University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Rajvir Dahiya, PhD

Rajvir Dahiya, PhD

Professor and Director, Urology Research Center, Department of Urology, UCSF

Cancer Center Program Memberships

Prostate Cancer

Research Summary

I have strong record of training post-doctoral fellows and visiting scientists. I have trained more than 50 postdoctoral fellows during my career, and most of my trainees currently hold faculty positions. I have published more than 300 research manuscripts in peer-reviewed journals. I have a broad background in molecular biology and genetics, with specific training and expertise in key research areas for this application. As a postdoctoral fellow at the University of Chicago, I gained expertise in the field of cancer biology. As PI or co-Investigator on previous NIH-funded grants, I laid the groundwork for the proposed research by developing various novel methods for epigenetic pathways, microRNAs, gene regulation, and function using both in vitro and in vivo models. In summary, I have a demonstrated record of successful and productive research projects in an area of cancer research that is a priority area since millions of people die of various malignancies every year.

Education

Kurukshetra University, India, MS, 1978, Biochemistry
Postgraduate Institute of Medical Education and Research, Chandigarh, India, PhD, 1982, Biochemistry
University of Chicago, Chicago, IL, Post-Doc, 1983-1987, Biochemistry


Professional Experience

  • 1987-1991
    Senior Scientist, Department of Medicine, University of California and VA Medical Center, San Francisco, CA
  • 1991-present
    Director of Urology Research, Department of Urology, University of California and VA Medical Center, San Francisco, CA
  • 1993-1997
    Associate Professor and Director Urology Research, Department of Urology, University of California and VA Medical Center, San Francisco, CA
  • 1997-present
    Professor, Department of Urology, University of California and VA Medical Center, San Francisco, CA
  • 2006-2011
    VA Research Career Scientist
  • 2011-2018
    VA Senior Research Career Scientist

Honors & Awards

  • 2006-2013
    Associate Editor, Cancer Research
  • 2013-present
    Associate Editor Clinical Cancer Research
  • 2011-present
    Academic Editor, PLoS ONE
  • 2011-present
    Senior Editor, Amer. J. Cancer Res.

