Douglas A. Corley, MD, MPH, PhD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Douglas A. Corley, MD, MPH, PhD

Clinical Professor, Department of Medicine, UCSF

douglas.corley@kp.org

Kaiser Permanente Medical Center

Cancer Center Membership

Associate Member » Non-aligned

Education

University of California, Berkeley, BA, 1987, Biophysics/History
University of Pennsylvania, School of Medicine, MD, 1991, Medicine
Brigham & Women's Hosp, Harvard Medical School, Internship, 1991-1992, Internal Medicine
Brigham & Women's Hosp, Harvard Medical School, Residency, 1992-1994, Internal Medicine
University of California, San Francisco, Fellowship, 1994-1997, Gastroenterology
University of California, Berkeley, MPH, 1998, Epidemiology
University of California, Berkeley, PhD, 2002, Epidemiology


Professional Experience

  • 1997-1998
    Clinical Instructor in Medicine, UCSF
  • 1998-2006
    Assistant Clinical Professor of Medicine, UCSF
  • 1998-2000
    Associate Director, Gastroenterology Faculty Practice, University of California, San Francisco
  • 2000-2001
    Director, Gastroenterology Faculty Practice, University of California, San Francisco
  • 2002-present
    Attending Gastroenterologist, Kaiser Permanente, San Francisco
  • 2002-2003
    Adjunct Investigator, Division of Research, Kaiser Permanente
  • 2003-2012
    Research Scientist II, Division of Research, Kaiser Permanente
  • 2006-2014
    Associate Clinical Professor of Medicine, UCSF
  • 2012-present
    Research Scientist III, Division of Research, Kaiser Permanente
  • 2014-present
    Clinical Professor of Medicine, UCSF

Honors & Awards

  • 1988
    McGraw-Hill Award, U of Penn, School of Medicine
  • 1989
    Lange Award, U of Penn, School of Medicine
  • 1991
    Alpha Omega Alpha, U of Penn, School of Medicine
  • 1991
    Spencer Morris Prize, U of Penn, School of Medicine
  • 1991
    Sandoz Award, U of Penn, School of Medicine
  • 1991
    Joel Gordon Miller Award, U of Penn, School of Medicine
  • 1991
    A.O.J. Kelly Prize, U of Penn, School of Medicine
  • 1991
    Permanent Alumni President, Class of 1991, U of Penn, School of Medicine
  • 1996
    Astra-Merck Senior Fellow AwardAmerican College of Gastroenterology
  • 1997, Outcomes Research Training AwardAmerican Digestive Health Foundation
  • 1998
    Endoscopic Outcomes and Effectiveness Developmental Research Award, American Digestive Health Foundation
  • 1999
    Outcomes Research Award, TAP/American Digestive Health Foundation
  • 2008
    Nominee, UCSF Kaiser Award for Excellence in Teaching, UCSF
  • 2008
    Special Recognition Award to an outstanding faculty member, Association of the Clinical Faculty; UCSF
  • 2015
    Morris Collen Research AwardThe Permanente Medical Group

