Robert J. Fletterick, PhD

Robert J. Fletterick, PhD

Professor, Departments of Biochemistry/Biophysics and Cellular/Molecular Pharmacology, UCSF

Phone: (415) 476-5080 (voice)
Box 2240, UCSF
San Francisco, CA 94143-2240

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Additional Websites


Marietta College, Marietta, Ohio, B.S., 1965, Chemistry
Cornell University, Ithaca, New York, Ph.D., 1970, Physical Chemistry
Yale University, New Haven, Connecticut, Department of Molecular Biophysics and Biochemistry, Laboratory of Prof. Thomas Steitz, Postdoctoral Fellow, 1970-1971, X-ray Crystallography
Yale University, New Haven, Connecticut, Department of Biophysics and Biochemistry, Postdoctoral Fellow, 1971-1973, X-ray Crystallography

Professional Experience

  • 1974-1977
    Assistant Professor, Biochemistry Department, University of Alberta, Canada
  • 1977-1979
    Associate Professor, Biochemistry Department, University of Alberta, Canada
  • 1974-1979
    Member, Medical Research Council Group in Protein Structure and Function, University of Alberta, Edmonton, Alberta, Canada
  • 1979-1982
    Associate Professor, Department of Biochemistry and Biophysics, University of California, San Francisco, California
  • 1980-present
    Joint appointment, Department of Pharmaceutical Chemistry, UCSF
  • 1982-1985
    Chairman, Department of Biochemistry and Biophysics, UCSF
  • 1982-present
    Professor, Department of Biochemistry and Biophysics, and Cellular and Molecular Pharmacology, UCSF
  • 1998-2000
    Vice Chair, Department of Biochemistry and Biophysics

Honors & Awards

  • 1965
    Graduated with Honors in Chemistry, Hobba Chemistry Prize
  • 1965-1970
    National Institutes of Health Research Studentship
  • 1970-1971
    National Institutes of Health Postdoctoral Fellowship
  • 1971-1973
    National Institutes of Health Postdoctoral Fellowship
  • 1983
    Robert Welch Foundation Lecturer
  • Federal and Public Scientific Advisory Boards
  • 1991
    Member, Structural Biology Committee, Federal Government of Spain
  • 1993-1995
    Member, Standing Committee, Protein Engineering Network, Medical Research Council of Canada
  • 1993-1994
    Structural Biology Scientific Advisory Board, Institute of Molecular Biology, Academia Sinica, Nankang, Taipei
  • 1993-1997
    Member, Scientific Advisory Committee of the Cancer Research Fund, Damon Runyon-Walter Winchell Foundation
  • 1994-present
    Protein Society Nominating Committee
  • 1997-2000
    University of California Biotechnology Star Program

