University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Sophie Dumont, PhD

Sophie Dumont, PhD

Assistant Professor, Dept of Cell & Tissue Biology, Dept of Cellular & Molecular Pharmacology, University of California, San Francisco

Cancer Center Program Memberships

Affiliate Member

Education

Princeton University, Princeton, NJ, USA, B.A., 08/95-06/99, Physics
University of Oxford, UK, D.Phil. candidate, 09/99-08/00, Theoretical Physics
University of California, Berkeley, CA, USA, Ph.D., 08/00-12/05, Molecular Biophysics
University of California, Berkeley, CA, USA, Postdoc, 01/06-03/06, Molecular Biophysics
Harvard Society of Fellows, Junior Fellow, 07/06-06/09, Cellular Biophysics
Harvard Medical School, Boston, MA, USA, Postdoc, 07/06-05/12, Cellular Biophysics
 


Professional Experience

  • 1997-1999
    Undergraduate Student Researcher, Princeton University, Advisor: Prof. Stanislas Leibler (Physics), Thesis: Thermal sensing network of E. coli
  • 1999-2000
    Graduate Student Researcher, University of Oxford, Advisor: Prof. Douglas Abraham (Theoretical Physics), Topic: Statistical mechanics of neural networks
  • 2000-2005
    Graduate Student Researcher, University of California, Berkeley, Advisor: Prof. Carlos Bustamante (Physics), Thesis: Force and helicase-catalyzed mechanical unfolding of single RNA molecules
  • 2006
    Postdoctoral fellow, University of California, Berkeley, Advisors: Prof. Carlos Bustamante (Physics), Prof. Ignacio Tinoco Jr. (Chemistry), Topic: Helicase mechanochemistry
  • 2006-2009
    Junior Fellow, Harvard Society of Fellows, Mentor: Prof. Timothy J. Mitchison (Systems Biology), Topic: Mechanical forces in cell division
  • 2006-2012
    Postdoctoral Fellow, Harvard Medical School, Mentor: Prof. Timothy J. Mitchison (Systems Biology), Topic: Mechanical forces in cell division
  • 2012-
    Assistant Professor, University of California, San Francisco, Dept of Cell & Tissue Biology, Dept of Cellular & Molecular Pharmacology

Honors & Awards

  • 1999
    Phi Beta Kappa; Sigma Xi
  • 1999
    Allen G. Shenstone Prize in Physics, Princeton University
  • 1999-2000
    Rhodes Scholarship
  • 1999-2001
    Québec Fund for Nature and Technology Research Fellowship (masters)
  • 2001-2003
    Natural Sciences and Engineering Council of Canada Fellowship (doctoral)
  • 2001-2004
    Québec Fund for Nature and Technology Research Fellowship (doctoral)
  • 2004
    Outstanding Graduate Student Instructor Award, UC Berkeley
  • 2004
    Teaching Effectiveness Graduate Student Instructor Award, UC Berkeley
  • 2004-2005
    Canadian Institutes of Health Research Fellowship (doctoral)
  • 2006
    Alan Bearden Outstanding Graduate Research Award, UC Berkeley
  • 2006
    Weintraub Graduate Student Award
  • 2006-2009
    Junior Fellow, Harvard Society of Fellows
  • 2007-2009
    Harvard University William F. Milton Fund Award
  • 2009-2011
    Charles A. King Trust Postdoctoral Fellowship
  • 2010-2015
    NIH K99/R00 Pathway to Independence Award
  • 2013-2015
    Sloan Research Fellow
  • 2013-2015
    Kimmel Cancer Foundation Scholar
  • 2013-2016
    Searle Scholar
  • 2013-2018
    Rita Allen Foundation and Milton E. Cassel Scholar
  • 2015-2020
    NIH New Innovator Award
  • 2016
    Margaret Oakley Dayhoff Award of the Biophysical Society

