Anthony L. DeFranco, PhD

Professor, Department of Microbiology and Immunology, UCSF

defranco@cgl.ucsf.edu

Phone: (415) 476-5488 (voice)
Box 0552, UCSF
San Francisco, CA 94143-0552

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Education

Harvard College, Cambridge MA, A.B., 1975, Biochemical & Molecular Biology
University of California, Berkeley, CA, Ph.D., 1979, Biochemistry
National Institutes of Health, Bethesda MD, Postdoctoral, 1979-83, Immunology

Professional Experience

• 1972-1975
  Undergraduate research, laboratory of Dr. Jack Strominger. HLA antigens.
• 1976-1979
  Graduate research, laboratory of Dr. Daniel E. Koshland, Jr. Bacterial chemotaxis.
• 1979-1983
  Postdoctoral research, laboratory of Dr. William E. Paul. B cell activation.
• 1983-1988
  Assistant Professor, UCSF, Department of Microbiology & Immunology,
• 1988-1994
  Associate Professor, UCSF, Department of Microbiology & Immunology
• 1989-1990
  Sabbatical with David Baltimore, Whitehead Insititute, MIT, Cambridge, MA
• 1994-present
  Professor, UCSF, Department of Microbiology & Immunology
• 1997-1998
  Sabbatical with Suzanne Cory, Walter and Eliza Hall Institute, Melbourne, Australia
• 1998-2004
  Scientific Advisory Board, Abgenix, Inc. Fremont, CA
• 1999-2009
  Chairman, Department of Microbiology & Immunology, UCSF

Honors & Awards

• 1974
  Dreyfuss Foundation Fellow
• 1975
  Phi Beta Kappa, Harvard University
• 1975-78
  NSF Predoctoral Fellow
• 1979-82
  Helen Hay Whitney Postdoctoral Fellow; 2nd Rose Lieberman Lecturer, NIH 10/93
• 1994
  NIAID Merit Award
• 1997-98
  NIH Fogarty Senior International Award

Selected Publications

1. Raetz M, Hwang SH, Wilhelm CL, Kirkland D, Benson A, Sturge CR, Mirpuri J, Vaishnava S, Hou B, Defranco AL, Gilpin CJ, Hooper LV, Yarovinsky F. Parasite-induced T(H)1 cells and intestinal dysbiosis cooperate in IFN-?-dependent elimination of Paneth cells. Nat Immunol. 2012 Dec 23; 14(2):136-42.
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2. Kim CC, Nelson CS, Wilson EB, Hou B, Defranco AL, Derisi JL. Splenic red pulp macrophages produce type I interferons as early sentinels of malaria infection but are dispensable for control. PLoS One. 2012; 7(10):e48126.
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3. Wheeler ML, Defranco AL. Prolonged production of reactive oxygen species in response to B cell receptor stimulation promotes B cell activation and proliferation. J Immunol. 2012 Nov 1; 189(9):4405-16.
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4. DeFranco AL, Rookhuizen DC, Hou B. Contribution of Toll-like receptor signaling to germinal center antibody responses. Immunol Rev. 2012 May; 247(1):64-72.
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5. Thompson AL, Johnson BT, Sempowski GD, Gunn MD, Hou B, DeFranco AL, Staats HF. Maximal adjuvant activity of nasally delivered IL-1a requires adjuvant-responsive CD11c(+) cells and does not correlate with adjuvant-induced in vivo cytokine production. J Immunol. 2012 Mar 15; 188(6):2834-46.
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6. Kirkland D, Benson A, Mirpuri J, Pifer R, Hou B, DeFranco AL, Yarovinsky F. B cell-intrinsic MyD88 signaling prevents the lethal dissemination of commensal bacteria during colonic damage. Immunity. 2012 Feb 24; 36(2):228-38.
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7. Shahaf G, Gross AJ, Sternberg-Simon M, Kaplan D, DeFranco AL, Mehr R. Lyn deficiency affects B-cell maturation as well as survival. Eur J Immunol. 2012 Feb; 42(2):511-21.
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8. Gross AJ, Proekt I, DeFranco AL. Elevated BCR signaling and decreased survival of Lyn-deficient transitional and follicular B cells. Eur J Immunol. 2011 Dec; 41(12):3645-55.
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9. Hammer GE, Turer EE, Taylor KE, Fang CJ, Advincula R, Oshima S, Barrera J, Huang EJ, Hou B, Malynn BA, Reizis B, DeFranco A, Criswell LA, Nakamura MC, Ma A. Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis. Nat Immunol. 2011 Dec; 12(12):1184-93.
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10. Scapini P, Lamagna C, Hu Y, Lee K, Tang Q, DeFranco AL, Lowell CA. B cell-derived IL-10 suppresses inflammatory disease in Lyn-deficient mice. Proc Natl Acad Sci U S A. 2011 Oct 11; 108(41):E823-32.
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11. Ismail AS, Severson KM, Vaishnava S, Behrendt CL, Yu X, Benjamin JL, Ruhn KA, Hou B, DeFranco AL, Yarovinsky F, Hooper LV. Gammadelta intraepithelial lymphocytes are essential mediators of host-microbial homeostasis at the intestinal mucosal surface. Proc Natl Acad Sci U S A. 2011 May 24; 108(21):8743-8.
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12. Hou B, Saudan P, Ott G, Wheeler ML, Ji M, Kuzmich L, Lee LM, Coffman RL, Bachmann MF, DeFranco AL. Selective utilization of Toll-like receptor and MyD88 signaling in B cells for enhancement of the antiviral germinal center response. Immunity. 2011 Mar 25; 34(3):375-84.
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13. Rahman AH, Zhang R, Blosser CD, Hou B, Defranco AL, Maltzman JS, Wherry EJ, Turka LA. Antiviral memory CD8 T-cell differentiation, maintenance, and secondary expansion occur independently of MyD88. Blood. 2011 Mar 17; 117(11):3123-30.
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14. Hou B, Benson A, Kuzmich L, DeFranco AL, Yarovinsky F. Critical coordination of innate immune defense against Toxoplasma gondii by dendritic cells responding via their Toll-like receptors. Proc Natl Acad Sci U S A. 2011 Jan 4; 108(1):278-83.
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15. Scapini P, Hu Y, Chu CL, Migone TS, Defranco AL, Cassatella MA, Lowell CA. Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice. J Exp Med. 2010 Aug 2; 207(8):1757-73.
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16. Mamchak AA, Thien CB, Dagger SA, Lyandres J, Jiang S, Langdon WY, DeFranco AL. Unaltered negative selection and Treg development of self-reactive thymocytes in TCR transgenic Fyn-deficient mice. Eur J Immunol. 2010 Feb; 40(2):539-47.
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17. Gross AJ, Lyandres JR, Panigrahi AK, Prak ET, DeFranco AL. Developmental acquisition of the Lyn-CD22-SHP-1 inhibitory pathway promotes B cell tolerance. J Immunol. 2009 May 1; 182(9):5382-92.
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18. DeFranco AL. "Dangerous crystals". Immunity. 2008 Nov 14; 29(5):670-1.
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19. Mamchak AA, Sullivan BM, Hou B, Lee LM, Gilden JK, Krummel MF, Locksley RM, DeFranco AL. Normal development and activation but altered cytokine production of Fyn-deficient CD4+ T cells. J Immunol. 2008 Oct 15; 181(8):5374-85.
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20. Hou B, Reizis B, DeFranco AL. Toll-like receptors activate innate and adaptive immunity by using dendritic cell-intrinsic and -extrinsic mechanisms. Immunity. 2008 Aug 15; 29(2):272-82.
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