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Joe W. Gray, PhD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
gray_joe

Gordon Moore Professor and Chair, Biomedical Engineering, Oregon Health and Science University (OHSU); Director, OHSU Center for Spatial Systems Biomedicine
Emeritus Professor, UCSF, and Visiting Faculty, Lawrence Berkeley National Laboratory
Co-Director, Breast Cancer SPORE

grayjo@ohsu.edu

Phone: (503) 494-6500 (voice)
Lawrence Berkeley Nat'l Laboratory, Life Sciences Division One Cyclotron Road, 977-225A, Berkeley, CA 94720


Additional Websites


Education

Colorado School of Mines, Golden, CO, Prof. Eng., 1968, Physics
Kansas State University, Manhattan, KS, Ph.D., 1972, Physics


Professional Experience

  • (selected positions since 1991)
  • 1991-2011
    Professor of Laboratory Medicine and Radiation Oncology, UCSF, San Francisco, CA
  • 1991-1997
    Director, Division of Molecular Cytometry, Dept. of Lab. Med. UCSF, San Francisco. CA
  • 1992-1998
    Senior Scientist (faculty), Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA
  • 1992-1998
    Director, Resource for Molecular Cytogenetics, LBNL, Berkeley, CA
  • 1995-1997
    Interim Director, UCSF Cancer Center, UCSF, San Francisco, CA
  • 1997-2011
    Program Leader; Breast Oncology and Cancer Genetics Research Programs, UCSF Helen Diller Family Comprehensive Cancer Center
  • 2003-2011
    Director, Division of Life Sciences; and Associate Director, Lawrence Berkeley National Laboratory, Berkeley, CA
  • 2011-present
    Gordon Moore Professor and Chair, Biomedical Engineering, Oregon Health and Science University
  • 2011-present
    Director, Oregon Health and Science University Center for Spatial Systems Biomedicine
  • 2011-present
    Emeritus Professor, UCSF
  • 2011-present
    Visiting Faculty, Lawrence Berkeley National Laboratory
  • 2011-present
    Co-Director, Bay Area Breast Cancer SPORE

Honors & Awards

  • Research Award, 13th Radiation Research Society, 1985
  • E.O. Lawrence Award, U.S. Department of Energy, 1986
  • Fellow, American Association for the Advancement of Science, 1996
  • Exceptional Service Award, U.S. Department of Energy, 1997
  • Schiffer Award, Cell Proliferation Society, 1999
  • Boerhaave Professor, Leiden University, the Netherlands, 2000
  • Curt Stern Award, American Society for Human Genetics, 2001
  • SPORE Leadership Award, National SPORE office, 2003
  • Alumni Fellow, Kansas State University, 2005
  • Distinguished Achievement Award, Colorado School of Mines, 2005
  • Doctor of Medicine, Honoris Causa, Tampere University, 2005
  • DOD Innovator Award, 2007
  • Brinker Award for Scientific Distinction: Basic Science, 2007
  • AACR Team Science Award, 2008
  • Stand Up to Cancer Award, American Association for Cancer Research, Entertainment Industry Foundation, 2009
  • Fellow of the American Institute for Medical and Biological Engineering, 2009
  • Fulwyler Award, International Society for for the Advancement of Cytometry, 2010
  • Honor thy Healer Award, Zero Breast Cancer 2010

