University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Michael R. Harrison, MD

Michael R. Harrison, MD

Professor, Department of Surgery (Pediatric Surgery), UCSF

Research Summary

As founding director of UCSF's Fetal Treatment Center, Harrison is internationally renowned for his expertise and innovation in pediatric and fetal surgery. Widely regarded as the "father of fetal surgery," Harrison, over the last three decades, concentrated his lab efforts to establish the developmental pathophysiology of correctable birth defects in animal models, and develop and test techniques for fetal intervention (including maternal-fetal anesthesia), prior to clinical application. Now, a decade into the new century, the pioneering spirit continues and manifests in a new direction of innovation-i.e., original thought combined with the first presentation of work that leads to a milestone in the advancement of surgical care. Harrison's current research focuses on pediatric orphan device development, particularly devices employing the use of magnetic force. His most recent work has earned him one of three prestigious stimulus grants awarded by the FDA to fund a pediatric device consortium at UCSF.

Over the last six years, the Harrison lab has explored the use of magnetic force to correct a variety of problems and deformities. They began with the Magnetic Mini-Mover Procedure (3MP) to correct pectus excavatum in children, and tested the Magnimplant device in an FDA-sponsored trial with an FDA-approved IDE. In addition to the Magnetic Mini-Mover, they are continuing to develop and test:

- The Magnamosis device which uses specially designed magnets to create a secure compression anastomosis between any two pieces of intestine

- A magnetic internal-control contraction device to assist in laparoscopic surgery

- The Robo-Implant device, which uses magnetic coupling to activate and lengthen and shorten an internal growing rod for treatment of scoliosis and for limb lengthening.

In the course of developing and testing these magnetic implant treatments, the Harrison Lab most recently began considering the use of magnetic force for the treatment of obstructive sleep apnea. The concept is simple. In the same way that they implant a titanium-encased rare earth magnet on the sternum in patients with pectus excavatum and then, later, the patients use an external magnet orthotic device to gradually pull the 'sunken chest' out, Harrison et al are considering the possibility of implanting a similar magnet on the hyoid bone and letting the patient use an external orthotic magnetic device to pull the hyoid forward and open the airway when sleeping. With this approach the patient is unaffected while awake during the day and the implanted device is essentially invisible.

Under the auspices of the UCSF Pediatric Device Consortium, the mission of the Harrison Lab is to facilitate the development, production, and distribution of pediatric medical devices by:

- Encouraging innovation and connecting qualified individuals with pediatric device ideas with potential manufacturers

- Mentoring and managing pediatric device projects through the development process, including product identification, prototype design, device development, and marketing

- Connecting innovators and physicians to existing Federal and non-Federal resources

- Assessing the scientific and medical merit of proposed pediatric device projects

- Providing assistance and advice as needed on business development, personnel training, prototype development, and post-marketing needs

