CD97 in Thyroid Cancer Cell Lines. Thyroid 15: 222-31, 2005.
  • Kebebew E, Greenspan FS, Clark OH, Woeber KA, Grunwell J: Extent of disease and practice patterns for medullary thyroid cancer. JACS 200: 890-896, 2005.
  • Sherman SI, Angelos P, Ball DW, Beenken SW, Byrd D, Clark OH, Daniels GH et al: Thyroid Carcinoma. Natl Comprehensive Canc Netw, 3: 404-57, 2005.
  • Sturgeon C, Clark OH: Familial Nonmedullary Thyroid Cancer. Thyroid, 15: 588-593, 2005. Kebebew E, Peng M, Reiff E, Duh QY, Clark OH, McMillan A: ECM1 and TMPRSS4 are diagnostic markers of malignant thyroid neopolasms and improve the accuracy of fine needle aspiratoin biopsy. Ann Surg 242:353-61, 2005.