Selected Publications

  1. Lee JK, Liles EG, Bent S, Levin TR, Corley DA. Accuracy of Fecal Immunochemical Tests for Colorectal Cancer: Systematic Review and Meta-analysis. Aspirin and non-aspirin NSAIDs increase risk of colonic diverticular bleeding: a systematic review and meta-analysis. Ann Int Med. 2014 Feb 4;160(3):171. doi: 10.7326/M13-1484. PMCID: 4189821.
  2. Corley DA, Jensen CD, Marks AR, Zhao WK, Lee JK, Doubeni CA, Cauber AG, de Boer J, Fireman BH, Schottinger JE, Quinn VP, Ghai NR, Levin TR, Quesenberry CP. Physician adenoma detection rate and colorectal cancer risk and death. New Engl J Med. 2014 Apr 3;370(14):1298-306. doi; 10.1056/NEJMoa1309086. PMCID: 4036494.
  3. Tiro JA, Kamineni A, , Levin TR, Schottinger JE, Zhen Y, Chubak J, Corley D, Doubeni C, Gupta S, Halm E, Skinner CS, Rutter C, Wernli K, Klabunde CN. The CRC screening process in community settings: A conceptual model for the Population-based Research Optimizing Screening through Personalized Regimens (PROSPR) Consortium. Cancer Epidemiology, Biomarkers, and Prevention, 2014 Jul;23(7): 1147-58. doi: 10.1158/1055-9965.EPI-13-1217. Epub 2014 Jun 10. PMCID: 4148641.
  4. McGlynn EA, Lieu TA, Durham ML, Bauck A, Laws R, Go AS, Chen J, Spencer-Feigelson H, Corley DA, Young Rohm D, Nelson AF, Davidson AJ, Morales LS, Kahn MG. Developing a data infrastructure for a learning health system: the PORTAL network. J Am Med Assoc. 2014 Jul;21(4):596-601. doi: 10.1136/amiajnl-2014-002746. Epub 2014 May 12. PMCID: 4078291.
  5. Buas MF, Levine DM, Makar KW, Utsugi H, Onstad L, Li X, Galipeau PC, Shaheen NJ, Hardie LJ, Romero Y, Bernstein L, Gammon MD, Casson AG, Bird NC, Risch HA, Ye W, Liu G, Corley DA, Blount PL, Fitzgerald RC, Whiteman DC, Wu AH, Reid BJ, Vaughan TL. Integrative post genome-wide association analysis of CDKN2A and TP53 SNPs and risk of esophageal adenocarcinoma. Carcinogenesis. 2014 Dec; 35(12):2740-7. doi: 10.1093/carcin/bgu207. Epub 2014 Oct 3.PMCID: 4247522.
  6. Thrift AP, Shaheen NJ, Gammon MD, Bernstein L, Reid BJ, Onstad L, Risch HA, Liu G, Bird NC, Wu AH, Corley DA, Romero Y, Chanock SJ, Chow WH, Casson AG, Levine DM, Zhang R, Ek WE, MacGregor S, Ye W, Hardie LJ, Vaughan TL, Whiteman DC. Obesity and Risk of Esophageal Adenocarcinoma and Barrett's Esophagus: A Mendelian Randomization Study. J Natl Cancer Inst. 2014 Sep 30;106(11). pii. dju252. doi: 10.1093/jnci/dju252. PMCID: 4200028.
  7. Kubo A, Block G, Quesenberry CP Jr, Buffler P, Corley DA. Dietary guideline adherence for gastroesophageal reflux disease. BMC Gastroenterol. 2014 Aug 14;14:144. Doi: 10.1186/1471-230X-14-144. PMCID: 4139138.
  8. Cook MB, Corley DA, Murray LJ, Liao LM, Kamangar F, Ye W, Gammon MD, Risch HA, Casson AG, Freedman ND, Chow WH, Wu AH, Bernstein L, Nyrén O, Pandeya N, Whiteman DC, Vaughan TL. Gastroesophageal reflux in relation to adenocarcinomas of the esophagus: a pooled analysis from the Barrett's and Esophageal Adenocarcinoma Consortium (BEACON). PLoS One. 2014 Jul 30;9(7):e103508. Doi: 10.1371/journal.pone.0103508. eCollection 2014. PMCID: 4116205.
