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Daphne A. Haas-Kogan, MD


Professor, Vice-Chair for Research, Department of Radiation Oncology, UCSF

Phone: (415) 353-9807 (appts)
Box 1708, UCSF
San Francisco, CA 94143-1708

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Harvard University Cambridge, MA, A.B., 1986, Biochemical Sciences
University of California, San Francisco, M.D., 1991, Medicine
University of California, San Francisco, Postdoctorate, 1993, Radiation Oncology
University of California, San Francisco, Residency, 1997, Radiation Oncology

Professional Experience

  • 1989-1990
    Research Fellow, Laboratory of Dr. J. Michael Bishop, G. W. Hooper Foundation, University of California, San Francisco, CA
  • 1991-1992
    Medical Intern, California Pacific Medical Center, San Francisco, CA
  • 1992-1994
    Postdoctoral Fellow, Laboratory of Dr. Mark Israel, Brain Tumor Research Institute, University of California, San Francisco, CA
  • 1994-1997
    Resident, Department of Radiation Oncology, University of California, San Francisco, CA.
  • 1996-1997
    Chief Resident, Department of Radiation Oncology, University of California, San Francisco, CA
  • 1997-2003
    Assistant Professor, Dept. of Radiation Oncology, University of California, San Francisco, CA
  • 2002-2011
    Associate Professor, Dept. of Radiation Oncology, University of California, San Francisco, CA
  • 2003-present
    Vice-Chair for Research, Dept. of Radiation Oncology, University of California, San Francisco, CA
  • 2011-present
    Professor, Dept. of Radiation Oncology, University of California, San Francisco, CA

Honors & Awards

  • 1985
    Joseph L. Barrett Award for Teaching, Harvard University
  • 1986
    Phi Beta Kappa, Harvard University
  • 1986
    Thomas T. Hoopes Prize awarded to Senior Honors Thesis
  • 1986
    Summa cum laude awarded to Senior Honors Thesis
  • 1991
    Alpha Omega Alpha, University of California, San Francisco
  • 1995
    ASTRO Basic Scientist Research Award
  • 1995
    Junior Scientist Travel Award, 10th International Congress of Radiation Research
  • 1995
    American Cancer Society Clinical Oncology Fellowship
  • 1997
    Radiological Society of North America Scholar Award
  • 1998
    UCSF Dean representative to Association of American Medical Colleges Professional Development Seminar for Junior Women Faculty, Santa Fe, New Mexico.
  • 1999
    Pfizer Scholars Grant for New Faculty.
  • 1999
    First place: CAP competition, General Clinical Research Center National Meeting; Arlington, VA.
  • 1999
    UCSF-Mount Zion Clinical Investigator Award.
  • 2000
    American Society of Clinical Oncology Career Development Award.
  • 2002
    Henry J. Kaiser Award for Excellence in Teaching, UCSF School of Medicine.
  • 2002
    UCSF Nominee, Assoc of American Medical Colleges (AAMC) Humanism in Medicine Award.
  • 2003
    Nominated for Teaching Award, UCSF School of Medicine.
  • 2004
    Nominee: Henry J. Kaiser Award for Excellence in Teaching, UCSF School of Medicine.
  • 2005
    Selected one of Best San Francisco Doctors for San Francisco Magazine, January 2005.
  • 2006
    Alpha Omega Alpha, nominated by Medical Student Class of 2007 for AOA membership in the alumni category at the University of California, San Francisco.
  • 2009-2010
    Mentor: Howard Hughes Medical Institute Research Training Fellowship for Medical Students.
  • 2007-2011
    Best Doctors in America®