Selected Publications

  1. Tucker MD, Zhu J, Marin D, Gupta RT, Gupta S, Berry WR, Ramalingam S, Zhang T, Harrison M, Wu Y, Healy P, Lisi S, George DJ, Armstrong AJ. Pembrolizumab in men with heavily treated metastatic castrate-resistant prostate cancer. Cancer Med. 2019 Jul 03.
    View on PubMed
  2. Ellison EC, Ponsky JL, Harrison MR, McGrath MH, Angelos P, Krummel TM. Presidential Forum. Ann Surg. 2019 Jul 03.
    View on PubMed
  3. Winkler SM, Harrison MR, Messersmith PB. Biomaterials in fetal surgery. Biomater Sci. 2019 May 17.
    View on PubMed
  4. Lebares CC, Graves CE, Lin MY, Fidelman N, Cello J, Harrison MR, Rogers S. Endoscopic Magnetic Compression Anastomosis For Small Bowel Bypass in a High Operative Risk Setting. Surg Laparosc Endosc Percutan Tech. 2019 May 15.
    View on PubMed
  5. Meleis L, Moore R, Inman BA, Harrison MR. Retrospective analysis of the efficacy and safety of neoadjuvant gemcitabine and cisplatin in muscle-invasive bladder cancer. J Oncol Pharm Pract. 2019 May 12; 1078155219845434.
    View on PubMed
  6. Muensterer OJ, Sterlin A, Oetzmann von Sochaczewski C, Lindner A, Heimann A, Balus A, Dickmann J, Nuber M, Patel VH, Manfredi MA, Jennings RW, Smithers CJ, Fauza DO, Harrison MR. An experimental study on magnetic esophageal compression anastomosis in piglets. J Pediatr Surg. 2019 May 11.
    View on PubMed
  7. Holl EK, McNamara MA, Healy P, Anand M, Concepcion RS, Breland CD, Dumbudze I, Tutrone R, Shore N, Armstrong AJ, Harrison M, Wallace JA, Wu Y, George DJ. Prolonged PSA stabilization and overall survival following sipuleucel-T monotherapy in metastatic castration-resistant prostate cancer patients. Prostate Cancer Prostatic Dis. 2019 Apr 12.
    View on PubMed
  8. Oetzmann von Sochaczewski C, Lindner A, Heimann A, Balus A, Patel VH, Harrison MR, Muensterer OJ. Beyond Magnamosis: A Method to Test Sutureless Esophageal Anastomotic Devices in Living Swine by Creating an Esophageal Bypass Loop for Natural Oral Nutrition. J Laparoendosc Adv Surg Tech A. 2019 Mar 18.
    View on PubMed
  9. Martínez Chanzá N, Xie W, Asim Bilen M, Dzimitrowicz H, Burkart J, Geynisman DM, Balakrishnan A, Bowman IA, Jain R, Stadler W, Zakharia Y, Narayan V, Beuselinck B, McKay RR, Tripathi A, Pachynski R, Hahn AW, Hsu J, Shah SA, Lam ET, Rose TL, Mega AE, Vogelzang N, Harrison MR, Mortazavi A, Plimack ER, Vaishampayan U, Hammers H, George S, Haas N, Agarwal N, Pal SK, Srinivas S, Carneiro BA, Heng DYC, Bosse D, Choueiri TK, Harshman LC. Cabozantinib in advanced non-clear-cell renal cell carcinoma: a multicentre, retrospective, cohort study. Lancet Oncol. 2019 Apr; 20(4):581-590.
    View on PubMed
  10. Ho XN, Wee IJ, Syn N, Harrison M, Wilson L, Choong AM. The endovascular repair of blunt traumatic thoracic aortic injury in Asia: A systematic review and meta-analysis. Vascular. 2019 Apr; 27(2):213-223.
    View on PubMed
  11. Labriola MK, Batich KA, Zhu J, McNamara MA, Harrison MR, Armstrong AJ, George DJ, Zhang T. Immunotherapy Is Changing First-Line Treatment of Metastatic Renal-Cell Carcinoma. Clin Genitourin Cancer. 2019 Feb 05.
    View on PubMed
  12. Khouri MG, Harrison MR. Look and You Will Find It: Practical Considerations for Improving Multidisciplinary Management of Androgen-Deprivation Therapy-Induced Cardiometabolic Toxicity. J Oncol Pract. 2018 Oct; 14(10):591-593.
    View on PubMed
  13. Bruns NE, Glenn IC, Craner DR, Schomisch SJ, Harrison MR, Ponsky TA. Magnetic compression anastomosis (magnamosis) in a porcine esophagus: Proof of concept for potential application in esophageal atresia. J Pediatr Surg. 2019 Mar; 54(3):429-433.
    View on PubMed
  14. Gopalakrishna A, Chang A, Longo TA, Fantony JJ, Harrison MR, Wischmeyer PE, Inman BA. Dietary patterns and health-related quality of life in bladder cancer survivors. Urol Oncol. 2018 10; 36(10):469.e21-469.e29.
    View on PubMed
  15. Ramalingam S, George DJ, Harrison MR. How we treat brain metastases in metastatic renal cell carcinoma. Clin Adv Hematol Oncol. 2018 Feb; 16(2):110-114.
    View on PubMed
  16. Brousell SC, Fantony JJ, Van Noord MG, Harrison MR, Inman BA. Vinflunine for the treatment of advanced or metastatic transitional cell carcinoma of the urothelial tract: an evidence-based review of safety, efficacy, and place in therapy. Core Evid. 2018; 13:1-12.
    View on PubMed
  17. Ashok M, Hung D, Rojas-Smith L, Halpern MT, Harrison M. Framework for Research on Implementation of Process Redesigns. Qual Manag Health Care. 2018 Jan/Mar; 27(1):17-23.
    View on PubMed
  18. Humeniuk MS, Gupta RT, Healy P, McNamara M, Ramalingam S, Harrison M, George D, Zhang T, Wu Y, Armstrong AJ. Platinum sensitivity in metastatic prostate cancer: does histology matter? Prostate Cancer Prostatic Dis. 2018 04; 21(1):92-99.
    View on PubMed
  19. Toselli L, Martinez-Ferro M, Cervio G, Kwiat D, Imamura-Ching J, Graves CE, Gaston B, Harrison M. Magnetic Compression Anastomosis (Magnamosis) for Functional Undiversion of Ileostomy in Pediatric Patients. J Laparoendosc Adv Surg Tech A. 2017 Dec; 27(12):1314-1317.
    View on PubMed
  20. Frisoli TM, Nowak R, Evans KL, Harrison M, Alani M, Varghese S, Rahman M, Noll S, Flannery KR, Michaels A, Tabaku M, Jacobsen G, McCord J. Henry Ford HEART Score Randomized Trial: Rapid Discharge of Patients Evaluated for Possible Myocardial Infarction. Circ Cardiovasc Qual Outcomes. 2017 Oct; 10(10).
    View on PubMed

Go to UCSF Profiles, powered by CTSI