University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
David V. Glidden, PhD

David V. Glidden, PhD

Professor of Biostatistics, UCSF

Research Summary

My work focuses on the prevention and treatment of HIV infection.

I have been involved in studies of HIV prevention (specifically, truvada for PrEP) for over 12 years. I was the statistician for the iPrEx trial -- the first trial to report the efficacy of oral PrEP and worked on the drugs approval by the FDA. My current work involves studies of the global scale-up of PrEP, innovative designs/statistical analyses of new PrEP agents, and pharmacologic markers of PrEP exposure.

I also collaborate on studies on the outcomes of HIV treatment in resource limited settings. In these settings many patients are absent from clinics. This data requires handling several statistical issues including clustering, competing risk/multiple outcomes, time-dependent covariates and informative censoring. My colleagues and I have pioneered sampling based approaches to losses to follow-up which have given rigorous information about treatment outcomes.

I also collaborate for groups in neurology, pediatrics, LGBT health and nephrology and teach in my department's MCR and Ph.D. program.

Education

University of California, Berkeley, CA, BA, 1988, Statistics
University of Washington, Seattle, WA, PhD, 1993, Biostatistics
Harvard University, Boston, MA, Fellowship, 1995, Biostatistics


Professional Experience

  • 1988 - 1993
    University of Washington Research Assistant
  • 1993 - 1995
    Harvard University Research Fellow
  • 1995 - 1997
    Harvard University Research Associate
  • 1997 - 2003
    University of California, San Francisco Assistant Adjunct Professor
  • 2003 - 2007
    University of California, San Francisco Associate Professor in Residence
  • 2007 -
    University of California, San Francisco Professor in Residence

Honors & Awards

  • 1988
    W.W. Stout Fellowship, Graduate School, University of Washington
  • 1988 - 1990
    Graduate Fellowship Award, Graduate School, University of Washington
  • 1990 - 1993
    National Research Service Award, National Heart, Lung and Blood Institute
  • 1993
    School of Public Health Outstanding Student Citation for Biostatistics, Univ. of Washington
  • 2007
    TICR Award for Excellence in Teaching

