About UCSF Search UCSF UCSF Medical Center

Kathleen Giacomini, PhD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
giacomini_kathleen

Professor and Co-Chair, Department of Bioengineering and Therapeutic Sciences; Professor, Departments of Biopharmaceutical Sciences, Pharmaceutical Chemistry, and Cellular & Molecular Pharmacology, UCSF

kmg@itsa.ucsf.edu

Phone: (415) 476-1936 (voice)
Box 0446, UCSF
San Francisco, CA 94143-0446

View on UCSF Profiles


Additional Websites


Education

University of Houston, Houston, TX, B.S., 1973, Pharmacy
State University of New York at Buffalo, Buffalo, NY, Ph.D., 1979, Pharmaceutical Sciences
Stanford University, Stanford, CA, Postdoc, 1979-81, Pharmacology /Clinical Pharmacology


Professional Experience

  • 1981-87
    Assistant Professor of Pharmacy/ Pharmaceutical Chem. & Pharmacology
  • 1987-91
    Associate Professor of Pharmacy/ Pharmaceutical Chem. & Pharmacology
  • 1998-2009
    Chair of the Department of Biopharmaceutical Sciences
  • 1992-present
    Professor of Biopharmaceutical Sciences, Pharmaceutical Chemistry, and Cellular & Molecular Pharmacology, UCSF
  • 2009-present
    Co-chair, Department of Bioengineering and Therapeutic Sciences, UCSF

Honors & Awards

  • 1973
    Rho Chi, Honorary Pharmacy Fraternity
  • 1983-84
    Long Foundation Award for Excellence in Teaching, School of Pharmacy, UCSF
  • 1984-85
    UCSF Nominee, Recognition Award for Young Scholars, American Association of University Women
  • 1985-86
    Distinguished Teaching Award, UCSF, Academic Senate
  • 1990
    Leon Goldberg Young Investigator Award, American Society for Clinical Pharmacology and Therapeutics
  • 1990-94
    Member of Pharmacological Science Review Committee; National Institutes of Health (GM)
  • 1990-94
    Member of Generic Drugs Advisory Committee; Food and Drug Administration
  • 1992
    Recipient, Fogarty International Fellowship; National Institutes of Health
  • 1993
    Elected Fellow, American Association of Pharmaceutical Scientists
  • 1994
    UCSF, Dr. Martin Luther King, Jr. Award for the Advancement of Women and Minorities
  • 1996-97
    Vice President, American Society for Clinical Pharmacology and Therapeutics
  • 1996-97
    UCSF, Chancellor's Award for the Advancement of Women
  • 1999
    Recognition Award for Distinguished Achievement of Filipino at UCSF
  • 1999
    International Pharmaceutical Federation (FIP), Pharmaceutical Scientist of the Year
  • 2001
    Elected Fellow, American Association for the Advancement of Science
  • 2002
    Distinguished Bill Abram's Lectureship (FDA)
  • 2002
    First Distinguished Gerhard Levy Lectureship (SUNY Buffalo)
  • 2002
    Speaker: State Legislative Presentation 'The Impact of the Human Genome Pronect on Drug Development and Use: Tailoring Drugs to Individuals'
  • 2005
    Paul Dawson Biotechnology Award, American Association of College of Pharmacy
  • 2006
    Distinguished Scientist in Drug Metabolism, American Association of Pharmaceutical Scientists
  • 2006
    Elected Member, Institute of Medicine
  • 2007
    International Pharmaceutical Sciences World Congress (PSWC) Research Achievement Award
  • 2007
    International Woman Scientist Award, Academy of Pharmaceutical Sciences and Technology, Japan
  • 2008
    Japan Society for the Promotion of Sciences (JSPS) Invitation Fellowship Program for Research in Japan
  • 2009
    Rawls-Palmer Progress in Medicine Award, American Society for Clinical Pharmacology and Therapeutics (ASCPT)
  • 2009
    UCSF Postdoctoral Scholars Association Outstanding Mentor Award
  • 2010
    American College of Clinical Pharmacy Therapeutic Frontiers Lecture Award
  • 2011
    Scheele Award, Swedish Academy of Pharmaceutical Sciences

