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Robert J. Fletterick, PhD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
fletterick_robert

Professor, Departments of Biochemistry/Biophysics and Cellular/Molecular Pharmacology, UCSF

flett@msg.ucsf.edu

Phone: (415) 476-5080 (voice)
Box 2240, UCSF
San Francisco, CA 94143-2240

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Additional Websites


Education

Marietta College, Marietta, Ohio, B.S., 1965, Chemistry
Cornell University, Ithaca, New York, Ph.D., 1970, Physical Chemistry
Yale University, New Haven, Connecticut, Department of Molecular Biophysics and Biochemistry, Laboratory of Prof. Thomas Steitz, Postdoctoral Fellow, 1970-1971, X-ray Crystallography
Yale University, New Haven, Connecticut, Department of Biophysics and Biochemistry, Postdoctoral Fellow, 1971-1973, X-ray Crystallography


Professional Experience

  • 1974-1977
    Assistant Professor, Biochemistry Department, University of Alberta, Canada
  • 1977-1979
    Associate Professor, Biochemistry Department, University of Alberta, Canada
  • 1974-1979
    Member, Medical Research Council Group in Protein Structure and Function, University of Alberta, Edmonton, Alberta, Canada
  • 1979-1982
    Associate Professor, Department of Biochemistry and Biophysics, University of California, San Francisco, California
  • 1980-present
    Joint appointment, Department of Pharmaceutical Chemistry, UCSF
  • 1982-1985
    Chairman, Department of Biochemistry and Biophysics, UCSF
  • 1982-present
    Professor, Department of Biochemistry and Biophysics, and Cellular and Molecular Pharmacology, UCSF
  • 1998-2000
    Vice Chair, Department of Biochemistry and Biophysics

Honors & Awards

  • 1965
    Graduated with Honors in Chemistry, Hobba Chemistry Prize
  • 1965-1970
    National Institutes of Health Research Studentship
  • 1970-1971
    National Institutes of Health Postdoctoral Fellowship
  • 1971-1973
    National Institutes of Health Postdoctoral Fellowship
  • 1983
    Robert Welch Foundation Lecturer
  • Federal and Public Scientific Advisory Boards
  • 1991
    Member, Structural Biology Committee, Federal Government of Spain
  • 1993-1995
    Member, Standing Committee, Protein Engineering Network, Medical Research Council of Canada
  • 1993-1994
    Structural Biology Scientific Advisory Board, Institute of Molecular Biology, Academia Sinica, Nankang, Taipei
  • 1993-1997
    Member, Scientific Advisory Committee of the Cancer Research Fund, Damon Runyon-Walter Winchell Foundation
  • 1994-present
    Protein Society Nominating Committee
  • 1997-2000
    University of California Biotechnology Star Program

