University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Stephen Floor, PhD

Stephen Floor, PhD

Assistant Professor, Dept. of Cell and Tissue Biology, UCSF

Cancer Center Program Memberships

Neurologic Oncology | Pediatric Malignancies

Education

University of Kansas, Lawrence, Kansas, Bachelor of Science, 05/2005, Computer Science
University of Kansas, Lawrence, Kansas, Bachelor of Science, 05/2005, Physics
University of California, San Francisco, Doctor of Philosophy, 09/2011, Biophysics
University of California, Berkeley, Postdoctoral Fellow, 2017, Molecular and Cell Biology


Professional Experience

  • 2000-2001
    Undergraduate Research Assistant, University of Kansas, Physics Department
  • 2002-2004
    Undergraduate Research Assistant, University of Kansas, Physics Department
  • 2004-2004
    Undergraduate Research Assistant, University of Michigan, Physics Department
  • 2005-2011
    Graduate Research Assistant, UCSF, Biophysics Graduate Group
  • 2011-2017
    Postdoctoral Fellow, University of California, Berkeley, Dept. of Molecular and Cell Biology
  • 2017-present
    Assistant Professor, Dept. of Cell and Tissue Biology, UCSF

Honors & Awards

  • 2004
    Barry M. Goldwater Scholar, The Barry Goldwater Scholarship and Excellence in Education Foundation
  • 2007
    Achievement Rewards for College Scientists Scholar, ARCS Foundation
  • 2007
    Genentech-Sandler Graduate Research Opportunity Fellow, UCSF
  • 2009
    Mel Jones Award for College Scientists Scholar, ARCS Foundation
  • 2010
    Achievement Rewards for College Scientists Scholar, ARCS Foundation
  • 2011
    Frank M. Goyan Award for Outstanding Physical Chemistry Thesis, UCSF
  • 2013
    Helen Hay Whitney Foundation Postdoctoral Fellow, Helen Hay Whitney Foundation

Selected Publications

  1. John D Blair, Dirk Hockemeyer, Jennifer A Doudna, Helen S Bateup, Stephen N Floor. Widespread translational remodeling during human neuronal differentiation. bioRxiv preprint. 2017.
    View on PubMed
  2. Chris D. Richardson, Katelynn R. Kazane, Sharon J. Feng, Nicholas L. Bray, Axel J. Schaefer, Stephen Floor, Jacob Corn. CRISPR-Cas9 Genome Editing In Human Cells Works Via The Fanconi Anemia Pathway. bioRxiv preprint. 2017.
    View on PubMed
  3. Staahl BT, Benekareddy M, Coulon-Bainier C, Banfal AA, Floor SN, Sabo JK, Urnes C, Munares GA, Ghosh A, Doudna JA. Efficient genome editing in the mouse brain by local delivery of engineered Cas9 ribonucleoprotein complexes. Nat Biotechnol. 2017 May; 35(5):431-434.
    View on PubMed
  4. Iwasaki S, Floor SN, Ingolia NT. Rocaglates convert DEAD-box protein eIF4A into a sequence-selective translational repressor. Nature. 2016 06 23; 534(7608):558-61.
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  5. Oh S, Flynn RA, Floor SN, Purzner J, Martin L, Do BT, Schubert S, Vaka D, Morrissy S, Li Y, Kool M, Hovestadt V, Jones DT, Northcott PA, Risch T, Warnatz HJ, Yaspo ML, Adams CM, Leib RD, Breese M, Marra MA, Malkin D, Lichter P, Doudna JA, Pfister SM, Taylor MD, Chang HY, Cho YJ. Medulloblastoma-associated DDX3 variant selectively alters the translational response to stress. Oncotarget. 2016 May 10; 7(19):28169-82.
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  6. Floor SN, Doudna JA. Tunable protein synthesis by transcript isoforms in human cells. Elife. 2016 Jan 06; 5.
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  7. Floor SN, Barkovich KJ, Condon KJ, Shokat KM, Doudna JA. Analog sensitive chemical inhibition of the DEAD-box protein DDX3. Protein Sci. 2016 Mar; 25(3):638-49.
    View on PubMed
  8. Floor SN, Doudna JA. Get in LINE: Competition for Newly Minted Retrotransposon Proteins at the Ribosome. Mol Cell. 2015 Dec 03; 60(5):712-4.
    View on PubMed
  9. Floor SN, Condon KJ, Sharma D, Jankowsky E, Doudna JA. Autoinhibitory Interdomain Interactions and Subfamily-specific Extensions Redefine the Catalytic Core of the Human DEAD-box Protein DDX3. J Biol Chem. 2016 Jan 29; 291(5):2412-21.
    View on PubMed
  10. Aglietti RA, Floor SN, McClendon CL, Jacobson MP, Gross JD. Active site conformational dynamics are coupled to catalysis in the mRNA decapping enzyme Dcp2. Structure. 2013 Sep 3; 21(9):1571-80.
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  11. Floor SN, Borja MS, Gross JD. Interdomain dynamics and coactivation of the mRNA decapping enzyme Dcp2 are mediated by a gatekeeper tryptophan. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):2872-7.
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  12. Floor SN, Jones BN, Hernandez GA, Gross JD. A split active site couples cap recognition by Dcp2 to activation. Nat Struct Mol Biol. 2010 Sep; 17(9):1096-101.
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  13. Lampe JN, Floor SN, Gross JD, Nishida CR, Jiang Y, Trnka MJ, Ortiz de Montellano PR. Ligand-induced conformational heterogeneity of cytochrome P450 CYP119 identified by 2D NMR spectroscopy with the unnatural amino acid (13)C-p-methoxyphenylalanine. J Am Chem Soc. 2008 Dec 3; 130(48):16168-9.
    View on PubMed
  14. Floor SN, Jones BN, Gross JD. Control of mRNA decapping by Dcp2: An open and shut case? RNA Biol. 2008 Oct-Dec; 5(4):189-92.
    View on PubMed
  15. Neher SB, Bradshaw N, Floor SN, Gross JD, Walter P. SRP RNA controls a conformational switch regulating the SRP-SRP receptor interaction. Nat Struct Mol Biol. 2008 Sep; 15(9):916-23.
    View on PubMed
  16. Deshmukh MV, Jones BN, Quang-Dang DU, Flinders J, Floor SN, Kim C, Jemielity J, Kalek M, Darzynkiewicz E, Gross JD. mRNA decapping is promoted by an RNA-binding channel in Dcp2. Mol Cell. 2008 Feb 15; 29(3):324-36.
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  17. Floor, S. N., Melott, A. L., & Motl, P. M.. Simulated versus observed cluster eccentricity evolution. The Astrophysical Journal. 2004; 611:153.
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  18. Floor, S. N., Melott, A. L., Miller, C. J., & Bryan, G. L.. Eccentricity evolution in simulated galaxy clusters. The Astrophysical Journal. 2003; 591:741.
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  19. Clark ST, Hackman G, Janssens RV, Clark RM, Fallon P, Floor SN, Lane GJ, Macchiavelli AO, Norris J, Sanders SJ, Svensson CE. Empirical investigation of extreme single-particle behavior of nuclear quadrupole moments in highly collective A approximately 150 superdeformed bands. Phys Rev Lett. 2001 Oct 22; 87(17):172503.
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