John Fike, PhD

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Education

Calif. State Univ. Long Beach, CA, B.A., 1970, Biology
Univ. Calif. Irvine, Irvine, CA, M.S., 1972, Radiological Sci.
Colorado St. Univ. Ft. Collins, CO, Ph.D., 1978, Radiol. & Radiat. Biol.
George Wash. Univ. Washington, D.C., Post Doc, 1979, Radiation Biology

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Professional Experience

• 1970 - 1971
  Research Associate, Dept. of Radiological Sciences, University of California, Irvine, CA
• 1972 - 1973
  Research Assistant, Dept. of Radiation Biology, University of Wisconsin, Madison, WI
• 1974 - 1975
  Research Associate, Department of Immunochemistry, Evanston Hospital, Evanston, IL
• 1975 - 1976
  NIH Predoctoral Trainee, Dept. of Radiology and Radiation Biology, Colorado State University, Fort Collins, CO
• 1978 - 1979
  NIH Postdoctoral Fellow, Dept. of Radiation Biology, George Washington University Medical Center, Washington, DC
• 1979 - 1980
  NIH Postdoctoral Fellow, Dept. of Radiation Oncology, University of California, San Francisco, CA
• 1980 - 1981
  Assistant Research Biologist, Dept. of Radiation Oncology, University of California, San Francisco, CA
• 1981 - 1983
  Adjunct Assistant Professor, Departments of Radiation Oncology and Radiology, University of California, San Francisco, CA
• 1983 - 1991
  Assistant Professor In-Residence, Departments of Radiation Oncology, Radiology, and Neurological Surgery, University of California, San Francisco, CA
• 1991 - 1998
  Associate Professor In-Residence, Departments of Neurological Surgery, Radiation Oncology, and Radiology, University of California, San Francisco, CA
• 1998-present
  Professor In-Residence, Departments of Neurological Surgery, Radiation Oncology, and Radiology, University of California, San Francisco, CA

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Honors & Awards

• 2003
  Henry Ford Neurosurgery Distinguished Researcher Lecture. Henry Ford Hospital, Detroit Michigan

