Kathleen Giacomini, PhD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Kathleen Giacomini, PhD

Professor and Co-Chair, Department of Bioengineering and Therapeutic Sciences; Professor, Departments of Biopharmaceutical Sciences, Pharmaceutical Chemistry, and Cellular & Molecular Pharmacology, UCSF

kmg@itsa.ucsf.edu

Phone: (415) 476-1936 (voice)
Box 0446, UCSF
San Francisco, CA 94143-0446

UCSF Profiles | Giacomini Lab

Cancer Center Membership

Program Member » Developmental Therapeutics» Cancer Genetics

Research Summary

I am a world-renowned pharmacologist with many years of research experience particularly focused on transporter biology and pharmacogenomics. My research is focused on influx transporters, especially influx transporters involved in drug disposition and targeting. In the early 2000s, we began a comprehensive research program focused on the pharmacogenomics of membrane transporters. We published many papers ranging from functional genomics of transporter polymorphisms to clinical studies elucidating the role of transporter polymorphisms on clinical drug response. Our NIH-funded center, the Pharmacogenomics of Membrane Transporters Center, part of the NIH Pharmacogenomics Research Network, is widely recognized as the leading research unit in the world for the discovery, functional characterization and clinical relevance of polymorphisms in drug transporters. We have been leaders in the field of human genetic studies focused on metformin with a particular emphasis on membrane transporters.

Most recently, I am a co-Director of a FDA grant to establish a Center with education, exchange, and collaborative research programs that will greatly advance the ability of the FDA to evaluate and approve safe and effective drugs. This is a collaborative program between Stanford and UCSF that will develop quantitative and computer-based methods for the evaluation of new drug products. Importantly, research will focus on issues of bioequivalence between generic drug products including metformin tablets.

Education

University of Houston, Houston, TX, B.S., 1973, Pharmacy
State University of New York at Buffalo, Buffalo, NY, Ph.D., 1979, Pharmaceutical Sciences
Stanford University, Stanford, CA, Postdoc, 1979-81, Pharmacology /Clinical Pharmacology


Professional Experience

  • 1981-87
    Assistant Professor of Pharmacy/ Pharmaceutical Chem. & Pharmacology
  • 1987-91
    Associate Professor of Pharmacy/ Pharmaceutical Chem. & Pharmacology
  • 1998-2009
    Chair of the Department of Biopharmaceutical Sciences
  • 1992-present
    Professor of Biopharmaceutical Sciences, Pharmaceutical Chemistry, and Cellular & Molecular Pharmacology, UCSF
  • 2009-present
    Co-chair, Department of Bioengineering and Therapeutic Sciences, UCSF

Honors & Awards

  • 1973
    Rho Chi, Honorary Pharmacy Fraternity
  • 1983-84
    Long Foundation Award for Excellence in Teaching, School of Pharmacy, UCSF
  • 1984-85
    UCSF Nominee, Recognition Award for Young Scholars, American Association of University Women
  • 1985-86
    Distinguished Teaching Award, UCSF, Academic Senate
  • 1990
    Leon Goldberg Young Investigator Award, American Society for Clinical Pharmacology and Therapeutics
  • 1990-94
    Member of Pharmacological Science Review Committee; National Institutes of Health (GM)
  • 1990-94
    Member of Generic Drugs Advisory Committee; Food and Drug Administration
  • 1992
    Recipient, Fogarty International Fellowship; National Institutes of Health
  • 1993
    Elected Fellow, American Association of Pharmaceutical Scientists
  • 1994
    UCSF, Dr. Martin Luther King, Jr. Award for the Advancement of Women and Minorities
  • 1996-97
    Vice President, American Society for Clinical Pharmacology and Therapeutics
  • 1996-97
    UCSF, Chancellor's Award for the Advancement of Women
  • 1999
    Recognition Award for Distinguished Achievement of Filipino at UCSF
  • 1999
    International Pharmaceutical Federation (FIP), Pharmaceutical Scientist of the Year
  • 2001
    Elected Fellow, American Association for the Advancement of Science
  • 2002
    Distinguished Bill Abram's Lectureship (FDA)
  • 2002
    First Distinguished Gerhard Levy Lectureship (SUNY Buffalo)
  • 2002
    Speaker: State Legislative Presentation 'The Impact of the Human Genome Pronect on Drug Development and Use: Tailoring Drugs to Individuals'
  • 2005
    Paul Dawson Biotechnology Award, American Association of College of Pharmacy
  • 2006
    Distinguished Scientist in Drug Metabolism, American Association of Pharmaceutical Scientists
  • 2006
    Elected Member, Institute of Medicine
  • 2007
    International Pharmaceutical Sciences World Congress (PSWC) Research Achievement Award
  • 2007
    International Woman Scientist Award, Academy of Pharmaceutical Sciences and Technology, Japan
  • 2008
    Japan Society for the Promotion of Sciences (JSPS) Invitation Fellowship Program for Research in Japan
  • 2009
    Rawls-Palmer Progress in Medicine Award, American Society for Clinical Pharmacology and Therapeutics (ASCPT)
  • 2009
    UCSF Postdoctoral Scholars Association Outstanding Mentor Award
  • 2010
    American College of Clinical Pharmacy Therapeutic Frontiers Lecture Award
  • 2011
    Scheele Award, Swedish Academy of Pharmaceutical Sciences

