Charles S. Cobbs, MD

Associate Clinical Professor, Department of Neurological Surgery, UCSF

Phone: (415) 600-7760
Box 0112, UCSF
San Francisco, CA 94143-0112

Education

Princeton University, B.A., 1985
University of Alabama, School of Medicine (UAB), M.D., 1991
University of California, San Francisco, Neurosurgical Residency, 1992-1997
University of California, San Francisco, Postdoctoral Fellowship, 1994-1995, Molecular Neuro-oncology

Professional Experience

• 1997-2005
  Chief, Neurosurgery Section, Birmingham VA Medical Center
• 1997-2001
  Assistant Professor, Division of Neurosurgery, UAB
• 1997-present
  Associate Professor, Department of Neurobiology, UAB
• 1998-present
  Associate Scientist, UAB, Comprehensive Cancer Center
• 2001-present
  Associate Professor, Division of Neurosurgery, UAB
• 2002-present
  UAB Medical Scientist Training Program, (MD/PhD) Committee Member
• 2002-present
  Associate Professor, Department of Cell Biology, UAB
• 2005-present
  Neurosurgeon, California Pacific Medical Center, San Francisco, CA
• 2005-present
  Scientist, California Pacific Medical Center Research Institute
• 2002-present
  Associate Clinical Professor, Department of Neurological Surgery, UCSF

Honors & Awards

• 
  AOA Medical Honor Society
• 1987
  NIH Summer Student Research Fellowship
• 1989-1990
  NIAID/NIH Research Training Award (IRTA)