Selected Publications

  1. Shah KN, Bhatt R, Rotow J, Rohrberg J, Olivas V, Wang VE, Hemmati G, Martins MM, Maynard A, Kuhn J, Galeas J, Donnella HJ, Kaushik S, Ku A, Dumont S, Krings G, Haringsma HJ, Robillard L, Simmons AD, Harding TC, McCormick F, Goga A, Blakely CM, Bivona TG, Bandyopadhyay S. Aurora kinase A drives the evolution of resistance to third-generation EGFR inhibitors in lung cancer. Nat Med. 2018 Nov 26.
    View on PubMed
  2. Elting MW, Suresh P, Dumont S. The Spindle: Integrating Architecture and Mechanics across Scales. Trends Cell Biol. 2018 Aug 06.
    View on PubMed
  3. Serra-Marques A, Dumont S. Shining light on spindle positioning. Elife. 2018 Jul 09; 7.
    View on PubMed
  4. Hueschen CL, Kenny SJ, Xu K, Dumont S. NuMA recruits dynein activity to microtubule minus-ends at mitosis. Elife. 2017 Nov 29; 6.
    View on PubMed
  5. Elting MW, Prakash M, Udy DB, Dumont S. Mapping Load-Bearing in the Mammalian Spindle Reveals Local Kinetochore Fiber Anchorage that Provides Mechanical Isolation and Redundancy. Curr Biol. 2017 Jul 24; 27(14):2112-2122.e5.
    View on PubMed
  6. Hueschen CL, Kenny SJ, Xu K, Dumont S. NuMA Targets Dynein to Microtubule Minus-Ends at Mitosis. BioRxiv doi.org/10.1101/148692. 2017.
    View on PubMed
  7. Long AF, Udy DB, Dumont S. Hec1 Tail Phosphorylation Differentially Regulates Mammalian Kinetochore Coupling to Polymerizing and Depolymerizing Microtubules. Curr Biol. 2017 Jun 05; 27(11):1692-1699.e3.
    View on PubMed
  8. Kuhn J, Dumont S. Spindle assembly checkpoint satisfaction occurs via end-on but not lateral attachments under tension. J Cell Biol. 2017 06 05; 216(6):1533-1542.
    View on PubMed
  9. Karg T, Elting MW, Vicars H, Dumont S, Sullivan W. The chromokinesin Klp3a and microtubules facilitate acentric chromosome segregation. J Cell Biol. 2017 06 05; 216(6):1597-1608.
    View on PubMed
  10. Guild J, Ginzberg MB, Hueschen CL, Mitchison TJ, Dumont S. Increased lateral microtubule contact at the cell cortex is sufficient to drive mammalian spindle elongation. Mol Biol Cell. 2017 Jul 07; 28(14):1975-1983.
    View on PubMed
  11. Guild J, Haque A, Gheibi P, Gao Y, Son KJ, Foster E, Dumont S, Revzin A. Embryonic Stem Cells Cultured in Microfluidic Chambers Take Control of Their Fate by Producing Endogenous Signals Including LIF. Stem Cells. 2016 06; 34(6):1501-12.
    View on PubMed
  12. Hueschen CL, Long AF, Dumont S. Kinesin-5: A Team Is Just the Sum of Its Parts. Dev Cell. 2015 Sep 28; 34(6):609-10.
    View on PubMed
  13. Udy DB, Voorhies M, Chan PP, Lowe TM, Dumont S. Draft De Novo Transcriptome of the Rat Kangaroo Potorous tridactylus as a Tool for Cell Biology. PLoS One. 2015; 10(8):e0134738.
    View on PubMed
  14. Dumont S, Prakash M. Emergent mechanics of biological structures. Mol Biol Cell. 2014 Nov 05; 25(22):3461-5.
    View on PubMed
  15. Elting MW, Hueschen CL, Udy DB, Dumont S. Force on spindle microtubule minus ends moves chromosomes. J Cell Biol. 2014 Jul 21; 206(2):245-56.
    View on PubMed
  16. Dumont S. Spindle size: small droplets and a big step forward. Curr Biol. 2014 Feb 03; 24(3):R116-8.
    View on PubMed
  17. Kuhn J, Dumont S. Imaging and physically probing kinetochores in live dividing cells. Methods Cell Biol. 2014; 123:467-87.
    View on PubMed
  18. Dumont S, Salmon ED, Mitchison TJ. Deformations within moving kinetochores reveal different sites of active and passive force generation. Science. 2012 Jul 20; 337(6092):355-8.
    View on PubMed
  19. Dumont S, Mitchison TJ. Comprehensive Biophysics. Mechanical Forces in Mitosis. 2012; 298-320.
    View on PubMed
  20. Dumont S. Chromosome segregation: spindle mechanics come to life. Curr Biol. 2011 Sep 27; 21(18):R688-90.
    View on PubMed

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