Dexter Hadley, MD, PhD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Dexter Hadley, MD, PhD

Assistant Professor, Department of Pediatrics, UCSF

Dexter.Hadley@ucsf.edu

Phone: (415) 514-0513
Box 0110, UCSF
San Francisco, CA 94143

UCSF Profiles

Cancer Center Membership

Program Member » Non-aligned

Research Summary

Dr. Hadley's expertise is in translating big data into precision medicine and digital health. His background is in genomics and computational biology and he has training in clinical pathology. His research generates, annotates, and ultimately reasons over large multi-modal data stores to identify novel biomarkers and potential therapeutics for disease. His early work resulted in a successful precision medicine clinical trial for ADHD (ClinicalTrials.gov Identifier: NCT02286817) for a first-in-class, non-stimulant neuromodulator to be targeted across the neuropsychiatric disease spectrum. More recently, his laboratory was funded by the NIH Big Data to Knowledge initiative to develop the stargeo.org online portal to crowd-source annotations of open genomics big data that allows users to discover the functional genes and biological pathways that are defective in disease. In addition to his genomics work, he develops state-of-the-art data driven models of clinical intelligence that drive clinical applications to more precisely screen, diagnose, and manage disease. Towards this end, he has been repeatedly recognized by UCSF with various awards including the inaugural UCSF Marcus Award for Precision Medicine to develop a digital learning health system to use smartphones to screen for skin cancer as well as a pilot award in precision imaging to better screen mammograms for invasive breast cancer. In general, the end point of his work is rapid proofs of concept clinical trials in humans that translate into better patient outcomes and reduced morbidity and mortality across the spectrum of disease.

Education

New College of Florida, Sarasota, FL, B.S., 05/1999, Natural Science
University of Pennsylvania, Philadelphia, PA, M.S.E., 05/2003, Systems Engineering
University of Pennsylvania, Philadelphia, PA, Ph.D., 10/2007, Genomics & Comp Bio
University of Pennsylvania, Philadelphia, PA, M.D., 05/2009, Medicine
Hospital of the University of Pennsylvania, PA, Internship, 06/2010, General Surgery
Stanford University, Stanford, CA, Residency, 06/2013, Clinical Pathology


Professional Experience

  • 07/10 – 06/12
    Lead Clinical Genomics Analyst, Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA
  • 09/13 – 03/15
    Research Associate, Division of Systems Medicine, Department of Pediatrics, Stanford University, Stanford, CA
  • 04/15 – present
    Assistant Professor, Department of Pediatrics, UCSF, San Francisco, CA

Honors & Awards

  • 2000
    Center of Excellence Fellowship
  • 2000
    NIH/NHLBI Fellowship
  • 2007
    AAAS Excellence in Science Scholar
  • 2003 – 2007
    NIH Computational Biology Training Grant
  • 2009
    Penn Biotech Group Entrepreneurial Competition Winner
  • 2011
    NIH LRP award for outstanding pediatric clinical research
  • 2015
    AMIA Design Challenge Competition Winner

