Professor and Co-Chair, Department of Bioengineering and Therapeutic Sciences; Professor, Departments of Biopharmaceutical Sciences, Pharmaceutical Chemistry, and Cellular & Molecular Pharmacology, UCSF
Additional Websites
Education
University of Houston, Houston, TX, B.S., 1973, Pharmacy
State University of New York at Buffalo, Buffalo, NY, Ph.D., 1979, Pharmaceutical Sciences
Stanford University, Stanford, CA, Postdoc, 1979-81, Pharmacology /Clinical Pharmacology
Professional Experience
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1981-87
Assistant Professor of Pharmacy/ Pharmaceutical Chem. & Pharmacology
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1987-91
Associate Professor of Pharmacy/ Pharmaceutical Chem. & Pharmacology
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1998-2009
Chair of the Department of Biopharmaceutical Sciences
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1992-present
Professor of Biopharmaceutical Sciences, Pharmaceutical Chemistry, and Cellular & Molecular Pharmacology, UCSF
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2009-present
Co-chair, Department of Bioengineering and Therapeutic Sciences, UCSF
Honors & Awards
- 1973
Rho Chi, Honorary Pharmacy Fraternity - 1983-84
Long Foundation Award for Excellence in Teaching, School of Pharmacy, UCSF - 1984-85
UCSF Nominee, Recognition Award for Young Scholars, American Association of University Women - 1985-86
Distinguished Teaching Award, UCSF, Academic Senate - 1990
Leon Goldberg Young Investigator Award, American Society for Clinical Pharmacology and Therapeutics - 1990-94
Member of Pharmacological Science Review Committee; National Institutes of Health (GM) - 1990-94
Member of Generic Drugs Advisory Committee; Food and Drug Administration - 1992
Recipient, Fogarty International Fellowship; National Institutes of Health - 1993
Elected Fellow, American Association of Pharmaceutical Scientists - 1994
UCSF, Dr. Martin Luther King, Jr. Award for the Advancement of Women and Minorities - 1996-97
Vice President, American Society for Clinical Pharmacology and Therapeutics - 1996-97
UCSF, Chancellor's Award for the Advancement of Women - 1999
Recognition Award for Distinguished Achievement of Filipino at UCSF - 1999
International Pharmaceutical Federation (FIP), Pharmaceutical Scientist of the Year - 2001
Elected Fellow, American Association for the Advancement of Science - 2002
Distinguished Bill Abram's Lectureship (FDA) - 2002
First Distinguished Gerhard Levy Lectureship (SUNY Buffalo) - 2002
Speaker: State Legislative Presentation 'The Impact of the Human Genome Pronect on Drug Development and Use: Tailoring Drugs to Individuals' - 2005
Paul Dawson Biotechnology Award, American Association of College of Pharmacy - 2006
Distinguished Scientist in Drug Metabolism, American Association of Pharmaceutical Scientists - 2006
Elected Member, Institute of Medicine - 2007
International Pharmaceutical Sciences World Congress (PSWC) Research Achievement Award - 2007
International Woman Scientist Award, Academy of Pharmaceutical Sciences and Technology, Japan - 2008
Japan Society for the Promotion of Sciences (JSPS) Invitation Fellowship Program for Research in Japan - 2009
Rawls-Palmer Progress in Medicine Award, American Society for Clinical Pharmacology and Therapeutics (ASCPT) - 2009
UCSF Postdoctoral Scholars Association Outstanding Mentor Award - 2010
American College of Clinical Pharmacy Therapeutic Frontiers Lecture Award - 2011
Scheele Award, Swedish Academy of Pharmaceutical Sciences
Selected Publications
- Geier EG, Schlessinger A, Fan H, Gable JE, Irwin JJ, Sali A, Giacomini KM. Structure-based ligand discovery for the Large-neutral Amino Acid Transporter 1, LAT-1. Proc Natl Acad Sci U S A. 2013 Apr 2; 110(14):5480-5.
View on PubMed - Dahlin A, Geier E, Stocker SL, Cropp CD, Grigorenko E, Bloomer M, Siegenthaler J, Xu L, Basile AS, Tang-Liu DD, Giacomini KM. Gene Expression Profiling of Transporters in the Solute Carrier and ATP-Binding Cassette Superfamilies in Human Eye Substructures. Mol Pharm. 2013 Feb 4; 10(2):650-63.
View on PubMed - Wittwer MB, Zur AA, Khuri N, Kido Y, Kosaka A, Zhang X, Morrissey KM, Sali A, Huang Y, Giacomini KM. Discovery of Potent, Selective Multidrug and Toxin Extrusion Transporter 1 (MATE1, SLC47A1) Inhibitors Through Prescription Drug Profiling and Computational Modeling. J Med Chem. 2013 Feb 14; 56(3):781-95.
View on PubMed - Morrissey KM, Stocker SL, Wittwer MB, Xu L, Giacomini KM. Renal transporters in drug development. Annu Rev Pharmacol Toxicol. 2013 Jan 6; 53:503-29.
View on PubMed - Zamek-Gliszczynski MJ, Hoffmaster KA, Tweedie DJ, Giacomini KM, Hillgren KM. Highlights from the international transporter consortium second workshop. Clin Pharmacol Ther. 2012 Nov; 92(5):553-6.
