Anthony L. DeFranco, PhD

Anthony L. DeFranco, PhD

Professor, Department of Microbiology and Immunology, UCSF

Phone: (415) 476-5488 (voice)
Box 0552, UCSF
San Francisco, CA 94143-0552

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Harvard College, Cambridge MA, A.B., 1975, Biochemical & Molecular Biology
University of California, Berkeley, CA, Ph.D., 1979, Biochemistry
National Institutes of Health, Bethesda MD, Postdoctoral, 1979-83, Immunology

Professional Experience

  • 1972-1975
    Undergraduate research, laboratory of Dr. Jack Strominger. HLA antigens.
  • 1976-1979
    Graduate research, laboratory of Dr. Daniel E. Koshland, Jr. Bacterial chemotaxis.
  • 1979-1983
    Postdoctoral research, laboratory of Dr. William E. Paul. B cell activation.
  • 1983-1988
    Assistant Professor, UCSF, Department of Microbiology & Immunology,
  • 1988-1994
    Associate Professor, UCSF, Department of Microbiology & Immunology
  • 1989-1990
    Sabbatical with David Baltimore, Whitehead Insititute, MIT, Cambridge, MA
  • 1994-present
    Professor, UCSF, Department of Microbiology & Immunology
  • 1997-1998
    Sabbatical with Suzanne Cory, Walter and Eliza Hall Institute, Melbourne, Australia
  • 1998-2004
    Scientific Advisory Board, Abgenix, Inc. Fremont, CA
  • 1999-2009
    Chairman, Department of Microbiology & Immunology, UCSF
  • 2012
    Scientific Advisory Board, CB Celltech, Slough, UK

Honors & Awards

  • 1974
    Dreyfuss Foundation Fellow
  • 1975
    Phi Beta Kappa, Harvard University
  • 1975-78
    NSF Predoctoral Fellow
  • 1979-82
    Helen Hay Whitney Postdoctoral Fellow; 2nd Rose Lieberman Lecturer, NIH 10/93
  • 1994
    NIAID Merit Award
  • 1997-98
    NIH Fogarty Senior International Award