Selected Publications

  1. Kreissman SG, Seeger RC, Matthay KK, London WB, Sposto R, Grupp SA, Haas-Kogan DA, Laquaglia MP, Yu AL, Diller L, Buxton A, Park JR, Cohn SL, Maris JM, Reynolds CP, Villablanca JG. Purged versus non-purged peripheral blood stem-cell transplantation for high-risk neuroblastoma (COG A3973): a randomised phase 3 trial. Lancet Oncol. 2013 Sep; 14(10):999-1008.
    View on PubMed
  2. Gibbs IC, Haas-Kogan D, Terezakis S, Kavanagh BD. The subventricular zone neural progenitor cell hypothesis in glioblastoma: epiphany, Trojan Horse, or Cheshire fact? Int J Radiat Oncol Biol Phys. 2013 Jul 15; 86(4):606-8.
    View on PubMed
  3. Cage TA, Samagh SP, Mueller S, Nicolaides T, Haas-Kogan D, Prados M, Banerjee A, Auguste KI, Gupta N. Feasibility, safety, and indications for surgical biopsy of intrinsic brainstem tumors in children. Childs Nerv Syst. 2013 Aug; 29(8):1313-9.
    View on PubMed
  4. Dasgupta T, Haas-Kogan DA. The combination of novel targeted molecular agents and radiation in the treatment of pediatric gliomas. Front Oncol. 2013; 3:110.
    View on PubMed
  5. Mueller S, Sear K, Hills NK, Chettout N, Afghani S, Gastelum E, Haas-Kogan D, Fullerton HJ. Risk of first and recurrent stroke in childhood cancer survivors treated with cranial and cervical radiation therapy. Int J Radiat Oncol Biol Phys. 2013 Jul 15; 86(4):643-8.
    View on PubMed
  6. Phillips JJ, Aranda D, Ellison DW, Judkins AR, Croul SE, Brat DJ, Ligon KL, Horbinski C, Venneti S, Zadeh G, Santi M, Zhou S, Appin CL, Sioletic S, Sullivan LM, Martinez-Lage M, Robinson AE, Yong WH, Cloughesy T, Lai A, Phillips HS, Marshall R, Mueller S, Haas-Kogan DA, Molinaro AM, Perry A. PDGFRA amplification is common in pediatric and adult high-grade astrocytomas and identifies a poor prognostic group in IDH1 mutant glioblastoma. Brain Pathol. 2013 Sep; 23(5):565-73.
    View on PubMed
  7. Mueller S, Bhargava S, Molinaro AM, Yang X, Kolkowitz I, Olow A, Wehmeijer N, Orbach S, Chen J, Matthay KK, Haas-Kogan DA. Poly (ADP-Ribose) polymerase inhibitor MK-4827 together with radiation as a novel therapy for metastatic neuroblastoma. Anticancer Res. 2013 Mar; 33(3):755-62.
    View on PubMed
  8. Raleigh DR, Haas-Kogan DA. Molecular targets and mechanisms of radiosensitization using DNA damage response pathways. Future Oncol. 2013 Feb; 9(2):219-33.
    View on PubMed
  9. Dasgupta T, Haas-Kogan DA, Yang X, Olow A, Yang DX, Gragg A, Orloff LA, Yom SS. Genotype-dependent cooperation of ionizing radiation with BRAF inhibition in BRAF V600E-mutated carcinomas. Invest New Drugs. 2013 Oct; 31(5):1136-41.
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  10. Gajjar A, Packer RJ, Foreman NK, Cohen K, Haas-Kogan D, Merchant TE. Children's Oncology Group's 2013 blueprint for research: central nervous system tumors. Pediatr Blood Cancer. 2013 Jun; 60(6):1022-6.
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  11. Seo Y, Gustafson WC, Dannoon SF, Nekritz EA, Lee CL, Murphy ST, VanBrocklin HF, Hernandez-Pampaloni M, Haas-Kogan DA, Weiss WA, Matthay KK. Tumor dosimetry using [124I]m-iodobenzylguanidine microPET/CT for [131I]m-iodobenzylguanidine treatment of neuroblastoma in a murine xenograft model. Mol Imaging Biol. 2012 Dec; 14(6):735-42.
    View on PubMed
  12. Tinkle CL, Haas-Kogan D. Hepatocellular carcinoma: natural history, current management, and emerging tools. Biologics. 2012; 6:207-19.
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  13. Mueller S, Phillips J, Onar-Thomas A, Romero E, Zheng S, Wiencke JK, McBride SM, Cowdrey C, Prados MD, Weiss WA, Berger MS, Gupta N, Haas-Kogan DA. PTEN promoter methylation and activation of the PI3K/Akt/mTOR pathway in pediatric gliomas and influence on clinical outcome. Neuro Oncol. 2012 Sep; 14(9):1146-52.
    View on PubMed
  14. Cage TA, Mueller S, Haas-Kogan D, Gupta N. High-grade gliomas in children. Neurosurg Clin N Am. 2012 Jul; 23(3):515-23.
    View on PubMed
  15. Schoenfeld A, Pekmezci M, Barnes MJ, Tihan T, Gupta N, Lamborn KR, Banerjee A, Mueller S, Chang S, Berger MS, Haas-Kogan D. The superiority of conservative resection and adjuvant radiation for craniopharyngiomas. J Neurooncol. 2012 May; 108(1):133-9.
    View on PubMed
  16. Venkatesh HS, Chaumeil MM, Ward CS, Haas-Kogan DA, James CD, Ronen SM. Reduced phosphocholine and hyperpolarized lactate provide magnetic resonance biomarkers of PI3K/Akt/mTOR inhibition in glioblastoma. Neuro Oncol. 2012 Mar; 14(3):315-25.
    View on PubMed
  17. Pejavar S, Polley MY, Rosenberg-Wohl S, Chennupati S, Prados MD, Berger MS, Banerjee A, Gupta N, Haas-Kogan D. Pediatric intracranial ependymoma: the roles of surgery, radiation and chemotherapy. J Neurooncol. 2012 Jan; 106(2):367-75.
    View on PubMed
  18. Mueller S, Yang X, Sottero TL, Gragg A, Prasad G, Polley MY, Weiss WA, Matthay KK, Davidoff AM, DuBois SG, Haas-Kogan DA. Cooperation of the HDAC inhibitor vorinostat and radiation in metastatic neuroblastoma: efficacy and underlying mechanisms. Cancer Lett. 2011 Jul 28; 306(2):223-9.
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  19. More SS, Itsara M, Yang X, Geier EG, Tadano MK, Seo Y, Vanbrocklin HF, Weiss WA, Mueller S, Haas-Kogan DA, Dubois SG, Matthay KK, Giacomini KM. Vorinostat increases expression of functional norepinephrine transporter in neuroblastoma in vitro and in vivo model systems. Clin Cancer Res. 2011 Apr 15; 17(8):2339-49.
    View on PubMed
  20. Polishchuk AL, Dubois SG, Haas-Kogan D, Hawkins R, Matthay KK. Response, survival, and toxicity after iodine-131-metaiodobenzylguanidine therapy for neuroblastoma in preadolescents, adolescents, and adults. Cancer. 2011 Sep 15; 117(18):4286-93.
    View on PubMed

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