Selected Publications

  1. Irwin JJ, Pottel J, Zou L, Wen H, Zuk S, Zhang X, Sterling T, Shoichet BK, Lionberger R, Giacomini KM. A Molecular Basis for Innovation in Drug Excipients. Clin Pharmacol Ther. 2016 Aug 24.
    View on PubMed
  2. Hsueh CH, Yoshida K, Zhao P, Meyer TW, Zhang L, Huang SM, Giacomini KM. Identification and Quantitative Assessment of Uremic Solutes as Inhibitors of Renal Organic Anion Transporters, OAT1 and OAT3. Mol Pharm. 2016 Aug 9.
    View on PubMed
  3. Zhou K, Yee SW, Seiser EL, van Leeuwen N, Tavendale R, Bennett AJ, Groves CJ, Coleman RL, van der Heijden AA, Beulens JW, de Keyser CE, Zaharenko L, Rotroff DM, Out M, Jablonski KA, Chen L, Javorský M, Židzik J, Levin AM, Williams LK, Dujic T, Semiz S, Kubo M, Chien HC, Maeda S, Witte JS, Wu L, Tkác I, Kooy A, van Schaik RH, Stehouwer CD, Logie L. Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin. Nat Genet. 2016 Aug 8.
    View on PubMed
  4. Yee SW, Giacomini MM, Hsueh CH, Weitz D, Liang X, Goswami S, Kinchen JM, Coelho A, Zur AA, Mertsch K, Brian W, Kroetz DL, Giacomini KM. Metabolomic and Genome-wide Association Studies Reveal Potential Endogenous Biomarkers for OATP1B1. Clin Pharmacol Ther. 2016 Jul 22.
    View on PubMed
  5. Goswami S, Yee SW, Xu F, Sridhar SB, Mosley JJ, Takahashi A, Kubo M, Maeda S, Davis RL, Roden DM, Hedderson MM, Giacomini KM, Savic RM. A Longitudinal HbA1c Model Elucidates Genes Linked to Disease Progression on Metformin. Clin Pharmacol Ther. 2016 Jul 14.
    View on PubMed
  6. Rotroff DM, Oki NO, Liang X, Yee SW, Stocker SL, Corum DG, Meisner M, Fiehn O, Motsinger-Reif AA, Giacomini KM, Kaddurah-Daouk R. Pharmacometabolomic Assessment of Metformin in Non-diabetic, African Americans. Front Pharmacol. 2016; 7:135.
    View on PubMed
  7. Yee SW, Momozawa Y, Kamatani Y, Tyndale RF, Weinshilboum RM, Ratain MJ, Giacomini KM, Kubo M. Genomewide Association Studies in Pharmacogenomics: Meeting Report of the NIH Pharmacogenomics Research Network-RIKEN (PGRN-RIKEN) Collaboration. Clin Pharmacol Ther. 2016 Jun 3.
    View on PubMed
  8. Hibma JE, Zur AA, Castro RA, Wittwer MB, Keizer RJ, Yee SW, Goswami S, Stocker SL, Zhang X, Huang Y, Brett CM, Savic RM, Giacomini KM. The Effect of Famotidine, a MATE1-Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin. Clin Pharmacokinet. 2016 Jun; 55(6):711-21.
    View on PubMed
  9. Altman RB, Prabhu S, Sidow A, Zook JM, Goldfeder R, Litwack D, Ashley E, Asimenos G, Bustamante CD, Donigan K, Giacomini KM, Johansen E, Khuri N, Lee E, Liang XS, Salit M, Serang O, Tezak Z, Wall DP, Mansfield E, Kass-Hout T. A research roadmap for next-generation sequencing informatics. Sci Transl Med. 2016 Apr 20; 8(335):335ps10.
    View on PubMed
  10. Augustyn E, Finke K, Zur AA, Hansen L, Heeren N, Chien HC, Lin L, Giacomini KM, Colas C, Schlessinger A, Thomas AA. LAT-1 activity of meta-substituted phenylalanine and tyrosine analogs. Bioorg Med Chem Lett. 2016 Jun 1; 26(11):2616-21.