Selected Publications

  • Neve, R.M., Chin, K., Fridlyand, J., Yeh, J., Baehner, F., Fevr, T., Clark, L., Bayani, N., Coppe, J.P., Tong, F., Speed, T. Spellman, P.T., DeVries, S., Lapuk, A., Wang, N.J., Kuo, W.-L., Stilwell, J.L., Pinkel, D., Albertson, D.G., Waldman, F.M., McCormick, F., Dickson, R.B., Johnson, M.D., Lippman, M., Ethier, S., Gazdar, A., and Gray, J.W. (2006) A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Cancer Cell, 10(6):515-27.
  • Chin, K., DeVries, S., Fridlyand, J., Spellman, P.T., Roydasgupta, R., Kuo, W.-L., Lapuk, A., Neve, R.M., Qian, Z., Ryder, T., Chen, F., Feiler, H., Tokuyasu, T., Kingsley, C., Dairkee, S., Meng, Z., Chew, K., Pinkel, D., Jain, A., Ljung, B.M., Esserman, L., Albertson, D.G., Waldman, F.M., and Gray, J.W. (2006) Genomic and transcriptional aberrations linked to breast cancer pathophysiologies. Cancer Cell, 10(6):529-41.
  • Mirzoeva, O.K., Das, D., Heiser, L.M., Bhattacharya, S., Siwak, D., Gendelman, R., Bayani, N., Wang, N.J., Neve, R.M., Guan, Y., Hu, Z., Knight, Z., Feiler, H.S., Gascard, P., Parvin, B., Spellman, P.T., Shokat, K.M., Wyrobek, A.J., Bissell, M.J., McCormick, F., Kuo, W.L,, Mills, G.B., Gray, J.W., and Korn, W.M. (2009) Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition. Cancer Res., 69(2):565-72. PMC2737189
  • Weigelt, B., Lo, A.T., Park, C.C., Gray, J.W., and Bissell, M.J. (2009) HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironment. Breast Cancer Res. Treat., 2009 Aug 22. [Epub ahead of print]. PMID: 19701706 NIHMSID: 156204
  • Kuo, W.-L., Das, D., Ziyad, S., Bhattacharya, S., Gibb, W.J., Heiser, L.M., Sadanandam, A., Fontenay, G.V., Hu, Z., Wang, N.J., Bayani, N., Feiler, H.S., Neve, R.M., Wyrobek, A.J., Spellman, P.T., Marton, L.J. and Gray, J.W. (2009) A systems analysis of chemosensitivity of breast cancer cells to the polyamine analogue PG-11047. BMC Med., 7:77. PMC2803786
  • Salaita, K., Nair, P.M., Petit, R.S., Neve, R.M., Debopriya, D., Gray, J.W., and Groves, J.T. (2010) Restriction of receptor movement alters cellular response: Physical force sensing by EPHA2. Science, 327(5971):1380-85. PMID: NIHMSID: 192048
  • Han, J., Chang, H., Fontenay, G., Wang, N.J., Gray, J.W., and Parvin, B. (2009) Morphometric subtyping for a panel of breast cancer cell lines. Proc IEEE Int. Symp. Biomed. Imaging, (6):791-794. PMC2791417
  • Lapuk, A., Marr, H., Jakkula, L., Pedro, H., Bhattacharya, S., Purdom, E., Hu, Z., Simpson, K., Pachter, L., Durinck, S., Wang, N., Parvin, B., Fontenay, G., Speed, T., Garbe, J., Stampfer, M., Bayandorian, H., Dorton, S., Clark, T.A., Schweitzer, A., Wyrobek, A., Feiler, H., Spellman, P., Conboy, J., and Gray, J.W. (2010) Exon-level microarray analyses identify alternative splicing programs in breast cancer. Mol. Cancer Res., 8(7): 961-74. PMC2911965
  • Nautiyal, S., Carlton, V.E., Lu, Y., Ireland, J.S., Flaucher, D., Moorhead, M., Gray, J.W., Spellman, P., Mindrinos, M., Berg, P., and Faham, M. (2010) A high throughput method for analyzing methylation of CpGs in targeted genomic regions. Proc. Natl. Acad. Sci. USA, 107(28):12587-92. PMID: 20616066
  • Shayesteh, L., Lu, Y., Kuo, W.-L., Baldocchi, R., Godfrey, T., Collins, C., Pinkel, D., Powell, B., Mills, G.B., and Gray, J.W. (1999) PIK3CA is implicated as an oncogene in ovarian cancer. Nat. Genet., 21(1):99-102.
  • Hodgson, J.G., Malek, T., Bornstein, S., Hariono, S., Ginzinger, D.G., Muller, W.J., and Gray, J.W. (2005) Copy number aberrations in mouse breast tumors reveal loci and genes important in tumorigenic receptor tyrosine kinase signaling. Cancer Res., 65(21):9695-704.
  • Chin, K., de Solorzano, C.O., Knowles, D., Jones, A., Chou, W., Rodriguez, E.G., Kuo, W.-L., Ljung, B.M., Chew, K., Myambo, K., Miranda, M., Krig, S., Garbe, J., Stampfer, M., Yaswen, P., Gray, J.W., and Lockett, S.J. (2004) In situ analyses of genome instability in breast cancer. Nat. Genet., 36(9):984-8.
  • Macrae, M., Neve, R.M., Rodriguez-Viciana, P., Haqq, C., Yeh, J., Chen, C., Gray, J.W., and McCormick, F. (2005) A conditional feedback loop regulates Ras activity through EphA2. Cancer Cell, 8(2):111-8.
  • Chin, L. and Gray, J.W. (2008) Translating insights from the cancer genome into clinical practice. Nature, 452(7187):553-63. PMC2730524
  • Cancer Genome Atlas Research Network. (2008) Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature, 455(7216):1061-8. PMC2671642