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Selected Publications

1. Raber J, Allen AR, Rosi S, Sharma S, Dayger C, Davis MJ, Fike JR. Effects of (56)Fe radiation on hippocampal function in mice deficient in chemokine receptor 2 (CCR2). Behav Brain Res. 2013 Mar 13.
   View on PubMed
2. Raber J, Allen AR, Rosi S, Sharma S, Dayger C, Davis MJ, Fike JR. Effects of whole body 56Fe radiation on contextual freezing and Arc-positive cells in the dentate gyrus. Behav Brain Res. 2013 Feb 27.
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3. Belarbi K, Jopson T, Arellano C, Fike JR, Rosi S. CCR2 Deficiency Prevents Neuronal Dysfunction and Cognitive Impairments Induced by Cranial Irradiation. Cancer Res. 2013 Feb 1; 73(3):1201-10.
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4. Zou Y, Corniola R, Leu D, Khan A, Sahbaie P, Chakraborti A, Clark DJ, Fike JR, Huang TT. Extracellular superoxide dismutase is important for hippocampal neurogenesis and preservation of cognitive functions after irradiation. Proc Natl Acad Sci U S A. 2012 Dec 26; 109(52):21522-7.
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5. Corniola R, Zou Y, Leu D, Fike JR, Huang TT. Paradoxical Relationship between Mn Superoxide Dismutase Deficiency and Radiation-Induced Cognitive Defects. PLoS One. 2012; 7(11):e49367.
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6. Chakraborti A, Allen A, Allen B, Rosi S, Fike JR. Cranial irradiation alters dendritic spine density and morphology in the hippocampus. PLoS One. 2012; 7(7):e40844.
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7. Rosi S, Ferguson R, Fishman K, Allen A, Raber J, Fike JR. The polyamine inhibitor alpha-difluoromethylornithine modulates hippocampus-dependent function after single and combined injuries. PLoS One. 2012; 7(1):e31094.
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8. Andres-Mach M, Fike JR, Luszczki JJ. Neurogenesis in the epileptic brain: a brief overview from temporal lobe epilepsy. Pharmacol Rep. 2011 Nov; 63(6):1316-23.
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9. Fike JR. Physiopathology of radiation-induced neurotoxicity. Rev Neurol (Paris). 2011 Oct; 167(10):746-50.
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10. Raber J, Rosi S, Chakraborti A, Fishman K, Dayger C, Davis MJ, Villasana L, Fike JR. Effects of 56Fe-particle cranial radiation on hippocampus-dependent cognition depend on the salience of the environmental stimuli. Radiat Res. 2011 Oct; 176(4):521-6.
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11. Acharya MM, Christie LA, Lan ML, Giedzinski E, Fike JR, Rosi S, Limoli CL. Human neural stem cell transplantation ameliorates radiation-induced cognitive dysfunction. Cancer Res. 2011 Jul 15; 71(14):4834-45.
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12. Raber J, Villasana L, Rosenberg J, Zou Y, Huang TT, Fike JR. Irradiation enhances hippocampus-dependent cognition in mice deficient in extracellular superoxide dismutase. Hippocampus. 2011 Jan; 21(1):72-80.
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13. Rosi S, Belarbi K, Ferguson RA, Fishman K, Obenaus A, Raber J, Fike JR. Trauma-induced alterations in cognition and Arc expression are reduced by previous exposure to 56Fe irradiation. Hippocampus. 2012 Mar; 22(3):544-54.
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14. Mao XW, Favre CJ, Fike JR, Kubinova L, Anderson E, Campbell-Beachler M, Jones T, Smith A, Rightnar S, Nelson GA. High-LET radiation-induced response of microvessels in the Hippocampus. Radiat Res. 2010 Apr; 173(4):486-93.
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15. Acharya MM, Christie LA, Lan ML, Donovan PJ, Cotman CW, Fike JR, Limoli CL. Rescue of radiation-induced cognitive impairment through cranial transplantation of human embryonic stem cells. Proc Natl Acad Sci U S A. 2009 Nov 10; 106(45):19150-5.
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16. Soussain C, Ricard D, Fike JR, Mazeron JJ, Psimaras D, Delattre JY. CNS complications of radiotherapy and chemotherapy. Lancet. 2009 Nov 7; 374(9701):1639-51.
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17. Fishman K, Baure J, Zou Y, Huang TT, Andres-Mach M, Rola R, Suarez T, Acharya M, Limoli CL, Lamborn KR, Fike JR. Radiation-induced reductions in neurogenesis are ameliorated in mice deficient in CuZnSOD or MnSOD. Free Radic Biol Med. 2009 Nov 15; 47(10):1459-67.
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18. Woodward WA, Bristow RG, Clarke MF, Coppes RP, Cristofanilli M, Duda DG, Fike JR, Hambardzumyan D, Hill RP, Jordan CT, Milas L, Pajonk F, Curran WJ, Dicker AP, Chen Y. Radiation Therapy Oncology Group translational research program stem cell symposium: incorporating stem cell hypotheses into clinical trials. Int J Radiat Oncol Biol Phys. 2009 Aug 1; 74(5):1580-91.
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19. Rosi S, Ramirez-Amaya V, Vazdarjanova A, Esparza EE, Larkin PB, Fike JR, Wenk GL, Barnes CA. Accuracy of hippocampal network activity is disrupted by neuroinflammation: rescue by memantine. Brain. 2009 Sep; 132(Pt 9):2464-77.
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20. Potts MB, Rola R, Claus CP, Ferriero DM, Fike JR, Noble-Haeusslein LJ. Glutathione peroxidase overexpression does not rescue impaired neurogenesis in the injured immature brain. J Neurosci Res. 2009 Jun; 87(8):1848-57.
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