  9. Thrift AP, Cook MB, Vaughan TL, Anderson LA, Murray LJ, Whiteman DC, Shaheen NJ, Corley DA. Alcohol and the Risk of Barrett's Esophagus: A Pooled Analysis from the International BEACON Consortium. Am J Gastroenterol. 2014 Oct;109(10):1586-94. Doi: 10.1038/ajg.2014.206. Epub 2014 Jul 22. PMCID: 4189971.
  10. Kubo A, Shlager L, Marks AR, Lakritz D, Beaumont C, Gabellini K, Corley DA. Prevention of vertical transmission of hepatitis B: an observational study. Ann Intern Med. 2014 Jun 17;160(12):828-35. Doi: 10.7326/M13-2529. PMCID: 4086733.
  11. Thrift AP, Risch HA, Onstad L, Shaheen NJ, Casson AG, Bernstein L, Corley DA, Levine DM, Chow WH, Reid BJ, Romero Y, Hardie LJ, Liu G, Wu AH, Bird NC, Gammon MD, Ye W, Whiteman DC, Vaughan TL. Risk of esophageal adenocarcinoma decreases with height, based on consortium analysis and confirmed by mendelian randomization. Clin Gastroenterol Hepatol. 2014 Oct;12(10):1667-76.e1. doi: 10.1016/j,cgh.2014.01.039. Epub 2014 Feb 12. PMCID: 4130803.
  12. Corley DA Jensen CD, Doubeni CA, Quinn VP, Levin TR, Zauber AG, Schottinger JE, Marks AR, Zhao WK, Lee JK, Ghai NR, Schneider JL, Fireman BH, Quesenberry CP. Adjusting for Patient Demographics has Minimal Effects on Rates of Adenoma Detection in a Large, Community-Based Setting. Clin Gastroenterol Hepatol. 2015 Apr; 13(4):739-46, doi: 10.1016/j.cgh. 2014.10.020. Epub 2014 Oct 25. PMCID: 4369190.
  13. Hillyer GC, Lebwohl B, Rosenberg RM, Neugut AI, Wolf R, Basch CH, Mata J, Hernandez E, Corley DA, Shea S, Basch CE. Assessing bowel preparation quality using the mean number of adenomas per colonoscopy. Therap Adv Gastroenterol. 2014 Nov;7(6):238-46. doi: 1177/1756283X14540222. PMCID: 4212469.
  14. Lu Y1, Ek WE1, Whiteman D2, Vaughan TL3, Spurdle AB4, Easton DF5, Pharoah PD5, Thompson DJ6, Dunning AM7, Hayward NK8, Chenevix-Trench G9; Q-MEGA and AMFS Investigators; ANECS-SEARCH; UKOPS-SEARCH; BEACON Consortium, Macgregor S. Most common 'sporadic' cancers have a significant germline genetic component. Hum Mol Genet. 2014 Nov 15;23(22):6112-8. doi: 10.1093/hmg/ddu312. Epub 2014 Jun 18. PMCID: 4271103.
  15. Palles C, Chegwidden L, Li X, Findlay JM, Farnham G, Giner FC, Peppelenbosch MP, Kovac M, Adams CL, Prenen H, Briggs S, Harrison R, Sanders S, MacDonald D, Haigh C, Tucker A, Love S, Nanji M, deCaestecker J, Ferry D, Rathbone B, Hapeshi J, Barr H, Zietek B, Maroo N, Gay L, Underwood T, Boulter L, McMurtry H, Monk D, Patel P, Ragunath K, Al Dulaimi D, Murray I, Koss K, Veitch A, Trudgill N, Nwokolo C, Rembacken B, Atherfold P, Green E, Ang Y, Kuipers EJ, Chow W, Paterson S, Kadri S, Beales I, Grimley C, Mullins P, Beckett C, Farrant M, Dixon A, Kelly S, Johnson M, Wajed S, Dhar A, Sawyer E, Roylance R, Onstad L, Gammon MD, Corley DA, Shaheen NJ, Bird NC, Hardie LJ, Reid BJ, Ye W, Liu G, Romero Y, Bernstein L, Wu AH, Casson AG, Fitzgerald R, Whiteman DC, Risch HA, Levine DM, Vaughan TL, Verhaar AP, van den Brande J, Toxopeus EL, Spaander MC, Wijnhoven BP, van der Laan LJ, Krishnadath K, Wijmenga C, Trynka G, McManus R, Reynolds JV, O'Sullivan J, MacMathuna P, McGarrigle SA, Kelleher D, Vermeire S, Cleynen I, Bisschops R, Tomlinson I, Jankowski J. Polymorphisms Near TBX5 and GDF7 Are Associated With Increased Risk for Barrett's Esophagus. Gastroenterology. 2015 Feb;148(2):367-78. doi: 10.1053/j.gastro.2014.10.014. Epub 2014 Nov 5. PMCID: 4315134.