Selected Publications

  1. Yamamoto Y, Tsunedomi R, Fujita Y, Otori T, Ohba M, Kawai Y, Hirata H, Matsumoto H, Haginaka J, Suzuki S, Dahiya R, Hamamoto Y, Matsuyama K, Hazama S, Nagano H, Matsuyama H. Pharmacogenetics-based area-under-curve model can predict efficacy and adverse events from axitinib in individual patients with advanced renal cell carcinoma. Oncotarget. 2018 Mar 30; 9(24):17160-17170.
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  2. Dasgupta P, Kulkarni P, Majid S, Varahram S, Hashimoto Y, Bhat NS, Shiina M, Deng G, Saini S, Tabatabai ZL, Yamamura S, Tanaka Y, Dahiya R. MicroRNA-203 inhibits long noncoding RNA HOTAIR and regulates tumorigenesis through epithelial-to-mesenchymal transition pathway in renal cell carcinoma. Mol Cancer Ther. 2018 Feb 13.
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  3. Bhagirath D, Yang TL, Bucay N, Sekhon K, Majid S, Shahryari V, Dahiya R, Tanaka Y, Saini S. microRNA-1246 Is an Exosomal Biomarker for Aggressive Prostate Cancer. Cancer Res. 2018 Apr 01; 78(7):1833-1844.
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  4. Yoshino H, Nohata N, Miyamoto K, Yonemori M, Sakaguchi T, Sugita S, Itesako T, Kofuji S, Nakagawa M, Dahiya R, Enokida H. PHGDH as a Key Enzyme for Serine Biosynthesis in HIF2a-Targeting Therapy for Renal Cell Carcinoma. Cancer Res. 2017 Nov 15; 77(22):6321-6329.
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  5. Imai-Sumida M, Chiyomaru T, Majid S, Saini S, Nip H, Dahiya R, Tanaka Y, Yamamura S. Silibinin suppresses bladder cancer through down-regulation of actin cytoskeleton and PI3K/Akt signaling pathways. Oncotarget. 2017 Nov 03; 8(54):92032-92042.
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  6. Yamamura S, Imai-Sumida M, Tanaka Y, Dahiya R. Interaction and cross-talk between non-coding RNAs. Cell Mol Life Sci. 2018 Feb; 75(3):467-484.
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  7. Bhat NS, Colden M, Dar AA, Saini S, Arora P, Shahryari V, Yamamura S, Tanaka Y, Kato T, Majid S, Dahiya R. MicroRNA-720 Regulates E-cadherin-aE-catenin Complex and Promotes Renal Cell Carcinoma. Mol Cancer Ther. 2017 Dec; 16(12):2840-2848.
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  8. Chang I, Mitsui Y, Kim SK, Sun JS, Jeon HS, Kang JY, Kang NJ, Fukuhara S, Gill A, Shahryari V, Tabatabai ZL, Greene KL, Dahiya R, Shin DM, Tanaka Y. Cytochrome P450 1B1 inhibition suppresses tumorigenicity of prostate cancer via caspase-1 activation. Oncotarget. 2017 Jun 13; 8(24):39087-39100.
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  9. Bucay N, Bhagirath D, Sekhon K, Yang T, Fukuhara S, Majid S, Shahryari V, Tabatabai Z, Greene KL, Hashimoto Y, Shiina M, Yamamura S, Tanaka Y, Deng G, Dahiya R, Saini S. A novel microRNA regulator of prostate cancer epithelial-mesenchymal transition. Cell Death Differ. 2017 07; 24(7):1263-1274.
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  10. Hashimoto Y, Shiina M, Kato T, Yamamura S, Tanaka Y, Majid S, Saini S, Shahryari V, Kulkarni P, Dasgupta P, Mitsui Y, Sumida M, Deng G, Tabatabai L, Kumar D, Dahiya R. The role of miR-24 as a race related genetic factor in prostate cancer. Oncotarget. 2017 Mar 07; 8(10):16581-16593.
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  11. Mitsui Y, Shiina H, Kato T, Maekawa S, Hashimoto Y, Shiina M, Imai-Sumida M, Kulkarni P, Dasgupta P, Wong RK, Hiraki M, Arichi N, Fukuhara S, Yamamura S, Majid S, Saini S, Deng G, Dahiya R, Nakajima K, Tanaka Y. Versican Promotes Tumor Progression, Metastasis and Predicts Poor Prognosis in Renal Carcinoma. Mol Cancer Res. 2017 Jul; 15(7):884-895.
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  12. Shiina M, Hashimoto Y, Kato T, Yamamura S, Tanaka Y, Majid S, Saini S, Varahram S, Kulkarni P, Dasgupta P, Mitsui Y, Sumida M, Tabatabai L, Deng G, Kumar D, Dahiya R. Differential expression of miR-34b and androgen receptor pathway regulate prostate cancer aggressiveness between African-Americans and Caucasians. Oncotarget. 2017 Jan 31; 8(5):8356-8368.
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  13. Colden M, Dar AA, Saini S, Dahiya PV, Shahryari V, Yamamura S, Tanaka Y, Stein G, Dahiya R, Majid S. MicroRNA-466 inhibits tumor growth and bone metastasis in prostate cancer by direct regulation of osteogenic transcription factor RUNX2. Cell Death Dis. 2017 01 26; 8(1):e2572.
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  14. Bucay N, Sekhon K, Majid S, Yamamura S, Shahryari V, Tabatabai ZL, Greene K, Tanaka Y, Dahiya R, Deng G, Saini S. Novel tumor suppressor microRNA at frequently deleted chromosomal region 8p21 regulates epidermal growth factor receptor in prostate cancer. Oncotarget. 2016 Oct 25; 7(43):70388-70403.
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  15. Nip H, Dar AA, Saini S, Colden M, Varahram S, Chowdhary H, Yamamura S, Mitsui Y, Tanaka Y, Kato T, Hashimoto Y, Shiina M, Kulkarni P, Dasgupta P, Imai-Sumida M, Tabatabai ZL, Greene K, Deng G, Dahiya R, Majid S. Oncogenic microRNA-4534 regulates PTEN pathway in prostate cancer. Oncotarget. 2016 Oct 18; 7(42):68371-68384.
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  16. Sekhon K, Bucay N, Majid S, Dahiya R, Saini S. MicroRNAs and epithelial-mesenchymal transition in prostate cancer. Oncotarget. 2016 Oct 11; 7(41):67597-67611.
    View on PubMed
  17. Shahryari V, Nip H, Saini S, Dar AA, Yamamura S, Mitsui Y, Colden M, Bucay N, Tabatabai LZ, Greene K, Deng G, Tanaka Y, Dahiya R, Majid S. Pre-clinical Orthotopic Murine Model of Human Prostate Cancer. J Vis Exp. 2016 Aug 29; (114).
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  18. Mitsui Y, Chang I, Kato T, Hashimoto Y, Yamamura S, Fukuhara S, Wong DK, Shiina M, Imai-Sumida M, Majid S, Saini S, Shiina H, Nakajima K, Deng G, Dahiya R, Tanaka Y. Functional role and tobacco smoking effects on methylation of CYP1A1 gene in prostate cancer. Oncotarget. 2016 Aug 02; 7(31):49107-49121.
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  19. Mitsui Y, Chang I, Fukuhara S, Hiraki M, Arichi N, Yasumoto H, Hirata H, Yamamura S, Shahryari V, Deng G, Wong DK, Majid S, Shiina H, Dahiya R, Tanaka Y. CYP1B1 promotes tumorigenesis via altered expression of CDC20 and DAPK1 genes in renal cell carcinoma. BMC Cancer. 2015 Dec 01; 15:942.
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  20. Bucay N, Shahryari V, Majid S, Yamamura S, Mitsui Y, Tabatabai ZL, Greene K, Deng G, Dahiya R, Tanaka Y, Saini S. miRNA Expression Analyses in Prostate Cancer Clinical Tissues. J Vis Exp. 2015 Sep 08; (103).
    View on PubMed

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