Rik Derynck, PhD

Professor, Departments of Cell/Tissue Biology and Anatomy, UCSF

derynck@itsa.ucsf.edu

Phone: (415) 476-7322, 476-6081 (voice)
Box 0640, UCSF
San Francisco, CA 94143-0640

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Additional Websites

• Lab Website

Education

University of Louvain, Belgium, Lic.Sc.(M.Sc.), 1974, Zoology
University of Ghent, Belgium, Ph.D., 1981, Molecular Biology

Professional Experience

• 1973-1974
  Undergraduate thesis with Dr. Henri Koch, Catholic University, Louvain, Belgium
• 1974-1981
  Predoctoral Fellow/Research Associate with Dr. Walter Fiers, State University, Ghent, Belgium
• 1981-1985
  Scientist, Dept. of Molecular Biology, Genentech Inc., South San Francisco
• 1985-1990
  Senior Scientist, Departments of Molecular and Developmental Biology, Genentech Inc., South San Francisco
• 1991-present
  Professor, Department of Cell and Tissue Biology and Department of Anatomy, University of California San Francisco
• 2002-present
  Director, UCSF Program in Craniofacial and Mesenchymal Biology, University of California San Francisco
• 2002-present
  Co-Director, UCSF Institute for Regeneration Medicine

Selected Publications

1. Lamouille S, Subramanyam D, Blelloch R, Derynck R. Regulation of epithelial-mesenchymal and mesenchymal-epithelial transitions by microRNAs. Curr Opin Cell Biol. 2013 Apr; 25(2):200-7.
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2. Katsuno Y, Lamouille S, Derynck R. TGF-ß signaling and epithelial-mesenchymal transition in cancer progression. Curr Opin Oncol. 2013 Jan; 25(1):76-84.
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3. Sakaki-Yumoto M, Katsuno Y, Derynck R. TGF-ß family signaling in stem cells. Biochim Biophys Acta. 2013 Feb; 1830(2):2280-96.
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4. Xu P, Liu J, Derynck R. Post-translational regulation of TGF-ß receptor and Smad signaling. FEBS Lett. 2012 Jul 4; 586(14):1871-84.
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5. Xu P, Liu J, Sakaki-Yumoto M, Derynck R. TACE activation by MAPK-mediated regulation of cell surface dimerization and TIMP3 association. Sci Signal. 2012 May 1; 5(222):ra34.
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6. Lamouille S, Connolly E, Smyth JW, Akhurst RJ, Derynck R. TGF-ß-induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion. J Cell Sci. 2012 Mar 1; 125(Pt 5):1259-73.
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7. Upadhyay G, Yin Y, Yuan H, Li X, Derynck R, Glazer RI. Stem cell antigen-1 enhances tumorigenicity by disruption of growth differentiation factor-10 (GDF10)-dependent TGF-beta signaling. Proc Natl Acad Sci U S A. 2011 May 10; 108(19):7820-5.
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8. Subramanyam D, Lamouille S, Judson RL, Liu JY, Bucay N, Derynck R, Blelloch R. Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells. Nat Biotechnol. 2011 May; 29(5):443-8.
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9. Lamouille S, Derynck R. Emergence of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin axis in transforming growth factor-ß-induced epithelial-mesenchymal transition. Cells Tissues Organs. 2011; 193(1-2):8-22.
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10. Chang JL, Brauer DS, Johnson J, Chen CG, Akil O, Balooch G, Humphrey MB, Chin EN, Porter AE, Butcher K, Ritchie RO, Schneider RA, Lalwani A, Derynck R, Marshall GW, Marshall SJ, Lustig L, Alliston T. Tissue-specific calibration of extracellular matrix material properties by transforming growth factor-ß and Runx2 in bone is required for hearing. EMBO Rep. 2010 Oct; 11(10):765-71.
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11. Xu P, Derynck R. Direct activation of TACE-mediated ectodomain shedding by p38 MAP kinase regulates EGF receptor-dependent cell proliferation. Mol Cell. 2010 Feb 26; 37(4):551-66.
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12. Lamouille S, Derynck R. Oncogene and tumour suppressor: the two faces of SnoN. EMBO J. 2009 Nov 18; 28(22):3459-60.
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13. Wharton K, Derynck R. TGFbeta family signaling: novel insights in development and disease. Development. 2009 Nov; 136(22):3691-7.
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14. Piscopo DM, Johansen EB, Derynck R. Identification of the GATA factor TRPS1 as a repressor of the osteocalcin promoter. J Biol Chem. 2009 Nov 13; 284(46):31690-703.
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15. Kang JS, Liu C, Derynck R. New regulatory mechanisms of TGF-beta receptor function. Trends Cell Biol. 2009 Aug; 19(8):385-94.
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16. Liu C, Xu P, Lamouille S, Xu J, Derynck R. TACE-mediated ectodomain shedding of the type I TGF-beta receptor downregulates TGF-beta signaling. Mol Cell. 2009 Jul 10; 35(1):26-36.
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17. Wu L, Derynck R. Essential role of TGF-beta signaling in glucose-induced cell hypertrophy. Dev Cell. 2009 Jul; 17(1):35-48.
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18. Xu J, Lamouille S, Derynck R. TGF-beta-induced epithelial to mesenchymal transition. Cell Res. 2009 Feb; 19(2):156-72.
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19. Liu IM, Schilling SH, Knouse KA, Choy L, Derynck R, Wang XF. TGFbeta-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFbeta switch. EMBO J. 2009 Jan 21; 28(2):88-98.
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20. Imhof I, Gasper WJ, Derynck R. Association of tetraspanin CD9 with transmembrane TGF{alpha} confers alterations in cell-surface presentation of TGF{alpha} and cytoskeletal organization. J Cell Sci. 2008 Jul 1; 121(Pt 13):2265-74.
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