  16. Hoffman J, Corley DA, Zhao WK, Colt JS, Shuch B, Chow WH, Purdue MP. Chronic kidney disease and risk of renal cell carcinoma: differences by race within Kaiser Permanente Northern California. Epidemiology. 2015 Jan;26(1): 59-67. doi: 10.1097/EDE.0000000000000205. PMCID: 4422565.
  17. Schneider JL, Zhao WK, Corley DA. Aspirin and Nonsteroidal Anti-Inflammatory Drug Use and the Risk of Barrett's Esophagus. Dig Dis and Sci. 2015 Feb;60(2):436-46. doi: 10.1007/s10620-014-3349-2. Epub 2014 Sep 12. PMCID: 4304909.
  18. Hoffman TJ, Sakoda LC, Shen L, Jorgenson E, Habel LA, Liu J, Kvale MN, Asgari MM, Banda Y, Corley DA, Kushi LH, Quesenberry CP Jr, Schaefer C, Van Den Eeden SK, Risch N, Witte JS. Imputation of the rare HOXB13 G84E mutation and cancer risk in a large population-based cohort. PLOS Genetics. 2015 Jan 28’ 11(1): e 1004930. doi: 10.1371/journal.pgen.1004930. eCollectin 2015 Jan. PMCID: 4483271.
  19. Almers LM, Graham JE, Havel PJ, Corley DA. Adiponectin may modify the risk of Barrett’s esophagus in patients with gastroesophageal reflux disease. Clin Gastroenterol Hepatol. 2015 Jan 26. pii: S1542-3565(15)00095-6. doi: 10.1016/j.cgh.2015.01.009. [Epub ahead of print]. PMCID: 4515407.
  20. Lee JK, Jensen CD, Lee A, Doubeni CA, Zauber AG, Levin TR, Zhao WK, Corley DA. Development and validation of an algorithm for classifying colonoscopy indication. Gastrointest Endoscop 2015 Mar; 81(3): 575-582.e4. doi: 10.1016/j.gie.2014.07.031. Epub 2015 Jan 8. PMCID: 4340717.
  21. Meester RG, Doubeni CA, Zauber AG, Goede SL, Levin TR, Corley DA, Jemal A, Lansdorp-Vogelar I. Public health impact of achieving 80% colorectal cancer screening rates in the United States by 2018. Cancer. 2015 Mar 12. doi: 10.1002/cncr.29336 [Epub ahead of print]. PMCID 4567966.
  22. Abnet, CC, Corley DA, Freedman ND, Kamangar F. Diet and gastrointestinal malignancies. Gastroenterology 2015 May;1486(6):1234-43.e4. doi: 10.1053/j.gastro.2015.02.007. Epub 2015 Feb 11. PMCID: 4414068.
  23. Lo Re V, Carbonari DM, Forde KA Goldberg D, Lewis JS, Haynes K, Leidl KBF, Reddy R, Roy J, Sha D, Marks AR, Schneider JL, Strom BL, Corley DA. Validity of diagnostic codes and laboratory tests of liver dysfunction to identify acute liver failure events. Pharm and Drug Safety. 2015 April 10. doi: 10.1002/pds.3774. [Epub ahead of print] PMCID: 4509617.
  24. Bennet C, Moayyedi P, Corely DA, DeCaestecker J, Falck-Ytter Y, Falk G, Vakil N, Sanders S, Vieth M, Inadomi J, Aldulaimi D, Ho KY, Odze R, Meltzer SJ, Quigley E, Gittens S, Watson P, Zaninotto G, Iver PG, Alexander L, Ang Y, Callaghan J, Harrison R, Singh R, Bhandari P, Bisschops R, Geramizaheh B, Kaye P Krishnadath S, Fennerty MB, Manner H, Nason KS, Pech O, Konda V, Raqunath K, Rahman I, Romero Y, Sampliner R, Siersema PD, Tack J, Tham TC, Trudgill N, Weinberg DS, Wang J, Wang K, Attwood S, Malfertheiner P, MacDonald D, Barr H, Ferguson MK, Jankowski J. BOB CAT: a large-scale review and Delphi consensus for management of Barrett’s esophagus with no dysplasia, indefinite for, or low grade dysplasia. Am J Gastroenterol. 2015 May;110(5):662-682; quiz 683. doi: 10.1038/ajg.2015.55. Epub 2015 Apr 14. PMCID: 4436697.