Selected Publications

• Cobbs CS, Malech HL, Leto TL, Freeman SM, Blaese RM, Gallin JJ, Lomax KJ: Retroviral expression of recombinant47phox protein by Epstein-Barr virus-transformed B lymphocytes from a patient with autosomal chronic granulomatous disease. Blood 79(7):1829-35, 1992.
• Cobbs CS, Brenman JE, Aldape KD, Bredt DS, Israel MA: Expression of nitric oxide synthase in human central nervous system tumors. Cancer Res 55(4):727-30, 1995.
• Cobbs CS, Fenoy A, Bredt DS, Noble LJ: Expression of nitric oxide synthase in the cerebral microvascular after traumatic brain injury in the rat. Brain Res 75(2):336-38, 1996.
• Cobbs CS, Levi DS, Aldape KD, Israel MA: Manganese superoxide dismutase expression in human central nervous system tumors, Cancer Res 56(14):3192-3195, 1996.
• Sinor AD, Irmin SM, Cobbs CS, Chen J, Graham SH, Greenberg DA: Hypoxic induction of vascular endothelial growth factor (VEGF) protein in astroglial cultures. Brain Research 812(1-2):289-291, 1998.
• Cobbs CS, Chen J, Greenberg DA, Graham SH: Vascular endothelial growth factor (VEGF) expression in transient focal cerebral ischemia in the rat. Neuroscience Letters 249:79-82, 1998.
• Matz PG, Cobbs C, Berger MS. Intraoperative cortical mapping as a guide to the surgical resection of gliomas. J Neuro-oncol. 42(3):233-245. 1999.
• Fischbein NJ, Dillon WP, Cobbs CS, Weinstein P: "Pre-Syrinx": Potentially reversible cervical spinal cord edema that may progress to frank cavitation. AJNR, Amer. J. Neuroradiology 20(1):7-20, 1999.
• Wang D, Grammer JR, Cobbs CS, Stewart JE Jr, Liu Z, Rhoden R, Hecker TP, Ding Q, Gladson CL. p125 Focal adhesion kinase promotes malignant astrocytoma cell proliferation in vivo. J Cell Sci. 113(23):4221- 30. 2000.
• Cobbs CS, Wilson CB. Intrasellar cavernous hemangioma. Case report. J Neurosurg. 94(3):520-522. 2001.
• Zmijewski JW, Song L, Harkins L, Cobbs CS, Jope RS: Oxidative stress and heat shock stimulate RGS2 expression in 1321N1 astrocytoma cells. Arch Biochem Biophys. 392(2):192-6. 2001.
• Zmijewski JW, Song L, Harkins L, Cobbs CS, Jope RS. Oxidative stress and heat shock stimulate RGS2 expression in 1321N1 astrocytoma cells. Arch biochem Biophys. 392(2):192-6. 2001.
• Jackson CA, Cobbs C, Peduzzi JD, Novak M, Morrow CD: Repetitive intrathecal injections of poliovirus replicons result in gene expression in neurons of the central nervous system without pathogenesis. Hum Gene Ther.12(15):1827-41. 2001.
• Cobbs CS, Samanta M, Harkins LE, Gillespie GY, Merrick jBa, MacMillan-Crow LA: Evidence for peroxynitrite-mediated modifications to p53 in human gliomas: possible functional consequences. Arch Biochem Biophys.394 (2):167-72. 2001.
• Zmijewski JW, Song L, Harkins L, Cobbs CS, Jope RS: Second messengers regulate RGS2 expression which is targeted to the nucleus. Biochem Biophys Acts.1541(3):201-11. 2001.
• Cobbs CS, Harkins L, Samanta M, Gillespie GY, Bharara S, King PH, Nabors LB, Cobbs CG, Britt WJ: Human cytomegalovirus infection and expression in human malignant glioma. Cancer Res. ;62(12) :3347-50. 2002.
• W A Weiss, M Israel, C Cobbs, E Holland ,C D James, D N Louis, Cheryl Marks, A McClatchey, T Roberts, T Van Dyke, C Wetmore, I Chiu, M Giovannini, A Guha, R Higgins, S Marino, I Radovanovic, K Reilly, K Aldape. Neuropathology of genetically engineered mice: consensus report and recommendations from an international forum. Oncogene 21(49):7453-63. 2002.
• Harkins L, Volk AL, Samanta M. Mikolaenko I, Britt WJ, Bland KI, Cobbs CS Specific localization of human cytomegalovirus nucleic acids and proteins in human colorectal cancer. Lancet 360(9345):1557-63. 2002.
• Samanta M, Harkins L, Klemm K, Britt WJ, Cobbs CS. High prevalence of human cytomegalovirus in prostatic intraepithelial neoplasia and prostatic carcinoma J Urol.; 170 (3):998-1002. 2003.
• Cobbs CS, Whisenhunt TR, Wesemann DR, Harkins LE, Van Meir EG, Samanta, M. Inactivation of wild-type p53 protein function by reactive oxygen and nitrogen species in malignant glioma cells. Cancer Res. 63(24):8670-3. 2003.
• Shao, W., J. Tang, M. T. Dorak, W. Song, E. Lobashevsky, C. S. Cobbs, M. R. Wrensch, and R. A. Kaslow. Molecular typing of human leukocyte antigen and related polymorphisms following whole genome amplification. Tissue Antigens 2004.
• Tang J, Shao W, Dorak MT, Li Y, Miike R, Lobashevsky E, Wiencke JK, Wrensch M, Kaslow RA, Cobbs CS. Positive and negative associations of human leukocyte antigen variants with the onset and prognosis of adult glioblastoma multiforme. Cancer Epidemiol Biomarkers Prev. 2005 Aug;14(8):2040-4.
• Scheurer ME, El-Zein R., Bondy ML, Harkins L, Cobbs CS. Re:"Lack of association of herpesviruses with brain tumors". J Neurovirol. 2007.; 13(1) :85.
• Cobbs C.S., Soroceanu L., Denham S., Zhang W., Britt W J, Pieper R., Kraus M. Human cytomegalovirus induces cellular tyrosine kinase signaling and promotes glioma cell invasiveness. J. Neuro-Oncology, 2007, June 23, Epub ahead of print:DOI 10.1007/s11060-007-9423.
• Cobbs CS, Soroceanu L, Denham S, Zhang W, Kraus M. Modulation of Oncogenic Phenotype in Human Glioma Cells by Cytomegalovirus IE1-Mediated Mitogenicity. Cancer Research 68, 724-730, February 1, 2008. doi: 10.1158/0008-5472.CAN-07-2291.
• Soroceanu L., Akhavan A., & Cobbs, SC. Platelet-derived growth factor- receptor activation is required for human cytomegalovirus infection. Nature. Sept 18, 2008.