Selected Publications

  1. Paik H, Chen B, Sirota M, Hadley D, Butte AJ. Integrating Clinical Phenotype and Gene Expression Data to Prioritize Novel Drug Uses. CPT Pharmacometrics Syst Pharmacol. 2016 Nov 14.
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  2. Hinney A, Kesselmeier M, Jall S, Volckmar AL, Föcker M, Antel J. Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index. Mol Psychiatry. 2017 Feb; 22(2):192-201.
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  3. Desai A, Connolly JJ, March M, Hou C, Chiavacci R, Kim C, Lyon G, Hadley D, Hakonarson H. Systematic data-querying of large pediatric biorepository identifies novel Ehlers-Danlos Syndrome variant. BMC Musculoskelet Disord. 2016; 17(1):80.
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  4. Mohamad Omar Hadied, Osama El-Sayed, Bilal Zaidi, Jihad Al-Jabban, Shuaib Raza, Imad Al-Jabban, James Pan, Tej Azad, Dexter Hadley. Open Forum Infectious Diseases . Novel Meta-Analyses of Microarray Data First Step Toward Malaria Disease Signature Development. 2015; 2(suppl 1):1608.
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  5. Osama El-Sayed, Omar Hadied, Jihad Al-Jabban, Bilal Zaidi, Shuaib Raza, James Pan, Tej Azad, Imad Al-Jabban, Dexter Hadley. Meta-Analyses of Microarray Data Reveals Interferon Signaling Is Top Canonical Pathway in Human Immunodeficiency Virus (HIV). 2015; 2(suppl 1):1608.
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  6. Chen B, Sirota M, Fan-Minogue H, Hadley D, Butte AJ. Relating hepatocellular carcinoma tumor samples and cell lines using gene expression data in translational research. BMC Med Genomics. 2015; 8 Suppl 2:S5.
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  7. Hadley D, et al.. Human Computation of Big Data in Biomedicine: Making STAR annotations for large scale functional characterization of disease. 2015.
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  8. Hadley D, et al.. Search Tag Analyze Resource (STAR): An online platform to crowd-source genomic disease signatures from open digital samples. 2015.
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  9. Fan-Minogue H, ... Hadley D., et al.. GenePool: A Cloud-Based Platform for Interactive Visualization and Integrative Analysis of Genomics and Clinical Data. 2015.
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  10. Waggoner JJ, Sahadeo NS, Brown A, Mohamed-Hadley A, Hadley D, Carrington L, Carrington CV, Pinsky BA. Improved serotype-specific dengue virus detection in Trinidad and Tobago using a multiplex, real-time RT-PCR. Diagn Microbiol Infect Dis. 2015 Feb; 81(2):105-6.
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  11. Hadley D, Wu ZL, Kao C, Kini A, Mohamed-Hadley A, Thomas K, Vazquez L, Qiu H, Mentch F, Pellegrino R, Kim C, Connolly J. The impact of the metabotropic glutamate receptor and other gene family interaction networks on autism. Nat Commun. 2014; 5:4074.
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  12. Cousminer DL, Stergiakouli E, Berry DJ, Ang W, Groen-Blokhuis MM, Körner A, Siitonen N, Ntalla I, Marinelli M, Perry JR, Kettunen J, Jansen R, Surakka I, Timpson NJ, Ring S, Mcmahon G, Power C, Wang C, Kähönen M, Viikari J, Lehtimäki T, Middeldorp CM, Hulshoff Pol HE, Neef M, Weise S, Pahkala K, Niinikoski H, Zeggini E, Panoutsopoulou K, Bustamante M, Penninx BW. Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty. Hum Mol Genet. 2014 Aug 15; 23(16):4452-64.
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  13. Matsunami N, Hensel CH, Baird L, Stevens J, Otterud B, Leppert T, Varvil T, Hadley D, Glessner JT, Pellegrino R, Kim C, Thomas K, Wang F, Otieno FG, Ho K, Christensen GB, Li D, Prekeris R, Lambert CG, Hakonarson H, Leppert MF. Identification of rare DNA sequence variants in high-risk autism families and their prevalence in a large case/control population. Mol Autism. 2014; 5(1):5.
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  14. Sleiman P, Wang D, Glessner J, Hadley D, Gur RE, Cohen N, Li Q, Hakonarson H. GWAS meta analysis identifies TSNARE1 as a novel Schizophrenia / Bipolar susceptibility locus. Sci Rep. 2013; 3:3075.