  25. Goldberg DS, Forde KA, Carbonari DM, Lewis JD, Leidl KBF, Reddy KR, Haynes K, Roy J, Sha D, Marks AR, Schneider JL, Strom BL, Corley DA, Lo Re V. Population-Representative Incidence of Drug-Induced Acute Liver Failure in an Integrated Healthcare System. Gastroenterology. 2015 Jun;148(7):1353-1361.e3 doi: 10.1035/j.gastro.2015.02.050. Epub 2015 Feb 28. PMCID: 4446162.
  26. Schneider J, Corley DA. A Review of the Epidemiology of Barrett's Esophagus and Esophageal Adenocarcinoma. Best Practice & Research: Clinical Gastroenterology. 2015 Feb;29(1):29-39. doi: 10.1016/j.bpg.2014.11.008. Epub 2014 Dec 3.
  27. Corley DA, Feigelson HS, Lieu TA, McGlynn EA.. Building Data Infrastructure to Evaluate and Improve Quality: PCORnet. Journal of Oncology Practice. 2015 May;11(3):204-6. doi: 10.1200/JOP. 2014.003194. PMCID: 4438109.
  28. Lo Re 3rd, Haynes K, Forde KA, Goldberg DS, Lewis JD, Carbonari DM, Leidl KB, Reddy KR, Nezamzaheh MS, Roy J, Sha D, Marks AR, De Boer J, Schneider JL, Strom BL, Corley DA. Risk of Acute Liver Failure in Patients with Drug-Induced Hepatitis: Evaluation of Hy's Law and a Novel Prognostic Model. Clin Gastroenterol Hepatol. 2015 Jun 27. pii: S1542-3565(15)00844-7. Doi: 10.1016/j.cgh.2015.06020.. [Epub ahead of print]
  29. Meester RG, Doubeni CA, Lansdorp-Vogelaar I, Goede SL, Levin TR, Quinn VP, Schottinger JE, Zauber AG, Corley DA, van Ballegooijen M. Variation in Adenoma Detection Rate and the Lifetime Benefits and Cost of Colorectal Cancer Screening: A Microsimulation Model. JAMA. 2015 Jun 16;313(23):2349-58. Doi: 10.1001/jama.2015.6251. PMCID: 4631392.
  30. Atkins L, Hunkeler EM, Jesnsen CD, Michie S, Lee JK, Doubeni CA, Zauber AG, Levin TR, Quinn VP, Corley DA. Understanding Factors Influencing Variation in Physician Adenoma Detection Rates: a Theory-Based Approach. Gastrointestinal Endoscopy. 2015 Sep 11. pii: S0016-5107(15)02848-5. doi: 10.1016/j.gie. 2015.08.075. [Epub ahead of print]
  31. Buas, MF, Onstad L, Levine DM, Risch HA, Chow WH, Liu G, Fitzgerald RC, Bernstien L, Ye W, Bird NC, Romero Y, Casson AG, Corley DA, Shaheen NJ, Wu AH, Gammon MD, Reid BJ, Hardie LJ, Peters U, Whitemna DC, Vaughan TL. MiRNA-related SNPs and risk of esophageal adenocarcinoma and Barrett’s esophagus: Post genome-wide association analysis in the BEACON consortium. PLoS One. 2015 Jun3;10(6):e0128617. doi: 10.1371/journal.pone.0127617. eCollection 2015. PMCID: 4454432.
  32. Lagergren K, Ek WE, Levine D, Chow WH, Bernstein L, Casson AG, Risch HA, Shaheen NJ, Bird NC, Reid BJ, Corley DA, Hardie LJ, Wu AH, Fitzgerald RC, Pharoah P, Caldas C, Romero Y, Vaughan TC, MacGregor S, Whiteman D, Westberg L, Nyren O, Lagergren J. Polymorphisms in genes of relevance for estrogen and oxytocin pathways and risk of Barrett's esophagus and esophageal adenocarcinoma. PLoS One. 2015 Sep 25;10(9):e0138738. doi: 10.1371/journal.pone. 0138738. eCollection 2015. PMCID: 4583498.