Selected Publications

  1. Rookhuizen DC, DeFranco AL. Toll-like receptor 9 signaling acts on multiple elements of the germinal center to enhance antibody responses. Proc Natl Acad Sci U S A. 2014 Aug 5; 111(31):E3224-33.
    View on PubMed
  2. Yu M, Zhou H, Zhao J, Xiao N, Roychowdhury S, Schmitt D, Hu B, Harding CV, Hise AG, Hazen SL, Defranco AL, Fox PL, Morton RE, Dicorleto PE, Febbraio M, Nagy LE, Smith JD, Wang JA, Li X. MyD88-dependent interplay between myeloid and endothelial cells in the initiation and progression of obesity-associated inflammatory diseases. J Exp Med. 2014 May 5; 211(5):887-907.
    View on PubMed
  3. Hua Z, Gross AJ, Lamagna C, Ramos-Hernández N, Scapini P, Ji M, Shao H, Lowell CA, Hou B, Defranco AL. Requirement for MyD88 Signaling in B Cells and Dendritic Cells for Germinal Center Anti-Nuclear Antibody Production in Lyn-Deficient Mice. J Immunol. 2014 Feb 1; 192(3):875-85.
    View on PubMed
  4. Lamagna C, Hu Y, Defranco AL, Lowell CA. B cell-specific loss of lyn kinase leads to autoimmunity. J Immunol. 2014 Feb 1; 192(3):919-28.
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  5. Wheeler ML, Dong MB, Brink R, Zhong XP, DeFranco AL. Diacylglycerol kinase ? limits B cell antigen receptor-dependent activation of ERK signaling to inhibit early antibody responses. Sci Signal. 2013 Oct 15; 6(297):ra91.
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  6. Lamagna C, Scapini P, van Ziffle JA, DeFranco AL, Lowell CA. Hyperactivated MyD88 signaling in dendritic cells, through specific deletion of Lyn kinase, causes severe autoimmunity and inflammation. Proc Natl Acad Sci U S A. 2013 Aug 27; 110(35):E3311-20.
    View on PubMed
  7. Han D, Walsh MC, Cejas PJ, Dang NN, Kim YF, Kim J, Charrier-Hisamuddin L, Chau L, Zhang Q, Bittinger K, Bushman FD, Turka LA, Shen H, Reizis B, Defranco AL, Wu GD, Choi Y. Dendritic cell expression of the signaling molecule TRAF6 is critical for gut microbiota-dependent immune tolerance. Immunity. 2013 Jun 27; 38(6):1211-22.
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  8. Callahan JA, Hammer GE, Agelides A, Duong BH, Oshima S, North J, Advincula R, Shifrin N, Truong HA, Paw J, Barrera J, DeFranco A, Rosenblum MD, Malynn BA, Ma A. Cutting edge: ABIN-1 protects against psoriasis by restricting MyD88 signals in dendritic cells. J Immunol. 2013 Jul 15; 191(2):535-9.
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  9. Raetz M, Hwang SH, Wilhelm CL, Kirkland D, Benson A, Sturge CR, Mirpuri J, Vaishnava S, Hou B, Defranco AL, Gilpin CJ, Hooper LV, Yarovinsky F. Parasite-induced TH1 cells and intestinal dysbiosis cooperate in IFN-?-dependent elimination of Paneth cells. Nat Immunol. 2013 Feb; 14(2):136-42.
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  10. Kim CC, Nelson CS, Wilson EB, Hou B, DeFranco AL, DeRisi JL. Splenic red pulp macrophages produce type I interferons as early sentinels of malaria infection but are dispensable for control. PLoS One. 2012; 7(10):e48126.
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  11. Wheeler ML, Defranco AL. Prolonged production of reactive oxygen species in response to B cell receptor stimulation promotes B cell activation and proliferation. J Immunol. 2012 Nov 1; 189(9):4405-16.
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  12. DeFranco AL, Rookhuizen DC, Hou B. Contribution of Toll-like receptor signaling to germinal center antibody responses. Immunol Rev. 2012 May; 247(1):64-72.
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  13. Thompson AL, Johnson BT, Sempowski GD, Gunn MD, Hou B, DeFranco AL, Staats HF. Maximal adjuvant activity of nasally delivered IL-1a requires adjuvant-responsive CD11c(+) cells and does not correlate with adjuvant-induced in vivo cytokine production. J Immunol. 2012 Mar 15; 188(6):2834-46.
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  14. Kirkland D, Benson A, Mirpuri J, Pifer R, Hou B, DeFranco AL, Yarovinsky F. B cell-intrinsic MyD88 signaling prevents the lethal dissemination of commensal bacteria during colonic damage. Immunity. 2012 Feb 24; 36(2):228-38.
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  15. Shahaf G, Gross AJ, Sternberg-Simon M, Kaplan D, DeFranco AL, Mehr R. Lyn deficiency affects B-cell maturation as well as survival. Eur J Immunol. 2012 Feb; 42(2):511-21.
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  16. Gross AJ, Proekt I, DeFranco AL. Elevated BCR signaling and decreased survival of Lyn-deficient transitional and follicular B cells. Eur J Immunol. 2011 Dec; 41(12):3645-55.
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  17. Hammer GE, Turer EE, Taylor KE, Fang CJ, Advincula R, Oshima S, Barrera J, Huang EJ, Hou B, Malynn BA, Reizis B, DeFranco A, Criswell LA, Nakamura MC, Ma A. Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis. Nat Immunol. 2011 Dec; 12(12):1184-93.
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  18. Scapini P, Lamagna C, Hu Y, Lee K, Tang Q, DeFranco AL, Lowell CA. B cell-derived IL-10 suppresses inflammatory disease in Lyn-deficient mice. Proc Natl Acad Sci U S A. 2011 Oct 11; 108(41):E823-32.
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  19. Ismail AS, Severson KM, Vaishnava S, Behrendt CL, Yu X, Benjamin JL, Ruhn KA, Hou B, DeFranco AL, Yarovinsky F, Hooper LV. Gammadelta intraepithelial lymphocytes are essential mediators of host-microbial homeostasis at the intestinal mucosal surface. Proc Natl Acad Sci U S A. 2011 May 24; 108(21):8743-8.
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  20. Hou B, Saudan P, Ott G, Wheeler ML, Ji M, Kuzmich L, Lee LM, Coffman RL, Bachmann MF, DeFranco AL. Selective utilization of Toll-like receptor and MyD88 signaling in B cells for enhancement of the antiviral germinal center response. Immunity. 2011 Mar 25; 34(3):375-84.
    View on PubMed

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