Selected Publications

  1. Benod C, Villagomez R, Filgueira CS, Hwang PK, Leonard PG, Poncet-Montange G, Rajagopalan S, Fletterick RJ, Gustafsson JÅ, Webb P. The Human Orphan Nuclear Receptor Tailless (TLX, NR2E1) Is Druggable. PLoS One. 2014; 9(6):e99440.
    View on PubMed
  2. Bhattacharya S, Lou X, Hwang P, Rajashankar KR, Wang X, Gustafsson JÅ, Fletterick RJ, Jacobson RH, Webb P. Structural and functional insight into TAF1-TAF7, a subcomplex of transcription factor II D. Proc Natl Acad Sci U S A. 2014 Jun 24; 111(25):9103-8.
    View on PubMed
  3. Larsen CC, Dumitrescu A, Guerra-Argüero LM, Gállego-Suárez C, Vazquez-Mellado A, Vinogradova M, Fletterick R, Refetoff S, Weiss RE. Incidental Identification of a Thyroid Hormone Receptor Beta (THRB) Gene Variant in a Family with Autoimmune Thyroid Disease. Thyroid. 2013 Dec; 23(12):1638-43.
    View on PubMed
  4. Benod C, Carlsson J, Uthayaruban R, Hwang P, Irwin JJ, Doak AK, Shoichet BK, Sablin EP, Fletterick RJ. Structure-based discovery of antagonists of nuclear receptor LRH-1. J Biol Chem. 2013 Jul 5; 288(27):19830-44.
    View on PubMed
  5. Kumar A, Möcklinghoff S, Yumoto F, Jaroszewski L, Farr CL, Grzechnik A, Nguyen P, Weichenberger CX, Chiu HJ, Klock HE, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Conklin BR, Fletterick RJ, Wilson IA. Structure of a novel winged-helix like domain from human NFRKB protein. PLoS One. 2012; 7(9):e43761.
    View on PubMed
  6. Yumoto F, Nguyen P, Sablin EP, Baxter JD, Webb P, Fletterick RJ. Structural basis of coactivation of liver receptor homolog-1 by ß-catenin. Proc Natl Acad Sci U S A. 2012 Jan 3; 109(1):143-8.
    View on PubMed
  7. Benod C, Vinogradova MV, Jouravel N, Kim GE, Fletterick RJ, Sablin EP. Nuclear receptor liver receptor homologue 1 (LRH-1) regulates pancreatic cancer cell growth and proliferation. Proc Natl Acad Sci U S A. 2011 Oct 11; 108(41):16927-31.
    View on PubMed
  8. Buzón V, Carbó LR, Estruch SB, Fletterick RJ, Estébanez-Perpiñá E. A conserved surface on the ligand binding domain of nuclear receptors for allosteric control. Mol Cell Endocrinol. 2012 Jan 30; 348(2):394-402.
    View on PubMed
  9. De Leon JT, Iwai A, Feau C, Garcia Y, Balsiger HA, Storer CL, Suro RM, Garza KM, Lee S, Kim YS, Chen Y, Ning YM, Riggs DL, Fletterick RJ, Guy RK, Trepel JB, Neckers LM, Cox MB. Targeting the regulation of androgen receptor signaling by the heat shock protein 90 cochaperone FKBP52 in prostate cancer cells. Proc Natl Acad Sci U S A. 2011 Jul 19; 108(29):11878-83.
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  10. Hjelm RP, Stone DB, Fletterick RJ, Mendelson RA. Decoration of microtubules in solution by the kinesin-14, Ncd. Acta Crystallogr D Biol Crystallogr. 2010 Nov; 66(Pt 11):1218-23.
    View on PubMed
  11. Wilbur JD, Hwang PK, Ybe JA, Lane M, Sellers BD, Jacobson MP, Fletterick RJ, Brodsky FM. Conformation switching of clathrin light chain regulates clathrin lattice assembly. Dev Cell. 2010 May 18; 18(5):841-8.
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  12. Pfaff SJ, Fletterick RJ. Hormone binding and co-regulator binding to the glucocorticoid receptor are allosterically coupled. J Biol Chem. 2010 May 14; 285(20):15256-67.
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  13. Wilbur JD, Hwang PK, Brodsky FM, Fletterick RJ. Accommodation of structural rearrangements in the huntingtin-interacting protein 1 coiled-coil domain. Acta Crystallogr D Biol Crystallogr. 2010 Mar; 66(Pt 3):314-8.
    View on PubMed
  14. Vinogradova MV, Malanina GG, Reddy AS, Fletterick RJ. Structure of the complex of a mitotic kinesin with its calcium binding regulator. Proc Natl Acad Sci U S A. 2009 May 19; 106(20):8175-9.
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  15. Jouravel N, Sablin E, Togashi M, Baxter JD, Webb P, Fletterick RJ. Molecular basis for dimer formation of TRbeta variant D355R. Proteins. 2009 Apr; 75(1):111-7.
    View on PubMed
  16. Sablin EP, Woods A, Krylova IN, Hwang P, Ingraham HA, Fletterick RJ. The structure of corepressor Dax-1 bound to its target nuclear receptor LRH-1. Proc Natl Acad Sci U S A. 2008 Nov 25; 105(47):18390-5.
    View on PubMed
  17. Sablin EP, Blind RD, Krylova IN, Ingraham JG, Cai F, Williams JD, Fletterick RJ, Ingraham HA. Structure of SF-1 bound by different phospholipids: evidence for regulatory ligands. Mol Endocrinol. 2009 Jan; 23(1):25-34.
    View on PubMed
  18. Cruz LA, Estébanez-Perpiñá E, Pfaff S, Borngraeber S, Bao N, Blethrow J, Fletterick RJ, England PM. 6-Azido-7-nitro-1,4-dihydroquinoxaline-2,3-dione (ANQX) forms an irreversible bond to the active site of the GluR2 AMPA receptor. J Med Chem. 2008 Sep 25; 51(18):5856-60.
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  19. Wilbur JD, Chen CY, Manalo V, Hwang PK, Fletterick RJ, Brodsky FM. Actin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chain. J Biol Chem. 2008 Nov 21; 283(47):32870-9.
    View on PubMed
  20. Vinogradova MV, Malanina GG, Reddy VS, Reddy AS, Fletterick RJ. Structural dynamics of the microtubule binding and regulatory elements in the kinesin-like calmodulin binding protein. J Struct Biol. 2008 Jul; 163(1):76-83.
    View on PubMed

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