  33. Beaber EF, Kim JJ, Schapira MM, Tosteson AN, Zauber AG, Geiger AM, Kamineni A, Weaver DL, Tiro JA. on behalf of Populationp-based Research Optimizing Screening through Personalized Regimens consortium. Unifying screening processes within the PROSPR consortium: a conceptual model for breast, cervical and colorectal cancer screening. J Natl Cancer Inst. 2015 107(6):djv120. doi: 10.1093/jnci/djv120. Print 2015 Jun.
  34. Marks AR, Pietrofesa RA, Jensen CD, Zebrowski A, Corley DA, Doubeni CA. Metformin Use and Risk of Colorectal Adenoma After Polypectomy in Patients with Type 2 Diabetes Mellitus. Cancer Epidemiol Biomarkers Prev. 2015 Nov;24(11):1692-8. doi: 10.1158/1055-9965. EPI-0559. Epub 2015 Sep 16. PMCID: 4633388.
  35. Dai JY, Tapsoba JD, Buas MF, Onstad LE, Levine DM, Risch HA, Chow WH, Bernstein L, Ye W, Lagergren J, Bird NC, Corley DA, Shaheen NJ, Wu AH, Reid BJ, Hardie LJ, Whiteman DC, Vaughan TL.A newly identified susceptibility locus near FOXP1 modifies the association of gastroesophageal reflux with Barrett's esophagus. Cancer Epidemiol Biomarkers Prev. 2015 2015 Nov;24(11):1739-47. doi: 10.1158/9965. EPI-15-0507. Epub 2015 Sep 16.
  36. Atkins L, Hunkeler EM, Jensen CD, Michie S, Lee JK, Doubeni CA, Zauber AG, Levin TR, Quinn VP, Corley DA. Factors Influencing Variation in Physician Adenoma Detection Rates: a Theory-Based Approach for Performance Improvement. Gastrointest Endosc. 2015 Sep 11. pii: S0016-5107(15)02848-5. [Epub ahead of print].
  37. Lee E, Stram DO, Ek WE, Onstad LE, Macgregor S, Gharahkhani P, Ye W, Lagergren J, Shaheen NJ, Murray LJ, Hardie LJ, Gammon MD, Chow WH, Risch HA, Corley DA, Levine DM, Whiteman DC, Bernstein L, Bird NC, Vaughan TL, Wu AH. Pleiotropic analysis of cancer risk loci on esophageal adenocarcinoma risk. Cancer Epidemiol Biomarkers Prev. 2015 Nov;24(11):1801-3. doi: 10.1158/1055-9965. EPI-15-0596. Epub 2015 Sep 12. PMCID: 4648999.
  38. Goodman M, Fletcher RH, Doria-Rose VP, Jensen CD, Zebrowski AM, Becerra TA, Quinn VP, Zauber AG, Corley DA, Doubeni CA. Observational methods to assess the effectiveness of screening colonoscopy in reducing right colon cancer mortality risk: SCOLAR. J Comp Eff Res. 2015 Jul 23:1-11. [Epub ahead of print]
  39. Thomas SJ, Almers L, Schneider J, Graham JE, Havel PJ, Corley DA. Ghrelin and Leptin Have a Complex Relationship with Risk of Barrett’s Esophagus. Dig Dis Sci. 2015 Sep 22. [Epub ahead of print].
  40. Schneider J, Francesca K, Corley DA. Risk of gastric cancer, gastrointestinal cancers, and other cancers: a comparison of treatment with pantoprazole and other proton pump inhibitors (PPIs). Alimentary Pharmacology & Therapeutics. 2015. Nov 6. doi: 10.1111/apt. 13450. [Epub ahead of print].
  41. Chubak J, Garcia MP, Burnett-Hartman A, Zheng Y, Corley DA, Halm EA, Singal AG, Klabunde CN, Doubeni CA, Kamineni A, Levin TR, Schottinger JE, Green BB, Quinn VP, Rutter CR. Time to colonoscopy after positive fecal blood test in four U.S. healthcare systems. Cancer Epidemiol Biomarkers Prev. 2015 [in press].