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  15. Cousminer DL, Berry DJ, Timpson NJ, Ang W, Thiering E, Byrne EM, Taal HR, Huikari V, Bradfield JP, Kerkhof M, Groen-Blokhuis MM, Kreiner-Møller E, Marinelli M, Holst C, Leinonen JT, Perry JR, Surakka I, Pietiläinen O, Kettunen J, Anttila V, Kaakinen M, Sovio U, Pouta A, Das S, Lagou V, Power C, Prokopenko I, Evans DM, Kemp JP, St Pourcain B, Ring S, Palotie A, Kajantie E, Osmond C, Lehtimäki T, Viikari JS, Kähönen M, Warrington NM, Lye SJ, Palmer LJ, Tiesler CM, Flexeder C, Montgomery GW, Medland SE, Hofman A, Hakonarson H, Guxens M, Bartels M, Salomaa V. Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. Hum Mol Genet. 2013 Jul 1; 22(13):2735-47.
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  16. Matsunami N, Hadley D, Hensel CH, Christensen GB, Kim C, Frackelton E, Thomas K, da Silva RP, Stevens J, Baird L, Otterud B, Ho K, Varvil T, Leppert T, Lambert CG, Leppert M, Hakonarson H. Identification of rare recurrent copy number variants in high-risk autism families and their prevalence in a large ASD population. PLoS One. 2013; 8(1):e52239.
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  17. Sanna-Cherchi S, Kiryluk K, Burgess KE, Bodria M, Sampson MG, Hadley D, Nees SN, Verbitsky M, Perry BJ, Sterken R, Lozanovski VJ, Materna-Kiryluk A, Barlassina C, Kini A, Corbani V, Carrea A, Somenzi D, Murtas C, Ristoska-Bojkovska N, Izzi C, Bianco B, Zaniew M, Flogelova H, Weng PL, Kacak N, Giberti S, Gigante M, Arapovic A, Drnasin K, Caridi G, Curioni S, Allegri F, Ammenti A, Ferretti S, Goj V, Bernardo L, Jobanputra V, Chung WK, Lifton RP, Sanders S, State M, Clark LN, Saraga M, Padmanabhan S, Dominiczak AF, Foroud T, Gesualdo L, Gucev Z, Allegri L, Latos-Bielenska A, Cusi D, Scolari F, Tasic V, Hakonarson H, Ghiggeri GM, Gharavi AG. Copy-number disorders are a common cause of congenital kidney malformations. Am J Hum Genet. 2012 Dec 7; 91(6):987-97.
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  18. Bradfield JP, Taal HR, Timpson NJ, Scherag A, Lecoeur C, Warrington NM, Hypponen E, Holst C, Valcarcel B, Thiering E, Salem RM, Schumacher FR, Cousminer DL, Sleiman PM, Zhao J, Berkowitz RI, Vimaleswaran KS, Jarick I, Pennell CE, Evans DM, St Pourcain B, Berry DJ, Mook-Kanamori DO, Hofman A, Rivadeneira F, Uitterlinden AG, van Duijn CM, van der Valk RJ, de Jongste JC, Postma DS, Boomsma DI, Gauderman WJ, Hassanein MT, Lindgren CM, Mägi R, Boreham CA, Neville CE, Moreno LA, Elliott P, Pouta A, Hartikainen AL, Li M, Raitakari O, Lehtimäki T, Eriksson JG, Palotie A, Dallongeville J, Das S, Deloukas P, McMahon G, Ring SM, Kemp JP, Buxton JL, Blakemore AI, Bustamante M, Guxens M, Hirschhorn JN, Gillman MW, Kreiner-Møller E, Bisgaard H, Gilliland FD, Heinrich J, Wheeler E, Barroso I, O'Rahilly S, Meirhaeghe A, Sørensen TI, Power C, Palmer LJ, Hinney A, Widen E, Farooqi IS, McCarthy MI, Froguel P, Meyre D, Hebebrand J, Jarvelin MR, Jaddoe VW, Smith GD, Hakonarson H, Grant SF. A genome-wide association meta-analysis identifies new childhood obesity loci. Nat Genet. 2012 May; 44(5):526-31.
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  19. Taal HR, St Pourcain B, Thiering E, Das S, Mook-Kanamori DO, Warrington NM, Kaakinen M, Kreiner-Møller E, Bradfield JP, Freathy RM, Geller F, Guxens M, Cousminer DL, Kerkhof M, Timpson NJ, Ikram MA, Beilin LJ, Bønnelykke K, Buxton JL, Charoen P, Chawes BL, Eriksson J, Evans DM, Hofman A, Kemp JP, Kim CE, Klopp N, Lahti J, Lye SJ, McMahon G, Mentch FD, Müller-Nurasyid M, O'Reilly PF, Prokopenko I, Rivadeneira F, Steegers EA, Sunyer J, Tiesler C, Yaghootkar H. Common variants at 12q15 and 12q24 are associated with infant head circumference. Nat Genet. 2012 May; 44(5):532-8.
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  20. Ikram MA, Fornage M, Smith AV, Seshadri S, Schmidt R, Debette S, Vrooman HA, Sigurdsson S, Ropele S, Taal HR, Mook-Kanamori DO, Coker LH, Longstreth WT, Niessen WJ, DeStefano AL, Beiser A, Zijdenbos AP, Struchalin M, Jack CR, Rivadeneira F, Uitterlinden AG, Knopman DS, Hartikainen AL, Pennell CE, Thiering E, Steegers EA, Hakonarson H, Heinrich J, Palmer LJ, Jarvelin MR, McCarthy MI, Grant SF, St Pourcain B, Timpson NJ, Smith GD, Sovio U. Common variants at 6q22 and 17q21 are associated with intracranial volume. Nat Genet. 2012 May; 44(5):539-44.
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