Dai Horiuchi, PhD


Assistant Professional Researcher, Dept of Cell & Tissue Biology, UC San Francisco

Phone: (415) 476-4187
UCSF Box 0512
San Francisco, CA 94143-0512

View on UCSF Profiles

Cancer Center Membership

Associate Member » Breast Oncology» Cancer Genetics


Kobe University, Japan B.S. 2000 Biochemistry & Mol. Biol.
Indiana University, Bloomington Ph.D. 2007 Cell biology & Genetics
University of California, San Francisco Post-doc 2013 Cancer Biology

Professional Experience

  • 1999-2000
    Undergraduate researcher, Kobe University Biosignal Research Center, Japan
  • 2000-2001
    Graduate Student, Program in Neuroscience, Indiana University, Bloomington, IN
  • 2002-2007
    Graduate Student, Department of Biology, Indiana University, Bloomington, IN
  • 2007-2013
    Post-Doctoral Fellow, Department of Medicine, University of California, San Francisco
  • 2012-present
    Founding member & board of directors, Science Policy Group at UCSF
  • 2013-present
    Assistant Professional Researcher IV, University of California, San Francisco

Honors & Awards

  • 2004-2005
    American Heart Association Pre-doctoral Fellowship Award (0410070Z)
  • 2006
    American Heart Association Pre-doctoral Fellowship Award (0610055Z);
  • 2009-2011
    California Breast Cancer Research Program Post-Doctoral Fellowship Award (15FB-0006)
  • 2010
    Best-in-Show Poster Presentation Award, The Bay Area Breast Oncology Program Retreat, San Francisco, CA.
  • 2010 Invited speaker, AACR Special Conference on Cell Death Mechanisms and Cancer Therapy, San Diego, CA.
  • 2011-2012
    California Breast Cancer Research Program, Innovative, Developmental, and Exploratory Award (17IB-0024), co-written with Andrei Goga, M.D., Ph.D.
  • 2013-2018
    NIH/NCI K99/R00 Pathway to Independence Award (1K99CA175700)

Selected Publications

  1. Martins MM, Zhou AY, Corella A, Horiuchi D, Yau C, Rakshandehroo T, Gordan JD, Levin RS, Johnson J, Jascur J, Shales M, Sorrentino A, Cheah J, Clemons PA, Shamji AF, Schreiber SL, Krogan NJ, Shokat KM, McCormick F, Goga A, Bandyopadhyay S. Linking Tumor Mutations to Drug Responses via a Quantitative Chemical-Genetic Interaction Map. Cancer Discov. 2015 Feb; 5(2):154-67.
    View on PubMed
  2. Horiuchi D, Anderton B, Goga A. Taking on challenging targets: making MYC druggable. Am Soc Clin Oncol Educ Book. 2014; e497-502.
    View on PubMed
  3. Balko JM, Giltnane JM, Wang K, Schwarz LJ, Young CD, Cook RS, Owens P, Sanders ME, Kuba MG, Sánchez V, Kurupi R, Moore PD, Pinto JA, Doimi FD, Gómez H, Horiuchi D, Goga A, Lehmann BD, Bauer JA, Pietenpol JA, Ross JS, Palmer GA, Yelensky R, Cronin M, Miller VA, Stephens PJ, Arteaga CL. Molecular profiling of the residual disease of triple-negative breast cancers after neoadjuvant chemotherapy identifies actionable therapeutic targets. Cancer Discov. 2014 Feb; 4(2):232-45.
    View on PubMed
  4. Horiuchi D, Huskey NE, Kusdra L, Wohlbold L, Merrick KA, Zhang C, Creasman KJ, Shokat KM, Fisher RP, Goga A. Chemical-genetic analysis of cyclin dependent kinase 2 function reveals an important role in cellular transformation by multiple oncogenic pathways. Proc Natl Acad Sci U S A. 2012 Apr 24; 109(17):E1019-27.
    View on PubMed
  5. Horiuchi D, Kusdra L, Huskey NE, Chandriani S, Lenburg ME, Gonzalez-Angulo AM, Creasman KJ, Bazarov AV, Smyth JW, Davis SE, Yaswen P, Mills GB, Esserman LJ, Goga A. MYC pathway activation in triple-negative breast cancer is synthetic lethal with CDK inhibition. J Exp Med. 2012 Apr 9; 209(4):679-96.
    View on PubMed
  6. Merrick KA, Wohlbold L, Zhang C, Allen JJ, Horiuchi D, Huskey NE, Goga A, Shokat KM, Fisher RP. Switching Cdk2 on or off with small molecules to reveal requirements in human cell proliferation. Mol Cell. 2011 Jun 10; 42(5):624-36.
    View on PubMed
  7. Huang TH, Wu F, Loeb GB, Hsu R, Heidersbach A, Brincat A, Horiuchi D, Lebbink RJ, Mo YY, Goga A, McManus MT. Up-regulation of miR-21 by HER2/neu signaling promotes cell invasion. J Biol Chem. 2009 Jul 3; 284(27):18515-24.
    View on PubMed
  8. Barkus RV, Klyachko O, Horiuchi D, Dickson BJ, Saxton WM. Identification of an axonal kinesin-3 motor for fast anterograde vesicle transport that facilitates retrograde transport of neuropeptides. Mol Biol Cell. 2008 Jan; 19(1):274-83.
    View on PubMed
  9. Horiuchi D, Collins CA, Bhat P, Barkus RV, Diantonio A, Saxton WM. Control of a kinesin-cargo linkage mechanism by JNK pathway kinases. Curr Biol. 2007 Aug 7; 17(15):1313-7.
    View on PubMed
  10. Pilling AD, Horiuchi D, Lively CM, Saxton WM. Kinesin-1 and Dynein are the primary motors for fast transport of mitochondria in Drosophila motor axons. Mol Biol Cell. 2006 Apr; 17(4):2057-68.
    View on PubMed
  11. Horiuchi D, Barkus RV, Pilling AD, Gassman A, Saxton WM. APLIP1, a kinesin binding JIP-1/JNK scaffold protein, influences the axonal transport of both vesicles and mitochondria in Drosophila. Curr Biol. 2005 Dec 6; 15(23):2137-41.
    View on PubMed
  12. Sato K, Kimoto M, Kakumoto M, Horiuchi D, Iwasaki T, Tokmakov AA, Fukami Y. Adaptor protein Shc undergoes translocation and mediates up-regulation of the tyrosine kinase c-Src in EGF-stimulated A431 cells. Genes Cells. 2000 Sep; 5(9):749-64.
    View on PubMed

Go to UCSF Profiles, powered by CTSI