View on PubMed - Gong L, Goswami S, Giacomini KM, Altman RB, Klein TE. Metformin pathways: pharmacokinetics and pharmacodynamics. Pharmacogenet Genomics. 2012 Nov; 22(11):820-7.
View on PubMed - Morrissey KM, Wen CC, Johns SJ, Zhang L, Huang SM, Giacomini KM. The UCSF-FDA TransPortal: A Public Drug Transporter Database. Clin Pharmacol Ther. 2012 Nov; 92(5):545-6.
View on PubMed - Stocker SL, Morrissey KM, Yee SW, Castro RA, Xu L, Dahlin A, Ramirez AH, Roden DM, Wilke RA, McCarty CA, Davis RL, Brett CM, Giacomini KM. The Effect of Novel Promoter Variants in MATE1 and MATE2 on the Pharmacokinetics and Pharmacodynamics of Metformin. Clin Pharmacol Ther. 2013 Feb; 93(2):186-94.
View on PubMed - Giacomini KM, Yee SW, Ratain MJ, Weinshilboum RM, Kamatani N, Nakamura Y. Pharmacogenomics and patient care: one size does not fit all. Sci Transl Med. 2012 Sep 26; 4(153):153ps18.
View on PubMed - Dubois SG, Geier E, Batra V, Yee SW, Neuhaus J, Segal M, Martinez D, Pawel B, Yanik G, Naranjo A, London WB, Kreissman S, Baker D, Attiyeh E, Hogarty MD, Maris JM, Giacomini K, Matthay KK. Evaluation of Norepinephrine Transporter Expression and Metaiodobenzylguanidine Avidity in Neuroblastoma: A Report from the Children's Oncology Group. Int J Mol Imaging. 2012; 2012:250834.
View on PubMed - Schlessinger A, Wittwer MB, Dahlin A, Khuri N, Bonomi M, Fan H, Giacomini KM, Sali A. High Selectivity of the ?-Aminobutyric Acid Transporter 2 (GAT-2, SLC6A13) Revealed by Structure-based Approach. J Biol Chem. 2012 Nov 2; 287(45):37745-56.
View on PubMed - Smith DE, Rowland M, Giacomini KM, Amidon GL. Dedication to professor Leslie Z. Benet: 50 years of scientific excellence and still going strong! Pharm Res. 2012 Sep; 29(9):2345-53.
View on PubMed - Yee SW, Chen L, Giacomini KM. The role of ATM in response to metformin treatment and activation of AMPK. Nat Genet. 2012 Apr; 44(4):359-60.
View on PubMed - Chen L, Hong C, Chen EC, Yee SW, Xu L, Almof EU, Wen C, Fujii K, Johns SJ, Stryke D, Ferrin TE, Simko J, Chen X, Costello JF, Giacomini KM. Genetic and epigenetic regulation of the organic cation transporter 3, SLC22A3. Pharmacogenomics J. 2013 Apr; 13(2):110-20.
View on PubMed - Ramsey LB, Bruun GH, Yang W, Treviño LR, Vattathil S, Scheet P, Cheng C, Rosner GL, Giacomini KM, Fan Y, Sparreboom A, Mikkelsen TS, Corydon TJ, Pui CH, Evans WE, Relling MV. Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition. Genome Res. 2012 Jan; 22(1):1-8.
View on PubMed - Innocenti F, Owzar K, Cox NL, Evans P, Kubo M, Zembutsu H, Jiang C, Hollis D, Mushiroda T, Li L, Friedman P, Wang L, Glubb D, Hurwitz H, Giacomini KM, McLeod HL, Goldberg RM, Schilsky RL, Kindler HL, Nakamura Y, Ratain MJ. A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303. Clin Cancer Res. 2012 Jan 15; 18(2):577-84.
View on PubMed - Choi JH, Yee SW, Ramirez AH, Morrissey KM, Jang GH, Joski PJ, Mefford JA, Hesselson SE, Schlessinger A, Jenkins G, Castro RA, Johns SJ, Stryke D, Sali A, Ferrin TE, Witte JS, Kwok PY, Roden DM, Wilke RA, McCarty CA, Davis RL, Giacomini KM. A common 5'-UTR variant in MATE2-K is associated with poor response to metformin. Clin Pharmacol Ther. 2011 Nov; 90(5):674-84.
View on PubMed - Schlessinger A, Geier E, Fan H, Irwin JJ, Shoichet BK, Giacomini KM, Sali A. Structure-based discovery of prescription drugs that interact with the norepinephrine transporter, NET. Proc Natl Acad Sci U S A. 2011 Sep 20; 108(38):15810-5.
View on PubMed - Kido Y, Matsson P, Giacomini KM. Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. J Med Chem. 2011 Jul 14; 54(13):4548-58.
View on PubMed - Picard N, Levoir L, Lamoureux F, Yee SW, Giacomini KM, Marquet P. Interaction of sirolimus and everolimus with hepatic and intestinal organic anion-transporting polypeptide transporters. Xenobiotica. 2011 Sep; 41(9):752-7.
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