Selected Publications

  1. Torres IO, Kuchenbecker KM, Nnadi CI, Fletterick RJ, Kelly MJ, Fujimori DG. Histone demethylase KDM5A is regulated by its reader domain through a positive-feedback mechanism. Nat Commun. 2015; 6:6204.
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  2. Bayrer JR, Mukkamala S, Sablin EP, Webb P, Fletterick RJ. Silencing LRH-1 in colon cancer cell lines impairs proliferation and alters gene expression programs. Proc Natl Acad Sci U S A. 2015 Feb 24; 112(8):2467-72.
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  3. Gallastegui N, Mackinnon JA, Fletterick RJ, Estébanez-Perpiñá E. Advances in our structural understanding of orphan nuclear receptors. Trends Biochem Sci. 2015 Jan; 40(1):25-35.
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  4. Blind RD, Sablin EP, Kuchenbecker KM, Chiu HJ, Deacon AM, Das D, Fletterick RJ, Ingraham HA. The signaling phospholipid PIP3 creates a new interaction surface on the nuclear receptor SF-1. Proc Natl Acad Sci U S A. 2014 Oct 21; 111(42):15054-9.
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  5. Nagavalli S, Fletterick RJ, Ford G, Boston BA, Gianoukakis AG. Computer Modeling of a Newly Identified THRB Gene Mutation (S350L) Associated with Resistance to Thyroid Hormone in Three Unrelated Patients. Thyroid. 2014 Sep; 24(9):1430-1.
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  6. Benod C, Villagomez R, Filgueira CS, Hwang PK, Leonard PG, Poncet-Montange G, Rajagopalan S, Fletterick RJ, Gustafsson JÅ, Webb P. The Human Orphan Nuclear Receptor Tailless (TLX, NR2E1) Is Druggable. PLoS One. 2014; 9(6):e99440.
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  7. Bhattacharya S, Lou X, Hwang P, Rajashankar KR, Wang X, Gustafsson JÅ, Fletterick RJ, Jacobson RH, Webb P. Structural and functional insight into TAF1-TAF7, a subcomplex of transcription factor II D. Proc Natl Acad Sci U S A. 2014 Jun 24; 111(25):9103-8.
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  8. Larsen CC, Dumitrescu A, Guerra-Argüero LM, Gállego-Suárez C, Vazquez-Mellado A, Vinogradova M, Fletterick R, Refetoff S, Weiss RE. Incidental Identification of a Thyroid Hormone Receptor Beta (THRB) Gene Variant in a Family with Autoimmune Thyroid Disease. Thyroid. 2013 Dec; 23(12):1638-43.
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  9. Benod C, Carlsson J, Uthayaruban R, Hwang P, Irwin JJ, Doak AK, Shoichet BK, Sablin EP, Fletterick RJ. Structure-based discovery of antagonists of nuclear receptor LRH-1. J Biol Chem. 2013 Jul 5; 288(27):19830-44.
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  10. Kumar A, Möcklinghoff S, Yumoto F, Jaroszewski L, Farr CL, Grzechnik A, Nguyen P, Weichenberger CX, Chiu HJ, Klock HE, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Conklin BR, Fletterick RJ, Wilson IA. Structure of a novel winged-helix like domain from human NFRKB protein. PLoS One. 2012; 7(9):e43761.
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  11. Yumoto F, Nguyen P, Sablin EP, Baxter JD, Webb P, Fletterick RJ. Structural basis of coactivation of liver receptor homolog-1 by ß-catenin. Proc Natl Acad Sci U S A. 2012 Jan 3; 109(1):143-8.
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  12. Benod C, Vinogradova MV, Jouravel N, Kim GE, Fletterick RJ, Sablin EP. Nuclear receptor liver receptor homologue 1 (LRH-1) regulates pancreatic cancer cell growth and proliferation. Proc Natl Acad Sci U S A. 2011 Oct 11; 108(41):16927-31.
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  13. Buzón V, Carbó LR, Estruch SB, Fletterick RJ, Estébanez-Perpiñá E. A conserved surface on the ligand binding domain of nuclear receptors for allosteric control. Mol Cell Endocrinol. 2012 Jan 30; 348(2):394-402.
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  14. De Leon JT, Iwai A, Feau C, Garcia Y, Balsiger HA, Storer CL, Suro RM, Garza KM, Lee S, Kim YS, Chen Y, Ning YM, Riggs DL, Fletterick RJ, Guy RK, Trepel JB, Neckers LM, Cox MB. Targeting the regulation of androgen receptor signaling by the heat shock protein 90 cochaperone FKBP52 in prostate cancer cells. Proc Natl Acad Sci U S A. 2011 Jul 19; 108(29):11878-83.
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  15. Hjelm RP, Stone DB, Fletterick RJ, Mendelson RA. Decoration of microtubules in solution by the kinesin-14, Ncd. Acta Crystallogr D Biol Crystallogr. 2010 Nov; 66(Pt 11):1218-23.
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  16. Wilbur JD, Hwang PK, Ybe JA, Lane M, Sellers BD, Jacobson MP, Fletterick RJ, Brodsky FM. Conformation switching of clathrin light chain regulates clathrin lattice assembly. Dev Cell. 2010 May 18; 18(5):841-8.
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  17. Pfaff SJ, Fletterick RJ. Hormone binding and co-regulator binding to the glucocorticoid receptor are allosterically coupled. J Biol Chem. 2010 May 14; 285(20):15256-67.
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  18. Wilbur JD, Hwang PK, Brodsky FM, Fletterick RJ. Accommodation of structural rearrangements in the huntingtin-interacting protein 1 coiled-coil domain. Acta Crystallogr D Biol Crystallogr. 2010 Mar; 66(Pt 3):314-8.
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  19. Vinogradova MV, Malanina GG, Reddy AS, Fletterick RJ. Structure of the complex of a mitotic kinesin with its calcium binding regulator. Proc Natl Acad Sci U S A. 2009 May 19; 106(20):8175-9.
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  20. Jouravel N, Sablin E, Togashi M, Baxter JD, Webb P, Fletterick RJ. Molecular basis for dimer formation of TRbeta variant D355R. Proteins. 2009 Apr; 75(1):111-7.
    View on PubMed

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