    View on PubMed
  11. Morrissey KM, Stocker SL, Chen EC, Castro RA, Brett CM, Giacomini KM. The Effect of Nizatidine, a MATE2K Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin in Healthy Volunteers. Clin Pharmacokinet. 2016 Apr; 55(4):495-506.
    View on PubMed
  12. Chhibber A, French CE, Yee SW, Gamazon ER, Theusch E, Qin X, Webb A, Papp AC, Wang A, Simmons CQ, Konkashbaev A, Chaudhry AS, Mitchel K, Stryke D, Ferrin TE, Weiss ST, Kroetz DL, Sadee W, Nickerson DA, Krauss RM, George AL, Schuetz EG, Medina MW, Cox NJ, Scherer SE, Giacomini KM, Brenner SE. Transcriptomic variation of pharmacogenes in multiple human tissues and lymphoblastoid cell lines. Pharmacogenomics J. 2016 Feb 9.
    View on PubMed
  13. Chien HC, Zur AA, Maurer TS, Yee SW, Tolsma J, Jasper P, Scott DO, Giacomini KM. Rapid Method To Determine Intracellular Drug Concentrations in Cellular Uptake Assays: Application to Metformin in Organic Cation Transporter 1-Transfected Human Embryonic Kidney 293 Cells. Drug Metab Dispos. 2016 Mar; 44(3):356-64.
    View on PubMed
  14. Altman RB, Khuri N, Salit M, Giacomini KM. Unmet needs: Research helps regulators do their jobs. Sci Transl Med. 2015 Nov 25; 7(315):315ps22.
    View on PubMed
  15. Liang X, Chien HC, Yee SW, Giacomini MM, Chen EC, Piao M, Hao J, Twelves J, Lepist EI, Ray AS, Giacomini KM. Metformin Is a Substrate and Inhibitor of the Human Thiamine Transporter, THTR-2 (SLC19A3). Mol Pharm. 2015 Dec 7; 12(12):4301-10.
    View on PubMed
  16. Temple W, Mendelsohn L, Kim GE, Nekritz E, Gustafson WC, Lin L, Giacomini K, Naranjo A, Van Ryn C, Yanik GA, Kreissman SG, Hogarty M, Matthay KK, DuBois SG. Vesicular monoamine transporter protein expression correlates with clinical features, tumor biology, and MIBG avidity in neuroblastoma: a report from the Children's Oncology Group. Eur J Nucl Med Mol Imaging. 2016 Mar; 43(3):474-81.
    View on PubMed
  17. Yee SW, Lin L, Merski M, Keiser MJ, Gupta A, Zhang Y, Chien HC, Shoichet BK, Giacomini KM. Prediction and validation of enzyme and transporter off-targets for metformin. J Pharmacokinet Pharmacodyn. 2015 Oct; 42(5):463-75.
    View on PubMed
  18. Lin L, Yee SW, Kim RB, Giacomini KM. SLC transporters as therapeutic targets: emerging opportunities. Nat Rev Drug Discov. 2015 Aug; 14(8):543-60.
    View on PubMed
  19. Chen EC, Liang X, Yee SW, Geier EG, Stocker SL, Chen L, Giacomini KM. Targeted disruption of organic cation transporter 3 attenuates the pharmacologic response to metformin. Mol Pharmacol. 2015 Jul; 88(1):75-83.
    View on PubMed
  20. Wen CC, Yee SW, Liang X, Hoffmann TJ, Kvale MN, Banda Y, Jorgenson E, Schaefer C, Risch N, Giacomini KM. Genome-wide association study identifies ABCG2 (BCRP) as an allopurinol transporter and a determinant of drug response. Clin Pharmacol Ther. 2015 May; 97(5):518-25.
    View on PubMed

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