University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Akiko Hata, PhD

Akiko Hata, PhD

Professor, Dept. of Biochemistry & Biophysics, Cardiovascular Research Institute, UCSF

Cancer Center Program Memberships

Cancer Genetics

Education

Tokyo University of Science, Tokyo, Japan, B.A., 03/1988, Pharmacy
University of Tokyo, Tokyo, Japan, M.S., 03/1990, Biochemistry
Rockefeller University, NY, Ph.D., 06/1995, Cell Biology


Professional Experience

  • 1995-1998
    Post-doctoral Research Fellow, Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY
  • 1999-2000
    Research Associate, Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY
  • 2000-2008
    Assistant Professor of Biochemistry, Tufts University School of Medicine, Boston, MA
  • 2000-2008
    Assistant Professor of Medicine, Tufts University School of Medicine, Boston, MA
  • 2000-present
    Director of Molecular Signaling Laboratory, Molecular Cardiology Research Institute, Tufts-New England Medical Center, Boston, MA
  • 2008-2011
    Associate Professor of Biochemistry, Tufts University School of Medicine, Boston, MA
  • 2008-2011
    Associate Professor of Medicine, Tufts University School of Medicine, Boston, MA
  • 2011-present
    Professor of Dept. of Biochemistry & Biophysics, Cardiovascular Research Institute, University of California San Francisco

Selected Publications

  1. Jiang X, Hawkins JS, Lee J, Lizama CO, Bos FL, Zape JP, Ghatpande P, Peng Y, Louie J, Lagna G, Zovein AC, Hata A. Let-7 microRNA-dependent control of leukotriene signaling regulates the transition of hematopoietic niche in mice. Nat Commun. 2017 Jul 25; 8(1):128.
    View on PubMed
  2. Kashima R, Redmond PL, Ghatpande P, Roy S, Kornberg TB, Hanke T, Knapp S, Lagna G, Hata A. Hyperactive locomotion in a Drosophila model is a functional readout for the synaptic abnormalities underlying fragile X syndrome. Sci Signal. 2017 May 02; 10(477).
    View on PubMed
  3. Celona B, Dollen JV, Vatsavayai SC, Kashima R, Johnson JR, Tang AA, Hata A, Miller BL, Huang EJ, Krogan NJ, Seeley WW, Black BL. Suppression of C9orf72 RNA repeat-induced neurotoxicity by the ALS-associated RNA-binding protein Zfp106. Elife. 2017 Jan 10; 6.
    View on PubMed
  4. Hata A, Chen YG. TGF-ß Signaling from Receptors to Smads. Cold Spring Harb Perspect Biol. 2016 Sep 01; 8(9).
    View on PubMed
  5. Kashima R, Roy S, Ascano M, Martinez-Cerdeno V, Ariza-Torres J, Kim S, Louie J, Lu Y, Leyton P, Bloch KD, Kornberg TB, Hagerman PJ, Hagerman R, Lagna G, Hata A. Augmented noncanonical BMP type II receptor signaling mediates the synaptic abnormality of fragile X syndrome. Sci Signal. 2016 Jun 07; 9(431):ra58.
    View on PubMed
  6. Kang H, Hata A. Quantitative Real-Time PCR Analysis of MicroRNAs and Their Precursors Regulated by TGF-ß Signaling. Methods Mol Biol. 2016; 1344:313-23.
    View on PubMed
  7. Hata A, Kashima R. Dysregulation of microRNA biogenesis machinery in cancer. Crit Rev Biochem Mol Biol. 2016 May-Jun; 51(3):121-34.
    View on PubMed
  8. Morrell NW, Bloch DB, ten Dijke P, Goumans MJ, Hata A, Smith J, Yu PB, Bloch KD. Targeting BMP signalling in cardiovascular disease and anaemia. Nat Rev Cardiol. 2016 Feb; 13(2):106-20.
    View on PubMed
  9. Nazer B, Ghahghaie F, Kashima R, Khokhlova T, Perez C, Crum L, Matula T, Hata A. Therapeutic Ultrasound Promotes Reperfusion and Angiogenesis in a Rat Model of Peripheral Arterial Disease. Circ J. 2015; 79(9):2043-9.
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  10. Kang H, Hata A. The role of microRNAs in cell fate determination of mesenchymal stem cells: balancing adipogenesis and osteogenesis. BMB Rep. 2015 Jun; 48(6):319-23.
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  11. Cushing L, Costinean S, Xu W, Jiang Z, Madden L, Kuang P, Huang J, Weisman A, Hata A, Croce CM, Lü J. Disruption of miR-29 Leads to Aberrant Differentiation of Smooth Muscle Cells Selectively Associated with Distal Lung Vasculature. PLoS Genet. 2015 May; 11(5):e1005238.
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  12. Hata A, Lieberman J. Dysregulation of microRNA biogenesis and gene silencing in cancer. Sci Signal. 2015 Mar 17; 8(368):re3.
    View on PubMed
  13. Hata A, Kang H. Functions of the bone morphogenetic protein signaling pathway through microRNAs (review). Int J Mol Med. 2015 Mar; 35(3):563-8.
    View on PubMed
  14. Kim S, Hata A, Kang H. Down-regulation of miR-96 by bone morphogenetic protein signaling is critical for vascular smooth muscle cell phenotype modulation. J Cell Biochem. 2014 May; 115(5):889-95.
    View on PubMed
  15. Nazer B, Gerstenfeld EP, Hata A, Crum LA, Matula TJ. Cardiovascular applications of therapeutic ultrasound. J Interv Card Electrophysiol. 2014 Apr; 39(3):287-94.
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  16. Chang J, Davis-Dusenbery BN, Kashima R, Jiang X, Marathe N, Sessa R, Louie J, Gu W, Lagna G, Hata A. Acetylation of p53 stimulates miRNA processing and determines cell survival following genotoxic stress. EMBO J. 2013 Dec 11; 32(24):3192-205.
    View on PubMed
  17. Arora P, Wu C, Khan AM, Bloch DB, Davis-Dusenbery BN, Ghorbani A, Spagnolli E, Martinez A, Ryan A, Tainsh LT, Kim S, Rong J, Huan T, Freedman JE, Levy D, Miller KK, Hata A, Del Monte F, Vandenwijngaert S, Swinnen M, Janssens S, Holmes TM, Buys ES, Bloch KD, Newton-Cheh C, Wang TJ. Atrial natriuretic peptide is negatively regulated by microRNA-425. J Clin Invest. 2013 Aug; 123(8):3378-82.
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  18. Sessa R, Hata A. Role of microRNAs in lung development and pulmonary diseases. Pulm Circ. 2013 Apr; 3(2):315-28.
    View on PubMed
  19. Blahna MT, Hata A. Regulation of miRNA biogenesis as an integrated component of growth factor signaling. Curr Opin Cell Biol. 2013 Apr; 25(2):233-40.
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  20. Hata A. Functions of microRNAs in cardiovascular biology and disease. Annu Rev Physiol. 2013; 75:69-93.
    View on PubMed

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