University of California San Francisco
Helen Diller Family Comprehensive Cancer Center

Walter Holleran, PharmD

Adjunct Professor, Dept. of Dermatology, UCSF

Cancer Center Program Memberships

Affiliate Member

Selected Publications

  1. Zhang L, Ferreyros M, Feng W, Hupe M, Crumrine DA, Chen J, Elias PM, Holleran WM, Niswander L, Hohl D, Williams T, Torchia EC, Roop DR. Defects in Stratum Corneum Desquamation Are the Predominant Effect of Impaired ABCA12 Function in a Novel Mouse Model of Harlequin Ichthyosis. PLoS One. 2016; 11(8):e0161465.
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  2. Park K, Ikushiro H, Seo HS, Shin KO, Kim YI, Kim JY, Lee YM, Yano T, Holleran WM, Elias P, Uchida Y. ER stress stimulates production of the key antimicrobial peptide, cathelicidin, by forming a previously unidentified intracellular S1P signaling complex. Proc Natl Acad Sci U S A. 2016 Mar 08; 113(10):E1334-42.
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  3. Tiganescu A, Hupe M, Jiang YJ, Celli A, Uchida Y, Mauro TM, Bikle DD, Elias PM, Holleran WM. UVB induces epidermal 11ß-hydroxysteroid dehydrogenase type 1 activity in vivo. Exp Dermatol. 2015 May; 24(5):370-6.
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  4. Kim YI, Park K, Kim JY, Seo HS, Shin KO, Lee YM, Holleran WM, Elias PM, Uchida Y. An endoplasmic reticulum stress-initiated sphingolipid metabolite, ceramide-1-phosphate, regulates epithelial innate immunity by stimulating ß-defensin production. Mol Cell Biol. 2014 Dec; 34(24):4368-78.
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  5. Park K, Kim YI, Shin KO, Seo HS, Kim JY, Mann T, Oda Y, Lee YM, Holleran WM, Elias PM, Uchida Y. The dietary ingredient, genistein, stimulates cathelicidin antimicrobial peptide expression through a novel S1P-dependent mechanism. J Nutr Biochem. 2014 Jul; 25(7):734-40.
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  6. Tiganescu A, Hupe M, Uchida Y, Mauro T, Elias PM, Holleran WM. Increased glucocorticoid activation during mouse skin wound healing. J Endocrinol. 2014 Apr; 221(1):51-61.
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  7. Elias PM, Gruber R, Crumrine D, Menon G, Williams ML, Wakefield JS, Holleran WM, Uchida Y. Formation and functions of the corneocyte lipid envelope (CLE). Biochim Biophys Acta. 2014 Mar; 1841(3):314-8.
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  8. Loiseau N, Obata Y, Moradian S, Sano H, Yoshino S, Aburai K, Takayama K, Sakamoto K, Holleran WM, Elias PM, Uchida Y. Altered sphingoid base profiles predict compromised membrane structure and permeability in atopic dermatitis. J Dermatol Sci. 2013 Dec; 72(3):296-303.
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  9. Youm JK, Park K, Uchida Y, Chan A, Mauro TM, Holleran WM, Elias PM. Local blockade of glucocorticoid activation reverses stress- and glucocorticoid-induced delays in cutaneous wound healing. Wound Repair Regen. 2013 Sep-Oct; 21(5):715-22.
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  10. Bourguignon LY, Wong G, Xia W, Man MQ, Holleran WM, Elias PM. Selective matrix (hyaluronan) interaction with CD44 and RhoGTPase signaling promotes keratinocyte functions and overcomes age-related epidermal dysfunction. J Dermatol Sci. 2013 Oct; 72(1):32-44.
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  11. Park K, Elias PM, Hupe M, Borkowski AW, Gallo RL, Shin KO, Lee YM, Holleran WM, Uchida Y. Resveratrol stimulates sphingosine-1-phosphate signaling of cathelicidin production. J Invest Dermatol. 2013 Aug; 133(8):1942-9.
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  12. Park K, Elias PM, Shin KO, Lee YM, Hupe M, Borkowski AW, Gallo RL, Saba J, Holleran WM, Uchida Y. A novel role of a lipid species, sphingosine-1-phosphate, in epithelial innate immunity. Mol Cell Biol. 2013 Feb; 33(4):752-62.
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  13. Goto-Inoue N, Hayasaka T, Zaima N, Nakajima K, Holleran WM, Sano S, Uchida Y, Setou M. Imaging mass spectrometry visualizes ceramides and the pathogenesis of dorfman-chanarin syndrome due to ceramide metabolic abnormality in the skin. PLoS One. 2012; 7(11):e49519.
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  14. Celli A, Mackenzie DS, Zhai Y, Tu CL, Bikle DD, Holleran WM, Uchida Y, Mauro TM. SERCA2-controlled Ca²+-dependent keratinocyte adhesion and differentiation is mediated via the sphingolipid pathway: a therapeutic target for Darier's disease. J Invest Dermatol. 2012 Apr; 132(4):1188-95.
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  15. Kim H, Kim J, Park J, Kim SH, Uchida Y, Holleran WM, Cho Y. Water extract of gromwell (Lithospermum erythrorhizon) enhances migration of human keratinocytes and dermal fibroblasts with increased lipid synthesis in an in vitro wound scratch model. Skin Pharmacol Physiol. 2012; 25(2):57-64.
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  16. Chan A, Holleran WM, Ferguson T, Crumrine D, Goker-Alpan O, Schiffmann R, Tayebi N, Ginns EI, Elias PM, Sidransky E. Skin ultrastructural findings in type 2 Gaucher disease: diagnostic implications. Mol Genet Metab. 2011 Dec; 104(4):631-6.
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  17. Park K, Elias PM, Oda Y, Mackenzie D, Mauro T, Holleran WM, Uchida Y. Regulation of cathelicidin antimicrobial peptide expression by an endoplasmic reticulum (ER) stress signaling, vitamin D receptor-independent pathway. J Biol Chem. 2011 Sep 30; 286(39):34121-30.
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  18. Rodriguez-Martin M, Martin-Ezquerra G, Man MQ, Hupe M, Youm JK, Mackenzie DS, Cho S, Trullas C, Holleran WM, Radek KA, Elias PM. Expression of epidermal CAMP changes in parallel with permeability barrier status. J Invest Dermatol. 2011 Nov; 131(11):2263-70.
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  19. Martin-Ezquerra G, Man MQ, Hupe M, Rodriguez-Martin M, Youm JK, Trullas C, Mackenzie DS, Radek KA, Holleran WM, Elias PM. Psychological stress regulates antimicrobial peptide expression by both glucocorticoid and ß-adrenergic mechanisms. Eur J Dermatol. 2011 May; 21 Suppl 2:48-51.
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  20. Glenn DJ, Wang F, Nishimoto M, Cruz MC, Uchida Y, Holleran WM, Zhang Y, Yeghiazarians Y, Gardner DG. A murine model of isolated cardiac steatosis leads to cardiomyopathy. Hypertension. 2011 Feb; 57(2):216-22.
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