Selected Publications

  1. Meyers K, Wu Y, Qian H, Sandfort T, Huang X, Xu J, Zhang J, Xia W, Glidden D, Wu H, Shang H. Interest in Long-Acting Injectable PrEP in a Cohort of Men Who have Sex with Men in China. AIDS Behav. 2018 Apr; 22(4):1217-1227.
    View on PubMed
  2. Glidden DV, Mulligan K, McMahan V, Anderson PL, Guanira J, Chariyalertsak S, Buchbinder SP, Bekker LG, Schechter M, Grinsztejn B, Grant RM. Metabolic Effects of Pre-Exposure Prophylaxis with Co-Formulated Tenofovir Disoproxal Fumarate and Emtricitabine. Clin Infect Dis. 2018 Feb 03.
    View on PubMed
  3. Holmes CB, Sikazwe I, Sikombe K, Eshun-Wilson I, Czaicki N, Beres LK, Mukamba N, Simbeza S, Bolton Moore C, Hantuba C, Mwaba P, Phiri C, Padian N, Glidden DV, Geng E. Estimated mortality on HIV treatment among active patients and patients lost to follow-up in 4 provinces of Zambia: Findings from a multistage sampling-based survey. PLoS Med. 2018 Jan; 15(1):e1002489.
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  4. Hojilla JC, Mehrotra M, Truong HM, Glidden DV, Amico KR, McMahan V, Vlahov D, Chariyalertsak S, Guanira JV, Grant RM. HIV sero disclosure among men who have sex with men and transgender women on HIV pre-exposure prophylaxis. AIDS Care. 2018 Apr; 30(4):466-472.
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  5. Cutrell A, Donnell D, Dunn DT, Glidden DV, Grobler A, Hanscom B, Stancil BS, Meyer RD, Wang R, Cuffe RL. HIV prevention trial design in an era of effective pre-exposure prophylaxis. HIV Clin Trials. 2017 Nov-Dec; 18(5-6):177-188.
    View on PubMed
  6. Glidden DV, Mulligan K, McMahan V, Anderson PL, Guanira J, Chariyalertsak S, Buchbinder SP, Bekker LG, Schechter M, Grinsztejn B, Grant RM. Brief Report: Recovery of Bone Mineral Density After Discontinuation of Tenofovir-Based HIV Pre-exposure Prophylaxis. J Acquir Immune Defic Syndr. 2017 10 01; 76(2):177-182.
    View on PubMed
  7. Semeere A, Freeman E, Wenger M, Glidden D, Bwana M, Kanyesigye M, Asirwa FC, Rotich E, Busakhala N, Oga E, Jedy-Agba E, Kwaghe V, Iregbu K, Adebamowo C, Jaquet A, Dabis F, Phiri S, Bohlius J, Egger M, Yiannoutsos CT, Wools-Kaloustian K, Martin J. Updating vital status by tracking in the community among patients with epidemic Kaposi sarcoma who are lost to follow-up in sub-Saharan Africa. BMC Cancer. 2017 Sep 02; 17(1):611.
    View on PubMed
  8. Perito ER, Ajmera V, Bass NM, Rosenthal P, Lavine JE, Schwimmer JB, Yates KP, Diehl AM, Molleston JP, Murray KF, Scheimann A, Gill R, Glidden D, Aouizerat B. Association Between Cytokines and Liver Histology in Children with Nonalcoholic Fatty Liver Disease. Hepatol Commun. 2017 Sep; 1(7):609-622.
    View on PubMed
  9. Bershetyn A, Odeny TA, Lyamuya R, Nakiwogga-Muwanga A, Diero L, Bwana M, Braitstein P, Somi G, Kambugu A, Bukusi E, Hartogensis W, Glidden DV, Wools-Kaloustian K, Yiannoutsos C, Martin J, Geng EH. The Causal Effect of Tracing by Peer Health Workers on Return to Clinic Among Patients Who Were Lost to Follow-up From Antiretroviral Therapy in Eastern Africa: A "Natural Experiment" Arising From Surveillance of Lost Patients. Clin Infect Dis. 2017 Jun 01; 64(11):1547-1554.
    View on PubMed
  10. Glidden DV, Mayer K, Grant RM. Response to: A double-edged sword: does highly active antiretroviral therapy contribute to syphilis incidence by impairing immunity to Treponema pallidum? Sex Transm Infect. 2017 08; 93(5):313.
    View on PubMed
  11. Rushakoff RJ, Sullivan MM, MacMaster HW, Shah AD, Rajkomar A, Glidden DV, Kohn MA. Association Between a Virtual Glucose Management Service and Glycemic Control in Hospitalized Adult Patients: An Observational Study. Ann Intern Med. 2017 May 02; 166(9):621-627.
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  12. Christopoulos KA, Hartogensis W, Glidden DV, Pilcher CD, Gandhi M, Geng EH. Limitations of using the Lorenz curve framework to understand the distribution of population viral load: authors' reply. AIDS. 2017 Mar 13; 31(5):742-743.
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  13. Koss CA, Bacchetti P, Hillier SL, Livant E, Horng H, Mgodi N, Mirembe BG, Gomez Feliciano K, Horn S, Liu AY, Glidden DV, Grant RM, Benet LZ, Louie A, van der Straten A, Chirenje ZM, Marrazzo JM, Gandhi M. Differences in Cumulative Exposure and Adherence to Tenofovir in the VOICE, iPrEx OLE, and PrEP Demo Studies as Determined via Hair Concentrations. AIDS Res Hum Retroviruses. 2017 Mar 02.
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  14. Cederkvist L, Holst KK, Andersen KK, Glidden DV, Frederiksen K, Kjaer SK, Scheike TH. Incorporation of the time aspect into the liability-threshold model for case-control-family data. Stat Med. 2017 May 10; 36(10):1599-1618.
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  15. Christopoulos KA, Hartogensis W, Glidden DV, Pilcher CD, Gandhi M, Geng EH. The Lorenz curve: a novel method for understanding viral load distribution at the population level. AIDS. 2017 Jan 14; 31(2):309-310.
    View on PubMed
  16. Kalema N, Lindan C, Glidden D, Yoo SD, Katamba A, Alfred A, Katagira W, Byanyima P, Musisi E, Kaswabuli S, Ingvar S, Zawedde J, Yoon C, Ayakaka I, Davis JL, Huang L, Worodria W, Cattamanchi A. Predictors and short-term outcomes of recurrent pulmonary tuberculosis, Uganda: a cohort study. S Afr Respir J. 2017; 23(4):106-112.
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  17. Ku E, Lipkowitz MS, Appel LJ, Parsa A, Gassman J, Glidden DV, Smogorzewski M, Hsu CY. Strict blood pressure control associates with decreased mortality risk by APOL1 genotype. Kidney Int. 2017 02; 91(2):443-450.
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  18. Castillo-Mancilla J, Seifert S, Campbell K, Coleman S, McAllister K, Zheng JH, Gardner EM, Liu A, Glidden DV, Grant R, Hosek S, Wilson CM, Bushman LR, MaWhinney S, Anderson PL. Emtricitabine-Triphosphate in Dried Blood Spots as a Marker of Recent Dosing. Antimicrob Agents Chemother. 2016 Nov; 60(11):6692-6697.
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  19. Glidden DV, Anderson PL, Grant RM. Pharmacology supports on-demand PrEP. Lancet HIV. 2016 09; 3(9):e405-e406.
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  20. Gandhi M, Glidden DV, Mayer K, Schechter M, Buchbinder S, Grinsztejn B, Hosek S, Casapia M, Guanira J, Bekker LG, Louie A, Horng H, Benet LZ, Liu A, Grant RM. Association of age, baseline kidney function, and medication exposure with declines in creatinine clearance on pre-exposure prophylaxis: an observational cohort study. Lancet HIV. 2016 Nov; 3(11):e521-e528.
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