Selected Publications

  1. Smith RP, Eckalbar WL, Morrissey KM, Luizon MR, Hoffmann TJ, Sun X, Jones SL, Force Aldred S, Ramamoorthy A, Desta Z, Liu Y, Skaar TC, Trinklein ND, Giacomini KM, Ahituv N. Genome-wide discovery of drug-dependent human liver regulatory elements. PLoS Genet. 2014 Oct; 10(10):e1004648.
    View on PubMed
  2. Pawlyk AC, Giacomini KM, McKeon C, Shuldiner AR, Florez JC. Metformin pharmacogenomics: current status and future directions. Diabetes. 2014 Aug; 63(8):2590-9.
    View on PubMed
  3. Chen L, Shu Y, Liang X, Chen EC, Yee SW, Zur AA, Li S, Xu L, Keshari KR, Lin MJ, Chien HC, Zhang Y, Morrissey KM, Liu J, Ostrem J, Younger NS, Kurhanewicz J, Shokat KM, Ashrafi K, Giacomini KM. OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin. Proc Natl Acad Sci U S A. 2014 Jul 8; 111(27):9983-8.
    View on PubMed
  4. Goswami S, Gong L, Giacomini K, Altman RB, Klein TE. PharmGKB summary: very important pharmacogene information for SLC22A1. Pharmacogenet Genomics. 2014 Jun; 24(6):324-8.
    View on PubMed
  5. Goswami S, Yee SW, Stocker S, Mosley JD, Kubo M, Castro R, Mefford JA, Wen C, Liang X, Witte J, Brett C, Maeda S, Simpson MD, Hedderson MM, Davis RL, Roden DM, Giacomini KM, Savic RM. Genetic variants in transcription factors are associated with the pharmacokinetics and pharmacodynamics of metformin. Clin Pharmacol Ther. 2014 Sep; 96(3):370-9.
    View on PubMed
  6. Clancy JP, Johnson SG, Yee SW, McDonagh EM, Caudle KE, Klein TE, Cannavo M, Giacomini KM. Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for Ivacaftor Therapy in the Context of CFTR Genotype. Clin Pharmacol Ther. 2014 Jun; 95(6):592-7.
    View on PubMed
  7. Hsu V, de L T Vieira M, Zhao P, Zhang L, Zheng JH, Nordmark A, Berglund EG, Giacomini KM, Huang SM. Towards quantitation of the effects of renal impairment and probenecid inhibition on kidney uptake and efflux transporters, using physiologically based pharmacokinetic modelling and simulations. Clin Pharmacokinet. 2014 Mar; 53(3):283-93.
    View on PubMed
  8. Geier EG, Chen EC, Webb A, Papp AC, Yee SW, Sadee W, Giacomini KM. Profiling solute carrier transporters in the human blood-brain barrier. Clin Pharmacol Ther. 2013 Dec; 94(6):636-9.
    View on PubMed
  9. Drake KA, Torgerson DG, Gignoux CR, Galanter JM, Roth LA, Huntsman S, Eng C, Oh SS, Yee SW, Lin L, Bustamante CD, Moreno-Estrada A, Sandoval K, Davis A, Borrell LN, Farber HJ, Kumar R, Avila PC, Brigino-Buenaventura E, Chapela R, Ford JG, Lenoir MA, Lurmann F, Meade K, Serebrisky D, Thyne S, Rodríguez-Cintrón W, Sen S, Rodríguez-Santana JR, Hernandez RD, Giacomini KM, Burchard EG. A genome-wide association study of bronchodilator response in Latinos implicates rare variants. J Allergy Clin Immunol. 2014 Feb; 133(2):370-378.e15.
    View on PubMed
  10. Giacomini KM, Huang SM. Transporters in drug development and clinical pharmacology. Clin Pharmacol Ther. 2013 Jul; 94(1):3-9.
    View on PubMed
  11. Schlessinger A, Yee SW, Sali A, Giacomini KM. SLC classification: an update. Clin Pharmacol Ther. 2013 Jul; 94(1):19-23.
    View on PubMed
  12. Giacomini KM, Balimane PV, Cho SK, Eadon M, Edeki T, Hillgren KM, Huang SM, Sugiyama Y, Weitz D, Wen Y, Xia CQ, Yee SW, Zimdahl H, Niemi M. International Transporter Consortium commentary on clinically important transporter polymorphisms. Clin Pharmacol Ther. 2013 Jul; 94(1):23-6.
    View on PubMed
  13. Mushiroda T, Giacomini KM, Kubo M. Special Section on Pharmacogenomics: recent advances and future directions. J Hum Genet. 2013 Jun; 58(6):305.
    View on PubMed
  14. Yee SW, Mefford JA, Singh N, Percival ME, Stecula A, Yang K, Witte JS, Takahashi A, Kubo M, Matsuda K, Giacomini KM, Andreadis C. Impact of polymorphisms in drug pathway genes on disease-free survival in adults with acute myeloid leukemia. J Hum Genet. 2013 Jun; 58(6):353-61.
    View on PubMed
  15. Yee SW, Nguyen AN, Brown C, Savic RM, Zhang Y, Castro RA, Cropp CD, Choi JH, Singh D, Tahara H, Stocker SL, Huang Y, Brett CM, Giacomini KM. Reduced renal clearance of cefotaxime in asians with a low-frequency polymorphism of OAT3 (SLC22A8). J Pharm Sci. 2013 Sep; 102(9):3451-7.
    View on PubMed
  16. Hillgren KM, Keppler D, Zur AA, Giacomini KM, Stieger B, Cass CE, Zhang L. Emerging transporters of clinical importance: an update from the International Transporter Consortium. Clin Pharmacol Ther. 2013 Jul; 94(1):52-63.
    View on PubMed
  17. Geier EG, Schlessinger A, Fan H, Gable JE, Irwin JJ, Sali A, Giacomini KM. Structure-based ligand discovery for the Large-neutral Amino Acid Transporter 1, LAT-1. Proc Natl Acad Sci U S A. 2013 Apr 2; 110(14):5480-5.
    View on PubMed
  18. Dahlin A, Geier E, Stocker SL, Cropp CD, Grigorenko E, Bloomer M, Siegenthaler J, Xu L, Basile AS, Tang-Liu DD, Giacomini KM. Gene expression profiling of transporters in the solute carrier and ATP-binding cassette superfamilies in human eye substructures. Mol Pharm. 2013 Feb 4; 10(2):650-63.
    View on PubMed
  19. Wittwer MB, Zur AA, Khuri N, Kido Y, Kosaka A, Zhang X, Morrissey KM, Sali A, Huang Y, Giacomini KM. Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling. J Med Chem. 2013 Feb 14; 56(3):781-95.
    View on PubMed
  20. Schlessinger A, Khuri N, Giacomini KM, Sali A. Molecular modeling and ligand docking for solute carrier (SLC) transporters. Curr Top Med Chem. 2013; 13(7):843-56.
    View on PubMed

Go to UCSF Profiles, powered by CTSI