Rik Derynck, PhD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
derynck_rik

Professor, Departments of Cell/Tissue Biology and Anatomy, UCSF

derynck@itsa.ucsf.edu

Phone: (415) 476-7322, 476-6081 (voice)
Box 0640, UCSF
San Francisco, CA 94143-0640

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Additional Websites


Education

University of Louvain, Belgium, Lic.Sc.(M.Sc.), 1974, Zoology
University of Ghent, Belgium, Ph.D., 1981, Molecular Biology


Professional Experience

  • 1973-1974
    Undergraduate thesis with Dr. Henri Koch, Catholic University, Louvain, Belgium
  • 1974-1981
    Predoctoral Fellow/Research Associate with Dr. Walter Fiers, State University, Ghent, Belgium
  • 1981-1985
    Scientist, Dept. of Molecular Biology, Genentech Inc., South San Francisco
  • 1985-1990
    Senior Scientist, Departments of Molecular and Developmental Biology, Genentech Inc., South San Francisco
  • 1991-present
    Professor, Department of Cell and Tissue Biology and Department of Anatomy, University of California San Francisco
  • 2002-present
    Director, UCSF Program in Craniofacial and Mesenchymal Biology, University of California San Francisco
  • 2002-present
    Co-Director, UCSF Institute for Regeneration Medicine

Selected Publications

  1. Kehrl JH, Wakefield LM, Roberts AB, Jakowlew S, Alvarez-Mon M, Derynck R, Sporn MB, Fauci AS. Pillars Article: Production of Transforming Growth Factor ß by Human T Lymphocytes and Its Potential Role in the Regulation of T Cell Growth. J Exp Med. 1986. 163: 1037-1050. J Immunol. 2014 Apr 1; 192(7):2939-52.
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  2. Xu J, Derynck R. Does Smad6 methylation control BMP signaling in cancer? Cell Cycle. 2014 Apr 15; 13(8):1209-10.
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  3. Lamouille S, Xu J, Derynck R. Molecular mechanisms of epithelial-mesenchymal transition. Nat Rev Mol Cell Biol. 2014 Feb 21; 15(3):178-96.
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  4. Derynck R, Akhurst RJ. BMP-9 balances endothelial cell fate. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):18746-7.
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  5. Xu J, Wang AH, Oses-Prieto J, Makhijani K, Katsuno Y, Pei M, Yan L, Zheng YG, Burlingame A, Brückner K, Derynck R. Arginine Methylation Initiates BMP-Induced Smad Signaling. Mol Cell. 2013 Jul 11; 51(1):5-19.
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  6. Sakaki-Yumoto M, Liu J, Ramalho-Santos M, Yoshida N, Derynck R. Smad2 is essential for maintenance of the human and mouse primed pluripotent stem cell state. J Biol Chem. 2013 Jun 21; 288(25):18546-60.
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  7. Lamouille S, Subramanyam D, Blelloch R, Derynck R. Regulation of epithelial-mesenchymal and mesenchymal-epithelial transitions by microRNAs. Curr Opin Cell Biol. 2013 Apr; 25(2):200-7.
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  8. Katsuno Y, Lamouille S, Derynck R. TGF-ß signaling and epithelial-mesenchymal transition in cancer progression. Curr Opin Oncol. 2013 Jan; 25(1):76-84.
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  9. Sakaki-Yumoto M, Katsuno Y, Derynck R. TGF-ß family signaling in stem cells. Biochim Biophys Acta. 2013 Feb; 1830(2):2280-96.
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  10. Xu P, Liu J, Derynck R. Post-translational regulation of TGF-ß receptor and Smad signaling. FEBS Lett. 2012 Jul 4; 586(14):1871-84.
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  11. Xu P, Liu J, Sakaki-Yumoto M, Derynck R. TACE activation by MAPK-mediated regulation of cell surface dimerization and TIMP3 association. Sci Signal. 2012 May 1; 5(222):ra34.
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  12. Lamouille S, Connolly E, Smyth JW, Akhurst RJ, Derynck R. TGF-ß-induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion. J Cell Sci. 2012 Mar 1; 125(Pt 5):1259-73.
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  13. Upadhyay G, Yin Y, Yuan H, Li X, Derynck R, Glazer RI. Stem cell antigen-1 enhances tumorigenicity by disruption of growth differentiation factor-10 (GDF10)-dependent TGF-beta signaling. Proc Natl Acad Sci U S A. 2011 May 10; 108(19):7820-5.
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  14. Subramanyam D, Lamouille S, Judson RL, Liu JY, Bucay N, Derynck R, Blelloch R. Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells. Nat Biotechnol. 2011 May; 29(5):443-8.
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  15. Lamouille S, Derynck R. Emergence of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin axis in transforming growth factor-ß-induced epithelial-mesenchymal transition. Cells Tissues Organs. 2011; 193(1-2):8-22.
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  16. Chang JL, Brauer DS, Johnson J, Chen CG, Akil O, Balooch G, Humphrey MB, Chin EN, Porter AE, Butcher K, Ritchie RO, Schneider RA, Lalwani A, Derynck R, Marshall GW, Marshall SJ, Lustig L, Alliston T. Tissue-specific calibration of extracellular matrix material properties by transforming growth factor-ß and Runx2 in bone is required for hearing. EMBO Rep. 2010 Oct; 11(10):765-71.
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  17. Xu P, Derynck R. Direct activation of TACE-mediated ectodomain shedding by p38 MAP kinase regulates EGF receptor-dependent cell proliferation. Mol Cell. 2010 Feb 26; 37(4):551-66.
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  18. Lamouille S, Derynck R. Oncogene and tumour suppressor: the two faces of SnoN. EMBO J. 2009 Nov 18; 28(22):3459-60.
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  19. Wharton K, Derynck R. TGFbeta family signaling: novel insights in development and disease. Development. 2009 Nov; 136(22):3691-7.
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  20. Piscopo DM, Johansen EB, Derynck R. Identification of the GATA factor TRPS1 as a repressor of the osteocalcin promoter. J Biol Chem. 2009 Nov 13; 284(46):31690-703.
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